Prachi Stafford
@dodoscientist.bsky.social
Senior lecturer & Researcher in #microbiology, #cellbiology #platelets at Sheffield Hallam University, Sheffield, UK.
Speaks English, Français, Mauritian Creole (from the land of the dodos) & basic Hindi. She/her #WomenInStem #EDI
Speaks English, Français, Mauritian Creole (from the land of the dodos) & basic Hindi. She/her #WomenInStem #EDI
Reposted by Prachi Stafford
Why do pathological protein aggregates persist in cells and how can we overcome this?
In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored.
#Autophagy #Tau #Proteostasis
Out now 👇 www.biorxiv.org/content/10.6...
In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored.
#Autophagy #Tau #Proteostasis
Out now 👇 www.biorxiv.org/content/10.6...
www.biorxiv.org
February 14, 2026 at 1:34 PM
Why do pathological protein aggregates persist in cells and how can we overcome this?
In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored.
#Autophagy #Tau #Proteostasis
Out now 👇 www.biorxiv.org/content/10.6...
In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored.
#Autophagy #Tau #Proteostasis
Out now 👇 www.biorxiv.org/content/10.6...
Reposted by Prachi Stafford
No joke: I got angry hate mail today for writing an obituary of a Black woman scientist—because the person felt she did didn’t deserve the recognition.
Which just makes me want to share it again: www.nature.com/articles/d41...
Which just makes me want to share it again: www.nature.com/articles/d41...
Gladys Mae West obituary: mathematician who pioneered GPS technology
She made key contributions to US cold-war science despite facing huge barriers as a Black woman.
www.nature.com
February 6, 2026 at 9:09 AM
No joke: I got angry hate mail today for writing an obituary of a Black woman scientist—because the person felt she did didn’t deserve the recognition.
Which just makes me want to share it again: www.nature.com/articles/d41...
Which just makes me want to share it again: www.nature.com/articles/d41...
Reposted by Prachi Stafford
Immunologist Indira Nath would have been 88 years old today. She studied immune responses and the nerve damage caused by leprosy, which was highly prevalent in India at the time. By the end of her career, that prevalence had been knocked from 58/10,000 to 1/10,000.
#WomenInSTEM #BioSky 🧪🧬
#WomenInSTEM #BioSky 🧪🧬
January 14, 2026 at 2:54 PM
Immunologist Indira Nath would have been 88 years old today. She studied immune responses and the nerve damage caused by leprosy, which was highly prevalent in India at the time. By the end of her career, that prevalence had been knocked from 58/10,000 to 1/10,000.
#WomenInSTEM #BioSky 🧪🧬
#WomenInSTEM #BioSky 🧪🧬
Reposted by Prachi Stafford
Mathematician Gertrude Mary Cox was born 126 years ago today. She was one of the foremost statisticians of her time, whose 1950 text Experimental Designs was for decades the standard work on how to design experiments to produce statistically significant results.
#WomenInSTEM #MathSky #Statistics 🧮🧪
#WomenInSTEM #MathSky #Statistics 🧮🧪
January 13, 2026 at 3:11 PM
Mathematician Gertrude Mary Cox was born 126 years ago today. She was one of the foremost statisticians of her time, whose 1950 text Experimental Designs was for decades the standard work on how to design experiments to produce statistically significant results.
#WomenInSTEM #MathSky #Statistics 🧮🧪
#WomenInSTEM #MathSky #Statistics 🧮🧪
Reposted by Prachi Stafford
Two groundbreaking women of medicine share today as their birthday - Marie Durocher (b. 1809) dressed as a man to practice medicine in Brazil for a half century, while Harriette Chick (b. 1875) worked as a microbiologist, discovering the causes of both rickets and pellagra.
#WomenInSTEM 🧪⚕️
#WomenInSTEM 🧪⚕️
January 6, 2026 at 3:10 PM
Two groundbreaking women of medicine share today as their birthday - Marie Durocher (b. 1809) dressed as a man to practice medicine in Brazil for a half century, while Harriette Chick (b. 1875) worked as a microbiologist, discovering the causes of both rickets and pellagra.
