Yep. There for this.
www.youtube.com/watch?v=RYr2...
www.youtube.com/watch?v=RYr2...
Dogma | Official Trailer
YouTube video by Umbrella Entertainment
www.youtube.com
July 28, 2025 at 8:52 AM
Yep. There for this.
www.youtube.com/watch?v=RYr2...
www.youtube.com/watch?v=RYr2...
a better movie.. www.youtube.com/watch?v=RYr2...
Dogma | Official Trailer
YouTube video by Umbrella Entertainment
www.youtube.com
July 19, 2026 at 3:14 AM
a better movie.. www.youtube.com/watch?v=RYr2...
#Microtubule #SmoothMuscleCell Contractility
MT support #SarcoplasmicReticulum - #PlasmaMembrance contact
RyR2 channel clusters on tubulin filaments
Nocodazole
⏫Ca2+ spark spread
⏬RyR2-BKα co-localization
⏫myogenic tone
@vesselman.bsky.social #SciSignal 2017
www.science.org/doi/10.1126/...
MT support #SarcoplasmicReticulum - #PlasmaMembrance contact
RyR2 channel clusters on tubulin filaments
Nocodazole
⏫Ca2+ spark spread
⏬RyR2-BKα co-localization
⏫myogenic tone
@vesselman.bsky.social #SciSignal 2017
www.science.org/doi/10.1126/...
February 22, 2025 at 12:26 PM
#Microtubule #SmoothMuscleCell Contractility
MT support #SarcoplasmicReticulum - #PlasmaMembrance contact
RyR2 channel clusters on tubulin filaments
Nocodazole
⏫Ca2+ spark spread
⏬RyR2-BKα co-localization
⏫myogenic tone
@vesselman.bsky.social #SciSignal 2017
www.science.org/doi/10.1126/...
MT support #SarcoplasmicReticulum - #PlasmaMembrance contact
RyR2 channel clusters on tubulin filaments
Nocodazole
⏫Ca2+ spark spread
⏬RyR2-BKα co-localization
⏫myogenic tone
@vesselman.bsky.social #SciSignal 2017
www.science.org/doi/10.1126/...
4/1 für eine gezielte Therapie."
"Neue Behandlungsmethoden bieten einen Hoffnungsschimmer und umfassen entzündungshemmende Therapien, Medikamente, die auf das RAS, das NLRP3-Inflammasom, RYR2-Kanäle, virale Eintrittswege, Nahrungsergänzungsmittel und
"Neue Behandlungsmethoden bieten einen Hoffnungsschimmer und umfassen entzündungshemmende Therapien, Medikamente, die auf das RAS, das NLRP3-Inflammasom, RYR2-Kanäle, virale Eintrittswege, Nahrungsergänzungsmittel und
March 31, 2025 at 9:32 AM
4/1 für eine gezielte Therapie."
"Neue Behandlungsmethoden bieten einen Hoffnungsschimmer und umfassen entzündungshemmende Therapien, Medikamente, die auf das RAS, das NLRP3-Inflammasom, RYR2-Kanäle, virale Eintrittswege, Nahrungsergänzungsmittel und
"Neue Behandlungsmethoden bieten einen Hoffnungsschimmer und umfassen entzündungshemmende Therapien, Medikamente, die auf das RAS, das NLRP3-Inflammasom, RYR2-Kanäle, virale Eintrittswege, Nahrungsergänzungsmittel und
Israeli papers attack Peggy Flanagan as "anti-Israel." She is simply expressing concerns for Christian and Muslim Palestinians. This framing is also seen in US media. Why is being concerned for the lives of Christians and Muslims viewed by them as anti-Israel?! www.ynetnews.com/article/ryr2...
Another win for Democrats’ anti-Israel left as Peggy Flanagan takes Minnesota Senate primary
Flanagan, who has accused Israel of 'genocide' and said she would have voted to cut off military aid, defeated pro-Israel Rep. Angie Craig after making her rival’s past AIPAC support an issue in the c...
www.ynetnews.com
August 12, 2026 at 11:06 AM
Israeli papers attack Peggy Flanagan as "anti-Israel." She is simply expressing concerns for Christian and Muslim Palestinians. This framing is also seen in US media. Why is being concerned for the lives of Christians and Muslims viewed by them as anti-Israel?! www.ynetnews.com/article/ryr2...
