LightNews — News, ranked by scholars

@dlingenfelter.bsky.social

SARS-CoV-2 harms your vascular system. It disrupts the ACE2 receptors on your endothelial cells, leading to a cascade of harmful effects:

These mechanisms underline how SARS-CoV-2-induced endothelial dysfunction can cause severe cardiovascular complications.

Citations:
[1] https://www.nature.com/articles/s41598-023-41115-3
[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC9604693/
[3] https://pubmed.ncbi.nlm.nih.gov/33626315/
[4] https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1281263/full
[5] https://academic.oup.com/cardiovascres/article/120/1/34/7504580
[6] https://pmc.ncbi.nlm.nih.gov/articles/PMC7301835/
[7] https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1360364/full
[8] https://www.science.org/doi/10.1126/science.add2962

February 10, 2025 at 11:46 PM

Hao Yin

@haoyin.bsky.social

What are Markers of arterial adventitial fibroblast?
PDGFRA
DPEP1

3 fibroblast subsets
CD55+
LOX+
CXCL14+

CD55+ adventitial fibroblasts are enriched in thoracic aorta & carotid artery, but rare in other large arteries

#CardiovascRes 2023
academic.oup.com/cardiovascre...

January 28, 2026 at 8:43 PM

Hao Yin

@haoyin.bsky.social

Heart #Lymphangiogenesis

"Endogenous lymphangiogenesis⬇️TAC-induced 🫀 inflammation & perivascular fibrosis, delaying #HeartFailure development in C57BL/6 but not in Balb/c🐭"

anti-VEGFR3 Ab B6🐭
⏫perivasc fibrosis
⏫Mφ NK B

@hfpef-diva.bsky.social #CardiovascRes 2023
academic.oup.com/cardiovascre...

May 26, 2025 at 12:05 PM

Hao Yin

@haoyin.bsky.social

PRMT5 di-methylates H3R8 & H4R3▶️
⏬Myocardin-dependent #SmoothMuscleCell contractile gene transcription
⏫SMC proliferation/migration & intimal hyperplasia in injured🐭carotid artery

PRMT5 (& PRMT4) ⬆️in PDGBB-treated SMC &👤coronary #Atherosclerosis

#CardiovascRes 2023
academic.oup.com/cardiovascre...

November 22, 2025 at 8:22 PM

Hao Yin

@haoyin.bsky.social

#Atherosclerosis Epitranscriptomics

Mettl3-YTHDF3⏫m6A-MTRFA mRNA in SMCs➡️
⏫cholesterol-induced Mφ-like phenotype

SMC Mettl3 KO🐭+HFD AAV-PCSK9➡️
⏬Lesion burden, necrotic core, Mφ
👉Abolishes SMC contribution to lesion!
👉Reverted by AAV9-SM22-MRTFA

#CardiovascRes 2025
academic.oup.com/cardiovascre...

October 30, 2025 at 8:23 PM

Hao Yin

@haoyin.bsky.social

#SmoothMuscleCell m6A Epitranscriptomics

METTL3 as a direct target gene of YY1

METTL3-IGF2BP1 stabilizes MYH11 MYLK2 TGFβ2 mRNAs

SMC Yy1 or Mettl3 KO🐭
⏬vasoconstriction
↔️vasorelaxation

AAV-SM22-METTL2 iv ⏫arterial contractility of SMC Yy1 KO🐭

#CardiovascRes 2025
academic.oup.com/cardiovascre...

October 24, 2025 at 6:55 PM

Hao Yin

@haoyin.bsky.social

miR-26b as a repressor #AorticMedialCalcification

⏬Aortic Fibroblast BMP4 to #SmoothMuscleCell SMAD1 (direct target gene of miR-26) signaling

miR-26b KO➡️spontaneous aortic calcification
+ #EndothelialCell SMC Fibroblast states scRNAseq

#CardiovascRes 2025
academic.oup.com/cardiovascre...

April 28, 2026 at 12:01 PM

Hao Yin

@haoyin.bsky.social

Protein Arginine Methyltransferase 5 as a negative epigenetic regulator of SRF/Myocardin-mediated contractile phenotype of Smooth Muscle Cell

PRMT5 ⏫H3R8me2 H3R4me2

SMC Prmt5 KO🐭; Lenti-shPRMT5; EPZ015666 (PRMT5i)▶️
⏬Neointima in injured carotid

#CardiovascRes 2023
academic.oup.com/cardiovascre...

July 3, 2026 at 11:05 AM

Hao Yin

@haoyin.bsky.social

PRMT5 methylates & stabilizes KLF4 protein▶️
⏫#SmoothMuscleCell proliferation/migration & intimal hyperplasia in injured🐭carotid artery

Evidence from #SmoothMuscleCell PRMT5 KO🐭 & Lentiviral PRMT5

PRMT5⬆️ in👤carotid stenosis & PDGF-BB-treated SMC

#CardioVascRes 2023
academic.oup.com/cardiovascre...

November 20, 2025 at 8:10 PM

Hao Yin

@haoyin.bsky.social

Periaortic Lymphatic Vascular Dysfunction (density & drainage) in Thoracic Aortic Dissection

Evidence🐭+BAPN
Prox1-CreERT2:Vegfr3 f/f
Tracheobronchial lymph node removal
hVEGF-C156S i.p.
-/+ AMD3100 CXCRi✅

Lymphatic vessel density ⬇️in 👤TAD

#CardiovascRes 2025
academic.oup.com/cardiovascre...

