Congressman urges medical, dental groups to educate clinicians about antibiotic stewardship
www.cidrap.umn.edu
October 14, 2026 at 9:44 PM
Winter is coming…
#AMSsky
#AMSsky
📣 New #Communicable drops Mon 05 Oct!
Marc Bonten & Emily McDonald are joined by Valentijn Schweitzer & Sylvain Lother to discuss the use of macrolides in community-acquired pneumonia and how the available evidence informs clinical practice. Tune in!
#IDSky #clinmicro
Marc Bonten & Emily McDonald are joined by Valentijn Schweitzer & Sylvain Lother to discuss the use of macrolides in community-acquired pneumonia and how the available evidence informs clinical practice. Tune in!
#IDSky #clinmicro
October 3, 2026 at 10:44 PM
Winter is coming…
#AMSsky
#AMSsky
The OPTIMISE trial aimed to test 7 vs 14 days for treating MDR infections in ICU patients.
Although underpowered due to early stop, no signal of inefficacy was observed for short treatments
Pseudomonas were underrepresented in this trial 🙁
link.springer.com/article/10.1... #AMSsky #IDsky #PsWatch
Although underpowered due to early stop, no signal of inefficacy was observed for short treatments
Pseudomonas were underrepresented in this trial 🙁
link.springer.com/article/10.1... #AMSsky #IDsky #PsWatch
October 3, 2026 at 10:14 PM
The OPTIMISE trial aimed to test 7 vs 14 days for treating MDR infections in ICU patients.
Although underpowered due to early stop, no signal of inefficacy was observed for short treatments
Pseudomonas were underrepresented in this trial 🙁
link.springer.com/article/10.1... #AMSsky #IDsky #PsWatch
Although underpowered due to early stop, no signal of inefficacy was observed for short treatments
Pseudomonas were underrepresented in this trial 🙁
link.springer.com/article/10.1... #AMSsky #IDsky #PsWatch
Bad news for patients with MDR infections…
Merck has announced that imipenem/relebactam supply will be discontinued in US by the end of September.
Guess this will extend to Europe soon?
We definitely need new payment models for antibiotics 🙁
www.cidrap.umn.edu/antimicrobia... #IDsky #AMSsky #AMR
Merck has announced that imipenem/relebactam supply will be discontinued in US by the end of September.
Guess this will extend to Europe soon?
We definitely need new payment models for antibiotics 🙁
www.cidrap.umn.edu/antimicrobia... #IDsky #AMSsky #AMR
September 29, 2026 at 11:15 PM
Bad news for patients with MDR infections…
Merck has announced that imipenem/relebactam supply will be discontinued in US by the end of September.
Guess this will extend to Europe soon?
We definitely need new payment models for antibiotics 🙁
www.cidrap.umn.edu/antimicrobia... #IDsky #AMSsky #AMR
Merck has announced that imipenem/relebactam supply will be discontinued in US by the end of September.
Guess this will extend to Europe soon?
We definitely need new payment models for antibiotics 🙁
www.cidrap.umn.edu/antimicrobia... #IDsky #AMSsky #AMR
So, I think there still is a safe way for cefepime in clinical practice:
✅ Limited to patients with normal renal function.
✅ As empirical treatment for non-severe cases.
✅ As targeted therapy for low-MIC isolates.
Extended-infusion and TDM would probably help in many cases!
🧵(5/5) #IDsky #AMSsky
✅ Limited to patients with normal renal function.
✅ As empirical treatment for non-severe cases.
✅ As targeted therapy for low-MIC isolates.
Extended-infusion and TDM would probably help in many cases!
🧵(5/5) #IDsky #AMSsky
September 20, 2026 at 2:58 AM
We also have the efficacy question.
In my center we use EUCAST for susceptibility testing, whose MIC breakpoints are more restrictive than CLSI’s.
So, we use cefepime just for strains with lower MICs than our american colleagues, probably favoring PK/PD target achievement
🧵 (3/5) #IDsky #AMSsky
In my center we use EUCAST for susceptibility testing, whose MIC breakpoints are more restrictive than CLSI’s.
So, we use cefepime just for strains with lower MICs than our american colleagues, probably favoring PK/PD target achievement
🧵 (3/5) #IDsky #AMSsky
September 20, 2026 at 2:56 AM
Neurotoxicity is definitely an issue for cefepime.
But I find it to be very rare among patients with normal renal function and no prior seizure-predisposing conditions.
