🧵 Our paper out today in @naturemedicine.bsky.social
www.nature.com/articles/s41...
On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon
1/
#Immunosky #IDsky #MicroSky #globalhealth.
www.nature.com/articles/s41...
On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon
1/
#Immunosky #IDsky #MicroSky #globalhealth.
www.nature.com
August 8, 2025 at 9:09 AM
🧵 Our paper out today in @naturemedicine.bsky.social
www.nature.com/articles/s41...
On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon
1/
#Immunosky #IDsky #MicroSky #globalhealth.
www.nature.com/articles/s41...
On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon
1/
#Immunosky #IDsky #MicroSky #globalhealth.
Kanada verzeichnet eine Rekordzahl von Fällen invasiver Streptokokken der Gruppe A, einer bakteriellen Infektion, an der etwa einer von zehn Erkrankten stirbt. 6 Kinder in Ontario sind seit Oktober an invasiven Streptokokken der Gruppe A gestorben.
#LongCovid #COVID19 #StrepA
#LongCovid #COVID19 #StrepA
January 17, 2024 at 10:49 PM
Kanada verzeichnet eine Rekordzahl von Fällen invasiver Streptokokken der Gruppe A, einer bakteriellen Infektion, an der etwa einer von zehn Erkrankten stirbt. 6 Kinder in Ontario sind seit Oktober an invasiven Streptokokken der Gruppe A gestorben.
#LongCovid #COVID19 #StrepA
#LongCovid #COVID19 #StrepA
EBV, TB, strepA, shingles (varicella)... and exogenous ones, airborne or vector borne, from dengue to flu to chikungunya, also bacterial and fungal infections, as well as parasites like scabies.
Many of them could be deemed AIDS-defining diseases.
Many of them could be deemed AIDS-defining diseases.
December 18, 2025 at 10:33 PM
EBV, TB, strepA, shingles (varicella)... and exogenous ones, airborne or vector borne, from dengue to flu to chikungunya, also bacterial and fungal infections, as well as parasites like scabies.
Many of them could be deemed AIDS-defining diseases.
Many of them could be deemed AIDS-defining diseases.
VERY excited by our latest work on StrepA below, but also rhe multiple collaborations and work to come off the back of this at MRCG
🧵 Our paper out today in @naturemedicine.bsky.social
www.nature.com/articles/s41...
On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon
1/
#Immunosky #IDsky #MicroSky #globalhealth.
www.nature.com/articles/s41...
On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon
1/
#Immunosky #IDsky #MicroSky #globalhealth.
www.nature.com
August 8, 2025 at 9:14 AM
VERY excited by our latest work on StrepA below, but also rhe multiple collaborations and work to come off the back of this at MRCG
Danke, es sind wieder StrepA🤡
September 13, 2026 at 11:20 AM
Danke, es sind wieder StrepA🤡
Why did invasive #strepA infections increase in young children after the pandemic?
In this new @imperialinfect.bsky.social PREPRINT *not peer-reviewed* we look at antibody responses to #strepA and resp viruses in European children before and after the pandemic:
www.medrxiv.org/cgi/content/...
In this new @imperialinfect.bsky.social PREPRINT *not peer-reviewed* we look at antibody responses to #strepA and resp viruses in European children before and after the pandemic:
www.medrxiv.org/cgi/content/...
Immunity to Streptococcus pyogenes and Common Respiratory Viruses at Age 0-4 Years after COVID-19 restrictions: A Cross-Sectional Study
Importance The upsurge in invasive disease caused by Streptococcus pyogenes among children reported in several European countries during 2022-2023 has not been fully explained.
Objective To test the ...
www.medrxiv.org
April 25, 2025 at 5:16 PM
Why did invasive #strepA infections increase in young children after the pandemic?
In this new @imperialinfect.bsky.social PREPRINT *not peer-reviewed* we look at antibody responses to #strepA and resp viruses in European children before and after the pandemic:
www.medrxiv.org/cgi/content/...
In this new @imperialinfect.bsky.social PREPRINT *not peer-reviewed* we look at antibody responses to #strepA and resp viruses in European children before and after the pandemic:
www.medrxiv.org/cgi/content/...