#OPENACCESS: Different actions of RyR2 open and closed channel block explained by a multiscale Ca2+ release model. Derek R. Laver, James Welsh, Morris Vysma, and Bjorn C. Knollmann. buff.ly/ChjbT3u
Different actions of RyR2 open and closed channel block explained by a multiscale Ca2+ release model
RyR2 channels regulate Ca2+ release from the sarcoplasmic reticulum (SR), the Ca storage organelle in cardiac muscle. Altered RyR2 activity is a key factor promoting atrial and ventricular…
www.cell.com
September 26, 2026 at 6:02 PM
#OPENACCESS: Different actions of RyR2 open and closed channel block explained by a multiscale Ca2+ release model. Derek R. Laver, James Welsh, Morris Vysma, and Bjorn C. Knollmann. buff.ly/ChjbT3u
Le 21 juillet près de Bordeaux, un camion où se trouvaient deux sapeurs-pompiers avait été «piégé» par les flammes → https://l.lefigaro.fr/rYr2
August 13, 2026 at 10:00 PM
Le 21 juillet près de Bordeaux, un camion où se trouvaient deux sapeurs-pompiers avait été «piégé» par les flammes → https://l.lefigaro.fr/rYr2
Yale Medicine: 'How the Brain Protects Itself from Alzheimer’s Disease'
'Previous research has shown that RyR2 can become altered with age so that the faucet is constantly “on,” and that these changes are associated with Alzheimer’s disease and even Long COVID.'
medicine.yale.edu/news-article...
'Previous research has shown that RyR2 can become altered with age so that the faucet is constantly “on,” and that these changes are associated with Alzheimer’s disease and even Long COVID.'
medicine.yale.edu/news-article...
How the Brain Protects Itself from Alzheimer’s Disease
Researchers discovered a protective mechanism used by the brain to mitigate calcium dysfunction, a risk factor for neurodegeneration.
medicine.yale.edu
December 8, 2025 at 6:09 PM
Yale Medicine: 'How the Brain Protects Itself from Alzheimer’s Disease'
'Previous research has shown that RyR2 can become altered with age so that the faucet is constantly “on,” and that these changes are associated with Alzheimer’s disease and even Long COVID.'
medicine.yale.edu/news-article...
'Previous research has shown that RyR2 can become altered with age so that the faucet is constantly “on,” and that these changes are associated with Alzheimer’s disease and even Long COVID.'
medicine.yale.edu/news-article...
🧪In combination with SPINA-GR and whole-exome sequencing, calculating SPINA-GBeta made the discovery of a new form of monogenetic diabetes (MODY) possible. This new DM is characterised by primary insulin resistance and results from a missense variant of the type 2 ryanodine receptor (RyR2) gene. 🩺
Breaking news: In combination with whole-exome sequencing, #SPINA_Carb helped to discover a new form of #MODY #diabetes, caused by an atypical missense variant in the #RyR2 gene (coding the the type 2 #ryanodine receptor). doi.org/10.3389/fend... 🧪🩺
February 20, 2024 at 10:46 PM
🧪In combination with SPINA-GR and whole-exome sequencing, calculating SPINA-GBeta made the discovery of a new form of monogenetic diabetes (MODY) possible. This new DM is characterised by primary insulin resistance and results from a missense variant of the type 2 ryanodine receptor (RyR2) gene. 🩺
Breaking news: In combination with whole-exome sequencing, #SPINA_Carb helped to discover a new form of #MODY #diabetes, caused by an atypical missense variant in the #RyR2 gene (coding the the type 2 #ryanodine receptor). doi.org/10.3389/fend... 🧪🩺
February 20, 2024 at 5:19 PM
Breaking news: In combination with whole-exome sequencing, #SPINA_Carb helped to discover a new form of #MODY #diabetes, caused by an atypical missense variant in the #RyR2 gene (coding the the type 2 #ryanodine receptor). doi.org/10.3389/fend... 🧪🩺
the Moderna vaccine may affect the ion channel RYR2 (calcium flux), and may impact on contraction.
6/9
6/9
October 16, 2023 at 9:47 AM
the Moderna vaccine may affect the ion channel RYR2 (calcium flux), and may impact on contraction.
6/9
6/9
I’ll be presenting my research at #BPS2025 in LA on BIN1’s role in EC coupling in the heart!
Come check out my poster on how BIN1 impacts Cav1.2 and RyR2 using super-resolution microscopy, electrophysiology, and calcium transients.
Come check out my poster on how BIN1 impacts Cav1.2 and RyR2 using super-resolution microscopy, electrophysiology, and calcium transients.
