1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts - Nature Metabolism
Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.
www.nature.com
July 29, 2025 at 2:56 PM
1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts - Nature Metabolism
Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.
www.nature.com
July 30, 2025 at 5:10 AM
Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Two recipients of gene-edited pig kidneys have successfully received human organs, a milestone in the wider effort to advance xenografts. www.statnews.com/2026/09/03/r...
Recipients of gene-edited pig kidneys successfully receive human organs
Two recipients of gene-edited pig kidneys have successfully received human organs, a milestone in the wider effort to advance xenografts.
www.statnews.com
September 4, 2026 at 4:35 PM
Two recipients of gene-edited pig kidneys have successfully received human organs, a milestone in the wider effort to advance xenografts. www.statnews.com/2026/09/03/r...
Unser Immunsystem ist bisschen diffiziler als das männliche, sonst könnten wir nicht 40 Wochen lang Xenografts in unserem Uterus zusammenbauen.
Schwangerschaftsdiabetes, Pregnancy Brain, die Elastineinlagerungen, Gelenkentzündungen etc. sind alles Autoimmunerkrankungen btw.
Schwangerschaftsdiabetes, Pregnancy Brain, die Elastineinlagerungen, Gelenkentzündungen etc. sind alles Autoimmunerkrankungen btw.
October 20, 2023 at 7:58 AM
Unser Immunsystem ist bisschen diffiziler als das männliche, sonst könnten wir nicht 40 Wochen lang Xenografts in unserem Uterus zusammenbauen.
Schwangerschaftsdiabetes, Pregnancy Brain, die Elastineinlagerungen, Gelenkentzündungen etc. sind alles Autoimmunerkrankungen btw.
Schwangerschaftsdiabetes, Pregnancy Brain, die Elastineinlagerungen, Gelenkentzündungen etc. sind alles Autoimmunerkrankungen btw.
Happy to share a new #NORLUX study on how humanized patient-derived xenografts of #glioblastoma can be useful in investigating immunosuppression and clinically-relevant immunotherapy testing. See for more: www.biorxiv.org/content/10.1...
#immunotherapy, #preclinicalmodeling,
#immunotherapy, #preclinicalmodeling,
November 23, 2025 at 5:03 PM
Happy to share a new #NORLUX study on how humanized patient-derived xenografts of #glioblastoma can be useful in investigating immunosuppression and clinically-relevant immunotherapy testing. See for more: www.biorxiv.org/content/10.1...
#immunotherapy, #preclinicalmodeling,
#immunotherapy, #preclinicalmodeling,
In case you have not seen it. The latest paper from @caldaslab.bsky.social in @theaacr.bsky.social.
Xenografts as avatars!
aacrjournals.org/cancerres/ar...
Xenografts as avatars!
aacrjournals.org/cancerres/ar...
Modeling Drug Responses and Evolutionary Dynamics Using Patient-Derived Xenografts Reveals Precision Medicine Strategies for Triple-Negative Breast Cancer
Patient-derived tumor xenografts from treatment-naïve breast cancer samples can predict patient drug responses and model treatment-induced phenotypic and functional evolution, making them valuable pre...
aacrjournals.org
February 8, 2025 at 12:10 PM
In case you have not seen it. The latest paper from @caldaslab.bsky.social in @theaacr.bsky.social.
Xenografts as avatars!
aacrjournals.org/cancerres/ar...
Xenografts as avatars!
aacrjournals.org/cancerres/ar...
Scientific papers are full of fun phrases like "nude mice with human prostate tumor xenografts".
March 27, 2024 at 4:33 PM
Scientific papers are full of fun phrases like "nude mice with human prostate tumor xenografts".
📣 📣 Recruiting for an engineer position 🐠 🔬
We are looking for a person with strong background/experience with the #zebrafish model, ideally track record experience in #imaging, #xenografts and/or #cancer models. See below 👇
More info on the lab : www.goetzlab.fr
Please share !
We are looking for a person with strong background/experience with the #zebrafish model, ideally track record experience in #imaging, #xenografts and/or #cancer models. See below 👇
More info on the lab : www.goetzlab.fr
Please share !
October 8, 2026 at 9:01 AM
📣 📣 Recruiting for an engineer position 🐠 🔬
We are looking for a person with strong background/experience with the #zebrafish model, ideally track record experience in #imaging, #xenografts and/or #cancer models. See below 👇
More info on the lab : www.goetzlab.fr
Please share !