#WomenInSTEM 🧪⚕️
#WomenInSTEM 🧪⚕️
Reposted by Prachi Stafford
A recent paper reveals a surprising insight. The length of the cell cycle in a particular tissue determines the oncogenic transformation capacity of particular oncogenes, with tissues with shorter cell cycles most susceptible 3/n
July 26, 2025 at 2:14 PM
A recent paper reveals a surprising insight. The length of the cell cycle in a particular tissue determines the oncogenic transformation capacity of particular oncogenes, with tissues with shorter cell cycles most susceptible 3/n
Thrilled our proposal on 'the effects of carbon monoxide on platelets' has been funded by CO Research Trust! Excited to study this under-researched area & provide new insights.
#PublicHealth #CarbonMonoxide #Platelets
@herigstad.bsky.social, Caroline Dalton
@sheffieldhallamuni.bsky.social
#PublicHealth #CarbonMonoxide #Platelets
@herigstad.bsky.social, Caroline Dalton
@sheffieldhallamuni.bsky.social
Carbon monoxide and Platelets: The role of CO in clotting | CO Research
Carbon monoxide (CO) is a colourless, odourless gas commonly encountered in urban environments due to pollution, in occupational settings, and sometimes at home from faulty appliances. At toxic levels...
www.coresearchtrust.org
July 15, 2025 at 8:45 PM
Thrilled our proposal on 'the effects of carbon monoxide on platelets' has been funded by CO Research Trust! Excited to study this under-researched area & provide new insights.
#PublicHealth #CarbonMonoxide #Platelets
@herigstad.bsky.social, Caroline Dalton
@sheffieldhallamuni.bsky.social
#PublicHealth #CarbonMonoxide #Platelets
@herigstad.bsky.social, Caroline Dalton
@sheffieldhallamuni.bsky.social
📢 we have a fully-funded #PhDOpportunity 🎓🧬
#Oral Bacteria and #Alzheimer’s Disease: A Potential Role for the Integrated Stress Response.’’
📅 Deadline: May 13th
🔗 Apply here: www.findaphd.com/phds/project...
📢 Please share widely
#PhDOpportunity #GTA #AlzheimersResearch #Microbiology #ISR
#Oral Bacteria and #Alzheimer’s Disease: A Potential Role for the Integrated Stress Response.’’
📅 Deadline: May 13th
🔗 Apply here: www.findaphd.com/phds/project...
📢 Please share widely
#PhDOpportunity #GTA #AlzheimersResearch #Microbiology #ISR
Oral Bacteria and Alzheimer’s Disease: A Potential Role for the Integrated Stress Response at Sheffield Hallam University on FindAPhD.com
PhD Project - Oral Bacteria and Alzheimer’s Disease: A Potential Role for the Integrated Stress Response at Sheffield Hallam University, listed on FindAPhD.com
www.findaphd.com
April 16, 2025 at 10:21 PM
📢 we have a fully-funded #PhDOpportunity 🎓🧬
#Oral Bacteria and #Alzheimer’s Disease: A Potential Role for the Integrated Stress Response.’’
📅 Deadline: May 13th
🔗 Apply here: www.findaphd.com/phds/project...
📢 Please share widely
#PhDOpportunity #GTA #AlzheimersResearch #Microbiology #ISR
#Oral Bacteria and #Alzheimer’s Disease: A Potential Role for the Integrated Stress Response.’’
📅 Deadline: May 13th
🔗 Apply here: www.findaphd.com/phds/project...
📢 Please share widely
#PhDOpportunity #GTA #AlzheimersResearch #Microbiology #ISR
Reposted by Prachi Stafford
In this week's #mitophagy papers, Rab GTPases take the centre stage, with a systematic study their role in autophagy, showing that multiple "Rabs" selectively mediate the degradation of mitochondria and other cellular components.
Thanks to @biomednews.bsky.social
biomed.news/bims-tofagi/...