This association was already established in previous metaanalyses 🧵(2/5)
academic.oup.com/jac/article/... #IDsky #AMSsky
But I find it to be very rare among patients with normal renal function and no prior seizure-predisposing conditions.
This association was already established in previous metaanalyses 🧵(2/5)
academic.oup.com/jac/article/... #IDsky #AMSsky
Cefepime-induced neurotoxicity: systematic review
AbstractBackground. Cefepime-induced neurotoxicity (CIN) has been well acknowledged among clinicians, although there are no clear diagnostic criteria or sp
academic.oup.com
September 20, 2026 at 2:54 AM
Neurotoxicity is definitely an issue for cefepime.
But I find it to be very rare among patients with normal renal function and no prior seizure-predisposing conditions.
This association was already established in previous metaanalyses 🧵(2/5)
academic.oup.com/jac/article/... #IDsky #AMSsky
But I find it to be very rare among patients with normal renal function and no prior seizure-predisposing conditions.
This association was already established in previous metaanalyses 🧵(2/5)
academic.oup.com/jac/article/... #IDsky #AMSsky
I find cefepime very useful to diversify empiric antipseudomonal treatments among immunocompromised hosts, and as a carbapenem-sparing agent against ampC producers.
This recent metaanalysis made me wonder if I should stop using it… 🧵(1/5)
jamanetwork.com/journals/jam... #IDSky #AMSsky #IDOnc
This recent metaanalysis made me wonder if I should stop using it… 🧵(1/5)
jamanetwork.com/journals/jam... #IDSky #AMSsky #IDOnc
Cefepime and Mortality
This systematic review with bayesian meta-analysis of randomized clinical trials examined the association of cefepime with all-cause mortality compared with other β-lactam antibiotics.
jamanetwork.com
September 20, 2026 at 2:52 AM
I find cefepime very useful to diversify empiric antipseudomonal treatments among immunocompromised hosts, and as a carbapenem-sparing agent against ampC producers.
This recent metaanalysis made me wonder if I should stop using it… 🧵(1/5)
jamanetwork.com/journals/jam... #IDSky #AMSsky #IDOnc
This recent metaanalysis made me wonder if I should stop using it… 🧵(1/5)
jamanetwork.com/journals/jam... #IDSky #AMSsky #IDOnc
I recently heard from a geriatrician that all the urinary pathogens at a long-term care facility he covers are resistant to nitrofurantoin. Having worked at one, it doesn't surprise me since nurses and families often request antibiotics for assumed UTIs.
#AMSSky
kffhealthnews.org/aging/3-comm...
#AMSSky
kffhealthnews.org/aging/3-comm...
3 Common Drugs Older Adults Might Be Overusing - KFF Health News
Not all older people need benzodiazepines, antibiotics, or daily aspirin — and taking them can carry increased risks.
kffhealthnews.org
September 18, 2026 at 1:31 PM
I recently heard from a geriatrician that all the urinary pathogens at a long-term care facility he covers are resistant to nitrofurantoin. Having worked at one, it doesn't surprise me since nurses and families often request antibiotics for assumed UTIs.
#AMSSky
kffhealthnews.org/aging/3-comm...
#AMSSky
kffhealthnews.org/aging/3-comm...
When will medical schools and residency programs stop teaching trainees that not all hospitalized DFI cases require anti-MRSA and anti-pseudomonal coverage?
#AMSSky
#AMSSky
Five-year trends in antibiotic use and microbiology of hospitalized diabetic foot infections in the Bronx | Antimicrobial Stewardship & Healthcare Epidemiology | Cambridge Core
Five-year trends in antibiotic use and microbiology of hospitalized diabetic foot infections in the Bronx - Volume 6 Issue 1
www.cambridge.org
September 17, 2026 at 9:19 PM
When will medical schools and residency programs stop teaching trainees that not all hospitalized DFI cases require anti-MRSA and anti-pseudomonal coverage?
#AMSSky
#AMSSky
I've experienced the same challenges outlined in this study at my institution. The hardest factor to overcome is the emotions driving the need to order urine testing, such as a clinician's fear of missing a diagnosis or facing potential legal consequences.
#AMSSky
#AMSSky
Retrospective, multicenter evaluation of stricter reflex urine culture criteria and workflow changes in emergency departments across six hospitals and three off-campus sites | Antimicrobial Stewardshi...