Help - have room for one more song on my 1980s bands clinical microbiology lab mixtape 🎧 🎶
1. Milli Bacilli
2. Sammy Agar
3. CentriFugees
4. Run HPLC
5. Dire Substrates
6. Pipette Shop Boys
7. Gram- Rod Stewart
8. Salt-N-StrepA
9. Yeastie Boys
1. Milli Bacilli
2. Sammy Agar
3. CentriFugees
4. Run HPLC
5. Dire Substrates
6. Pipette Shop Boys
7. Gram- Rod Stewart
8. Salt-N-StrepA
9. Yeastie Boys
April 19, 2025 at 2:56 AM
Help - have room for one more song on my 1980s bands clinical microbiology lab mixtape 🎧 🎶
1. Milli Bacilli
2. Sammy Agar
3. CentriFugees
4. Run HPLC
5. Dire Substrates
6. Pipette Shop Boys
7. Gram- Rod Stewart
8. Salt-N-StrepA
9. Yeastie Boys
1. Milli Bacilli
2. Sammy Agar
3. CentriFugees
4. Run HPLC
5. Dire Substrates
6. Pipette Shop Boys
7. Gram- Rod Stewart
8. Salt-N-StrepA
9. Yeastie Boys
Just got discharged from the hospital after being admitted. My son was diagnosed with strep A. He’s on antibiotics and finally keeping food down! Still dealing with ketones, but we're working on getting those down. Let’s just hope his BS stays in range today.💙 #StrepA #T1D
January 22, 2025 at 4:43 PM
Super excited announce funded @wellcometrust.bsky.social extend #StrepA Human challenge inc. transfer to Gambia & identify correlates of protection. Great team @joshosowicki.bsky.social @precisionvaxlab.bsky.social @njmoreland.bsky.social @thushan-desilva.bsky.social y.social & others not on Bluesky
March 7, 2025 at 10:27 AM
Super excited announce funded @wellcometrust.bsky.social extend #StrepA Human challenge inc. transfer to Gambia & identify correlates of protection. Great team @joshosowicki.bsky.social @precisionvaxlab.bsky.social @njmoreland.bsky.social @thushan-desilva.bsky.social y.social & others not on Bluesky
Ach es gibt ja noch genügend anderes: StrepA 1x,2x…, Noros, Enteros, Mykoplasmen, Influenza…
November 19, 2023 at 8:09 PM
Ach es gibt ja noch genügend anderes: StrepA 1x,2x…, Noros, Enteros, Mykoplasmen, Influenza…
Hilfe. Irgendwann schicke ich alle Anderen Kitaeltern zu Dir, dann darfst Du die jungen Ärzte an denen herumexpimentieren lassen. Der 5yo hat wieder StrepA.
September 13, 2026 at 11:55 AM
Hilfe. Irgendwann schicke ich alle Anderen Kitaeltern zu Dir, dann darfst Du die jungen Ärzte an denen herumexpimentieren lassen. Der 5yo hat wieder StrepA.
Fantastic to see this immense body of excellent work published! Well done @alexjkeeley.bsky.social and everyone involved 👏
#StrepA
@floreyinstitute.bsky.social
@molmicrosheffield.bsky.social
#StrepA
@floreyinstitute.bsky.social
@molmicrosheffield.bsky.social
🧵 Our paper out today in @naturemedicine.bsky.social
www.nature.com/articles/s41...
On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon
1/
#Immunosky #IDsky #MicroSky #globalhealth.
www.nature.com/articles/s41...
On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon
1/
#Immunosky #IDsky #MicroSky #globalhealth.
www.nature.com
August 8, 2025 at 10:25 AM
Fantastic to see this immense body of excellent work published! Well done @alexjkeeley.bsky.social and everyone involved 👏
#StrepA
@floreyinstitute.bsky.social
@molmicrosheffield.bsky.social
#StrepA
@floreyinstitute.bsky.social
@molmicrosheffield.bsky.social
It's strepA 🫠 we got antibiotics and everything already but man, it sucks. It should be illegal for kids to get sick.
Little one is sick now too. Just a mild fever at least. I obviously brought the plague to the house 💀
September 4, 2026 at 11:44 PM
It's strepA 🫠 we got antibiotics and everything already but man, it sucks. It should be illegal for kids to get sick.
Latest from @mrcunitgambia.bsky.social #StrepA group. Show clinical decision rules developed elsewhere (mostly HIC) have poor performance in Gambia & molecular tests detect far more #StrepA than culture. Given burden of RhD in Africa we urgently need better & affordable tests for #StrepA diagnosis
Evaluating clinical decision rules and rapid diagnostic tests for the diagnosis of Streptococcus pyogenes pharyngitis in Gambian children: a diagnostic accuracy study
Accurate diagnosis of Streptococcus pyogenes (S. pyogenes) pharyngitis is imperative
in high rheumatic heart disease-burden countries. We aimed to assess the diagnostic
accuracy of two rapid diagnosti...
www.journalofinfection.com
July 6, 2025 at 1:00 PM
Latest from @mrcunitgambia.bsky.social #StrepA group. Show clinical decision rules developed elsewhere (mostly HIC) have poor performance in Gambia & molecular tests detect far more #StrepA than culture. Given burden of RhD in Africa we urgently need better & affordable tests for #StrepA diagnosis
Und StrepA ( Australien) x.com/leanhealth/s...
