Archaea the hornets of the microbial world. Discuss.
www.biorxiv.org/content/10.6...
TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria if you are a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.
www.biorxiv.org/content/10.6...
TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria if you are a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.
A Bactericidal Phospholipase from Archaea
Archaea kill bacteria, at least on occasion. The molecular underpinnings of these lethal interactions are barely understood. Here, we describe cinquedea, an α/β hydrolase secreted by the halophilic ar...
www.biorxiv.org
June 11, 2026 at 8:56 AM
Archaea the hornets of the microbial world. Discuss.
www.biorxiv.org/content/10.6...
TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria if you are a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.
www.biorxiv.org/content/10.6...
TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria if you are a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.
Archaea are the hornets of the microbial world. Discuss.
www.biorxiv.org/content/10.6...
TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria for a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.
www.biorxiv.org/content/10.6...
TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria for a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.
www.biorxiv.org
June 11, 2026 at 9:54 AM
Archaea are the hornets of the microbial world. Discuss.
www.biorxiv.org/content/10.6...
TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria for a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.
www.biorxiv.org/content/10.6...
TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria for a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.
How does the plasma #membrane preserve its #lipid identity under stress? The Baskin and Balla labs report a homeostatic circuit linking PI4P, phosphatidylserine, RhoB, and phospholipase D-driven phosphatidic acid. rupress.org/jcb/article/...
@jeremybaskin.bsky.social
@jeremybaskin.bsky.social
June 26, 2026 at 4:30 PM
How does the plasma #membrane preserve its #lipid identity under stress? The Baskin and Balla labs report a homeostatic circuit linking PI4P, phosphatidylserine, RhoB, and phospholipase D-driven phosphatidic acid. rupress.org/jcb/article/...
@jeremybaskin.bsky.social
@jeremybaskin.bsky.social
Phospholipase A2 (PLA2) regulates inhibitory amygdala circuitry and is a potential therapeutic target for trauma-related disorders
Phospholipase A2 downregulates inhibitory transmission in the amygdala and impairs fear extinction
Neuropsychopharmacology - Phospholipase A2 downregulates inhibitory transmission in the amygdala and impairs fear extinction
www.nature.com
September 7, 2026 at 5:31 PM
Phospholipase A2 (PLA2) regulates inhibitory amygdala circuitry and is a potential therapeutic target for trauma-related disorders
Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV
Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV
Davidson et al. demonstrated that liver lysosomes orchestrate the metabolic adaptation to cold by rewiring lipid processing. They show that phospholipase A2 group XV (PLA2G15) breaks down bis(monoacylglycerol)phosphate (BMP) lipids to shift lysosomal function and metabolism in response to direct transcription factor EB regulation.
dlvr.it
May 14, 2025 at 3:42 PM
Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV
every game at the geoff keighley shows is a soulslike called Graves of the Graveborn or a mihoyo style mimic gacha called Phospholipase
January 24, 2026 at 9:37 PM
every game at the geoff keighley shows is a soulslike called Graves of the Graveborn or a mihoyo style mimic gacha called Phospholipase
Check out this new work from @abu-remaileh.bsky.social and coworkers @stanford-chemh.bsky.social, a possible new target for treatment of neurodegenerative disease!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease - Nature
Lysosomal phospholipase PLA2G15 was identified as a physiological BMP hydrolase whose activity depends on unique esterification and stereochemistry of BMP and offers a potential therapeutic targe...
www.nature.com
May 12, 2025 at 12:23 PM
Check out this new work from @abu-remaileh.bsky.social and coworkers @stanford-chemh.bsky.social, a possible new target for treatment of neurodegenerative disease!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CBASS limits phage at no expense
A CBASS type encoding a phospholipase (CapV) effector limits the late stage of phage replication while maintaining Pseudomonas aeruginosa cell viability. CBASS limits packaged phage DNA, reducing virion production
www.cell.com/cell-host-mi...
A CBASS type encoding a phospholipase (CapV) effector limits the late stage of phage replication while maintaining Pseudomonas aeruginosa cell viability. CBASS limits packaged phage DNA, reducing virion production
www.cell.com/cell-host-mi...
