Happy New Paper Day! We're excited to share this @natchembio.nature.com on #SmallMoleculeInhibitors of NorA, an efflux pump that is an important mediator of #antibioticresistance in #MRSA. It pumps antibiotics out , lowering their concentration in the cell.
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Small-molecule inhibitors block NorA efflux by conformational trapping - Nature Chemical Biology
Multidrug efflux pumps expel antibiotics, contributing to antibiotic resistance. Now, high-throughput screening and structural characterization reveal an inhibitor of Staphylococcus aureus efflux pump...
doi.org
September 17, 2026 at 2:17 PM
Happy New Paper Day! We're excited to share this @natchembio.nature.com on #SmallMoleculeInhibitors of NorA, an efflux pump that is an important mediator of #antibioticresistance in #MRSA. It pumps antibiotics out , lowering their concentration in the cell.
doi.org/10.1038/s415...
doi.org/10.1038/s415...
This review summarizes #m6A reader proteins in #LiverDisease, highlighting their roles in #RNAmetabolism, disease progression, & therapeutic potential, while emphasizing the promise of #SmallMoleculeInhibitors targeting reader–mRNA interactions.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
April 11, 2026 at 2:45 AM
This review summarizes #m6A reader proteins in #LiverDisease, highlighting their roles in #RNAmetabolism, disease progression, & therapeutic potential, while emphasizing the promise of #SmallMoleculeInhibitors targeting reader–mRNA interactions.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
💊New article in @drugsincontext.bsky.social
Apremilast in osteoarthritis: exploring its therapeutic mechanisms
Rafiei et al.
www.drugsincontext.com/apremilast-i...
@medsky.social @me.pharmsky.app #osteoarthritis #smallmoleculeinhibitors #rheumatology
Apremilast in osteoarthritis: exploring its therapeutic mechanisms
Rafiei et al.
www.drugsincontext.com/apremilast-i...
@medsky.social @me.pharmsky.app #osteoarthritis #smallmoleculeinhibitors #rheumatology
December 29, 2025 at 11:37 AM
💊New article in @drugsincontext.bsky.social
Apremilast in osteoarthritis: exploring its therapeutic mechanisms
Rafiei et al.
www.drugsincontext.com/apremilast-i...
@medsky.social @me.pharmsky.app #osteoarthritis #smallmoleculeinhibitors #rheumatology
Apremilast in osteoarthritis: exploring its therapeutic mechanisms
Rafiei et al.
www.drugsincontext.com/apremilast-i...
@medsky.social @me.pharmsky.app #osteoarthritis #smallmoleculeinhibitors #rheumatology
💡Online now - the Spotlight "Drug ubiquitination: an unwelcome mode of action or a novel modality" from Richard de Heiden and Monique Mulder.
#NonCanonicalUbiquitination #Therapeutics #SmallMoleculeInhibitors
Read t it here: authors.elsevier.com/a/1m0Rm3S6Gf...
#NonCanonicalUbiquitination #Therapeutics #SmallMoleculeInhibitors
Read t it here: authors.elsevier.com/a/1m0Rm3S6Gf...
October 30, 2025 at 12:47 PM
💡Online now - the Spotlight "Drug ubiquitination: an unwelcome mode of action or a novel modality" from Richard de Heiden and Monique Mulder.
#NonCanonicalUbiquitination #Therapeutics #SmallMoleculeInhibitors
Read t it here: authors.elsevier.com/a/1m0Rm3S6Gf...
#NonCanonicalUbiquitination #Therapeutics #SmallMoleculeInhibitors
Read t it here: authors.elsevier.com/a/1m0Rm3S6Gf...
#GileadSciences #LEOPharma #strategicpartnership #drugdevelopment #atopicdermatitis #asthma #COPD #dermatology #skindiseases #respiratory #smallmoleculeinhibitors #targetedproteindegraders #STAT6pathway #oralSTAT6products #topicalSTAT6products
pharmatimes.com/uncategorize...
pharmatimes.com/uncategorize...
Gilead and LEO Pharma partner to develop oral STAT6 program - PharmaTimes
Companies aim to provide new treatments for inflammatory conditions
pharmatimes.com
January 13, 2025 at 3:11 PM