Uridine: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...
a great not-to-miss piece from the @lyssiotislab.bsky.social
a great not-to-miss piece from the @lyssiotislab.bsky.social
Uridine
Uridine is a pyrimidine nucleoside composed of an uracil base and a ribose sugar.
In cells, uridine is predominantly present in RNA (as uridine monophosphate, UMP).
Uridine can be produced through de ...
www.cell.com
June 15, 2025 at 6:43 AM
Uridine: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...
a great not-to-miss piece from the @lyssiotislab.bsky.social
a great not-to-miss piece from the @lyssiotislab.bsky.social
So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!
Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters
Uridine boosts aminoglycoside treatment efficiency against antibiotic-susceptible as well as antibiotic-resistant E. coli strains.
www.science.org
September 6, 2025 at 9:35 AM
So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!
Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉
Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team!
#NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social
🔗 www.nature.com/articles/s42...
🧵1/17
Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team!
#NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social
🔗 www.nature.com/articles/s42...
🧵1/17
Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
www.nature.com
November 13, 2025 at 10:19 AM
Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉
Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team!
#NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social
🔗 www.nature.com/articles/s42...
🧵1/17
Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team!
#NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social
🔗 www.nature.com/articles/s42...
🧵1/17
Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports
imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate
in the lung where they inhibit CD8+ T cells, promote fibr...
www.embopress.org
July 23, 2025 at 8:48 PM
Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....
Certain forms of pancreatic cancer, for example, rely on uridine when glucose is scarce.
So, they programmed the fat to eat just uridine, and they easily outcompeted these pancreatic cancer cells. This suggests that fat could be adapted to any cancer's dietary preferences.
So, they programmed the fat to eat just uridine, and they easily outcompeted these pancreatic cancer cells. This suggests that fat could be adapted to any cancer's dietary preferences.
February 5, 2025 at 5:20 PM
Certain forms of pancreatic cancer, for example, rely on uridine when glucose is scarce.
So, they programmed the fat to eat just uridine, and they easily outcompeted these pancreatic cancer cells. This suggests that fat could be adapted to any cancer's dietary preferences.
So, they programmed the fat to eat just uridine, and they easily outcompeted these pancreatic cancer cells. This suggests that fat could be adapted to any cancer's dietary preferences.
No uridine (U) ? You hate RNA? No m6a ?
May 15, 2026 at 3:40 PM
No uridine (U) ? You hate RNA? No m6a ?
Rich collections of papers on #mitochondrialdisease from the last 2 weeks! 📚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @mitoscientist.bsky.social
@gavinmcstay.bsky.social
Demethoxy-CoQ and NUDT5 in nucleotide synthesis
www.nature.com/articles/s42...
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @mitoscientist.bsky.social
@gavinmcstay.bsky.social
Demethoxy-CoQ and NUDT5 in nucleotide synthesis
www.nature.com/articles/s42...
Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
www.nature.com
November 23, 2025 at 11:59 AM
Rich collections of papers on #mitochondrialdisease from the last 2 weeks! 📚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @mitoscientist.bsky.social
@gavinmcstay.bsky.social
Demethoxy-CoQ and NUDT5 in nucleotide synthesis
www.nature.com/articles/s42...
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @mitoscientist.bsky.social
@gavinmcstay.bsky.social
Demethoxy-CoQ and NUDT5 in nucleotide synthesis
www.nature.com/articles/s42...
🚨 New preprint available! Third and final in the #CRISPR screen series!🚨
👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis
www.biorxiv.org/content/10.1...
By A. Strefeler in collaboration with Dave Pagliarini and team.
@DIB_UNIL @FBM_UNIL
🧵 1/9
👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis
www.biorxiv.org/content/10.1...
By A. Strefeler in collaboration with Dave Pagliarini and team.
@DIB_UNIL @FBM_UNIL
🧵 1/9
www.biorxiv.org
March 14, 2025 at 8:14 AM
🚨 New preprint available! Third and final in the #CRISPR screen series!🚨
👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis
www.biorxiv.org/content/10.1...
By A. Strefeler in collaboration with Dave Pagliarini and team.
@DIB_UNIL @FBM_UNIL
🧵 1/9
👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis
www.biorxiv.org/content/10.1...
By A. Strefeler in collaboration with Dave Pagliarini and team.