CBASS limits bacteriophage production while maintaining cell viability in Pseudomonas aeruginosa
Huiting, Shmidov, et al. report on a CBASS type encoding a phospholipase (CapV) effector
that can successfully limit the late stage of phage replication while maintaining
cell viability, rather than i...
www.cell.com
June 22, 2026 at 4:09 PM
CBASS limits phage at no expense
A CBASS type encoding a phospholipase (CapV) effector limits the late stage of phage replication while maintaining Pseudomonas aeruginosa cell viability. CBASS limits packaged phage DNA, reducing virion production
www.cell.com/cell-host-mi...
A CBASS type encoding a phospholipase (CapV) effector limits the late stage of phage replication while maintaining Pseudomonas aeruginosa cell viability. CBASS limits packaged phage DNA, reducing virion production
www.cell.com/cell-host-mi...
Now online in Cancer Discovery: Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response - by Alexandra Redding, Elda Grabocka, and colleagues doi.org/10.1158/2159...
March 18, 2025 at 2:32 PM
Now online in Cancer Discovery: Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response - by Alexandra Redding, Elda Grabocka, and colleagues doi.org/10.1158/2159...
The phospholipase PlcP-mediated membrane lipid remodelling is required for the intracellular survival of Burkholderia cenocepacia
#galleria #mellonella
www.sciencedirect.com/science/arti...
#galleria #mellonella
www.sciencedirect.com/science/arti...
The phospholipase PlcP-mediated membrane lipid remodelling is required for the intracellular survival of Burkholderia cenocepacia
Burkholderia cenocepacia is a problematic pathogen that infects people with cystic fibrosis and can cause fatal "cepacia syndrome". B. cenocepacia inf…
www.sciencedirect.com
September 30, 2026 at 6:22 AM
The phospholipase PlcP-mediated membrane lipid remodelling is required for the intracellular survival of Burkholderia cenocepacia
#galleria #mellonella
www.sciencedirect.com/science/arti...
#galleria #mellonella
www.sciencedirect.com/science/arti...
Archaea are the hornets of the microbial world. Discuss.
www.biorxiv.org/content/10.6...
TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria for a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.
Archaea are the hornets of the microbial world. Discuss.
www.biorxiv.org/content/10.6...
TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria for a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.
www.biorxiv.org
June 11, 2026 at 9:20 AM
Archaea are the hornets of the microbial world. Discuss.
www.biorxiv.org/content/10.6...
TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria for a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.
Archaea are the hornets of the microbial world. Discuss.
www.biorxiv.org/content/10.6...
TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria for a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.
We are only beginning to understand the breadth of enzyme diversity in the archaeal world. Here's an example of how an archaeon can deploy a phospholipase to kill certain bacteria...
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
June 11, 2026 at 10:44 AM
We are only beginning to understand the breadth of enzyme diversity in the archaeal world. Here's an example of how an archaeon can deploy a phospholipase to kill certain bacteria...
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
A Bactericidal Phospholipase from Archaea https://www.biorxiv.org/content/10.64898/2026.06.10.730825v1
June 11, 2026 at 4:17 AM
A Bactericidal Phospholipase from Archaea https://www.biorxiv.org/content/10.64898/2026.06.10.730825v1
Fantastic study out today by superstar postdoc @aakritijain.bsky.social! It identifies the unresolved function of LyLAP, a protein associated with poor prognosis in PDAC. It is not a phospholipase but a membrane protein protease! Happy that I could help through our untargeted lipidomics platform
SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...
www.science.org
March 28, 2025 at 12:57 AM
Fantastic study out today by superstar postdoc @aakritijain.bsky.social! It identifies the unresolved function of LyLAP, a protein associated with poor prognosis in PDAC. It is not a phospholipase but a membrane protein protease! Happy that I could help through our untargeted lipidomics platform
New tools open new biology...
🧪#chembio in action!
We are happy to have made a small contribution to this great work by Pavel and his fantastic co-worker Laura on the role of AMPylation for 5’-3’ exonuclease phospholipase D3 (PLD3) regulation - VERY important for neurodegenerative diseases! 🥳
🧪#chembio in action!