November 17, 2023 at 6:46 PM
Und StrepA ( Australien) x.com/leanhealth/s...
The #WellcomeTrust CDA Fellowship team is fully assembled! Saikou Bah, Henna Khalid, Sona Jabang & Jess Buddle, let the #StrepA research commence 🥳🎉 @molmicrosheffield.bsky.social #UniversityofSheffield
March 7, 2025 at 2:25 PM
The #WellcomeTrust CDA Fellowship team is fully assembled! Saikou Bah, Henna Khalid, Sona Jabang & Jess Buddle, let the #StrepA research commence 🥳🎉 @molmicrosheffield.bsky.social #UniversityofSheffield
Characterisation of UK StrepA isolates during the 2022-3 upsurge
www.microbiologyresearch.org/content/jour...
www.microbiologyresearch.org/content/jour...
Molecular characterization of Streptococcus pyogenes (StrepA) non-invasive isolates during the 2022–2023 UK upsurge
At the end of 2022 into early 2023, the UK Health Security Agency reported unusually high levels of scarlet fever and invasive disease caused by Streptococcus pyogenes (StrepA or group A Streptococcus...
www.microbiologyresearch.org
August 16, 2024 at 12:33 PM
Characterisation of UK StrepA isolates during the 2022-3 upsurge
www.microbiologyresearch.org/content/jour...
www.microbiologyresearch.org/content/jour...
Great thread 👇 & 📜:
A beautifully told story from complex serological data around
@joshosowicki.bsky.social #StrepA human challenge.
Amazing how much you can learn from controlled experimental challenge with 25 humans, setting standards for future CHIM / vaccine trials / seroepi ...
#IDSky
A beautifully told story from complex serological data around
@joshosowicki.bsky.social #StrepA human challenge.
Amazing how much you can learn from controlled experimental challenge with 25 humans, setting standards for future CHIM / vaccine trials / seroepi ...
#IDSky
🎉 I'm a #newPI , and I'm so excited to share our new paper out in Nature Comms today! 🧵
rdcu.be/d2gBV
Quick intro for the new followers:
I'm from Monash Uni in Melbourne, and we study T and B cell responses to viruses, bacteria & parasites with the goal of improving vaccines. #ImmunoSky #MicroSky
rdcu.be/d2gBV
Quick intro for the new followers:
I'm from Monash Uni in Melbourne, and we study T and B cell responses to viruses, bacteria & parasites with the goal of improving vaccines. #ImmunoSky #MicroSky
December 3, 2024 at 10:08 PM
Great thread 👇 & 📜:
A beautifully told story from complex serological data around
@joshosowicki.bsky.social #StrepA human challenge.
Amazing how much you can learn from controlled experimental challenge with 25 humans, setting standards for future CHIM / vaccine trials / seroepi ...
#IDSky
A beautifully told story from complex serological data around
@joshosowicki.bsky.social #StrepA human challenge.
Amazing how much you can learn from controlled experimental challenge with 25 humans, setting standards for future CHIM / vaccine trials / seroepi ...
#IDSky
... Einem Zustand der einer Immunsuppression ähnelt.
Im Übrigen lassen sich diese Effekte leider extrem gut an den Ländern die nie oder nur minimal Kinder geschützt haben (Schweden, Tennessee, Alberta, England) und den dortigen RSV/StrepA Erkrankungsmustern sehen
Im Übrigen lassen sich diese Effekte leider extrem gut an den Ländern die nie oder nur minimal Kinder geschützt haben (Schweden, Tennessee, Alberta, England) und den dortigen RSV/StrepA Erkrankungsmustern sehen
November 17, 2023 at 6:43 PM
... Einem Zustand der einer Immunsuppression ähnelt.
Im Übrigen lassen sich diese Effekte leider extrem gut an den Ländern die nie oder nur minimal Kinder geschützt haben (Schweden, Tennessee, Alberta, England) und den dortigen RSV/StrepA Erkrankungsmustern sehen
Im Übrigen lassen sich diese Effekte leider extrem gut an den Ländern die nie oder nur minimal Kinder geschützt haben (Schweden, Tennessee, Alberta, England) und den dortigen RSV/StrepA Erkrankungsmustern sehen
Phenomenal piece of work by a great team across @mrcunitgambia.bsky.social @lshtm.bsky.social @sheffielduni.bsky.social - Delighted to have played a small part in combining epidemiology & immunology to shed light on what protection for #StrepA might look like & help advance vaccine development.