Thanks to @biomednews.bsky.social
biomed.news/bims-tofagi/...
April 13, 2025 at 11:29 AM
In this week's #mitophagy papers, Rab GTPases take the centre stage, with a systematic study their role in autophagy, showing that multiple "Rabs" selectively mediate the degradation of mitochondria and other cellular components.
Thanks to @biomednews.bsky.social
biomed.news/bims-tofagi/...
Thanks to @biomednews.bsky.social
biomed.news/bims-tofagi/...
@campbellsg.bsky.social, might be of interest
Integrator loss leads to dsRNA formation that triggers the integrated stress response: Cell www.cell.com/cell/fulltex...
Integrator loss leads to dsRNA formation that triggers the integrated stress response
Integrator (INT) prevents the escape of immature RNAPII to ensure full-length mRNA
production. INT deficiency causes defects in RNAPII maturation that lead to premature
termination, accumulation of im...
www.cell.com
April 16, 2025 at 7:56 AM
@campbellsg.bsky.social, might be of interest
Reposted by Prachi Stafford
Our new paper!! Led by @drpauldijkstra.bsky.social with @jessrmorley.bsky.social and awesome medical student Yosra Mekki. #digitalhealth #medsky #episky
How to Read a Paper Involving AI.
bmjmedicine.bmj.com/content/4/1/...
How to Read a Paper Involving AI.
bmjmedicine.bmj.com/content/4/1/...
How to read a paper involving artificial intelligence (AI)
This paper guides readers through the critical appraisal of a paper that includes the use of artificial intelligence (AI) in clinical settings for healthcare delivery. A brief introduction to the diff...
bmjmedicine.bmj.com
April 16, 2025 at 6:43 AM
Our new paper!! Led by @drpauldijkstra.bsky.social with @jessrmorley.bsky.social and awesome medical student Yosra Mekki. #digitalhealth #medsky #episky
How to Read a Paper Involving AI.
bmjmedicine.bmj.com/content/4/1/...
How to Read a Paper Involving AI.
bmjmedicine.bmj.com/content/4/1/...
Reposted by Prachi Stafford
Important paper from the ISTH SSC Platelet Physiology group! Congrats @alexkzis.bsky.social @dianvanderwaldr.bsky.social and all the authors!
@isth.org @jthjournal.bsky.social
#platelets #thrombosisandhaemostasis
@isth.org @jthjournal.bsky.social
#platelets #thrombosisandhaemostasis
We have worked for 2 years with @dianvanderwaldr.bsky.social to propose a protocol for platelet desialylation, and we are excited to now share it. Communication from the ISTH SSC Platelet Physiology. - Journal of Thrombosis and Haemostasis www.jthjournal.org/article/S153... #hemsky #hemesky
Consensus protocol for platelet desialylation (β-galactose exposure) quantification using lectins by flow cytometry: Communication from the ISTH SSC Subcommittee on Platelet Physiology.
Platelets contain many heterogeneous carbohydrates (glycans): often capped by sialic
acid. The removal of sialic acid (desialylation) is important for platelet function
and clearance, leading to novel...
www.jthjournal.org
April 4, 2025 at 4:16 PM
Important paper from the ISTH SSC Platelet Physiology group! Congrats @alexkzis.bsky.social @dianvanderwaldr.bsky.social and all the authors!
@isth.org @jthjournal.bsky.social
#platelets #thrombosisandhaemostasis
@isth.org @jthjournal.bsky.social
#platelets #thrombosisandhaemostasis
Reposted by Prachi Stafford
"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL
rdcu.be/ehbaL
The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage
Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...
rdcu.be
April 10, 2025 at 2:17 PM
"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL
rdcu.be/ehbaL
Reposted by Prachi Stafford
(1/2) Very happy to study of my friend @hps2022.bsky.social @cniostopcancer.bsky.social now out also at @naturecomms.bsky.social.
Another contribution to the field showing the importance of #platelets in #metastasis
www.nature.com/articles/s41...
Another contribution to the field showing the importance of #platelets in #metastasis
www.nature.com/articles/s41...