We are happy to have made a small contribution to this great work by Pavel and his fantastic co-worker Laura on the role of AMPylation for 5’-3’ exonuclease phospholipase D3 (PLD3) regulation - VERY important for neurodegenerative diseases! 🥳
Proteoforms matter! We show how AMPylation impacts PLD3 proteolytic processing and catalytic activity. Congratulations to Laura Hoffmann and thanks to all collaborators @jaelab.bsky.social, @v-hornung.bsky.social, @hellmichgroup.bsky.social and Wei Xiang lab! www.biorxiv.org/content/10.1...
AMPylation regulates PLD3 processing
The 5’-3’ exonuclease phospholipase D3 (PLD3) is a single-pass transmembrane protein undergoing sequential post-translational modifications (PTM) by N -glycosylation, AMPylation and proteolytic cleava...
www.biorxiv.org
January 16, 2025 at 12:54 PM
New tools open new biology...
🧪#chembio in action!
We are happy to have made a small contribution to this great work by Pavel and his fantastic co-worker Laura on the role of AMPylation for 5’-3’ exonuclease phospholipase D3 (PLD3) regulation - VERY important for neurodegenerative diseases! 🥳
🧪#chembio in action!
We are happy to have made a small contribution to this great work by Pavel and his fantastic co-worker Laura on the role of AMPylation for 5’-3’ exonuclease phospholipase D3 (PLD3) regulation - VERY important for neurodegenerative diseases! 🥳
#Ceramide transfer protein regulates G-protein coupled phospholipase signalling in #photoreceptors. New study from Shirish Mishra, Padinjat Raghu @rpadinjat.bsky.social and colleagues @ncbsbangalore.bsky.social:
rupress.org/jcb/article/...
#Neuroscience #Membrane #lipid #Genetics #Drosophila
rupress.org/jcb/article/...
#Neuroscience #Membrane #lipid #Genetics #Drosophila
September 8, 2026 at 8:30 PM
#Ceramide transfer protein regulates G-protein coupled phospholipase signalling in #photoreceptors. New study from Shirish Mishra, Padinjat Raghu @rpadinjat.bsky.social and colleagues @ncbsbangalore.bsky.social:
rupress.org/jcb/article/...
#Neuroscience #Membrane #lipid #Genetics #Drosophila
rupress.org/jcb/article/...
#Neuroscience #Membrane #lipid #Genetics #Drosophila
Secreted phospholipase A2α generates a pathogen-derived lysophospholipid to signal local immunity https://www.biorxiv.org/content/10.64898/2026.05.15.725072v1
May 18, 2026 at 8:01 AM
Secreted phospholipase A2α generates a pathogen-derived lysophospholipid to signal local immunity https://www.biorxiv.org/content/10.64898/2026.05.15.725072v1
Ceramide transfer protein regulates G-protein–coupled phospholipase signalling in photoreceptors rupress.org/jcb/article-...
Ceramide transfer protein regulates G-protein–coupled phospholipase signalling in photoreceptors
CERT protein regulates the levels of ceramide and PE-Cer in photoreceptor neurons. CERT function is required to maintain the structure of, and protein loca
rupress.org
September 1, 2026 at 5:07 PM
Ceramide transfer protein regulates G-protein–coupled phospholipase signalling in photoreceptors rupress.org/jcb/article-...
Proteoforms matter! We show how AMPylation impacts PLD3 proteolytic processing and catalytic activity. Congratulations to Laura Hoffmann and thanks to all collaborators @jaelab.bsky.social, @v-hornung.bsky.social, @hellmichgroup.bsky.social and Wei Xiang lab! www.biorxiv.org/content/10.1...
AMPylation regulates PLD3 processing
The 5’-3’ exonuclease phospholipase D3 (PLD3) is a single-pass transmembrane protein undergoing sequential post-translational modifications (PTM) by N -glycosylation, AMPylation and proteolytic cleava...
www.biorxiv.org
January 16, 2025 at 12:44 PM
Proteoforms matter! We show how AMPylation impacts PLD3 proteolytic processing and catalytic activity. Congratulations to Laura Hoffmann and thanks to all collaborators @jaelab.bsky.social, @v-hornung.bsky.social, @hellmichgroup.bsky.social and Wei Xiang lab! www.biorxiv.org/content/10.1...
OUT NOW: Structural insights into tecovirimat antiviral activity and poxvirus resistance
@institutpasteur.bsky.social #microsky
www.nature.com/articles/s41...
@institutpasteur.bsky.social #microsky
www.nature.com/articles/s41...
