The aspartame sweetener was found to promote atherosclerosis in animal models
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation
Wu et al. provide new insights into how aspartame consumption exacerbates atherosclerosis
through an insulin-dependent mechanism. Aspartame-triggered high insulin levels upregulate
the endothelial mem...
www.cell.com
February 19, 2025 at 6:15 PM
The aspartame sweetener was found to promote atherosclerosis in animal models
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Like, the Y-chromosome is literally just a simplified X-chromosome with the SRY gene added
The SRY gene that is only active during a short window of fetal development in order to upregulate the gene that triggers testicular development, then permanently shuts off
The SRY gene that is only active during a short window of fetal development in order to upregulate the gene that triggers testicular development, then permanently shuts off
July 9, 2026 at 3:46 PM
Like, the Y-chromosome is literally just a simplified X-chromosome with the SRY gene added
The SRY gene that is only active during a short window of fetal development in order to upregulate the gene that triggers testicular development, then permanently shuts off
The SRY gene that is only active during a short window of fetal development in order to upregulate the gene that triggers testicular development, then permanently shuts off
🐦⬛Bowerbirds!🕺Sexual signals!🪹Bower construction!🚨Disruptions!
Our #EditorsChoice for the #AnimalBehaviourJournal:
“Male great bowerbirds upregulate multiple sexual signals following bower wall removal”
Read here:
doi.org/10.1016/j.anbehav.2026.123480
Our #EditorsChoice for the #AnimalBehaviourJournal:
“Male great bowerbirds upregulate multiple sexual signals following bower wall removal”
Read here:
doi.org/10.1016/j.anbehav.2026.123480
March 20, 2026 at 5:14 PM
🐦⬛Bowerbirds!🕺Sexual signals!🪹Bower construction!🚨Disruptions!
Our #EditorsChoice for the #AnimalBehaviourJournal:
“Male great bowerbirds upregulate multiple sexual signals following bower wall removal”
Read here:
doi.org/10.1016/j.anbehav.2026.123480
Our #EditorsChoice for the #AnimalBehaviourJournal:
“Male great bowerbirds upregulate multiple sexual signals following bower wall removal”
Read here:
doi.org/10.1016/j.anbehav.2026.123480
me when I upregulate the frontotemporal neuroprotective matrices and activate downstream afferent interactome cascades
March 12, 2025 at 2:47 PM
me when I upregulate the frontotemporal neuroprotective matrices and activate downstream afferent interactome cascades
The twist no one saw coming:
The vaccines actually upregulate PD-L1 on cancer cells.
Wait that sounds bad, right?
PD-L1 is the "don't kill me" flag tumors use to hide.
But here’s the genius: that makes them more visible to checkpoint inhibitors.
The vaccines actually upregulate PD-L1 on cancer cells.
Wait that sounds bad, right?
PD-L1 is the "don't kill me" flag tumors use to hide.
But here’s the genius: that makes them more visible to checkpoint inhibitors.
June 30, 2026 at 1:42 PM
The twist no one saw coming:
The vaccines actually upregulate PD-L1 on cancer cells.
Wait that sounds bad, right?
PD-L1 is the "don't kill me" flag tumors use to hide.
But here’s the genius: that makes them more visible to checkpoint inhibitors.
The vaccines actually upregulate PD-L1 on cancer cells.
Wait that sounds bad, right?
PD-L1 is the "don't kill me" flag tumors use to hide.
But here’s the genius: that makes them more visible to checkpoint inhibitors.
Just recently I wrote an opinion piece with Shingo Kajimura, based around the idea that adipocytes, besides having energy storage/endocrine function, also act as immune hubs #Immunosky 🧪
1/🧵
febs.onlinelibrary.wiley.com/doi/10.1111/...
1/🧵
febs.onlinelibrary.wiley.com/doi/10.1111/...
FEBS Press
Traditionally, adipocytes have been viewed as energy storage units, which upregulate inflammatory factors in response to obesity. However, emerging evidence demonstrates that adipocytes are highly re...
febs.onlinelibrary.wiley.com
December 7, 2024 at 9:31 AM
Just recently I wrote an opinion piece with Shingo Kajimura, based around the idea that adipocytes, besides having energy storage/endocrine function, also act as immune hubs #Immunosky 🧪
1/🧵
febs.onlinelibrary.wiley.com/doi/10.1111/...