@DIB_UNIL @FBM_UNIL
🧵 1/9
Unconventional monooxygenation by the O2-dependent tRNA wobble uridine hydroxylase TrhO www.nature.com/articles/s41... 🦠 cryo-electron microscopy structure of Bacillus subtilis TrhO–tRNAAla complex
Unconventional monooxygenation by the O2-dependent tRNA wobble uridine hydroxylase TrhO - Nature Chemical Biology
Shin et al. report the cryo-electron microscopy structure and catalytic mechanism of TrhO, a cofactor-independent enzyme that hydroxylates tRNA wobble uridine using molecular oxygen through a…
www.nature.com
June 10, 2026 at 5:48 PM
Unconventional monooxygenation by the O2-dependent tRNA wobble uridine hydroxylase TrhO www.nature.com/articles/s41... 🦠 cryo-electron microscopy structure of Bacillus subtilis TrhO–tRNAAla complex
📢We're recruiting📢
Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo!
Please share
#uridine #cancermetabolism #immunometabolism
@unil.bsky.social
🔗(PDF): www.jourdainlab.org/wp-content/u...
Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo!
Please share
#uridine #cancermetabolism #immunometabolism
@unil.bsky.social
🔗(PDF): www.jourdainlab.org/wp-content/u...
December 16, 2024 at 11:13 AM
📢We're recruiting📢
Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo!
Please share
#uridine #cancermetabolism #immunometabolism
@unil.bsky.social
🔗(PDF): www.jourdainlab.org/wp-content/u...
Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo!
Please share
#uridine #cancermetabolism #immunometabolism
@unil.bsky.social
🔗(PDF): www.jourdainlab.org/wp-content/u...
🧬 In 1995, Katalin Karikó was demoted at UPenn because her grants weren't landing and her papers weren't cited. The mRNA chemistry she developed over the next 20 years (modifying uridine to pseudouridine) became the COVID-19 vaccines and the 2023 Nobel Prize.
June 18, 2026 at 10:20 PM
🧬 In 1995, Katalin Karikó was demoted at UPenn because her grants weren't landing and her papers weren't cited. The mRNA chemistry she developed over the next 20 years (modifying uridine to pseudouridine) became the COVID-19 vaccines and the 2023 Nobel Prize.
'Our findings delineate a novel metabolic-immunological axis by demonstrating that uridine acts as a key modulator to potentiate IFN-γ secretion in CD8+ T cells. This enhancement is mechanistically driven by uridine’s role in promoting the N-glycosylation of CD45'
#Immunology #Metabolism
#Immunology #Metabolism
Uridine depletion impairs CD8⁺ T cell antitumor activity through N-glycosylation
Xiao et al. reveal that sorting nexin 17 (SNX17) promotes the synthesis of uridine
phosphorylase 1 (UPP1) in tumor cells, leading to a decrease in uridine concentration
within the tumor microenvironme...
www.cell.com
December 31, 2025 at 3:20 AM
'Our findings delineate a novel metabolic-immunological axis by demonstrating that uridine acts as a key modulator to potentiate IFN-γ secretion in CD8+ T cells. This enhancement is mechanistically driven by uridine’s role in promoting the N-glycosylation of CD45'
#Immunology #Metabolism
#Immunology #Metabolism
April 8, 2026 at 7:03 PM
We discovered that Yb acts as a U-content sensor. It selectively channels uridine-rich transcripts to piRNA biogenesis, effectively initiating their phased processing into piRNAs. (6/19)
February 13, 2026 at 3:11 PM
We discovered that Yb acts as a U-content sensor. It selectively channels uridine-rich transcripts to piRNA biogenesis, effectively initiating their phased processing into piRNAs. (6/19)
A new paper reports the cryo-EM structure and catalytic mechanism of TrhO, a cofactor-independent enzyme that hydroxylates tRNA wobble uridine using molecular oxygen through a reactive cysteine intermediate
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Unconventional monooxygenation by the O2-dependent tRNA wobble uridine hydroxylase TrhO - Nature Chemical Biology
Shin et al. report the cryo-electron microscopy structure and catalytic mechanism of TrhO, a cofactor-independent enzyme that hydroxylates tRNA wobble uridine using molecular oxygen through a reactive...
www.nature.com
January 20, 2026 at 8:48 PM
A new paper reports the cryo-EM structure and catalytic mechanism of TrhO, a cofactor-independent enzyme that hydroxylates tRNA wobble uridine using molecular oxygen through a reactive cysteine intermediate
www.nature.com/articles/s41...
www.nature.com/articles/s41...