🧵 Our paper out today in @naturemedicine.bsky.social
www.nature.com/articles/s41...
On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon
1/
#Immunosky #IDsky #MicroSky #globalhealth.
www.nature.com/articles/s41...
On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon
1/
#Immunosky #IDsky #MicroSky #globalhealth.
www.nature.com
August 8, 2025 at 3:28 PM
Phenomenal piece of work by a great team across @mrcunitgambia.bsky.social @lshtm.bsky.social @sheffielduni.bsky.social - Delighted to have played a small part in combining epidemiology & immunology to shed light on what protection for #StrepA might look like & help advance vaccine development.
The new paper is about immune responses to Streptococcus pyogenes #StrepA, a bacteria that causes Strep throat, invasive infections, and in some people can cause an autoimmune disease, rheumatic fever, overall resulting in ~500,000 deaths/year globally.
There is still no Strep A #vaccine. 💉
There is still no Strep A #vaccine. 💉
December 3, 2024 at 1:11 PM
Das COVID das Risiko für RSV um 40% erhöht wussten wir bereits. Nun ist der Nachweis auch für StrepA erbracht. Hazard-Ratio für Streptokokken-Mandelentzündung 4 bis 8 Monate nach der Diagnose erhöht mit Höhepunkt nach 6 Monaten (Hazard-Ratio 1,27).“
www.bmj.com/content/380/...
www.bmj.com/content/380/...
Long covid outcomes at one year after mild SARS-CoV-2 infection: nationwide cohort study
Objectives To determine the clinical sequelae of long covid for a year after infection in patients with mild disease and to evaluate its association with age, sex, SARS-CoV-2 variants, and vaccination...
www.bmj.com
December 2, 2023 at 2:09 PM
Das COVID das Risiko für RSV um 40% erhöht wussten wir bereits. Nun ist der Nachweis auch für StrepA erbracht. Hazard-Ratio für Streptokokken-Mandelentzündung 4 bis 8 Monate nach der Diagnose erhöht mit Höhepunkt nach 6 Monaten (Hazard-Ratio 1,27).“
www.bmj.com/content/380/...
www.bmj.com/content/380/...
New research article in The Lancet Microbe
#Streptococcus pyogenes carriage and infection within households in The Gambia: a longitudinal cohort study
www.thelancet.com/journals/lan...
#StrepA #MicroSky #IDSky #OpenAccess #OA
#Streptococcus pyogenes carriage and infection within households in The Gambia: a longitudinal cohort study
www.thelancet.com/journals/lan...
#StrepA #MicroSky #IDSky #OpenAccess #OA
May 9, 2024 at 11:41 AM
New research article in The Lancet Microbe
#Streptococcus pyogenes carriage and infection within households in The Gambia: a longitudinal cohort study
www.thelancet.com/journals/lan...
#StrepA #MicroSky #IDSky #OpenAccess #OA
#Streptococcus pyogenes carriage and infection within households in The Gambia: a longitudinal cohort study
www.thelancet.com/journals/lan...
#StrepA #MicroSky #IDSky #OpenAccess #OA
This #StrepA paper was a LONG labour of love from a great team 😊 Equal first & senior author credits buried at the very end, so I want to highlight the critical contributions of Dr Hannah Frost & @njmoreland.bsky.social & Dr Danika Hill @precisionvaxlab.bsky.social rdcu.be/d2gBV
Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections
Nature Communications - Streptococcus pyogenes is a deadly bacteria without a vaccine. Here, researchers measured antibodies in serum and saliva from a strep throat human challenge trial. Baseline...
rdcu.be
December 3, 2024 at 10:37 PM
This #StrepA paper was a LONG labour of love from a great team 😊 Equal first & senior author credits buried at the very end, so I want to highlight the critical contributions of Dr Hannah Frost & @njmoreland.bsky.social & Dr Danika Hill @precisionvaxlab.bsky.social rdcu.be/d2gBV
Erwartungen sind erfüllt worden. Mit der Expositionsprophylaxe war mir z.B. nicht klar. Aber das werden die Kliniken ja in die Wege leiten, bei invasiven StrepA Infektionen. Trotzdem wichtig zu wissen, da man Eltern diesbezüglich dann auch aufklären kann.
November 23, 2023 at 8:11 PM
Erwartungen sind erfüllt worden. Mit der Expositionsprophylaxe war mir z.B. nicht klar. Aber das werden die Kliniken ja in die Wege leiten, bei invasiven StrepA Infektionen. Trotzdem wichtig zu wissen, da man Eltern diesbezüglich dann auch aufklären kann.