#ryanodine
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rommieamaro.bsky.social
A project 10 years in the making w/ Terry Sejnowski, led by
@philosophaki.bsky.social

Insights into ryanodine receptor activation & calcium-induced Ca2+ release from a stochastic explicit-particle 3D simulation of cardiac dyad w/ realistic TEM geometry 🧪

www.sciencedirect.com/science/arti...
November 26, 2024 at 2:39 PM
rommieamaro.bsky.social
A project 10 years in the making w/ Terry Sejnowski, led by @philosophaki.bsky.social

Insights into ryanodine receptor activation & calcium-induced Ca2+ release from a stochastic explicit-particle 3D simulation of cardiac dyad w/ realistic geometry (from TEM)

www.sciencedirect.com/science/arti...
November 26, 2024 at 2:01 PM
marijnkuijpers.bsky.social
Our paper is finally out!

Neuronal autophagy controls excitability via ryanodine receptor-mediated regulation of calcium-activated potassium channel function.
www.pnas.org/doi/abs/10.1...
April 30, 2025 at 7:42 AM
olibclarke.bsky.social
Another little script I've wanted to make for a while: a CLI utility to just take a multiple alignment, and convert sequence numbering from one species to another.

When dealing with long sequences like ryanodine receptors (5000aas) this really helps (at least for me!):

github.com/olibclarke/p...
March 31, 2026 at 6:45 PM
landerlab.bsky.social
Our first competition at the CSHL #CryoEM course - each student tries to make a perfect grid of ryanodine receptors. We’ll be checking atlases after dinner… who will be tonight’s big winner? Thanks to @olibclarke.bsky.social for providing sample and gold grids!
March 12, 2025 at 9:45 PM
craigagoodman1.bsky.social
Muscle-specific Ryanodine receptor 1 properties underlie limb-girdle muscular dystrophy 2B/R2 progression
www.nature.com/articles/s41...
Muscle-specific Ryanodine receptor 1 properties underlie limb-girdle muscular dystrophy 2B/R2 progression - Nature Communications
In this study by Meizoso-Huesca et al. regional skeletal muscle differences in ryanodine receptor Ca2+ leak were found. Without dysferlin, this raised leak is not tolerated long-term and leads to limb...
www.nature.com
March 29, 2025 at 8:32 PM
plosbiology.org
What are the molecular targets of inhaled anesthetics, such as isoflurane? Hideaki Ueda &co @riken-bdr.bsky.social @utokyoofficial.bsky.social report that isoflurane binds type 1 ryanodine receptor, which can be targeted to modulate sensitivity to #anesthesia. 🧪
plos.io/45EsVlx
Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice
What are the molecular targets of inhaled anesthetics, such as isoflurane? This study reports that isoflurane binds type 1 ryanodine receptor, and determines that genetically disrupting a specific res...
plos.io
June 5, 2025 at 8:52 AM
mercuryal.bsky.social
RYANODINE
#wordchaingame
January 10, 2025 at 6:33 PM
mattmuscleguy.bsky.social
New #PNASNews paper: Targeting ryanodine receptors with allopurinol and xanthine derivatives for the treatment of cardiac and musculoskeletal weakness disorders. #Myoblue tinyurl.com/66p47v9p
Targeting ryanodine receptors with allopurinol and xanthine derivatives for the treatment of cardiac and musculoskeletal weakness disorders | PNAS
Ryanodine receptors (RyRs) are intracellular Ca2+ channels essential for muscle contraction. Caffeine, a xanthine derivative, has been known for de...
tinyurl.com
June 17, 2025 at 9:14 PM
channelomics.bsky.social
A new stress test for ryanodine receptors. Editorial…
@jgenphysiol.bsky.social

https://rupress.org/jgp/article/156/12/e202413716/277091/A-new-stress-test-for-ryanodine-receptorsA-new
December 3, 2024 at 6:28 PM
plosbiology.org
What are the molecular targets of inhaled anesthetics, such as isoflurane? Hideaki Ueda &co @riken-bdr.bsky.social @utokyoofficial.bsky.social report that isoflurane binds type 1 ryanodine receptor, which can be targeted to modulate sensitivity to #anesthesia. 🧪
plos.io/45EsVlx
Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice
What are the molecular targets of inhaled anesthetics, such as isoflurane? This study reports that isoflurane binds type 1 ryanodine receptor, and determines that genetically disrupting a specific res...
plos.io
June 4, 2025 at 4:46 PM
filipvanpetegem.bsky.social
Calcins are scorpion-derived peptides that can cross the plasma membrane and modulate the Ryanodine Receptor. Marvin presenting the latest cryoEM results from our lab at the 2024 Translational Arrhythmia Day (TADA) meeting.
(description also here: www.science.org/doi/10.1126/...)
November 23, 2024 at 10:20 PM
drjwdietrich.bsky.social
🧪In combination with SPINA-GR and whole-exome sequencing, calculating SPINA-GBeta made the discovery of a new form of monogenetic diabetes (MODY) possible. This new DM is characterised by primary insulin resistance and results from a missense variant of the type 2 ryanodine receptor (RyR2) gene. 🩺
spinateam.bsky.social SPINA Team @spinateam.bsky.social · Feb 20
Breaking news: In combination with whole-exome sequencing, #SPINA_Carb helped to discover a new form of #MODY #diabetes, caused by an atypical missense variant in the #RyR2 gene (coding the the type 2 #ryanodine receptor). doi.org/10.3389/fend... 🧪🩺
Family tree with affected and sequenced individuals. The p.N2291D is located in the RIH (RyR and IP3R Homology) domain of the protein and also overlaps hotspot II Both SPINA-GBeta and fasting proinsulin are significantly higher in RyR2 MODY diabetes. Increased SPINA-GBeta represents dynamical compensation of insulin resistance.
February 20, 2024 at 10:46 PM
pymundgenealogy.com
Just found out that the guy who discovered the ryanodine receptor, Sidney Fleischer, was my second cousin (twice removed)