That’s just be because you’re not campus admin and still have your sense of humor. One day when uridine you won’t find it funny anymore.
August 9, 2025 at 6:01 AM
That’s just be because you’re not campus admin and still have your sense of humor. One day when uridine you won’t find it funny anymore.
Check this out: we designed "U-ramp" reporters with entirely synthetic 3’ UTRs by varying in their uridine content (20% to 45%). The result was striking: U-density behaves like a threshold—below ~30% U, barely any piRNAs; above it, output shoots up in a Yb-dependent manner. (7/19)
February 13, 2026 at 3:11 PM
Check this out: we designed "U-ramp" reporters with entirely synthetic 3’ UTRs by varying in their uridine content (20% to 45%). The result was striking: U-density behaves like a threshold—below ~30% U, barely any piRNAs; above it, output shoots up in a Yb-dependent manner. (7/19)
Unconventional monooxygenation by the O2-dependent tRNA wobble uridine hydroxylase TrhO www.nature.com/articles/s41... 🦠 cryo-electron microscopy structure of Bacillus subtilis TrhO–tRNAAla complex
Unconventional monooxygenation by the O2-dependent tRNA wobble uridine hydroxylase TrhO - Nature Chemical Biology
Shin et al. report the cryo-electron microscopy structure and catalytic mechanism of TrhO, a cofactor-independent enzyme that hydroxylates tRNA wobble uridine using molecular oxygen through a…
www.nature.com
June 10, 2026 at 5:47 PM
Unconventional monooxygenation by the O2-dependent tRNA wobble uridine hydroxylase TrhO www.nature.com/articles/s41... 🦠 cryo-electron microscopy structure of Bacillus subtilis TrhO–tRNAAla complex
Out now in @natmetabolism.nature.com by @jourdainlab.bsky.social 📢
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interaction with PPAT.
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interaction with PPAT.
Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
doi.org
November 13, 2025 at 2:10 PM
Out now in @natmetabolism.nature.com by @jourdainlab.bsky.social 📢
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interaction with PPAT.
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interaction with PPAT.
Uridine depletion impairs CD8⁺ T cell antitumor activity through N-glycosylation @cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
December 29, 2025 at 5:22 PM
Uridine depletion impairs CD8⁺ T cell antitumor activity through N-glycosylation @cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Nature research paper: Structural basis of the RNA-editing cascade in trypanosome mitochondria
go.nature.com/3T9HlWV
go.nature.com/3T9HlWV
Structural basis of the RNA-editing cascade in trypanosome mitochondria - Nature
Cryo-electron microscopy sheds light on the architecture of the Trypanosoma brucei mitochondrial editosome and reveals how this assembly mediates mRNA editing through the insertion and deletion of uridine nucleotides.
go.nature.com
July 23, 2026 at 12:13 PM
Nature research paper: Structural basis of the RNA-editing cascade in trypanosome mitochondria
go.nature.com/3T9HlWV
go.nature.com/3T9HlWV
🎉 We’re excited to share our very first preprint!! 🎉
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells
Pluripotent stem cells (SCs) rely on metabolic rewiring to regulate self-renewal and differentiation. The hexosamine biosynthetic pathway (HBP) integrates multiple metabolic inputs to produce uridine ...
doi.org
August 24, 2025 at 11:29 AM
🎉 We’re excited to share our very first preprint!! 🎉
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
So excited to see @malinkjosavik.bsky.social beautiful work out @bmc.springernature.com 🤩! Check it out to see where the RNA-label ✨EU✨ shows up in our favourite sea anemone and how to catch your organism crafting DNA from RNA labelling tools 🧬👀.
#transcription
#transcription
February 1, 2026 at 9:35 PM
So excited to see @malinkjosavik.bsky.social beautiful work out @bmc.springernature.com 🤩! Check it out to see where the RNA-label ✨EU✨ shows up in our favourite sea anemone and how to catch your organism crafting DNA from RNA labelling tools 🧬👀.
#transcription
#transcription