We are looking for a person with strong background/experience with the #zebrafish model, ideally track record experience in #imaging, #xenografts and/or #cancer models. See below 👇
More info on the lab : www.goetzlab.fr
Please share !
Would you like to learn more about Zebrafish Cancer #Xenografts? Apply to this intensive hands-on course!
🗓️ 30 June - 4 July, 2025
📍 Champalimaud Foundation, Lisbon 🇵🇹
✏️ Application deadline: 9 May
✅ Confirmation: 13 May
👉 More info & registration form via 🔗: www.fchampalimaud.org/events/hands... 🧪
🗓️ 30 June - 4 July, 2025
📍 Champalimaud Foundation, Lisbon 🇵🇹
✏️ Application deadline: 9 May
✅ Confirmation: 13 May
👉 More info & registration form via 🔗: www.fchampalimaud.org/events/hands... 🧪
April 12, 2025 at 2:43 PM
Would you like to learn more about Zebrafish Cancer #Xenografts? Apply to this intensive hands-on course!
🗓️ 30 June - 4 July, 2025
📍 Champalimaud Foundation, Lisbon 🇵🇹
✏️ Application deadline: 9 May
✅ Confirmation: 13 May
👉 More info & registration form via 🔗: www.fchampalimaud.org/events/hands... 🧪
🗓️ 30 June - 4 July, 2025
📍 Champalimaud Foundation, Lisbon 🇵🇹
✏️ Application deadline: 9 May
✅ Confirmation: 13 May
👉 More info & registration form via 🔗: www.fchampalimaud.org/events/hands... 🧪
Big effort (> 7 years) from a large number of colleagues. Finally on BioRxiv and to be submitted in January
Pan-cancer N-glycoproteomic atlas of patient derived xenografts uncovers FAT2 as a therapeutic target for head and neck cancers
www.biorxiv.org/content/10.1...
Pan-cancer N-glycoproteomic atlas of patient derived xenografts uncovers FAT2 as a therapeutic target for head and neck cancers
www.biorxiv.org/content/10.1...
Pan-cancer N-glycoproteomic atlas of patient derived xenografts uncovers FAT2 as a therapeutic target for head and neck cancers
Cell surface proteins offer significant cancer therapeutic potential attributable to their accessible membrane localization and central role in cellular signaling. Despite this, their promise remains ...
www.biorxiv.org
December 14, 2024 at 4:38 PM
Big effort (> 7 years) from a large number of colleagues. Finally on BioRxiv and to be submitted in January
Pan-cancer N-glycoproteomic atlas of patient derived xenografts uncovers FAT2 as a therapeutic target for head and neck cancers
www.biorxiv.org/content/10.1...
Pan-cancer N-glycoproteomic atlas of patient derived xenografts uncovers FAT2 as a therapeutic target for head and neck cancers
www.biorxiv.org/content/10.1...
Gene-edited pig liver xenografts successfully maintain function in human blood circulation, generating critical safety data for advancing toward living patient trials.
https://news.gmj.ge/briefs/gene-edited-pig-livers-advance-toward-clinical-use-in-human-trials/
https://news.gmj.ge/briefs/gene-edited-pig-livers-advance-toward-clinical-use-in-human-trials/
Gene-Edited Pig Livers Advance Toward Clinical Use in Human Trials
Gene-edited pig liver xenografts successfully maintain function in human blood circulation, generating critical safety data for advancing toward living patient trials.
news.gmj.ge
October 6, 2026 at 11:27 PM
Gene-edited pig liver xenografts successfully maintain function in human blood circulation, generating critical safety data for advancing toward living patient trials.
https://news.gmj.ge/briefs/gene-edited-pig-livers-advance-toward-clinical-use-in-human-trials/
https://news.gmj.ge/briefs/gene-edited-pig-livers-advance-toward-clinical-use-in-human-trials/
Xenografts are crazy this is cool
June 21, 2026 at 9:11 PM
Xenografts are crazy this is cool
to scale up the grav panel industry.
