#stemcell-derived
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labspagnoli.bsky.social
📣 New Pre-print from my lab to wrap-up year!!!

🎉 🎉 led by #GeorginaGoss with support from
@alejotorrescano.bsky.social @heathermwilson.bsky.social & @habkcl.bsky.social

Pairing #spatialtranscriptomics with #stemcell–derived #multilineage-organoids to elucidate human pancreatic islet development 💥
biorxiv-devbio.bsky.social bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · Dec 14
Mesodermal-niche interactions direct specification and differentiation of pancreatic islet cells in human multilineage organoids https://www.biorxiv.org/content/10.64898/2025.12.13.694117v1
December 14, 2025 at 4:17 PM
danieljdrucker.bsky.social
Insights from derivation of human IPS #stemcell derived islet-like or off-target enterochromaffin (EC)-like cells in the pancreas #diabetes www.nature.com/articles/s41...
March 22, 2026 at 12:04 PM
embomolmed.org
📣 Metabolic #cardiomyopathies: untangling clinical heterogeneity with human #StemCell derived models

By A. Passadouro, @rhhoutkooper.bsky.social, S. Mosegaard & colleagues at University of Amsterdam

➡️ doi.org/10.1038/s443...
September 23, 2025 at 6:45 PM
celltransplant1992.bsky.social
Photobiomodulation-induced activation of Wnt signaling enhances differentiation of adipose-derived stem cells into tenocytes: Mechanistic insights into regenerative signaling pathways
doi.org/10.1177/0963...
#stemcell #regeneration #signalisart @journals.sagepub.com
August 12, 2026 at 8:16 AM
hansclevers.bsky.social
Exciting study by Amanda Andersson Rolf et al: In vitro expansion of a human fetal #pancreas #stemcell that generates all three pancreatic cell lineages”. www.cell.com/cell/fulltex...
New #organoid protocol allows the seemingly indefinite expansion of human fetal pancreatic Lgr5+ stem cell 1/
Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages
Identification of an LGR5 as a marker for a tripotent stem/progenitor cell of the human fetal pancreas. Organoids derived from single LGR5+ cells are capable of long-term expansion in vitro and genera...
www.cell.com
December 3, 2024 at 10:52 AM
danieljdrucker.bsky.social
An update on #Stemcell derived #islets for type 1 #diabetes investors.vrtx.com/news-release...
March 28, 2025 at 8:27 PM
berterolab.bsky.social
Struggling with #silencing of doxycycline-inducible transgenes in human pluripotent #stemcell derived lineages? You're not alone! In my very first #skeetorial I break down our latest paper on potential solutions to this common problem. Read on! 1/10

open-research-europe.ec.europa.eu/articles/4-2...
February 10, 2025 at 11:06 PM
jeffreymillman.bsky.social
🚨We have published our latest differentiation strategy for #stemcell derived islets. By depolymerizing F-actin at the beginning of differentiation, we enhanced β-cell formation, function, and safety for #diabetes cell therapy. 🧵below www.nature.com/articles/s41...
Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation - Nature Communications
This study demonstrates that cytoskeletal state at the onset of directed differentiation impacts the exit of stem cells from pluripotency and downstream lineage specification. These findings are utili...
www.nature.com
June 1, 2026 at 3:48 PM
roblab.bsky.social
Today in the 🇨🇦 National Grad course in #Islet Biology and #Diabetes we welcome superstars Cristina Nostro and @yassiag.bsky.social to discuss the latest on using #stemcell derived islet cells as a strategy to treat (cure?) #T1D!
a woman wearing sunglasses and a blue shirt is making a funny face and saying `` no autographs please '' .
ALT: a woman wearing sunglasses and a blue shirt is making a funny face and saying `` no autographs please '' .
media.tenor.com
January 21, 2026 at 4:36 PM
jeffreymillman.bsky.social
[please retweet] I’m #hiring! The Millman Lab is looking for a postdoctoral researcher to lead an exciting new project focused on vascularized #stemcell-derived islets for #diabetes disease modeling and cell replacement therapy. Email me your CV and cover letter.
August 28, 2025 at 5:06 PM
tum.de
We are part of the DLD #Health x BAIOSPHERE conference in #Munich—featuring pioneering work on #braincomputer interfaces and human #stemcell-derived #organoids! Looking forward to inspiring discussions on the future of medicine: t1p.de/dld-health26
DLD Conference: Digital-Life-Design
t1p.de
June 10, 2026 at 1:38 PM
lau-fed.bsky.social
physoc.onlinelibrary.wiley.com/doi/10.1113/...
#neuroscience #neuroskyence #cardiac #stemcell
Sympathetic neurons can modify the intrinsic structural and functional properties of human pluripotent stem cell‐derived cardiomyocytes
Abstract figure legend Schematic representation of the key differences between innervated and non-innervated hiPSC-CMs. Innervated hiPSC-CMs (right) exhibit several improved characteristics compared ...
physoc.onlinelibrary.wiley.com
February 27, 2025 at 5:43 PM
celltransplant1992.bsky.social
Impact of Kellgren–Lawrence grade on clinical outcomes following adipose-derived stem cell therapy for #knee #osteoarthritis: A propensity score–matched retrospective cohort study
doi.org/10.1177/0963...
#stemcell
@journals.sagepub.com
January 28, 2026 at 8:23 AM
celltransplant1992.bsky.social
Extracellular vesicles secreted by adipose-derived stem cells alleviate dedifferentiation and senescence in monolayer-expanded chondrocytes by suppressing interleukin-1β-induced MAPK signaling
doi.org/10.1177/0963...
#stemcell #signaling
@journals.sagepub.com
July 4, 2026 at 9:21 AM
stemcellsystems.bsky.social
Did you know that there are ~ 20,000 pluripotent stem cell lines available worldwide. Registries have an important role in the stewardship of these lines - particularly provenance and ethical use. But registries can also connect data about a line #pluripotent #stemcell www.cell.com/stem-cell-re...
Guidelines for managing and using the digital phenotypes of pluripotent stem cell lines
In this article, Kurtz, Wells, and colleagues consider how the registration of stem cell lines will contribute to the development of new digital phenotypes of stem cells and their derived materials an...
www.cell.com
November 19, 2024 at 5:01 AM
itmat.bsky.social
Allogeneic #StemCell -derived islet- #CellTherapy as a candidate to restore physiologic #IsletFunction www.nejm.org/doi/10.1056/... #DiabetesResearch #Diabetes #T1D #IsletBiology #TranslationalScience
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM
Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...
www.nejm.org
September 4, 2025 at 6:31 PM
jcb.org
Ben-Hamo-Arad, Toledano et al. reveal that #Drosophila cyst cells exist in two functionally distinct subpopulations: transient escort cells derived from #StemCell divisions & long-lived steady cyst cells that persist at the testis apex & mediate phagoptosis rupress.org/jcb/article/...
December 16, 2025 at 6:15 PM
itmat.bsky.social
Exploring the potential to restore physiologic islet function through fully differ¬entiated, allogeneic pluripotent stem cell–derived islet-cell therapy for #Type1Diabetes www.nejm.org/doi/10.1056/... #StemCell #CellTherapy #TranslationalScience
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM
Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...
www.nejm.org
June 24, 2025 at 4:11 PM
sciwhye23.bsky.social
Thrilled to share our latest #research efforts on #CDKL5 deficiency and #stemcell #diseasemodeling. This critical work took a tremendous team effort! #autism #epilepsy #intellectualdisability #raredisorders

