Embryonic EMT programs establish proteoglycan expression patterns that persist in adult human tissues #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-11070727/latest
https://www.researchsquare.com/article/rs-11070727/latest
October 8, 2026 at 10:01 AM
Embryonic EMT programs establish proteoglycan expression patterns that persist in adult human tissues #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-11070727/latest
https://www.researchsquare.com/article/rs-11070727/latest
Am I reading well that endocannabinoids are anti-inflammatory?
"Endocannabinoid stimulation shifts activated macrophage outputs away from pro-inflammatory cytokines (Il1b, Ccl2) toward extracellular matrix (ECM) proteoglycan remodeling and intercellular signaling."
www.biorxiv.org/content/10.6...
"Endocannabinoid stimulation shifts activated macrophage outputs away from pro-inflammatory cytokines (Il1b, Ccl2) toward extracellular matrix (ECM) proteoglycan remodeling and intercellular signaling."
www.biorxiv.org/content/10.6...
Metabolomics identifies endocannabinoid system remodeling during obesity associated inflammation in adipose tissue
Visceral white adipose tissue (vAT) is more susceptible than subcutaneous white adipose tissue (scAT) to obesity-associated metaflammation, but the metabolic pathways accompanying this depot specific ...
www.biorxiv.org
September 28, 2026 at 8:47 AM
Am I reading well that endocannabinoids are anti-inflammatory?
"Endocannabinoid stimulation shifts activated macrophage outputs away from pro-inflammatory cytokines (Il1b, Ccl2) toward extracellular matrix (ECM) proteoglycan remodeling and intercellular signaling."
www.biorxiv.org/content/10.6...
"Endocannabinoid stimulation shifts activated macrophage outputs away from pro-inflammatory cytokines (Il1b, Ccl2) toward extracellular matrix (ECM) proteoglycan remodeling and intercellular signaling."
www.biorxiv.org/content/10.6...
RRIDs were included in this in International Journal of Biological Sciences paper. RRIDs improve reproducibility in scientific research. #ReproducibleResearch #OpenScience #OpenResearch
Targeting the heparan sulfate proteoglycan/heparanase axis as a novel therapeutic strategy to drive adipogenesis and block tumor growth of dedifferentiated liposarcoma
Read the full paper: Targeting the heparan sulfate proteoglycan/heparanase axis as a novel therapeutic strategy to drive adipogenesis and block tumor growth of dedifferentiated liposarcoma
doi.org
September 16, 2026 at 7:34 PM
RRIDs were included in this in International Journal of Biological Sciences paper. RRIDs improve reproducibility in scientific research. #ReproducibleResearch #OpenScience #OpenResearch
#Hypertriglyceridaemia-induced acute
#pancreatitis is a complex inflammatory disease that
requires immediate medical attention and supportive
care www.thelancet.com/journals/lan...
#triglycerides
#MedSky #EndoSky #CardioSky #GastroSky
#pancreatitis is a complex inflammatory disease that
requires immediate medical attention and supportive
care www.thelancet.com/journals/lan...
#triglycerides
#MedSky #EndoSky #CardioSky #GastroSky
September 14, 2026 at 11:28 AM
#Hypertriglyceridaemia-induced acute
#pancreatitis is a complex inflammatory disease that
requires immediate medical attention and supportive
care www.thelancet.com/journals/lan...
#triglycerides
#MedSky #EndoSky #CardioSky #GastroSky
#pancreatitis is a complex inflammatory disease that
requires immediate medical attention and supportive
care www.thelancet.com/journals/lan...
#triglycerides
#MedSky #EndoSky #CardioSky #GastroSky
On the cover of #DevSIextracellular:
HNK1-positive enteric neural crest-derived cells (ENCDCs) migrate efficiently on fibronectin-coated stripes, whereas alternating chondroitin sulfate proteoglycan (CSPG)-coated stripes strongly inhibit their migration.
See Szőcs et al. doi.org/10.1242/dev....
HNK1-positive enteric neural crest-derived cells (ENCDCs) migrate efficiently on fibronectin-coated stripes, whereas alternating chondroitin sulfate proteoglycan (CSPG)-coated stripes strongly inhibit their migration.
See Szőcs et al. doi.org/10.1242/dev....
September 10, 2026 at 1:19 PM
On the cover of #DevSIextracellular:
HNK1-positive enteric neural crest-derived cells (ENCDCs) migrate efficiently on fibronectin-coated stripes, whereas alternating chondroitin sulfate proteoglycan (CSPG)-coated stripes strongly inhibit their migration.