Retrospective, multicenter evaluation of stricter reflex urine culture criteria and workflow changes in emergency departments across six hospitals and three off-campus sites - Volume 6 Issue 1
www.cambridge.org
September 12, 2026 at 5:56 PM
I've experienced the same challenges outlined in this study at my institution. The hardest factor to overcome is the emotions driving the need to order urine testing, such as a clinician's fear of missing a diagnosis or facing potential legal consequences.
#AMSSky
#AMSSky
This study should help dispel a common myth that all immunocompromised patients with CAP need empiric broad-spectrum antibiotic therapy over standard therapy because these patients have higher risk of infection with MRSA and Pseudomonas.
#AMSSky
#AMSSky
Risk factors for methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa community-acquired pneumonia at a high-volume transplant center | Antimicrobial Stewardship & Healthcare Epi...
Risk factors for methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa community-acquired pneumonia at a high-volume transplant center - Volume 6 Issue 1
www.cambridge.org
September 12, 2026 at 4:32 PM
This study should help dispel a common myth that all immunocompromised patients with CAP need empiric broad-spectrum antibiotic therapy over standard therapy because these patients have higher risk of infection with MRSA and Pseudomonas.
#AMSSky
#AMSSky
A good guide for stewards who are proposing a business case for a diagnostic stewardship project to their C-suite.
#AMSSky
#AMSSky
A business case for diagnostic stewardship: a practical guide from the Society for Healthcare Epidemiology of America (SHEA) Diagnostic Stewardship Special Interest Group | Antimicrobial Stewardship &...
A business case for diagnostic stewardship: a practical guide from the Society for Healthcare Epidemiology of America (SHEA) Diagnostic Stewardship Special Interest Group - Volume 6 Issue 1
www.cambridge.org
September 9, 2026 at 7:02 PM
A good guide for stewards who are proposing a business case for a diagnostic stewardship project to their C-suite.
#AMSSky
#AMSSky
New publication online in CID describing ceftriaxone serious adverse events (involving CPR or death) in 31 cases across 18 states! 💉
Product testing & trend analysis did not identify evidence of a new safety issue, but needs ongoing vigilance & reporting to Medwatch. #IDSky #AMSsky
Product testing & trend analysis did not identify evidence of a new safety issue, but needs ongoing vigilance & reporting to Medwatch. #IDSky #AMSsky
September 4, 2026 at 12:04 PM
💥🆕“Hospital Strategies to Improve Sepsis Outcomes”
IDSA/ACEP/ASM/PIDS/SCCM/SHEA/SHM/SIDP
👇Free
bit.ly/3UnauhT
@unmc-id.bsky.social @critcaremed.bsky.social @criticalcarereviews.com #IDSky #MedSky #PCCSky #ICUSky #EMIMCC #Ansky #EMSky #AMSSky #ClinMicro @cidjournal.bsky.social @cmicomms.bsky.social
IDSA/ACEP/ASM/PIDS/SCCM/SHEA/SHM/SIDP
👇Free
bit.ly/3UnauhT
@unmc-id.bsky.social @critcaremed.bsky.social @criticalcarereviews.com #IDSky #MedSky #PCCSky #ICUSky #EMIMCC #Ansky #EMSky #AMSSky #ClinMicro @cidjournal.bsky.social @cmicomms.bsky.social
IDSA/ACEP/ASM/PIDS/SCCM/SHEA/SHM/SIDP Multisociety Position Paper: Hospital Strategies to Improve Sepsis Outcomes
Abstract. Sepsis remains a leading cause of morbidity and mortality in US hospitals despite extensive efforts to improve early recognition and treatment, p
bit.ly
August 29, 2026 at 2:28 PM
💥🆕“Hospital Strategies to Improve Sepsis Outcomes”
IDSA/ACEP/ASM/PIDS/SCCM/SHEA/SHM/SIDP
👇Free
bit.ly/3UnauhT
@unmc-id.bsky.social @critcaremed.bsky.social @criticalcarereviews.com #IDSky #MedSky #PCCSky #ICUSky #EMIMCC #Ansky #EMSky #AMSSky #ClinMicro @cidjournal.bsky.social @cmicomms.bsky.social
IDSA/ACEP/ASM/PIDS/SCCM/SHEA/SHM/SIDP
👇Free
bit.ly/3UnauhT
@unmc-id.bsky.social @critcaremed.bsky.social @criticalcarereviews.com #IDSky #MedSky #PCCSky #ICUSky #EMIMCC #Ansky #EMSky #AMSSky #ClinMicro @cidjournal.bsky.social @cmicomms.bsky.social
Excited to see these NHSN AU Case Examples published to CDC’s website! We enjoyed strategizing, building, and distributing these reports to all hospitals with AU data in Colorado!