1/🧵
febs.onlinelibrary.wiley.com/doi/10.1111/...
#Pericyte #PulmonaryHypertension
1/2
A subpopulation of Higd1b+ lung capillary pericytes
👉Migrate to distal arteriole
👉Upregulate Vimentin
👉Acquire #SmoothMuscleCell identity (α-SMA, circumferential wrapping)
in🐭Hypoxic PH
#SciArt
Ke Yuan lab @embojournal.org 2025
www.embopress.org/doi/full/10....
1/2
A subpopulation of Higd1b+ lung capillary pericytes
👉Migrate to distal arteriole
👉Upregulate Vimentin
👉Acquire #SmoothMuscleCell identity (α-SMA, circumferential wrapping)
in🐭Hypoxic PH
#SciArt
Ke Yuan lab @embojournal.org 2025
www.embopress.org/doi/full/10....
January 27, 2025 at 1:41 PM
#Pericyte #PulmonaryHypertension
1/2
A subpopulation of Higd1b+ lung capillary pericytes
👉Migrate to distal arteriole
👉Upregulate Vimentin
👉Acquire #SmoothMuscleCell identity (α-SMA, circumferential wrapping)
in🐭Hypoxic PH
#SciArt
Ke Yuan lab @embojournal.org 2025
www.embopress.org/doi/full/10....
1/2
A subpopulation of Higd1b+ lung capillary pericytes
👉Migrate to distal arteriole
👉Upregulate Vimentin
👉Acquire #SmoothMuscleCell identity (α-SMA, circumferential wrapping)
in🐭Hypoxic PH
#SciArt
Ke Yuan lab @embojournal.org 2025
www.embopress.org/doi/full/10....
Happy to be on bluesky on #FollowFriday. I am the Director of GIA (@giaglyco.bsky.social) working on #glycotime w/ lectin microarrays and #systemsbiology . My lab uncovered important glycans in host response to #infections and #cancer. We also discovered #miRNA upregulate in dividing cells.
November 22, 2024 at 10:25 PM
Happy to be on bluesky on #FollowFriday. I am the Director of GIA (@giaglyco.bsky.social) working on #glycotime w/ lectin microarrays and #systemsbiology . My lab uncovered important glycans in host response to #infections and #cancer. We also discovered #miRNA upregulate in dividing cells.
This was me before my coach was like nah we’re gonna upregulate you, it’s been too long. I haven’t gained any weight in the last 6 weeks and I’m eating like 900 more calories a day. Pretty wild
September 24, 2026 at 5:43 PM
This was me before my coach was like nah we’re gonna upregulate you, it’s been too long. I haven’t gained any weight in the last 6 weeks and I’m eating like 900 more calories a day. Pretty wild
right. leakage from the owl-representing parts of the model is influencing which numbers the model "randomly" produces, and that covariance is a signal which fine-tuning can follow in order to upregulate owl-obsession.
July 22, 2025 at 7:42 PM
right. leakage from the owl-representing parts of the model is influencing which numbers the model "randomly" produces, and that covariance is a signal which fine-tuning can follow in order to upregulate owl-obsession.
With Emilio and Emily we hypothesized that cells would upregulate TERRA. Unexpectedly, TERRA levels actually stayed the same after ALT activation.
September 24, 2026 at 9:45 PM
With Emilio and Emily we hypothesized that cells would upregulate TERRA. Unexpectedly, TERRA levels actually stayed the same after ALT activation.
Just recently I wrote an opinion piece with Shingo Kajimura, based around the idea that adipocytes, besides having energy storage/endocrine function, also act as immune hubs. We’ve known for a long time that they’re responsive to cytokines & in turn express cytokines 1/🧵
#Immunosky 🧪
#Immunosky 🧪
FEBS Press
Traditionally, adipocytes have been viewed as energy storage units, which upregulate inflammatory factors in response to obesity. However, emerging evidence demonstrates that adipocytes are highly re...
febs.onlinelibrary.wiley.com
November 12, 2024 at 10:29 PM
Just recently I wrote an opinion piece with Shingo Kajimura, based around the idea that adipocytes, besides having energy storage/endocrine function, also act as immune hubs. We’ve known for a long time that they’re responsive to cytokines & in turn express cytokines 1/🧵
#Immunosky 🧪
#Immunosky 🧪
Very excited about latest report from @igorulitsky.bsky.social's lab
using an ASO to upregulate CHD2 expression!
using an ASO to upregulate CHD2 expression!
Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share:
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵
biorxiv.org/content/earl...
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵
biorxiv.org/content/earl...
Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression
Modes of action of long noncoding RNAs (lncRNAs) are poorly understood. CHASERR is a broadly expressed lncRNA located immediately upstream of the promoter of the CHD2 gene. We show that antisense olig...
biorxiv.org
May 30, 2025 at 4:03 PM
Very excited about latest report from @igorulitsky.bsky.social's lab
using an ASO to upregulate CHD2 expression!
using an ASO to upregulate CHD2 expression!
Vitamin B12 was found to decrease mRNA levels of neuroinflammatory CCL11, upregulate neuroprotective HGF, and, to a lesser extent, downregulated CSF2 and CXCL10 in the leukocytes of people with VCD and cognitive dysfunction in Long COVID. buff.ly/RVCDQ79
#medsky 😷🧪
#medsky 😷🧪
Vitamin B12 as an epidrug for regulating peripheral blood biomarkers in long COVID-associated visuoconstructive deficit - Scientific Reports
Scientific Reports - Vitamin B12 as an epidrug for regulating peripheral blood biomarkers in long COVID-associated visuoconstructive deficit
buff.ly
March 20, 2025 at 10:30 PM
Vitamin B12 was found to decrease mRNA levels of neuroinflammatory CCL11, upregulate neuroprotective HGF, and, to a lesser extent, downregulated CSF2 and CXCL10 in the leukocytes of people with VCD and cognitive dysfunction in Long COVID. buff.ly/RVCDQ79
#medsky 😷🧪
#medsky 😷🧪
'Our analysis uncovers that female thymic cells upregulate energy regulation, transcription, and antigen-presentation pathways, whereas male cells increase proinflammatory signaling, amino acid metabolism, and GPCR signaling'
#Immunology #Immunosky
www.cell.com/developmenta...
#Immunology #Immunosky
www.cell.com/developmenta...
October 11, 2024 at 8:01 AM
'Our analysis uncovers that female thymic cells upregulate energy regulation, transcription, and antigen-presentation pathways, whereas male cells increase proinflammatory signaling, amino acid metabolism, and GPCR signaling'
#Immunology #Immunosky
www.cell.com/developmenta...
#Immunology #Immunosky
www.cell.com/developmenta...
wife sent me furry art because it's cute, and then refused to tell me who drew it because "it has an American flag in it. and I don't want to upregulate harmful memes like the idea of America as a nation state." which is really funny but the worst part is i agree with her.
September 4, 2026 at 5:34 PM
wife sent me furry art because it's cute, and then refused to tell me who drew it because "it has an American flag in it. and I don't want to upregulate harmful memes like the idea of America as a nation state." which is really funny but the worst part is i agree with her.
Resilience isn't a fixed trait but a flexible skill, shaped by neural circuits that downregulate stress & upregulate positive emotions. Practice mindfulness to strengthen resilience by training the reward system. Affect-regulation strategies like reappraisal reduce stress exposure and adversity.
September 23, 2026 at 3:37 PM
Resilience isn't a fixed trait but a flexible skill, shaped by neural circuits that downregulate stress & upregulate positive emotions. Practice mindfulness to strengthen resilience by training the reward system. Affect-regulation strategies like reappraisal reduce stress exposure and adversity.