See Szőcs et al. doi.org/10.1242/dev....
HNK1-positive enteric neural crest-derived cells (ENCDCs) migrate efficiently on fibronectin-coated stripes, whereas alternating chondroitin sulfate proteoglycan (CSPG)-coated stripes strongly inhibit their migration.
See Szőcs et al. doi.org/10.1242/dev....
In posttraumatic osteoarthritis mouse models, synovial Foxp3+ Treg cells accumulated early after injury and acquired tissue-adapted features.
IL-2–mediated enrichment was associated with less synovitis & cartilage damage and partial preservation of load-bearing function
A&R
doi.org/10.1002/art....
IL-2–mediated enrichment was associated with less synovitis & cartilage damage and partial preservation of load-bearing function
A&R
doi.org/10.1002/art....
September 8, 2026 at 11:47 AM
In posttraumatic osteoarthritis mouse models, synovial Foxp3+ Treg cells accumulated early after injury and acquired tissue-adapted features.
IL-2–mediated enrichment was associated with less synovitis & cartilage damage and partial preservation of load-bearing function
A&R
doi.org/10.1002/art....
IL-2–mediated enrichment was associated with less synovitis & cartilage damage and partial preservation of load-bearing function
A&R
doi.org/10.1002/art....
Matsukiyo Introduces Next-Gen Beauty Product: Collagen Powder SP with Proteoglycan#Japan#Tokyo#Collagen#Matsukiyo#Proteoglycan
Matsukiyo Introduces Next-Gen Beauty Product: Collagen Powder SP with Proteoglycan
Matsukiyo has revamped its popular Collagen Powder SP, now enriched with the next-gen moisturizing ingredient, multilayer Proteoglycan, available from October 10.
third-news.com
September 1, 2026 at 7:07 AM
Matsukiyo Introduces Next-Gen Beauty Product: Collagen Powder SP with Proteoglycan#Japan#Tokyo#Collagen#Matsukiyo#Proteoglycan
RRIDs were included in this in bioRxiv paper. We value the author's support of reproducibility. #BetterScience #reproducibility #OpenResearch
A Novel Proteoglycan-4 Isoform Drives Skeletal Regeneration
Read the full paper: A Novel Proteoglycan-4 Isoform Drives Skeletal Regeneration
doi.org
August 9, 2026 at 7:06 AM
RRIDs were included in this in bioRxiv paper. We value the author's support of reproducibility. #BetterScience #reproducibility #OpenResearch
Can we do something about the sting? Using a CRISPR screen on human cells, we find that the Physalia venom enters the cells using heparan sulphate proteoglycan pathway. Quite amazingly, using heparin we can stop venom pain in mice 🐁. So bring your heparin shot to the beach if you see them coming! 8/
August 3, 2026 at 9:33 AM
Can we do something about the sting? Using a CRISPR screen on human cells, we find that the Physalia venom enters the cells using heparan sulphate proteoglycan pathway. Quite amazingly, using heparin we can stop venom pain in mice 🐁. So bring your heparin shot to the beach if you see them coming! 8/
Proteoglycan Mucoproteins Market Value & Growth Outlook 2035 | WiseGuyReports www.wiseguyreports.com/reports/prot...
Proteoglycan Mucoproteins Market Value & Growth Outlook 2035
The Proteoglycan Mucoproteins Market is expected to grow from 2,300 USD Million in 2025 to 3,500 USD Million by 2035. The Proteoglycan Mucoproteins Market CAGR (growth rate) is expected to be around 4...
www.wiseguyreports.com
July 30, 2026 at 6:02 AM
Proteoglycan Mucoproteins Market Value & Growth Outlook 2035 | WiseGuyReports www.wiseguyreports.com/reports/prot...