February 16, 2025 at 6:43 AM
I’ll be presenting my research at #BPS2025 in LA on BIN1’s role in EC coupling in the heart!
Come check out my poster on how BIN1 impacts Cav1.2 and RyR2 using super-resolution microscopy, electrophysiology, and calcium transients.
Come check out my poster on how BIN1 impacts Cav1.2 and RyR2 using super-resolution microscopy, electrophysiology, and calcium transients.
A novel RyR2-selective stabilizer prevents and ameliorates severe arrhythmias in stress-induced ventricular tachycardia https://www.biorxiv.org/content/10.1101/2024.11.26.625386v1
A novel RyR2-selective stabilizer prevents and ameliorates severe arrhythmias in stress-induced ventricular tachycardia https://www.biorxiv.org/content/10.1101/2024.11.26.625386v1
Background: Excessive activation of the type 2 ryanodine receptor (RyR2) causes lethal arrhythmias s
www.biorxiv.org
December 2, 2024 at 5:01 PM
A novel RyR2-selective stabilizer prevents and ameliorates severe arrhythmias in stress-induced ventricular tachycardia https://www.biorxiv.org/content/10.1101/2024.11.26.625386v1
CaMKII Phosphorylation of RyR2 is Essential for Arrhythmia in CPVT https://www.biorxiv.org/content/10.1101/2025.09.15.676430v1
September 18, 2025 at 3:02 PM
CaMKII Phosphorylation of RyR2 is Essential for Arrhythmia in CPVT https://www.biorxiv.org/content/10.1101/2025.09.15.676430v1
New study reveals how increased ryanodine receptor density (RyR2) in heart cells raises the likelihood of spontaneous Ca2+ release, offering insight into cardiac Ca2+ signaling and how RyR2 clustering contributes to arrhythmia risk. ow.ly/Xxnp50UpcmI
Expression level of cardiac ryanodine receptors dictates properties of Ca2+-induced Ca2+ release
The type 2 ryanodine receptor (RyR2) is the major Ca2+ release channel required for Ca2+-induced Ca2+ release (CICR) and cardiac excitation-contraction coupling. The cluster organization of RyR2 at the dyad is critical for efficient CICR. Despite its central role in cardiac Ca2+ signaling, the mechanisms that control CICR are not fully understood. As a single RyR2 Ca2+ flux dictates local CICR that underlies Ca2+ sparks, RyR2 density in a cluster, and therefore the distance between RyR2s, should have a profound impact on local CICR.
ow.ly
December 20, 2024 at 3:31 PM
New study reveals how increased ryanodine receptor density (RyR2) in heart cells raises the likelihood of spontaneous Ca2+ release, offering insight into cardiac Ca2+ signaling and how RyR2 clustering contributes to arrhythmia risk. ow.ly/Xxnp50UpcmI
In #HFmrEF/#HFpEF, sudden death was usually preceded by modest worsening of symptoms, declining quality of life, and rising NT-proBNP, similar to other causes of death, limiting prediction specificity.
ja.ma/4eFuGlq
ja.ma/4eFuGlq
June 23, 2026 at 12:00 PM
In #HFmrEF/#HFpEF, sudden death was usually preceded by modest worsening of symptoms, declining quality of life, and rising NT-proBNP, similar to other causes of death, limiting prediction specificity.
ja.ma/4eFuGlq
ja.ma/4eFuGlq
CaMKII Phosphorylation of RyR2 is Essential for Arrhythmia in CPVT https://www.biorxiv.org/content/10.1101/2025.09.15.676430v1
September 18, 2025 at 3:02 PM
CaMKII Phosphorylation of RyR2 is Essential for Arrhythmia in CPVT https://www.biorxiv.org/content/10.1101/2025.09.15.676430v1
🚨🔬Dore et al reveal why #thyroid hormone therapy doesn’t raise heart rate 🫀 in RTHα 🧬 Persistent bradycardia 💓 in TRα1 mutants linked to irreversibly altered ion channel expression (RyR2) despite T3 ⬆️ pacemaker channels
👉 www.nature.com/articles/s41...
#CardioSky #Science #Physiology #IonChannels
👉 www.nature.com/articles/s41...
