Maxim Igaev
@maxotubule.bsky.social
Computational Biophysicist and Royal Society University Research Fellow at Birkbeck, School of Natural Sciences 🇬🇧
Studying kinetochore-microtubule magic 🪄
Views are my own.
Studying kinetochore-microtubule magic 🪄
Views are my own.
Reposted by Maxim Igaev
Excited to share our new preprint! 📜
Here, we used CALVADOS and ultra-CG models to show how the kinetochore establishes a robust attachment to the dynamic microtubule end.
Spoiler: IDRs 🧵 1/n
www.biorxiv.org/content/10.6...
Here, we used CALVADOS and ultra-CG models to show how the kinetochore establishes a robust attachment to the dynamic microtubule end.
Spoiler: IDRs 🧵 1/n
www.biorxiv.org/content/10.6...
September 29, 2026 at 6:44 AM
Reposted by Maxim Igaev
Great news! 🎉 Congrats to @maxotubule.bsky.social @maksimkalutskii.bsky.social @mpi-nat.bsky.social and Birkbeck, University of London! Happy reading!! 📜
Excited to share our new preprint! 📜
Here, we used CALVADOS and ultra-CG models to show how the kinetochore establishes a robust attachment to the dynamic microtubule end.
Spoiler: IDRs 🧵 1/n
www.biorxiv.org/content/10.6...
Here, we used CALVADOS and ultra-CG models to show how the kinetochore establishes a robust attachment to the dynamic microtubule end.
Spoiler: IDRs 🧵 1/n
www.biorxiv.org/content/10.6...
September 24, 2026 at 10:29 AM
Great news! 🎉 Congrats to @maxotubule.bsky.social @maksimkalutskii.bsky.social @mpi-nat.bsky.social and Birkbeck, University of London! Happy reading!! 📜
Reposted by Maxim Igaev
Excited to share our new preprint! 📜
Here, we used CALVADOS and ultra-CG models to show how the kinetochore establishes a robust attachment to the dynamic microtubule end.
Spoiler: IDRs 🧵 1/n
www.biorxiv.org/content/10.6...
Here, we used CALVADOS and ultra-CG models to show how the kinetochore establishes a robust attachment to the dynamic microtubule end.
Spoiler: IDRs 🧵 1/n
www.biorxiv.org/content/10.6...
September 23, 2026 at 3:27 PM
Excited to share our new preprint! 📜
Here, we used CALVADOS and ultra-CG models to show how the kinetochore establishes a robust attachment to the dynamic microtubule end.
Spoiler: IDRs 🧵 1/n
www.biorxiv.org/content/10.6...
Here, we used CALVADOS and ultra-CG models to show how the kinetochore establishes a robust attachment to the dynamic microtubule end.
Spoiler: IDRs 🧵 1/n
www.biorxiv.org/content/10.6...
Reposted by Maxim Igaev
Dynamic microtubule-end structure governs multivalent kinetochore coupling by the Dam1c ring https://www.biorxiv.org/content/10.64898/2026.09.17.752406v1
September 23, 2026 at 2:47 PM
Dynamic microtubule-end structure governs multivalent kinetochore coupling by the Dam1c ring https://www.biorxiv.org/content/10.64898/2026.09.17.752406v1
Reposted by Maxim Igaev
🎉Just appeared online in #JCTC @pubs.acs.org "Improving Conformational Ensembles of Folded #Proteins in #GōMartini" @maksimkalutskii.bsky.social @maxotubule.bsky.social @carterjwilson.bsky.social pubs.acs.org/doi/10.1021/...
February 26, 2026 at 7:53 AM
🎉Just appeared online in #JCTC @pubs.acs.org "Improving Conformational Ensembles of Folded #Proteins in #GōMartini" @maksimkalutskii.bsky.social @maxotubule.bsky.social @carterjwilson.bsky.social pubs.acs.org/doi/10.1021/...
Reposted by Maxim Igaev
BioEmu is now on @science.org ! The revised version includes an upgraded model and makes a lot of MD simulation data internally generated at MSR available to the public. This took a lot of firepower from us in the last two years.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Scalable emulation of protein equilibrium ensembles with generative deep learning
Following the sequence and structure revolutions, predicting functionally relevant protein structure changes at scale remains an outstanding challenge. We introduce BioEmu, a deep learning system that...