The impact of a high fat diet and platelet activation on pre-metastatic niche formation - Nature Communications
Previous work has identified a link between obesity and breast cancer metastasis. Here, using preclinical mouse models, the authors show that high-fat diet promotes platelet and endothelial cell activ...
www.nature.com
April 2, 2025 at 5:32 PM
(1/2) Very happy to study of my friend @hps2022.bsky.social @cniostopcancer.bsky.social now out also at @naturecomms.bsky.social.
Another contribution to the field showing the importance of #platelets in #metastasis
www.nature.com/articles/s41...
Another contribution to the field showing the importance of #platelets in #metastasis
www.nature.com/articles/s41...
Interesting thread on how glycans targeting vaccines could help against coronaviruses. The possibility of a universal vaccine again them!
Les enrobages de sucre ne sont pas réservés aux bonbons, ils aident également les virus, comme celui de la COVID-19, à se cacher du système immunitaire de leur hôte. Des chercheurs ont mis au point un vaccin universel qui cible les coronavirus et les sucres qu'ils
trustmyscience.com/vaccin-unive...
trustmyscience.com/vaccin-unive...
Vaccin universel contre les coronavirus en vue : il serait efficace contre la COVID-19, le MERS et certains rhumes
Un nouveau vaccin universel pourrait neutraliser plusieurs coronavirus, dont ceux à l’origine de la COVID-19, du MERS et de certains rhumes.
trustmyscience.com
March 30, 2025 at 12:24 PM
Interesting thread on how glycans targeting vaccines could help against coronaviruses. The possibility of a universal vaccine again them!
Reposted by Prachi Stafford
Reposted by Prachi Stafford
Bastounis, E. E., Serrano-Alcalde, F., ..., García-Aznar, J. M., & Theriot, J. A. (2021). Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells. Developmental cell, 56(4), 443–460.e11. #EpithelialMechanics
buff.ly/c4eJTxW
buff.ly/c4eJTxW
March 24, 2025 at 7:00 AM
Bastounis, E. E., Serrano-Alcalde, F., ..., García-Aznar, J. M., & Theriot, J. A. (2021). Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells. Developmental cell, 56(4), 443–460.e11. #EpithelialMechanics
buff.ly/c4eJTxW
buff.ly/c4eJTxW
Reposted by Prachi Stafford
New paper from my laboratory in EMBO Reports doi.org/10.1038/s443.... Our study challenges what we know about #mitochondria & #aging.
Developmental mitochondrial complex I activity determines lifespan | EMBO reports
imageimageTemporal manipulation of CI function reveals development as critical window where
reduction of CI produces short-lived and stress sensitive adults characterised by
maladaptive transcriptomic...
www.embopress.org
March 23, 2025 at 7:29 AM
New paper from my laboratory in EMBO Reports doi.org/10.1038/s443.... Our study challenges what we know about #mitochondria & #aging.
Reposted by Prachi Stafford
Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice www.nature.com/articles/s41...
Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice - Nature Communications
Cerebellar ataxia, a hallmark of cerebellar degeneration (CBND), is driven by mitochondrial dysfunction in Purkinje cells. In this study, transplanting mitochondria into CBND mice improve mitochondria...
www.nature.com
March 23, 2025 at 3:29 PM
Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice www.nature.com/articles/s41...
Re: 23andme.com & company takeover. You might want to request deletion of your data & destruction of your sample if you used this service.
If you have used 23andme.com for analysis of your genome like me, you may wish to read this document from the California Attorney General about requesting deletion of your data and destruction of your sample before the company is taken over. oag.ca.gov/news/press-r...
DNA Genetic Testing For Health, Ancestry And More - 23andMe
23andMe offers DNA testing with the most comprehensive ancestry breakdown, personalized health insights and more.
23andme.com
March 24, 2025 at 9:08 PM
Re: 23andme.com & company takeover. You might want to request deletion of your data & destruction of your sample if you used this service.
