Increased Smoothened signaling promotes kidney fibrosis through inhibiting autophagy in fibroblasts

doi.org/10.1016/j.kint.2026.01.028

#OpenAccess #MedSky #NephSky #renalfibrosis #kidneyfibrosis

Repression of peroxisome proliferation-activated receptor γ coactivator-1α by p53 after #kidneyinjury promotes mitochondrial damage and maladaptive #kidney repair

doi.org/10.1016/j.kint.2025.02.009

#MedSky #NephSky #renalfibrosis #kidneyfibrosis #cisplatin #aki #acutekidneyinjury

This review highlights #StemCellDerived #exosomes as promising anti‑fibrotic and regenerative therapies for #RenalFibrosis, comparing them with stem cell treatments and discussing future strategies to enhance #kidney protection.

OpenAccess: doi.org/10.1016/j.ge...

TRPC6 knockout alleviates #RenalFibrosis by reducing fibrotic markers, #apoptosis, and #inflammation, while downregulating the PI3K/AKT/GSK3β pathway—supporting TRPC6 inhibition as a promising therapeutic strategy for #ChronicKidneyDisease.

Read more: doi.org/10.1007/s115...

Rhubarb (Rheum spp.) attenuates renal fibrosis in CKD. 🌿 Bridges traditional ethnopharmacology & modern drug discovery. Covers anthraquinones, stilbenes, polyphenols – multi-pathway anti-fibrotic effects. Calls for RCTs.
🔗 doi.org/10.1016/S187...

#RenalFibrosis #Ethnopharmacology #DrugDiscovery

A self-sustaining hypoxia inducible factor-1α–creatine kinase B feedforward circuit drives macrophage-mediated kidney fibrosis

doi.org/10.1016/j.kint.2026.07.019

#MedSky #NephSky #chronickidneydisease #CKD #fibrosis #renalfibrosis #HIF1a
@cuanschutz.bsky.social @uthealthhouston.bsky.social

TRPC6 knockdown alleviates #RenalFibrosis by reducing the expression of #fibrotic markers and mitigating #apoptosis and #inflammation of primary tubular epithelial cells (PTECs) via downregulating the PI3K/AKT/GSK3β pathway. #medsky

#MostDownloaded: link.springer.com/article/10.1...

UBC9-associated SUMOylation contributes to β-catenin activation and kidney fibrosis

doi.org/10.1016/j.kint.2025.07.005

#NephSky #MedSky #renalfibrosis #kidneyfibrosis

This review highlights #StemCellDerived #exosomes as promising anti‑fibrotic and regenerative therapies for #RenalFibrosis, comparing them with stem cell treatments and discussing future strategies to enhance #kidney protection.

OpenAccess: doi.org/10.1016/j.ge...

#Research
Matricellular protein #SMOC2 safeguards tubular integrity in acute #kidney injury via integrin β3-dependent inhibition of #CCND1-#CDK4/6 axis doi.org/10.1186/s435...
Researchers from University of Montreal

#SMOC2 #AcuteTubularInjury #RenalFibrosis #CellCycleArrest

#Research
Matricellular protein #SMOC2 safeguards tubular integrity in acute #kidney #injury via integrin β3-dependent inhibition of #CCND1-#CDK4/6 axis doi.org/10.1186/s435...

#CellCycleArrest #DNAdamage #RenalFibrosis

Online today! Loss of p300 in proximal tubular cells reduces #RenalFibrosis and endothelial-mesenchymal transition.

By Hyunsik Kim, Beom Seok Kim, Beom Jin Lim, Ho-Geun Yoon & colleagues at Yonsei University College of Medicine Seoul

🗞️ doi.org/10.1038/s443...