Structural insights into tecovirimat antiviral activity and poxvirus resistance - Nature Microbiology
Tecovirimat forces dimerization of the poxvirus phospholipase F13 blocking virus spread. Clinical monkeypox virus strains resistant to tecovirimat show mutations in the F13 dimer interface.
www.nature.com
February 12, 2025 at 6:15 PM
OUT NOW: Structural insights into tecovirimat antiviral activity and poxvirus resistance
@institutpasteur.bsky.social #microsky
www.nature.com/articles/s41...
@institutpasteur.bsky.social #microsky
www.nature.com/articles/s41...
Phospholipase A2receptor-positive membranous nephropathy detected by laser microdissection and mass spectrometry in patients negative by immunofluorescence for phospholipase A2receptor on kidney biopsy
doi.org/10.1016/j.kint.2025.04.032
#MedSky #NephSky #membranousnephropathy
doi.org/10.1016/j.kint.2025.04.032
#MedSky #NephSky #membranousnephropathy
June 9, 2025 at 11:38 AM
Phospholipase A2receptor-positive membranous nephropathy detected by laser microdissection and mass spectrometry in patients negative by immunofluorescence for phospholipase A2receptor on kidney biopsy
doi.org/10.1016/j.kint.2025.04.032
#MedSky #NephSky #membranousnephropathy
doi.org/10.1016/j.kint.2025.04.032
#MedSky #NephSky #membranousnephropathy
New paper from the lap spearheaded by Jacob Mackinder (not on here): journals.asm.org/doi/10.1128/...
Regulation of an important P. aeruginosa virulence factor by host-derived sphingosine - and look for more sphingolipid-related content from us later this year
#microsky #bacteria
Regulation of an important P. aeruginosa virulence factor by host-derived sphingosine - and look for more sphingolipid-related content from us later this year
#microsky #bacteria
Sphingosine induction of the Pseudomonas aeruginosa hemolytic phospholipase C/sphingomyelinase (PlcH) | Journal of Bacteriology
PlcH is a secreted phospholipase C/sphingomyelinase that is important for the virulence
of Pseudomonas aeruginosa. Here, we show that sphingosine, which presents itself or as a product of P. aeruginos...
journals.asm.org
February 27, 2024 at 2:27 PM
New paper from the lap spearheaded by Jacob Mackinder (not on here): journals.asm.org/doi/10.1128/...
Regulation of an important P. aeruginosa virulence factor by host-derived sphingosine - and look for more sphingolipid-related content from us later this year
#microsky #bacteria
Regulation of an important P. aeruginosa virulence factor by host-derived sphingosine - and look for more sphingolipid-related content from us later this year
#microsky #bacteria
#PhDone! 🎓 Congratulations Dr Amruta! 🎉
Amruta Naik from Prof Raghu Padinjat's lab successfully defended her thesis!
Scroll 🧵to learn about her work on studying the regulation of phospholipase D (PLD) using Drosophila photoreceptors 👇
(1/5)
@rpadinjat.bsky.social
Amruta Naik from Prof Raghu Padinjat's lab successfully defended her thesis!
Scroll 🧵to learn about her work on studying the regulation of phospholipase D (PLD) using Drosophila photoreceptors 👇
(1/5)
@rpadinjat.bsky.social
March 5, 2025 at 1:13 PM
#PhDone! 🎓 Congratulations Dr Amruta! 🎉
Amruta Naik from Prof Raghu Padinjat's lab successfully defended her thesis!
Scroll 🧵to learn about her work on studying the regulation of phospholipase D (PLD) using Drosophila photoreceptors 👇
(1/5)
@rpadinjat.bsky.social
Amruta Naik from Prof Raghu Padinjat's lab successfully defended her thesis!
Scroll 🧵to learn about her work on studying the regulation of phospholipase D (PLD) using Drosophila photoreceptors 👇
(1/5)
@rpadinjat.bsky.social
Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV: Cell Metabolism www.cell.com/cell-metabol...
Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV
Davidson et al. demonstrated that liver lysosomes orchestrate the metabolic adaptation
to cold by rewiring lipid processing. They show that phospholipase A2 group XV (PLA2G15)
breaks down bis(monoacyl...
www.cell.com
May 14, 2025 at 3:44 PM
Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV: Cell Metabolism www.cell.com/cell-metabol...