N-WZYDs consisted mainly of proteoglycan scaffolds and small-molecule active components. In chronic migraine (CM) rat models, N-WZYDs significantly alleviated symptoms with efficacy comparable to that of WZYD, potentially via inhibition of the IL-33/ST2/TRPA1 signaling pathway. (🧵 3/7)
July 21, 2026 at 8:34 AM
N-WZYDs consisted mainly of proteoglycan scaffolds and small-molecule active components. In chronic migraine (CM) rat models, N-WZYDs significantly alleviated symptoms with efficacy comparable to that of WZYD, potentially via inhibition of the IL-33/ST2/TRPA1 signaling pathway. (🧵 3/7)
Site-specific N-glycosylation differences between two recombinant human hyaluronan and proteoglycan link protein 1 forms with distinct hyaluronan–proteoglycan linking activity
www.sciencedirect.com
July 19, 2026 at 5:05 PM
Site-specific N-glycosylation differences between two recombinant human hyaluronan and proteoglycan link protein 1 forms with distinct hyaluronan–proteoglycan linking activity
Latest article from Journal of Biomechanics:
Synovium friction properties are influenced by proteoglycan content
https://doi.org/10.1016/j.jbiomech.2024.112272
#BiomechSky
Synovium friction properties are influenced by proteoglycan content
https://doi.org/10.1016/j.jbiomech.2024.112272
#BiomechSky
August 24, 2024 at 11:22 PM
Latest article from Journal of Biomechanics:
Synovium friction properties are influenced by proteoglycan content
https://doi.org/10.1016/j.jbiomech.2024.112272
#BiomechSky
Synovium friction properties are influenced by proteoglycan content
https://doi.org/10.1016/j.jbiomech.2024.112272
#BiomechSky
Another masterpiece from the Conant lab! Hapln2 is elevated in ApoE4 mice, yet another example of perineuronal net dysfunction in #Alzheimers
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Increased levels of HAPLN2, which anchors dense extracellular matrix, in the hippocampus of APOE4 targeted replacement mice
Hyaluronan and proteoglycan link protein 2 (HAPLN2) / Brain link protein-1 (Bral1) is important for the binding of chondroitin sulfate proteoglycans (CSPGs) to hyaluronan and thus for the formation of...
www.biorxiv.org
November 11, 2025 at 8:52 PM
Another masterpiece from the Conant lab! Hapln2 is elevated in ApoE4 mice, yet another example of perineuronal net dysfunction in #Alzheimers
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Essential regulation of heparan sulfate proteoglycan signalling controls cell behaviour to support cardiac development #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.07.23.666364v1
https://www.biorxiv.org/content/10.1101/2025.07.23.666364v1
July 28, 2025 at 7:00 AM
Essential regulation of heparan sulfate proteoglycan signalling controls cell behaviour to support cardiac development #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.07.23.666364v1
https://www.biorxiv.org/content/10.1101/2025.07.23.666364v1
In addition they make an extra mutation in a receptor for heparan sulfate proteoglycan, which facilitated liver transduction. The resulting capsid is called AAVzero1. This capsid still cross reacts with AAV2 antibodies. Authors test this in mice showing less muscle uptake and good muscle uptake.
June 1, 2026 at 9:22 AM
In addition they make an extra mutation in a receptor for heparan sulfate proteoglycan, which facilitated liver transduction. The resulting capsid is called AAVzero1. This capsid still cross reacts with AAV2 antibodies. Authors test this in mice showing less muscle uptake and good muscle uptake.
Salmon proteoglycan modulates TIMP–gelatinase regulation in intestinal epithelial cell#glycotimem#GlycoconjugateJournalal
Salmon proteoglycan modulates TIMP–gelatinase regulation in intestinal epithelial cells
Chondroitin sulfate (CS) and CS proteoglycans (CSPGs) are increasingly used in nutritional and biomedical applications. Although their functional benefits
link.springer.com
February 13, 2026 at 3:45 PM
Salmon proteoglycan modulates TIMP–gelatinase regulation in intestinal epithelial cell#glycotimem#GlycoconjugateJournalal
Heparan-6-O-endosulfatase 2, a cancer-related proteoglycan enzyme, is effectively inhibited by a specific sea cucumber fucosylated glycosaminoglycan
#glycotime #Glycobiology
#glycotime #Glycobiology
Heparan-6-O-endosulfatase 2, a cancer-related proteoglycan enzyme, is effectively inhibited by a specific sea cucumber fucosylated glycosaminoglycan
Abstract. Heparan-6-O-endosulfatase 2 (Sulf-2) is a proteoglycan enzyme that modifies sulfation of heparan sulfate proteoglycans. Dysregulation of Sulf-2 i
academic.oup.com
May 4, 2025 at 2:39 PM
Heparan-6-O-endosulfatase 2, a cancer-related proteoglycan enzyme, is effectively inhibited by a specific sea cucumber fucosylated glycosaminoglycan
#glycotime #Glycobiology
#glycotime #Glycobiology
#Medsky🧪 #IDsky #immunosky #publichealth #Endocan role in vascular homeostasis, endothelial cell adhesion, migration, angiogenesis through receptor-mediated pathways & the release of pro-inflammatory cytokines, chemokines, impacting sys inflammatory responses . www.frontiersin.org/journals/agi...