Coral grafts are in many ways simpler; coral-based xenografts exist today, and using grafts to convey antibiotics (and I think antivirals) is also already a Thing. But with Old Earth's oceans decimated and mariforming still an unpredictable practice, (7/8)
Coral grafts are in many ways simpler; coral-based xenografts exist today, and using grafts to convey antibiotics (and I think antivirals) is also already a Thing. But with Old Earth's oceans decimated and mariforming still an unpredictable practice, (7/8)
March 3, 2026 at 4:39 PM
to scale up the grav panel industry.
Coral grafts are in many ways simpler; coral-based xenografts exist today, and using grafts to convey antibiotics (and I think antivirals) is also already a Thing. But with Old Earth's oceans decimated and mariforming still an unpredictable practice, (7/8)
Coral grafts are in many ways simpler; coral-based xenografts exist today, and using grafts to convey antibiotics (and I think antivirals) is also already a Thing. But with Old Earth's oceans decimated and mariforming still an unpredictable practice, (7/8)
Lentiviral barcoding used to track the clonal growth of over 20,000 single-cell-derived clones in 110 xenografts from 26 patient-derived breast cancer xenograft models.
Beautiful work @nguyenlab.bsky.social!!
Beautiful work @nguyenlab.bsky.social!!
I am excited to share the latest publication from the Nguyen, Caldas @carloscaldas1960.bsky.social and Rueda labs @ruedalab.bsky.social. This was a massive effort from a fantastic team and I’m grateful to everyone on the paper for their work on this project! doi.org/10.1016/j.ce...
#bcsm #PDTX
#bcsm #PDTX
Redirecting
doi.org
May 12, 2025 at 8:34 PM
Lentiviral barcoding used to track the clonal growth of over 20,000 single-cell-derived clones in 110 xenografts from 26 patient-derived breast cancer xenograft models.
Beautiful work @nguyenlab.bsky.social!!
Beautiful work @nguyenlab.bsky.social!!
Excited to share the first preprint from our lab! We combined a DNA Typewriter lineage recorder with clone-resolved founder profiling to find what makes metastatic potential heritable in lung cancer xenografts. 1/13 www.biorxiv.org/content/10.6...
Time-resolved lineage recording reveals a pre-existing, heritable cell state underlying metastatic potential
Metastasis causes most cancer deaths, yet no recurrent mutation specifically drives it, raising the possibility that metastatic potential is a non-genetic yet heritable cell state. Classic experiments...
www.biorxiv.org
August 11, 2026 at 7:53 PM
Excited to share the first preprint from our lab! We combined a DNA Typewriter lineage recorder with clone-resolved founder profiling to find what makes metastatic potential heritable in lung cancer xenografts. 1/13 www.biorxiv.org/content/10.6...
Online Now: Spatial omics resolves adrenergic and mesenchymal cell states in neuroblastoma
Spatial omics resolves adrenergic and mesenchymal cell states in neuroblastoma
Patel et al. combine six spatial-omics platforms with single-cell/single-nucleus RNA sequencing across 54 neuroblastoma tumors to resolve a debate over malignant mesenchymal (MES) tumor cells. Using signatures from patient-derived xenografts, they identify MES tumor cells and show that a higher MES score predicts worse patient outcome.
dlvr.it
October 8, 2026 at 6:51 PM
Online Now: Spatial omics resolves adrenergic and mesenchymal cell states in neuroblastoma
Biologically relevant integration of transcriptomics profiles from cancer cell lines, patient-derived xenografts, and clinical tumors www.science.org/doi/10.1126/...
Biologically relevant integration of transcriptomics profiles from cancer cell lines, patient-derived xenografts, and clinical tumors using deep learning
A proposed deep learning method helps to bridge the gap between preclinical cancer models and clinical tumors.
www.science.org
January 22, 2025 at 1:29 PM
Biologically relevant integration of transcriptomics profiles from cancer cell lines, patient-derived xenografts, and clinical tumors www.science.org/doi/10.1126/...