@sahinm.bsky.social

@delaneywood.bsky.social

www.sciencedirect.com/science/arti...
Excitatory cortical neurons from CDKL5 deficiency disorder patient-derived organoids show early hyperexcitability not identified in neurogenin2 induced neurons
CDKL5 deficiency disorder (CDD) is a rare developmental and epileptic encephalopathy resulting from variants in cyclin-dependent kinase-like 5 (CDKL5)…
www.sciencedirect.com
September 15, 2025 at 5:07 PM
natmed.nature.com
An off-the-shelf #stemcell-derived #dopaminergic progenitor #therapy for #PD showed a favorable 12-month safety profile, with no graft-related adverse events, or tumor formation, though risks were associated with the immunosuppression regimen.
Human embryonic stem cell-derived dopaminergic cells for Parkinson’s disease: a phase 1/2 open-label trial - Nature Medicine
A phase 1/2 trial of an off-the-shelf stem cell-derived dopaminergic progenitor therapy demonstrated a favorable 12-month safety profile, with no graft-related adverse events, dyskinesias or tumor formation, although risks were associated with the immunosuppression regimen.
dlvr.it
July 10, 2026 at 3:09 PM
krizzot.bsky.social
www.nature.com/articles/s41... #endocrinology #reproduction #pituitary #stemcell
Gonadotrophs have a dual origin, with most derived from early postnatal pituitary stem cells - Nature Communications
Pituitary gonadotrophs secrete LH and FSH, regulating gonadal function. Here authors show that in the mouse pituitary most gonadotrophs originate from postnatal stem cells, while a minor population of...
www.nature.com
May 21, 2025 at 10:12 AM
celltransplant1992.bsky.social
Effects of human embryonic stem cell–derived Schwann cells for nerve regeneration after facial nerve injury
doi.org/10.1177/0963...
#stemcell #schwann #nerve #regeneration
@journals.sagepub.com
March 27, 2026 at 8:22 AM
ucsandiego.bsky.social
By pioneering the use of patient-derived organoids, researchers in the HUMANOID™ Center for Excellence are streamlining the process of getting safer, more effective drugs into clinical trials. Their innovative approach has already yielded several breakthroughs.

#StemCell #Research #Healthcare
Meet us at Phase 0: Inside the HUMANOID™ Center at UC San Diego
With world-class research capabilities and an ethic of service, the HUMANOID center at UC San Diego is revolutionizing drug discovery.
bit.ly
April 10, 2025 at 11:14 PM
neurodegeneration.bsky.social
🧠 New PubMed Article Alert!

One-step engineered mesenchymal stem cell-derived exosomes against hepatic ischemia-reperfusion injury.

https://pubmed.ncbi.nlm.nih.gov/39892672/

#neurodegeneration #FUS #stemcell
March 15, 2025 at 2:53 PM
stemcells.bsky.social
Weekly reads: robot grant-writing scientist (AI)?, stem cell-derived sperm make a baby, assembloids & sensory paths ipscell.com/2025/04/week... #stemcells #stemcell
Weekly reads: robot scientist, stem cell sperm make a baby, assembloids & sense - The Niche
Professor talks about life as a scientist and recent news in the stem cell and regenerative medicine field including on iPS cells.
ipscell.com
April 13, 2025 at 2:22 PM