Frontiers | Endocan, a novel glycoprotein with multiple biological activities, may play important roles in neurological diseases
Endothelial cell specific-1 (ESM-1), also known as endocan, is a soluble dermatan sulfate proteoglycan that is mainly secreted by endothelial cells. Endocan ...
www.frontiersin.org
June 23, 2025 at 5:07 AM
#Medsky🧪 #IDsky #immunosky #publichealth #Endocan role in vascular homeostasis, endothelial cell adhesion, migration, angiogenesis through receptor-mediated pathways & the release of pro-inflammatory cytokines, chemokines, impacting sys inflammatory responses . www.frontiersin.org/journals/agi...
Recap
Impact of #SARSCoV2 on the nervous system
www.sciencedirect.com/science/arti...
journals.viamedica.pl/neurologia_n...
journals.asm.org/doi/full/10....
Impact of #SARSCoV2 on the nervous system
www.sciencedirect.com/science/arti...
journals.viamedica.pl/neurologia_n...
journals.asm.org/doi/full/10....
January 4, 2025 at 4:55 AM
Recap
Impact of #SARSCoV2 on the nervous system
www.sciencedirect.com/science/arti...
journals.viamedica.pl/neurologia_n...
journals.asm.org/doi/full/10....
Impact of #SARSCoV2 on the nervous system
www.sciencedirect.com/science/arti...
journals.viamedica.pl/neurologia_n...
journals.asm.org/doi/full/10....
#MedSky🧪#IDSky #NeuroSky Increasing evidence suggests that #SARSCoV2 can invade both CNS ( doi.org/10.1016/S147... ) & #PNS (doi.org/10.1002/jcsm...) resulting in a variety of neurological disorders & people are more forgetful about #NeuroCovid
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
September 19, 2024 at 11:55 AM
#MedSky🧪#IDSky #NeuroSky Increasing evidence suggests that #SARSCoV2 can invade both CNS ( doi.org/10.1016/S147... ) & #PNS (doi.org/10.1002/jcsm...) resulting in a variety of neurological disorders & people are more forgetful about #NeuroCovid
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
MedSky🧪#Pathology Did you know that #proteoglycans are involved in various human diseases including global #infections, regenerative medicine & #angiogenesis? @iozzo_v
a comprehensive review on the global impact of proteoglycan on human diseases
www.cell.com/iscience/ful...
a comprehensive review on the global impact of proteoglycan on human diseases
www.cell.com/iscience/ful...
October 23, 2023 at 9:36 AM
MedSky🧪#Pathology Did you know that #proteoglycans are involved in various human diseases including global #infections, regenerative medicine & #angiogenesis? @iozzo_v
a comprehensive review on the global impact of proteoglycan on human diseases
www.cell.com/iscience/ful...
a comprehensive review on the global impact of proteoglycan on human diseases
www.cell.com/iscience/ful...
Inner Life Of A Cell #HarvardUniversity #CellLife #Leukocytes #LipidRaft #Cholesterol #Chemokine #Proteoglycan #Pores
husslook.tumblr.com/post/526247234…
husslook.tumblr.com/post/526247234…
Inner Life Of A Cell
#HarvardUniversity #CellLife #P-selectin #Leukocytes #LipidRaft #Cholesterol #Chemokine #Proteoglycan #Receptor #SpectrinTetramer #ActinFilaments #SeveringProtein #Microtubules #Vesicle #MotorProtein #Mitochondria #Centrosome #Centriole #Pores #Ribosome #Translocator #EndoplasmicReticulum #PlasmaMembrane #G-protein #Integrin #I-Cam
t.co
April 5, 2025 at 10:28 PM
#Popbela_com Ini Teknologi Anti-Aging Generasi Baru, Bikin Kulit Kencang!
Ini Teknologi Anti-Aging Generasi Baru, Bikin Kulit Kencang!
PG Gel Collagen hadir sebagai inovasi terbaru dari Jepang yang memadukan dua bahan unggulan: Soluble Proteoglycan dan Soluble Marine Collagen
www.popbela.com
August 26, 2025 at 5:27 PM
#Popbela_com Ini Teknologi Anti-Aging Generasi Baru, Bikin Kulit Kencang!