May 10, 2026 at 11:31 AM

Hao Yin

@haoyin.bsky.social

#AngiotensinConvertingEnzyme as a major regulator of Macrophage Lipid Metabolism
+a potential role of PPARα

ACE 10/10 mice are resistant to #Atherosclerosis, with ⏫M2-like CD206+IL10+ACE+ macrophages

So ACEi can exacerbate #Atherosclerosis???😧
#CardiovascRes 2023
academic.oup.com/cardiovascre...

June 27, 2024 at 11:56 AM

Chairman of the ESC Task Force Environment and Cardiologist

@tmuenzel28.bsky.social

Almost 20% of all #CVD #deaths are due to #environment ! This manuscript is a wakeup call !https://academic.oup.com/cardiovascres/advance-article-abstract/doi/10.1093/cvr/cvaf119/8230112?utm_source=advanceaccess&utm_campaign=cardiovascres&utm_medium=email

August 14, 2025 at 6:04 PM

Hao Yin

@haoyin.bsky.social

αSMA+ #SmoothMuscleCell-TRAP;Ldlr−/−;ApoB100/100🐭▶️SMC Translatome in #Atherosclerosis

Novel atherosclerosis proteins
Spink5
Atp1a4
Gm13293
Hs6st2
Itih4
Smim3
Pcdh11x
No EndMT trait detected

#CardiovascRes 2024
academic.oup.com/cardiovascre...

February 16, 2024 at 6:48 AM

Hao Yin

@haoyin.bsky.social

#AlternativeSplicing #SmoothMuscleCell

RBPMS, coordinating with RBFOX2, mediates splicing events of SMC contractile, focal adhesion & actin cytoskeleton genes

234 skipped exon events shared by high-level RBPMS overexpression in hESC adult aorta

#CardiovascRes 2024
academic.oup.com/cardiovascre...

October 17, 2024 at 6:56 PM

David it Up!

@david.notesforfriends.com

endothelial dysfunction: direct or ... https://academic.oup.com/cardiovascres/article/120/1/34/7504580
[5] Endothelial cells and blood vessels are major targets for COVID-19 ... https://pmc.ncbi.nlm.nih.gov/articles/PMC8771611/
[6] Long COVID 19 Syndrome: Is It Related to Microcirculation (17/19)

October 21, 2024 at 4:26 PM

Hao Yin

@haoyin.bsky.social

#SmoothMuscleCell MMP3 mediates #ArterialCalcification in mice+Vitamin D3 (How?🧐)

MMP3 is the only MMP upregulated in calcifying rat aortic SMCs (Pi/Ca2+)

Raul Guzman lab #CardiovascRes 2024
academic.oup.com/cardiovascre...

April 4, 2024 at 8:11 PM

Hao Yin

@haoyin.bsky.social

Microvascular dysmorphogenesis in BMP9 KO 129/Ola🐭

👉Liver 25~30 wk
⬆️Proliferation of hepatocytes & non-parenchymal cells

👉Kidney 17 wk
⬆️Glomerular capillary size
⬆️Renal fibrosis
⬇️Podocyte

👉 #ArterioVenousMalformation in Liver/Intestine/Uterus

#CardiovascRes 2024
academic.oup.com/cardiovascre...

June 1, 2026 at 11:06 AM

Hao Yin

@haoyin.bsky.social

Fibroblast TGFβ signaling in systolic & diastolic🫀functions

Protective▶️Lean 🐭
Pathogenic▶️Diabetic db/db🐭

Evidence from
Fibroblast Tgfbr2 or Smad3 KO🐭

Speckle-tracking echo
👉Peak systolic/diastolic longitudinal endocardial/epicardial strain

#CardiovascRes 2024
academic.oup.com/cardiovascre...

February 8, 2026 at 1:31 PM

Hao Yin

@haoyin.bsky.social

Transcriptional driver ZBTB11 of #Cardiomyocyte degeneration (#Autophagy #Apoptosis) in PKP2 #ArrhythmogenicCardiomyopathy

Tomo-seq
RNAseq of 214 100-μm cryosections of👤LV wall
Epicardium-to-Endocardium🤠

#SpatialTranscriptomics

#CardiovascRes 2022
academic.oup.com/cardiovascre...

January 17, 2024 at 5:28 AM

Hao Yin

@haoyin.bsky.social

Pericytes in the brain & heart: functional roles & response to ischaemia & reperfusion

"pericyte-mediated capillary constriction plays a key role in restricting blood flow after ischaemia"

Also in #SkeletalMuscle, Kidney or Diabetic Islets?😆

#CardiovascRes 2024
academic.oup.com/cardiovascre...

September 17, 2024 at 11:04 AM

Hao Yin

@haoyin.bsky.social

Genetic (p16-3MR) vs Pharmacological (ABT263) #Senolysis in ApoE-/-🐭#Atherosclerosis

p16-3MR: No benefits
ABT263:⏬lesion👉senolyis+leukocyte depletion

Proliferating Mφ are also p16+;SAβGal+
🧐#Senescence in situ?

Martin Bennett lab #CardiovascRes 2022
academic.oup.com/cardiovascre...

November 8, 2023 at 8:22 PM

LIMES-Institut Bonn

@limes-bonn.bsky.social

New paper out: #Macrophage recruitment is a hallmark of non-syndromic #myxomatous #mitral #valve #disease. #CardiovascRes @univ-nantes.fr @unibonn.bsky.social #MassLab #Inflammation; shorturl.at/5Q2kA

August 18, 2026 at 5:50 AM

BioMassSpec

@realbiomassspec.bsky.social

Integrated proteomics identifies troponin I isoform switch as a regulator of a sarcomere-metabolism axis during cardiac regeneration #CardiovascRes #MassSpec academic.oup.com/cardiovascre...