🤓📊💊
#AMSSky #IDSky
www.cdc.gov/nhsn/au-case...
🤓📊💊
#AMSSky #IDSky
www.cdc.gov/nhsn/au-case...
Colorado AU Feedback Reports | NHSN | CDC
www.cdc.gov
August 28, 2026 at 8:40 AM
Excited to see these NHSN AU Case Examples published to CDC’s website! We enjoyed strategizing, building, and distributing these reports to all hospitals with AU data in Colorado!
🤓📊💊
#AMSSky #IDSky
www.cdc.gov/nhsn/au-case...
🤓📊💊
#AMSSky #IDSky
www.cdc.gov/nhsn/au-case...
A (not so) new kid on the block!
Temocillin proved non-inferior to carbapenems against 3GR-Enterobacterales.
Hope to see this old drug widely available in Europe soon! 🤞🏻
www.thelancet.com/journals/lan... #AMSsky #IDsky
Temocillin proved non-inferior to carbapenems against 3GR-Enterobacterales.
Hope to see this old drug widely available in Europe soon! 🤞🏻
www.thelancet.com/journals/lan... #AMSsky #IDsky
Temocillin versus carbapenems for bacteraemia due to third-generation cephalosporin-resistant Enterobacterales in Spain (ASTARTÉ): a multicentre, phase 3, open-label, non-inferiority, randomised clini...
In patients with bacteraemia caused by 3GCR-E, temocillin was non-inferior to carbapenems
as targeted treatment. These findings support the use of temocillin as an effective
and safe alternative to ca...
www.thelancet.com
July 12, 2026 at 9:43 PM
A (not so) new kid on the block!
Temocillin proved non-inferior to carbapenems against 3GR-Enterobacterales.
Hope to see this old drug widely available in Europe soon! 🤞🏻
www.thelancet.com/journals/lan... #AMSsky #IDsky
Temocillin proved non-inferior to carbapenems against 3GR-Enterobacterales.
Hope to see this old drug widely available in Europe soon! 🤞🏻
www.thelancet.com/journals/lan... #AMSsky #IDsky
💥🆕 “Sepsis -Beyond the guidelines”
Critical Matters podcast
👇Free Access
bit.ly/4vWCmaA
@unmc.bsky.social @unmc-id.bsky.social @unmccom.bsky.social @critcaremed.bsky.social @criticalcarereviews.com #IDSky #MedSky #PCCSky #ICUSky #EMIMCC #Ansky #EMSky #AMSSky #meded #Pharmsky #MicroSky #ClinMicro
Critical Matters podcast
👇Free Access
bit.ly/4vWCmaA
@unmc.bsky.social @unmc-id.bsky.social @unmccom.bsky.social @critcaremed.bsky.social @criticalcarereviews.com #IDSky #MedSky #PCCSky #ICUSky #EMIMCC #Ansky #EMSky #AMSSky #meded #Pharmsky #MicroSky #ClinMicro
Sepsis - Beyond the guidelines
In a recent episode, Dr. Sergio Zanotti discussed the 2026 iteration of the Surviving Sepsis Guidelines. In this episode, the discussion continues, focusing on important aspects beyond clinical guidel...
bit.ly
July 9, 2026 at 9:22 PM
💥🆕 “Sepsis -Beyond the guidelines”
Critical Matters podcast
👇Free Access
bit.ly/4vWCmaA
@unmc.bsky.social @unmc-id.bsky.social @unmccom.bsky.social @critcaremed.bsky.social @criticalcarereviews.com #IDSky #MedSky #PCCSky #ICUSky #EMIMCC #Ansky #EMSky #AMSSky #meded #Pharmsky #MicroSky #ClinMicro
Critical Matters podcast
👇Free Access
bit.ly/4vWCmaA
@unmc.bsky.social @unmc-id.bsky.social @unmccom.bsky.social @critcaremed.bsky.social @criticalcarereviews.com #IDSky #MedSky #PCCSky #ICUSky #EMIMCC #Ansky #EMSky #AMSSky #meded #Pharmsky #MicroSky #ClinMicro
Can nurses lead outpatient UTI stewardship? This EHR-integrated triage tool improved symptom documentation, reduced unnecessary urine cultures, and cut antibiotic treatment of asymptomatic bacteriuria—all without increasing pyelonephritis. #ABXstewardship #NursingResearch doi.org/10.1017/ash....