www.science.org
July 10, 2025 at 6:09 PM
BioEmu is now on @science.org ! The revised version includes an upgraded model and makes a lot of MD simulation data internally generated at MSR available to the public. This took a lot of firepower from us in the last two years.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Maxim Igaev
New publication out on the evolution of protein-RNA interactions. Put together with Klára Hlouchová (@sciencecharles.bsky.social) during a lovely Czech spring.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
July 9, 2025 at 8:59 AM
New publication out on the evolution of protein-RNA interactions. Put together with Klára Hlouchová (@sciencecharles.bsky.social) during a lovely Czech spring.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Maxim Igaev
📌Carter @carterjwilson.bsky.social is presenting (P-2.44) "A Tale of Two #Aquaporins: Structural Mechanisms of Gating and Inhibition in Aqp3 and Aqp7" and + 📌Florian will explain (P-2.196) "How Loop #Dynamics Control Activity and Selectivity of a Short Chain #Reductase" Happy discussions! 👥
July 2, 2025 at 7:32 AM
📌Carter @carterjwilson.bsky.social is presenting (P-2.44) "A Tale of Two #Aquaporins: Structural Mechanisms of Gating and Inhibition in Aqp3 and Aqp7" and + 📌Florian will explain (P-2.196) "How Loop #Dynamics Control Activity and Selectivity of a Short Chain #Reductase" Happy discussions! 👥
Reposted by Maxim Igaev
Have a great D2@ #EBSA2025 in Rome🫠! Here are the posters of today's session: 📌Maksim @maksimkalutskii.bsky.social is presenting (P-2.195) his project addressing #Microtubule Dynamics Are Defined by Conformations and Stability of Clustered #Protofilaments 📜🔗 www.pnas.org/doi/10.1073/...
Microtubule dynamics are defined by conformations and stability of clustered protofilaments | PNAS
Microtubules are dynamic cytoskeletal polymers that add and lose tubulin dimers at
their ends. Microtubule growth, shortening, and transitions betw...
www.pnas.org
July 2, 2025 at 7:32 AM
Have a great D2@ #EBSA2025 in Rome🫠! Here are the posters of today's session: 📌Maksim @maksimkalutskii.bsky.social is presenting (P-2.195) his project addressing #Microtubule Dynamics Are Defined by Conformations and Stability of Clustered #Protofilaments 📜🔗 www.pnas.org/doi/10.1073/...
Reposted by Maxim Igaev
🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
June 23, 2025 at 1:00 PM
🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
Reposted by Maxim Igaev
the magic growing/shrinking GTP/GDP switch lies in the differential ability to bend out of plane and hold on neighbours.
Alone you go faster, together we go further.
Alone you go faster, together we go further.
Happy to contribute to this fantastic work by @maksimkalutskii.bsky.social and @maxotubule.bsky.social!
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
June 4, 2025 at 10:50 AM
the magic growing/shrinking GTP/GDP switch lies in the differential ability to bend out of plane and hold on neighbours.
Alone you go faster, together we go further.
Alone you go faster, together we go further.
Reposted by Maxim Igaev
Happy to contribute to this fantastic work by @maksimkalutskii.bsky.social and @maxotubule.bsky.social!
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
June 3, 2025 at 11:14 AM
Happy to contribute to this fantastic work by @maksimkalutskii.bsky.social and @maxotubule.bsky.social!
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
Reposted by Maxim Igaev
( #TubulinTuesday! )
Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.
June 10, 2025 at 11:29 PM
( #TubulinTuesday! )
Reposted by Maxim Igaev
UK immigration policy is destabilising international academics’ careers. The effort of staying compliant with fluctuating regulations diminishes the mental space for teaching, research and building belonging, say Zahra Sharifonnasabu et al
www.timeshighereducation.com/opinion/uk-i...
www.timeshighereducation.com/opinion/uk-i...
UK immigration policy is destabilising international academics’ careers
The effort of staying compliant with fluctuating regulations diminishes the mental space for teaching, research and building belonging, say Zahra Sharifonnasabi, Fleura Bardhi and Laetitia Mimoun
www.timeshighereducation.com
June 8, 2025 at 5:49 PM
UK immigration policy is destabilising international academics’ careers. The effort of staying compliant with fluctuating regulations diminishes the mental space for teaching, research and building belonging, say Zahra Sharifonnasabu et al
www.timeshighereducation.com/opinion/uk-i...
www.timeshighereducation.com/opinion/uk-i...
Reposted by Maxim Igaev
📜 Great work by Maksim and Co-authors! Congratulations to this latest #microtubule #publication in @pnas.org 🍾 @maxotubule.bsky.social @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social
Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.
June 5, 2025 at 8:56 AM
📜 Great work by Maksim and Co-authors! Congratulations to this latest #microtubule #publication in @pnas.org 🍾 @maxotubule.bsky.social @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social
Reposted by Maxim Igaev
Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.
June 3, 2025 at 9:08 AM
Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.
Reposted by Maxim Igaev
Our joint paper with Wonpil Im lab is now available as a preprint:
"Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations"
www.biorxiv.org/content/10.1...
"Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations"
www.biorxiv.org/content/10.1...
May 27, 2025 at 1:06 PM
Our joint paper with Wonpil Im lab is now available as a preprint:
"Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations"
www.biorxiv.org/content/10.1...
"Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations"
www.biorxiv.org/content/10.1...
Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.
June 3, 2025 at 9:08 AM
Excited to share our latest work in @pnas.org! Combining simulations and cryo-ET, we reveal how microtubules decide between growth and shortening. doi.org/10.1073/pnas... @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social @mpi-nat.bsky.social @qmul.ac.uk @dundee.ac.uk.
Reposted by Maxim Igaev
🚀 First Bluesky Post! 🎉 VMD 2.0 Alpha is here! Released today at BPS 2025, this is the biggest update in 30 years—new UI, real-time ray tracing, fast surfaces, UHD & touchscreen support. Monthly updates coming in 2025! Try it now! #VMD #BPS2025 #MolecularVisualization
www.ks.uiuc.edu/Research/vmd...
www.ks.uiuc.edu/Research/vmd...
February 17, 2025 at 6:56 AM
🚀 First Bluesky Post! 🎉 VMD 2.0 Alpha is here! Released today at BPS 2025, this is the biggest update in 30 years—new UI, real-time ray tracing, fast surfaces, UHD & touchscreen support. Monthly updates coming in 2025! Try it now! #VMD #BPS2025 #MolecularVisualization
www.ks.uiuc.edu/Research/vmd...
www.ks.uiuc.edu/Research/vmd...
Reposted by Maxim Igaev
Yean Ming Chew and I wrote doi.org/10.1042/BST2... about MT lattice switching. We discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.
February 12, 2025 at 4:22 PM
Yean Ming Chew and I wrote doi.org/10.1042/BST2... about MT lattice switching. We discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.
Reposted by Maxim Igaev
The regular registration for on-site participation has been closed. However, it is still possible to join our workshop online! You find the link to the according registration on our workshop website 🔗https://www.mpinat.mpg.de/workshop/huenfeld #TheoryHünfeld2025 #biophysics
📢 It's our great pleasure to invite you all to our upcoming #Workshop on "Computer Simulation and #Theory of Macromolecules" in #Hünfeld on March 7-8, 2025 in #hybrid format! See you online or on-site! More details are provided here: www.mpinat.mpg.de/workshop/hue... #TheoryHünfeld2025 #biophysics
January 7, 2025 at 9:55 AM
The regular registration for on-site participation has been closed. However, it is still possible to join our workshop online! You find the link to the according registration on our workshop website 🔗https://www.mpinat.mpg.de/workshop/huenfeld #TheoryHünfeld2025 #biophysics
Reposted by Maxim Igaev
We have a PhD position in Molecular chemical physics at UCT Prague, Czechia. It is closely related to our research of the evolution of #protein-RNA interactions. A pre-PhD #internship available from January 2025. Apply directly by email to [email protected].
December 14, 2024 at 1:04 PM
We have a PhD position in Molecular chemical physics at UCT Prague, Czechia. It is closely related to our research of the evolution of #protein-RNA interactions. A pre-PhD #internship available from January 2025. Apply directly by email to [email protected].
Reposted by Maxim Igaev
The inside of a cell is incredibly crowded! With advancing computing power and smart algorithms, this complex world is becoming more accessible through simulations.
This review summarizes the current state of modeling macromolecular crowding:
pubs.acs.org/doi/10.1021/...
#CompChem
This review summarizes the current state of modeling macromolecular crowding:
pubs.acs.org/doi/10.1021/...
#CompChem
Recent Progress in Modeling and Simulation of Biomolecular Crowding and Condensation Inside Cells
Macromolecular crowding in the cellular cytoplasm can potentially impact diffusion rates of proteins, their intrinsic structural stability, binding of proteins to their corresponding partners as well ...
pubs.acs.org
December 13, 2024 at 4:47 PM
The inside of a cell is incredibly crowded! With advancing computing power and smart algorithms, this complex world is becoming more accessible through simulations.
This review summarizes the current state of modeling macromolecular crowding:
pubs.acs.org/doi/10.1021/...
#CompChem
This review summarizes the current state of modeling macromolecular crowding:
pubs.acs.org/doi/10.1021/...
#CompChem
Reposted by Maxim Igaev
🎉 I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) 🎉
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org
Ewald Lab
@ EMBL-EBI. We identify and characterize chemical hazards to both humans and ecosystems with cell profiling data, machine learning, and integrative data analysis.
ewaldlab.org
December 13, 2024 at 2:12 PM
🎉 I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) 🎉
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org