📢Join us for "Catalysing Diversity – A Chemistry Seminar Series for All"! Hear from scientists from minoritised, LGBTQ+, & neurodivergent communities as they share their journeys & insights.
🎤 Speaker: Dr Pooja Goddard
📅 March 25th|⏰ 5–6
Hybrid
#chemsky #Inclusivity #Diversity #RSC
🎤 Speaker: Dr Pooja Goddard
📅 March 25th|⏰ 5–6
Hybrid
#chemsky #Inclusivity #Diversity #RSC
March 24, 2025 at 8:26 PM
📢Join us for "Catalysing Diversity – A Chemistry Seminar Series for All"! Hear from scientists from minoritised, LGBTQ+, & neurodivergent communities as they share their journeys & insights.
🎤 Speaker: Dr Pooja Goddard
📅 March 25th|⏰ 5–6
Hybrid
#chemsky #Inclusivity #Diversity #RSC
🎤 Speaker: Dr Pooja Goddard
📅 March 25th|⏰ 5–6
Hybrid
#chemsky #Inclusivity #Diversity #RSC
Reposted by Prachi Stafford
New discovery from Fabiola Del Carpio-Cano on the role of RUNX1 regulates platelet-megakaryocyte F13A1 expression, impacting clot stabilization.
Read the full study: www.rpthjournal.org/article/S247...
#platelets #RUNX1
Read the full study: www.rpthjournal.org/article/S247...
#platelets #RUNX1
www.rpthjournal.org
March 18, 2025 at 6:00 PM
New discovery from Fabiola Del Carpio-Cano on the role of RUNX1 regulates platelet-megakaryocyte F13A1 expression, impacting clot stabilization.
Read the full study: www.rpthjournal.org/article/S247...
#platelets #RUNX1
Read the full study: www.rpthjournal.org/article/S247...
#platelets #RUNX1
🔬 Happy #InternationalWomensDay! Proud to be one of the many women in #Biosciences & #Chemistry working to make a difference in #Science and #Education through #Research and #Teaching. 🧪📚 Love working with this inspiring bunch. #IWD2025 #WomenInSTEM @hallam-biosci-chem.bsky.social
#ChemSky #BioSky
#ChemSky #BioSky
March 8, 2025 at 5:59 PM
🔬 Happy #InternationalWomensDay! Proud to be one of the many women in #Biosciences & #Chemistry working to make a difference in #Science and #Education through #Research and #Teaching. 🧪📚 Love working with this inspiring bunch. #IWD2025 #WomenInSTEM @hallam-biosci-chem.bsky.social
#ChemSky #BioSky
#ChemSky #BioSky
Reposted by Prachi Stafford
📢Join us for "Catalysing Diversity – A Chemistry Seminar Series for All"! Hear from scientists from minoritised, LGBTQ+, & neurodivergent communities as they share their journeys & insights.
🎤 Speaker: Prof Robert Mokaya, OBE, FRS
📅 March 5th|⏰ 5–6
Hybrid
#chemsky #Inclusivity #Diversity #RSC
🎤 Speaker: Prof Robert Mokaya, OBE, FRS
📅 March 5th|⏰ 5–6
Hybrid
#chemsky #Inclusivity #Diversity #RSC
February 26, 2025 at 10:30 PM
📢Join us for "Catalysing Diversity – A Chemistry Seminar Series for All"! Hear from scientists from minoritised, LGBTQ+, & neurodivergent communities as they share their journeys & insights.
🎤 Speaker: Prof Robert Mokaya, OBE, FRS
📅 March 5th|⏰ 5–6
Hybrid
#chemsky #Inclusivity #Diversity #RSC
🎤 Speaker: Prof Robert Mokaya, OBE, FRS
📅 March 5th|⏰ 5–6
Hybrid
#chemsky #Inclusivity #Diversity #RSC
Reposted by Prachi Stafford
In a remarkable new paper, Qureshi and Duss use multi-colour single-molecule fluorescence microscopy to directly and simultaneously track transcription, translation & coupling 3/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 1, 2025 at 5:05 PM