#CardioSky #Science #Physiology #IonChannels
Resistance to thyroid hormone induced tachycardia in RTHα syndrome - Nature Communications
Patients with a mutant thyroid hormone receptor α1 are treated with high-dose thyroxine, but their heart rate remains low. Here, the authors show that the mutant receptor triggers cardiac reprogrammin...
www.nature.com
December 14, 2024 at 1:45 PM
🚨🔬Dore et al reveal why #thyroid hormone therapy doesn’t raise heart rate 🫀 in RTHα 🧬 Persistent bradycardia 💓 in TRα1 mutants linked to irreversibly altered ion channel expression (RyR2) despite T3 ⬆️ pacemaker channels
👉 www.nature.com/articles/s41...
#CardioSky #Science #Physiology #IonChannels
👉 www.nature.com/articles/s41...
#CardioSky #Science #Physiology #IonChannels
A novel provocation test clinically diagnosed #CalciumReleaseDeficiencySyndrome in a family with unexplained sudden cardiac arrest and death, with pause-dependent T-wave changes supporting CRDS risk stratification.
ja.ma/4e3pHKZ
ja.ma/4e3pHKZ
June 5, 2026 at 11:00 AM
A novel provocation test clinically diagnosed #CalciumReleaseDeficiencySyndrome in a family with unexplained sudden cardiac arrest and death, with pause-dependent T-wave changes supporting CRDS risk stratification.
ja.ma/4e3pHKZ
ja.ma/4e3pHKZ
Zheng et al. generate a triple phospho-ablation mouse model to show that RyR2 phosphorylation at canonical sites is dispensable for chronotropy and inotropy, but required for electrical stability during adrenergic stimulation.
rdcu.be/eArYg
doi.org/10.1038/s441...
rdcu.be/eArYg
doi.org/10.1038/s441...
Preventing the phosphorylation of RyR2 at canonical sites reduces Ca2+ leak and promotes arrhythmia by reactivating the INa current
Nature Cardiovascular Research - Zheng et al. generated a mouse model of phospho-ablation in all canonical ryanodine receptor 2 (RyR2) phosphorylation sites. They show that RyR2 phosphorylation at...
rdcu.be
August 12, 2025 at 4:44 PM
Zheng et al. generate a triple phospho-ablation mouse model to show that RyR2 phosphorylation at canonical sites is dispensable for chronotropy and inotropy, but required for electrical stability during adrenergic stimulation.
rdcu.be/eArYg
doi.org/10.1038/s441...
rdcu.be/eArYg
doi.org/10.1038/s441...
Patient-derived cells demonstrate that mutated RyR2 calcium leak underlies autism spectrum disorder and inherited arrhythmias https://www.medrxiv.org/content/10.1101/2025.07.26.25332119v1
July 28, 2025 at 10:56 PM
Patient-derived cells demonstrate that mutated RyR2 calcium leak underlies autism spectrum disorder and inherited arrhythmias https://www.medrxiv.org/content/10.1101/2025.07.26.25332119v1
@thermofishersci.bsky.social's resource, RRID:AB_2315633, was just reported to be used in the paper. Thanks for making your methods matter! #STMpublishing #OpenResearch #RRID
Type 2 Diabetes disrupts T-tubule and RyR2 organisation in male but not female rat ventricular muscle
Read the full paper: Type 2 Diabetes disrupts T-tubule and RyR2 organisation in male but not female rat ventricular muscle
doi.org
March 7, 2026 at 8:00 AM
@thermofishersci.bsky.social's resource, RRID:AB_2315633, was just reported to be used in the paper. Thanks for making your methods matter! #STMpublishing #OpenResearch #RRID
#Research by D'Artagnan Greene and Yohannes Shiferaw observed that APD restitution controls #arrhythmia emergence in cardiac tissue with #RyR2 dysfunction 💻 🫀
🔗 Read their work here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Read their work here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 15, 2026 at 2:02 PM
#Research by D'Artagnan Greene and Yohannes Shiferaw observed that APD restitution controls #arrhythmia emergence in cardiac tissue with #RyR2 dysfunction 💻 🫀
🔗 Read their work here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Read their work here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
MYBPC3 (c.194C>T) mutation-mediated RyR2 dysfunction contributes to pathogenic phenotypes of dilated cardiomyopathy revealed by hiPSC modeling https://www.medrxiv.org/content/10.1101/2025.02.17.25321993v1
February 24, 2025 at 5:56 AM
MYBPC3 (c.194C>T) mutation-mediated RyR2 dysfunction contributes to pathogenic phenotypes of dilated cardiomyopathy revealed by hiPSC modeling https://www.medrxiv.org/content/10.1101/2025.02.17.25321993v1