I just want to #welcome all the new members with a beautiful multinucleated #Ichthyosporean just before undergoing #cellularization to form a transient #multicellular stage.
Imaged using #Expansion #Microscopy ( #UExM )
Species: Sphaeroforma arctica
Blue: Nuclei
Magenta: Tubulin
Imaged using #Expansion #Microscopy ( #UExM )
Species: Sphaeroforma arctica
Blue: Nuclei
Magenta: Tubulin
November 20, 2024 at 8:03 PM
Excited to share our new preprint! 📜
Here, we used CALVADOS and ultra-CG models to show how the kinetochore establishes a robust attachment to the dynamic microtubule end.
Spoiler: IDRs 🧵 1/n
www.biorxiv.org/content/10.6...
Here, we used CALVADOS and ultra-CG models to show how the kinetochore establishes a robust attachment to the dynamic microtubule end.
Spoiler: IDRs 🧵 1/n
www.biorxiv.org/content/10.6...
September 29, 2026 at 6:44 AM
Have a nice cellfie for #FluorescenceFriday (check the alt for details) 🧪
November 27, 2024 at 6:32 AM
🔬 From JCB’s July issue (rupress.org/jcb/issue/22...): a PtK2 cell plated on a micropattern and injected with low doses of soluble actin (orange) and tubulin (blue) in order to generate speckles along the corresponding filaments. From @manuelthery.bsky.social group (rupress.org/jcb/article/...).
July 15, 2025 at 7:46 PM
#FluorescenceFriday
One of my personal faves 😀 The Skeleton of The Cell- The Cytoskeleton
#CellBiology
One of my personal faves 😀 The Skeleton of The Cell- The Cytoskeleton
#CellBiology
December 10, 2024 at 4:12 PM
We detected specialized microtubule organizations that provided answers.
Early (left), microtubules formed a meshwork which was interwoven with Buc condensates.
Later (right), microtubules formed a cage-like organization that encapsulated the mature Bb.
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Early (left), microtubules formed a meshwork which was interwoven with Buc condensates.
Later (right), microtubules formed a cage-like organization that encapsulated the mature Bb.
>
January 14, 2025 at 5:16 PM
We employ all-atom replica exchange molecular dynamics simulations to resolve a high-confidence neck-region conformation of the dimeric human kinesin-1 bound to a structurally realistic microtubule lattice and use this structure to simulate kinesin’s initial stepping motion.
April 14, 2026 at 5:01 AM
Microtubule comets in human iPSCs to kick off my first week of grad school! ☄️💫
June 9, 2026 at 11:53 PM
How did microtubules adapt to support life across 🐸 species at divergent thermal niches?
Now online & OA @currentbiology.bsky.social
Thanks to Ella, Luca, @biswashere.bsky.social & Carolyn @mpiib-berlin.mpg.de @BirkbeckUoL 🙌
Enjoy reading! 👉 www.cell.com/current-biol...
Now online & OA @currentbiology.bsky.social
Thanks to Ella, Luca, @biswashere.bsky.social & Carolyn @mpiib-berlin.mpg.de @BirkbeckUoL 🙌
Enjoy reading! 👉 www.cell.com/current-biol...
Mechanistic basis of temperature adaptation in microtubule dynamics across frog species
Despite tubulin’s evolutionary conservation, microtubule dynamics are highly temperature sensitive. Troman et al. use natural tubulin variants from closely related Xenopus species to show that a decrease in tubulin’s apparent activation energy and weakening of lateral lattice contacts stabilize microtubules in cold-adapted frogs.
www.cell.com
January 14, 2025 at 8:44 PM
#TubulinTuesday...!
Happy #MicroscopyMonday everyone! Today's image is from Charlie! It is an adult cochlea where beta-3 tubulin (or Tuj1) is highlighting the neurons (green) and the hair cells (blue) are highlighted by Myo7a🔬👂
March 11, 2025 at 8:17 PM
#TubulinTuesday...!
This surface pattern reflects a patterned cytoskeleton. Actually Stentor has two cytoskeletons: microtubules form parallel bundles called KM fibers (left), while centrin forms a network of contractile fibers called myonemes (right).
August 19, 2025 at 4:37 PM
#ExM has transformed how we perceive the microbial diversity all around us. Some gorgeous critters from the @EMBLHeidelberg pond - DNA red, centrin yellow, tubulin gray, images by @fmikus.bsky.social
Bonus points if you identify at least 4!
Want more? www.biorxiv.org/content/10.1... #PlanExM
Bonus points if you identify at least 4!
Want more? www.biorxiv.org/content/10.1... #PlanExM
November 20, 2024 at 8:04 PM
#TubulinTuesday...!
Very happy to announce that our new paper on how asymmetric #microtubule nucleation from Golgi is required for #microtubule #polarity in #neurons has been published online in @currentbiology.bsky.social. An amazing effort from postdoc Akila Yagoubat. authors.elsevier.com/a/1kiDc3QW8S...
March 4, 2025 at 3:59 PM
#TubulinTuesday...!
For #FluorescenceFriday, microtubule networks are shown in two adipocytes 🔬 #CellBiology #Microscopy
September 9, 2025 at 5:02 AM
Excited to share this collaborative work with @sarathomasy.bsky.social- spearheaded by Raneesh Ramarapu and William Stoehr- where we visualized the unique spatial localization of tubulin isotopes in neural crest-derived corneal tissues during development. 🤩
March 17, 2026 at 5:11 PM
The new release of #BigVolumeBrowser (0.1.0) finally adds animation render functionality to it, plus some other navigation improvements and bug fixes.
Here is a movie I've made for the microtubule network (via ExM) in different cell types. Contact me if you want it for educational/research purposes.
Here is a movie I've made for the microtubule network (via ExM) in different cell types. Contact me if you want it for educational/research purposes.
April 28, 2026 at 6:27 AM
How does C2CD3 contribute to distal appendage formation in centrioles? @centriolelab.bsky.social show that C2CD3 acts as a central architectural organizer of the distal #centriole, bridging the luminal distal ring complex & peripheral appendage sites @plosbiology.org 🧪 plos.io/496XZuH
December 16, 2025 at 7:56 PM
I've always preferred cyan, yellow, and magenta. Magenta and green work well, but cyan and green are too similar. Yellow, cyan, and magenta work well too. Example: EM of actin filaments (magenta), microtubules (immunogold, yellow), and clathrin pits (cyan).
August 18, 2026 at 10:13 PM
#TubulinTuesday, some extremely cool photons in extremely dark times
Featured image with Allan Carrillo-Baltodano
This is an image of a larva of a phoronid worm. To swim, the larva propels itself using cilia 💃
Find out about @allancarbal.bsky.social and his #EvoDevo research on marine annelids:
thenode.biologists.com/featured-ima...
This is an image of a larva of a phoronid worm. To swim, the larva propels itself using cilia 💃
Find out about @allancarbal.bsky.social and his #EvoDevo research on marine annelids:
thenode.biologists.com/featured-ima...
April 22, 2025 at 7:46 PM
#TubulinTuesday, some extremely cool photons in extremely dark times
#FluorescenceFriday: Given the recently grown interest in ciliary beating, here is a movie of beating cilia in a human airway model that I captured last week with lattice light-sheet microscopy. No AI „processing“, this is the raw data! Frame rate is ca. 170fps, displayed here at 25fps.
September 29, 2026 at 10:44 PM
Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
October 28, 2025 at 5:14 PM