Proud of @faezehjame.bsky.social and our latest paper on upregulation by #miRNA. miRNA upregulate protein expression of CD98hc, ST3GAL1 and ST3GAL2 in a coordinated manner. Regulation is bidirectional, changing the picture on how these #RNA work. #glycotime
www.science.org/doi/10.1126/... 🧪
www.science.org/doi/10.1126/... 🧪
Screening the human miRNA interactome reveals coordinated up-regulation in melanoma, adding bidirectional regulation to miRNA networks
Analysis of ST3GAL1/2 and CD98hc regulation by miRNA reveals co–up-regulation, adding a bidirectional twist to miRNA networks.
www.science.org
January 13, 2025 at 8:29 PM
Proud of @faezehjame.bsky.social and our latest paper on upregulation by #miRNA. miRNA upregulate protein expression of CD98hc, ST3GAL1 and ST3GAL2 in a coordinated manner. Regulation is bidirectional, changing the picture on how these #RNA work. #glycotime
www.science.org/doi/10.1126/... 🧪
www.science.org/doi/10.1126/... 🧪
Metabolic flexibility allows neutrophils to fight Candida
In response to C. albicans glucose consumption, neutrophils upregulate PYGL-mediated glycogenolysis through a dectin-1/PKA axis, thus sustaining antifungal function in glucose-deprived tissues
www.cell.com/cell-host-mi...
In response to C. albicans glucose consumption, neutrophils upregulate PYGL-mediated glycogenolysis through a dectin-1/PKA axis, thus sustaining antifungal function in glucose-deprived tissues
www.cell.com/cell-host-mi...
Glycogen phosphorylase L confers metabolic flexibility in neutrophils to fight fungal infections in nutrient-deprived tissues
Neutrophils depend on glucose for their antifungal activities. Candida albicans consumes
glucose, thus posing metabolic challenges for neutrophils. Choi and colleagues show
that neutrophils upregulate...
www.cell.com
March 18, 2026 at 6:38 PM
Metabolic flexibility allows neutrophils to fight Candida
In response to C. albicans glucose consumption, neutrophils upregulate PYGL-mediated glycogenolysis through a dectin-1/PKA axis, thus sustaining antifungal function in glucose-deprived tissues
www.cell.com/cell-host-mi...
In response to C. albicans glucose consumption, neutrophils upregulate PYGL-mediated glycogenolysis through a dectin-1/PKA axis, thus sustaining antifungal function in glucose-deprived tissues
www.cell.com/cell-host-mi...
Nature research paper: Oncogenic fusions converge on shared mechanisms in initiating astroblastoma
https://go.nature.com/4iYl8SJ
https://go.nature.com/4iYl8SJ
Oncogenic fusions converge on shared mechanisms in initiating astroblastoma - Nature
The molecular mechanisms of astroblastoma development are identified, whereby distinct gene fusions upregulate shared transcriptional networks to disrupt the normal development of ventral telencephalon neural progenitors, which leads to oncogenesis.
go.nature.com
May 15, 2025 at 7:59 AM
Nature research paper: Oncogenic fusions converge on shared mechanisms in initiating astroblastoma
https://go.nature.com/4iYl8SJ
https://go.nature.com/4iYl8SJ
Thrilled to share my first first-author paper is out
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density
Genetic studies implicate clusterin (CLU) in the pathogenesis of Alzheimer’s disease (AD), yet its precise molecular impact remains unclear. Through u…
www.sciencedirect.com
April 30, 2025 at 3:51 PM
Thrilled to share my first first-author paper is out
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
#Medsky🧪 #gynsky #oncosky #pharmasky first report that stromal changes in the #fallopiantube actually have a causative role in #ovariancancer initiation.The existing drugs that upregulate #AMPkinase could potentially prevent or reverse early changes in the #stroma that lead to #ovariancancer.
March 20, 2025 at 4:51 PM
#Medsky🧪 #gynsky #oncosky #pharmasky first report that stromal changes in the #fallopiantube actually have a causative role in #ovariancancer initiation.The existing drugs that upregulate #AMPkinase could potentially prevent or reverse early changes in the #stroma that lead to #ovariancancer.
UPREGULATE YOUR JOY, CITIZEN
April 17, 2025 at 7:22 AM
UPREGULATE YOUR JOY, CITIZEN
Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation: Cell Metabolism www.cell.com/cell-metabol... 🧪
Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation
Wu et al. provide new insights into how aspartame consumption exacerbates atherosclerosis
through an insulin-dependent mechanism. Aspartame-triggered high insulin levels upregulate
the endothelial mem...
www.cell.com
June 19, 2025 at 7:49 PM
Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation: Cell Metabolism www.cell.com/cell-metabol... 🧪