My genealogy and molecular biology worlds intersecting...
February 13, 2024 at 2:30 AM
plosbiology.org
What are the molecular targets of inhaled anesthetics, such as isoflurane? Hideaki Ueda &co @riken-bdr.bsky.social @utokyoofficial.bsky.social report that isoflurane binds type 1 ryanodine receptor, which can be targeted to modulate sensitivity to #anesthesia. 🧪
plos.io/45EsVlx
Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice
What are the molecular targets of inhaled anesthetics, such as isoflurane? This study reports that isoflurane binds type 1 ryanodine receptor, and determines that genetically disrupting a specific res...
plos.io
June 4, 2025 at 1:58 PM
olibclarke.bsky.social
FKBP12 & 12.6 - regulatory subunits of the ryanodine receptor, but also act as enzymes (proline isomerase), and have a bunch of other targets which they bind and regulate
January 27, 2026 at 3:40 PM
hrmem.bsky.social
We are excited to spotlight this structure of the type 3 ryanodine receptor determined by Yu Seby Chen and colleagues from UBC and the University of Siena!

It was a pleasure to collaborate with the Van Petegem (@filipvanpetegem.bsky.social) Lab on this lovely work!

www.nature.com/articles/s41...
Cryo-EM investigation of ryanodine receptor type 3 - Nature Communications
Ryanodine Receptor type 3 mediates ER Ca2+ release in different cell types. Here, the authors use cryo-EM to reveal a binding site for chloride and two distinct sites for ATP. Epileptic encephalopathy...
www.nature.com
April 22, 2025 at 11:19 PM
sgpweb.bsky.social
Join us for the next SGP EpIC Seminar on Tuesday, 7 July 2026, at 12:00 pm Eastern featuring a talk by Shanna Hamilton on “The cardiac ryanodine receptor: effects of calcium release beyond excitation-contraction coupling." As ever, registration is free and all are welcome: sgp-epic-seminars.com
July 4, 2026 at 1:05 AM
sempersincerus.bsky.social
If you know Ryan, you know that that he has named a "receptor" on you he likes to call his Ryanodine receptor 1 (RYR1). He enjoys this RYR1, triggering an excitation-contraction coupling until your muscles are weak.
He likes it so hot, he drives you to malignant hyperthermia.
Hot enough?
November 1, 2023 at 10:35 PM
biorxiv-biochem.bsky.social
Rapid small-scale nanobody-assisted purification of ryanodine receptors for cryo-EM https://www.biorxiv.org/content/10.1101/2024.04.03.587959v1
Rapid small-scale nanobody-assisted purification of ryanodine receptors for cryo-EM https://www.biorxiv.org/content/10.1101/2024.04.03.587959v1
Ryanodine receptors (RyRs) are large Ca2+ release channels residing in the endoplasmic or sarcoplasm
www.biorxiv.org
April 3, 2024 at 10:45 PM
bbmrieric.bsky.social
🧬 On December 2, BMC hosted Prof. Rasa Liutkeviciene and her team from the Lithuanian University of Health Sciences to discuss recent findings and future collaboration on ryanodine receptors in neuroendocrine tumors and tour the labs and biobank: buff.ly/Nw05TIC

🧵 6/8
December 9, 2025 at 8:52 AM
channelomics.bsky.social
A new stress test for ryanodine receptors | Journal of General Physiology… https://buff.ly/4eHP0Rb
November 24, 2024 at 8:24 AM
cryoempapers.bsky.social
Crystal structures of Ryanodine Receptor reveal dantrolene and azumolene interactions guiding inhibitor development pubmed.ncbi.nlm.nih.gov/41253812/ #cryoem
November 19, 2025 at 8:10 AM
cryoempapers.bsky.social
Cryo-EM Brings the Mechanisms of Activation, Inactivation, and Inhibition of Ryanodine Receptors into Focus pubmed.ncbi.nlm.nih.gov/41606279/ #cryoem
January 29, 2026 at 11:53 AM