Proud of this collaboration with Philip Van Damme’s team: we show that microglia and astrocytes behave differently in sporadic vs. C9orf72 ALS across human tissue, iPSC-derived cells and in vivo xenografts.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Client Challenge
www.nature.com
October 14, 2025 at 9:51 AM
Proud of this collaboration with Philip Van Damme’s team: we show that microglia and astrocytes behave differently in sporadic vs. C9orf72 ALS across human tissue, iPSC-derived cells and in vivo xenografts.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
RESEARCH | 🧪
@rjdlab.bsky.social
@jennifer-gill.bsky.social et al
(UTSWMed Center)
Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts
@rjdlab.bsky.social
@jennifer-gill.bsky.social et al
(UTSWMed Center)
Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts
Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts - Nature Metabolism
Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.
bit.ly
September 20, 2025 at 4:31 PM
RESEARCH | 🧪
@rjdlab.bsky.social
@jennifer-gill.bsky.social et al
(UTSWMed Center)
Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts
@rjdlab.bsky.social
@jennifer-gill.bsky.social et al
(UTSWMed Center)
Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts
how well do xenografts model metabolism of human tumors? this is a really helpful resource, congrats to @rjdlab.bsky.social et al!
pubmed.ncbi.nlm.nih.gov/40731149/
pubmed.ncbi.nlm.nih.gov/40731149/
Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts - PubMed
Patient-derived xenografts (PDXs) are frequently used as preclinical models, but their recapitulation of tumour metabolism in patients has not been closely examined. We developed a parallel workflow t...
pubmed.ncbi.nlm.nih.gov
August 4, 2025 at 12:10 PM
how well do xenografts model metabolism of human tumors? this is a really helpful resource, congrats to @rjdlab.bsky.social et al!
pubmed.ncbi.nlm.nih.gov/40731149/
pubmed.ncbi.nlm.nih.gov/40731149/
OK YOU CAN MAKE BONE XENOGRAFTS OUT OF CORAL according to Wikipedia??? and specifically we want Europan gene-modding tech to be important and Europa is like one of the only places left that coral exists in quantity HMMMMMMM
March 1, 2026 at 7:56 PM
OK YOU CAN MAKE BONE XENOGRAFTS OUT OF CORAL according to Wikipedia??? and specifically we want Europan gene-modding tech to be important and Europa is like one of the only places left that coral exists in quantity HMMMMMMM
Hypoxia preconditioned neural xenografts promote repair of brain tissue after stroke https://www.biorxiv.org/content/10.1101/2025.09.30.679547v1
October 2, 2025 at 8:15 PM
Hypoxia preconditioned neural xenografts promote repair of brain tissue after stroke https://www.biorxiv.org/content/10.1101/2025.09.30.679547v1
An annotated biobank of triple negative breast cancer patient-derived xenografts featuring treatment-naive and longitudinal samples throughout neoadjuvant chemotherapy https://www.biorxiv.org/content/10.1101/2024.11.25.625287v1
An annotated biobank of triple negative breast cancer patient-derived xenografts featuring treatment-naive and longitudinal samples throughout neoadjuvant chemotherapy https://www.biorxiv.org/content/10.1101/2024.11.25.625287v1
Triple negative breast cancer (TNBC) that fails to respond to neoadjuvant chemotherapy (NACT) can be
www.biorxiv.org
November 29, 2024 at 5:49 AM
An annotated biobank of triple negative breast cancer patient-derived xenografts featuring treatment-naive and longitudinal samples throughout neoadjuvant chemotherapy https://www.biorxiv.org/content/10.1101/2024.11.25.625287v1
We prebiously.showed cellular phenotypic heterogeneity of xenografts impacts drug responses 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response - Nature Communications
The heterogeneity of breast cancer has a major role in drug response and resistance. In this study, the authors use patient-derived tumour xenografts as a platform for drug testing and correlation wit...
www.nature.com
February 8, 2025 at 12:26 PM
We prebiously.showed cellular phenotypic heterogeneity of xenografts impacts drug responses 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Trying to identify preclinical models that resemble clinical tumors you work on? Check out our MOBER, now out in @science.org Advances! www.science.org/doi/10.1126/... . There's also a web app to explore the results mober.pythonanywhere.com
Biologically relevant integration of transcriptomics profiles from cancer cell lines, patient-derived xenografts, and clinical tumors using deep learning
A proposed deep learning method helps to bridge the gap between preclinical cancer models and clinical tumors.
www.science.org
January 22, 2025 at 5:20 PM
Trying to identify preclinical models that resemble clinical tumors you work on? Check out our MOBER, now out in @science.org Advances! www.science.org/doi/10.1126/... . There's also a web app to explore the results mober.pythonanywhere.com