Then in the 70s, other syndromes, such as 5alpha-reductase-2 deficiency were identified, which caused babies to look like one sex at birth, then the other at puberty. Worse, in some places 1 in 50 infants had this natural sex change, it was not rare there.
November 8, 2024 at 11:35 PM
Then in the 70s, other syndromes, such as 5alpha-reductase-2 deficiency were identified, which caused babies to look like one sex at birth, then the other at puberty. Worse, in some places 1 in 50 infants had this natural sex change, it was not rare there.
very interesting to me that prog is a weak 5a reductase inhibitor because i don't see that mentioned as much in community discussions
March 29, 2026 at 9:02 PM
very interesting to me that prog is a weak 5a reductase inhibitor because i don't see that mentioned as much in community discussions
H3-H4 histone dimers act as copper reductase. This is important because ETC and SOD1 require bio-usable Cu+ for function. This article shows a new mechanism by which chromatin histones can affect the cell metabolism via a new role in metal processing #redoxepigenetics www.science.org/doi/10.1126/...
The histone H3-H4 tetramer is a copper reductase enzyme
A eukaryotic histone complex can package DNA but is also a cupric reductase that provides biousable Cu1+ for the cell.
www.science.org
December 1, 2024 at 1:34 PM
H3-H4 histone dimers act as copper reductase. This is important because ETC and SOD1 require bio-usable Cu+ for function. This article shows a new mechanism by which chromatin histones can affect the cell metabolism via a new role in metal processing #redoxepigenetics www.science.org/doi/10.1126/...
Trump's lawyers are absolutely flailing in the courts right now
February 19, 2025 at 1:26 AM
Trump's lawyers are absolutely flailing in the courts right now
4 XX individuals can have male characteristics (SRY gene differences, 5 alpha reductase deficiency)
Not to mention sex and gender aren’t the same & can be non congruent
Making up executive orders doesn’t change science.
Not to mention sex and gender aren’t the same & can be non congruent
Making up executive orders doesn’t change science.
January 24, 2025 at 10:04 PM
4 XX individuals can have male characteristics (SRY gene differences, 5 alpha reductase deficiency)
Not to mention sex and gender aren’t the same & can be non congruent
Making up executive orders doesn’t change science.
Not to mention sex and gender aren’t the same & can be non congruent
Making up executive orders doesn’t change science.
hoo boy. this is not... uh, not a great sign.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
June 4, 2026 at 8:02 PM
hoo boy. this is not... uh, not a great sign.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
New preprint: Methyl co-enzme M reductase encoding (potentially methanogenic) Thermoproteota are widespread and transcriptionally active in diverse anoxic ecosystems! @dr-zj.bsky.social, Matthew Kollom & @emileyeloe-fadrosh.bsky.social www.biorxiv.org/cgi/content/... Funded by the DOE BER program.
October 16, 2025 at 9:10 PM
New preprint: Methyl co-enzme M reductase encoding (potentially methanogenic) Thermoproteota are widespread and transcriptionally active in diverse anoxic ecosystems! @dr-zj.bsky.social, Matthew Kollom & @emileyeloe-fadrosh.bsky.social www.biorxiv.org/cgi/content/... Funded by the DOE BER program.
I didn't know you were a carrier for quinoid dihydropteridine reductase autosomal recessive tetrahydrobiopterin-deficient hyperhenylalaninemia due to quinoid dihydropteridine reductase deficiency. What's that like
May 2, 2025 at 9:27 AM
I didn't know you were a carrier for quinoid dihydropteridine reductase autosomal recessive tetrahydrobiopterin-deficient hyperhenylalaninemia due to quinoid dihydropteridine reductase deficiency. What's that like
Antifungal 'Nystatin' is named for the NY State Department of Health.
'Statins', on the other hand, are from Latin 'stare' meaning to "stay or hold still" for their ability to slow or stop cholesterol production via inhibition of liver enzyme HMG-CoA reductase.
'Statins', on the other hand, are from Latin 'stare' meaning to "stay or hold still" for their ability to slow or stop cholesterol production via inhibition of liver enzyme HMG-CoA reductase.
Chemist Rachel Fuller Brown was born #OTD in 1898. She co-discovered the antifungal nystatin while doing research for the New York State Department of Health, hence the name. (1/2) 🧪 👩🔬
Image: Smithsonian Institution
Image: Smithsonian Institution
November 23, 2025 at 6:32 PM
Antifungal 'Nystatin' is named for the NY State Department of Health.
'Statins', on the other hand, are from Latin 'stare' meaning to "stay or hold still" for their ability to slow or stop cholesterol production via inhibition of liver enzyme HMG-CoA reductase.
'Statins', on the other hand, are from Latin 'stare' meaning to "stay or hold still" for their ability to slow or stop cholesterol production via inhibition of liver enzyme HMG-CoA reductase.
Semenya has the 46 XY DSD 5 alpha reductase deficiency. Details here:
bsky.app/profile/wome...
bsky.app/profile/wome...
'Without expert medical consultation, the neonate with 46 XY DSD and ambiguous genitalia may be misdiagnosed as female birth sex leading to female childhood upbringing, despite characteristic male rather than female internal genitalia.'
Useful paper.
academic.oup.com/edrv/article...
Useful paper.
academic.oup.com/edrv/article...
Toward a Robust Definition of Sport Sex
Abstract. Elite individual sports in which success depends on power, speed, or endurance are conventionally divided into male and female events using tradi
academic.oup.com
July 11, 2025 at 7:39 AM
Semenya has the 46 XY DSD 5 alpha reductase deficiency. Details here:
bsky.app/profile/wome...
bsky.app/profile/wome...