July 7, 2026 at 6:37 PM
Nurses can be valuable in diagnostic stewardship. However, the challenge remains in reassuring clinicians concerned about missed diagnoses and meeting patient satisfaction expectations when antibiotic therapy is expected.
#diagnosticstewardship #AMSSky
#diagnosticstewardship #AMSSky
Can nurses lead outpatient UTI stewardship? This EHR-integrated triage tool improved symptom documentation, reduced unnecessary urine cultures, and cut antibiotic treatment of asymptomatic bacteriuria—all without increasing pyelonephritis. #ABXstewardship #NursingResearch doi.org/10.1017/ash....
July 7, 2026 at 3:22 PM
Nurses can be valuable in diagnostic stewardship. However, the challenge remains in reassuring clinicians concerned about missed diagnoses and meeting patient satisfaction expectations when antibiotic therapy is expected.
#diagnosticstewardship #AMSSky
#diagnosticstewardship #AMSSky
Who exactly still needs antivirals for COVID? An Aussie/Kiwi take on it... TL:DR - in 2026 it's hard to define the tiny group who may benefit in the absence of good data.
#IDsky #AMSsky
onlinelibrary.wiley.com/doi/10.5694/...
#IDsky #AMSsky
onlinelibrary.wiley.com/doi/10.5694/...
Still Treating Yesterday's Risk? Reconsidering Antiviral Use for Mild‐to‐Moderate COVID‐19 Cases in a Broadly Immune Population
Antivirals for mild-to-moderate coronavirus disease 2019 (COVID-19) were adopted for use based on trials in unvaccinated adults during the pre-Omicron period. In today's broadly immune populations, w....
onlinelibrary.wiley.com
July 3, 2026 at 9:11 AM
Who exactly still needs antivirals for COVID? An Aussie/Kiwi take on it... TL:DR - in 2026 it's hard to define the tiny group who may benefit in the absence of good data.
#IDsky #AMSsky
onlinelibrary.wiley.com/doi/10.5694/...
#IDsky #AMSsky
onlinelibrary.wiley.com/doi/10.5694/...
Bringing #AMR into the outcome assessment of duration trials with the new DOOR-FRAME is very welcome!
Larger samples and systematic AMR assessment among participants will be likely required to prove benefit
academic.oup.com/ofid/article... #IDSky #AMSsky
Awesome work by @seanong.bsky.social et al
Larger samples and systematic AMR assessment among participants will be likely required to prove benefit
academic.oup.com/ofid/article... #IDSky #AMSsky
Awesome work by @seanong.bsky.social et al
June 23, 2026 at 1:36 AM
Bringing #AMR into the outcome assessment of duration trials with the new DOOR-FRAME is very welcome!
Larger samples and systematic AMR assessment among participants will be likely required to prove benefit
academic.oup.com/ofid/article... #IDSky #AMSsky
Awesome work by @seanong.bsky.social et al
Larger samples and systematic AMR assessment among participants will be likely required to prove benefit
academic.oup.com/ofid/article... #IDSky #AMSsky
Awesome work by @seanong.bsky.social et al
Antimicrobial Stewardship [vol.2] already running!
Did we miss someone? 😉 #AMSsky #IDsky #MicroSky #PharmSky
go.bsky.app/2qsEveQ
Did we miss someone? 😉 #AMSsky #IDsky #MicroSky #PharmSky
go.bsky.app/2qsEveQ
Hey, #IDSky stewards!
How about a starter pack for antimicrobial stewardship?
Use the tag #AMSsky in your posts to join the feed on this topic.
Let’s make sharing easy!
go.bsky.app/7KcDc2n
How about a starter pack for antimicrobial stewardship?
Use the tag #AMSsky in your posts to join the feed on this topic.
Let’s make sharing easy!
go.bsky.app/7KcDc2n
June 21, 2026 at 6:56 AM
Antimicrobial Stewardship [vol.2] already running!
Did we miss someone? 😉 #AMSsky #IDsky #MicroSky #PharmSky
go.bsky.app/2qsEveQ
Did we miss someone? 😉 #AMSsky #IDsky #MicroSky #PharmSky
go.bsky.app/2qsEveQ