One time I had to do a “peer to peer” because the patients insurer insisted on choosing the patient’s anticoagulation.
I asked the guy, who clearly wasn’t my peer, to tell me what he knew about Vitamin K epoxide reductase but it turns out he wasn’t too interested in that.
I asked the guy, who clearly wasn’t my peer, to tell me what he knew about Vitamin K epoxide reductase but it turns out he wasn’t too interested in that.
December 9, 2024 at 8:58 PM
One time I had to do a “peer to peer” because the patients insurer insisted on choosing the patient’s anticoagulation.
I asked the guy, who clearly wasn’t my peer, to tell me what he knew about Vitamin K epoxide reductase but it turns out he wasn’t too interested in that.
I asked the guy, who clearly wasn’t my peer, to tell me what he knew about Vitamin K epoxide reductase but it turns out he wasn’t too interested in that.
I told you you need to be eating more quinoid dihydropteridine reductase. You never listen to me
October 2, 2024 at 9:29 PM
I told you you need to be eating more quinoid dihydropteridine reductase. You never listen to me
Thrilled to share our new paper @Chouchani Lab in Cell; what a great way to end this year! We establish a deep mapping of the zinc-binding human cysteine proteome (ZnCPT) and discover glutathione reductase as zinc-targetable cancer vulnerability. www.cell.com/cell/fulltex...
The human zinc-binding cysteine proteome
A deep mapping of the human zinc-binding cysteine proteome (ZnCPT) defines thousands of zinc-binding protein cysteines across major domains of biology and discovers glutathione reductase as zinc-targetable cancer vulnerability.
www.cell.com
December 31, 2024 at 4:21 PM
Thrilled to share our new paper @Chouchani Lab in Cell; what a great way to end this year! We establish a deep mapping of the zinc-binding human cysteine proteome (ZnCPT) and discover glutathione reductase as zinc-targetable cancer vulnerability. www.cell.com/cell/fulltex...
From now on, at the beginning of any “peer to peer” reviews I’m going to give my “peer” a little quiz. Don’t know what Vitamin K epoxide reductase does? I get it. Coagulation is hard. But you’re clearly not my peer. And you don’t get to pick my patients anticoagulant.
April 15, 2026 at 2:45 PM
From now on, at the beginning of any “peer to peer” reviews I’m going to give my “peer” a little quiz. Don’t know what Vitamin K epoxide reductase does? I get it. Coagulation is hard. But you’re clearly not my peer. And you don’t get to pick my patients anticoagulant.
Sex development is incomplete, & virilisation of external genitalia which depends on conversion of testosterone into dihydrotestosterone (DHT) catalysed by the 5α-reductase enzyme, is atypical. A result of a mutation of the SRD5A2 gene located on chromosome 2 causing 5α-reductase type 2 deficiency.
June 2, 2025 at 9:44 AM
Sex development is incomplete, & virilisation of external genitalia which depends on conversion of testosterone into dihydrotestosterone (DHT) catalysed by the 5α-reductase enzyme, is atypical. A result of a mutation of the SRD5A2 gene located on chromosome 2 causing 5α-reductase type 2 deficiency.
Short press piece @unipotsdam.bsky.social about our new article @nature.com on methyl coenzyme M reductase (MCR)
www.uni-potsdam.de/en/headlines...
www.uni-potsdam.de/en/headlines...
Early life – Enzyme for biological methane production decoded
www.uni-potsdam.de
April 17, 2025 at 12:16 PM
Short press piece @unipotsdam.bsky.social about our new article @nature.com on methyl coenzyme M reductase (MCR)
www.uni-potsdam.de/en/headlines...
www.uni-potsdam.de/en/headlines...
Nature research paper: Structure of the ATP-driven methyl-coenzyme M reductase activation complex
https://go.nature.com/4jhc50h
https://go.nature.com/4jhc50h
Structure of the ATP-driven methyl-coenzyme M reductase activation complex - Nature
The structure and function of the MCR activation complex from Methanococcus maripaludis were revealed, demonstrating its ATP-dependent ability to activate MCR and form methane while uncovering a unique electron transfer pathway involving iron–sulfur clusters similar to the nitrogenase cofactor intermediates.
go.nature.com
April 19, 2025 at 11:03 AM
Nature research paper: Structure of the ATP-driven methyl-coenzyme M reductase activation complex
https://go.nature.com/4jhc50h
https://go.nature.com/4jhc50h
i misremembered and accidentally combined 5 alpha reductase deficiency and CYP11A defieincy into one thing in my brain oops
August 22, 2025 at 3:19 AM
i misremembered and accidentally combined 5 alpha reductase deficiency and CYP11A defieincy into one thing in my brain oops
I've always said it tasted like bilirubin reductase, but no one would listen to me.
January 8, 2024 at 8:35 PM
I've always said it tasted like bilirubin reductase, but no one would listen to me.
I'm truly excited to announce our new publication in @nature.com unraveling a central picture of the Methyl-coenzyme M reductase (MCR) activation machinery and it's strong ATP dependency - kudos to @rnfr2d2.bsky.social for the fantastic illustration!
LINK: www.nature.com/articles/s41...
LINK: www.nature.com/articles/s41...
April 16, 2025 at 4:20 PM
I'm truly excited to announce our new publication in @nature.com unraveling a central picture of the Methyl-coenzyme M reductase (MCR) activation machinery and it's strong ATP dependency - kudos to @rnfr2d2.bsky.social for the fantastic illustration!
LINK: www.nature.com/articles/s41...
LINK: www.nature.com/articles/s41...