Imagine if instead of making COVID isolation guidelines as weak as the flu...
We approved combo rapid tests like this and made them free and available for everyone...
So that people could tell how long they need to isolate based on science and not feelings, whatever the pathogen.
We approved combo rapid tests like this and made them free and available for everyone...
So that people could tell how long they need to isolate based on science and not feelings, whatever the pathogen.
March 3, 2024 at 10:08 PM
Imagine if instead of making COVID isolation guidelines as weak as the flu...
We approved combo rapid tests like this and made them free and available for everyone...
So that people could tell how long they need to isolate based on science and not feelings, whatever the pathogen.
We approved combo rapid tests like this and made them free and available for everyone...
So that people could tell how long they need to isolate based on science and not feelings, whatever the pathogen.
Fascinating and deeply satisfying resolution to why adenovirus-based vaccines produced blood clots in 1 out of 200,000 people.
Two factors interacted:
a mutation in an antibody gene + weak similarities between a viral protein & a human blood-clotting protein = induced clotting cascade.
Two factors interacted:
a mutation in an antibody gene + weak similarities between a viral protein & a human blood-clotting protein = induced clotting cascade.
Five years after the rollout of Covid-19 vaccines started, it seems the mystery of why the Astra-Zeneca and J&J vaccines led to a rare but deadly side effect of unusual blood clots and bleeding has finally been solved.
It's a fascinating case of molecular mimicry that may help make vaccine safer.🧪
It's a fascinating case of molecular mimicry that may help make vaccine safer.🧪
Rare, dangerous side effects of some COVID-19 vaccines explained
“Groundbreaking” study uncovers why adenovirus-based shots caused life-threatening blood clots and bleeding in some people
www.science.org
February 11, 2026 at 10:39 PM
Fascinating and deeply satisfying resolution to why adenovirus-based vaccines produced blood clots in 1 out of 200,000 people.
Two factors interacted:
a mutation in an antibody gene + weak similarities between a viral protein & a human blood-clotting protein = induced clotting cascade.
Two factors interacted:
a mutation in an antibody gene + weak similarities between a viral protein & a human blood-clotting protein = induced clotting cascade.
Our public health agencies have been monitoring VAERS, and despite its extreme limitations were able to detect the incredibly rare 0.48/1000000 risk associated with the non-mRNA, adenovirus-vector-based J&J vaccine and pull it.
These vaccines have been tracked more than any intervention in history
These vaccines have been tracked more than any intervention in history
September 12, 2025 at 6:22 PM
Our public health agencies have been monitoring VAERS, and despite its extreme limitations were able to detect the incredibly rare 0.48/1000000 risk associated with the non-mRNA, adenovirus-vector-based J&J vaccine and pull it.
These vaccines have been tracked more than any intervention in history
These vaccines have been tracked more than any intervention in history
A new study uncovers why adenovirus-based COVID-19 shots caused rare, dangerous side effects in some people.
Learn more: https://scim.ag/4qCgVrV
Learn more: https://scim.ag/4qCgVrV
February 17, 2026 at 2:31 PM
A new study uncovers why adenovirus-based COVID-19 shots caused rare, dangerous side effects in some people.
Learn more: https://scim.ag/4qCgVrV
Learn more: https://scim.ag/4qCgVrV
Five years after the rollout of Covid-19 vaccines started, it seems the mystery of why the Astra-Zeneca and J&J vaccines led to a rare but deadly side effect of unusual blood clots and bleeding has finally been solved.
It's a fascinating case of molecular mimicry that may help make vaccine safer.🧪
It's a fascinating case of molecular mimicry that may help make vaccine safer.🧪
Rare, dangerous side effects of some COVID-19 vaccines explained
“Groundbreaking” study uncovers why adenovirus-based shots caused life-threatening blood clots and bleeding in some people
www.science.org
February 11, 2026 at 10:10 PM
Five years after the rollout of Covid-19 vaccines started, it seems the mystery of why the Astra-Zeneca and J&J vaccines led to a rare but deadly side effect of unusual blood clots and bleeding has finally been solved.
It's a fascinating case of molecular mimicry that may help make vaccine safer.🧪
It's a fascinating case of molecular mimicry that may help make vaccine safer.🧪
Ok, I know promised a thread on the fascinating and important new research explaining what happened with the rare, serious side effects of AstraZeneca's and Johnson&Johnson's Covid-19 vaccines.
So, @science.org story is here and 🧪🧵 is coming:
www.science.org/content/arti...
So, @science.org story is here and 🧪🧵 is coming:
www.science.org/content/arti...
Rare, dangerous side effects of some COVID-19 vaccines explained
“Groundbreaking” study uncovers why adenovirus-based shots caused life-threatening blood clots and bleeding in some people
www.science.org
February 12, 2026 at 8:28 PM
Ok, I know promised a thread on the fascinating and important new research explaining what happened with the rare, serious side effects of AstraZeneca's and Johnson&Johnson's Covid-19 vaccines.
So, @science.org story is here and 🧪🧵 is coming:
www.science.org/content/arti...
So, @science.org story is here and 🧪🧵 is coming:
www.science.org/content/arti...
"Although [adenovirus-based] COVID-19 vaccines are out of the picture... an adenovirus-based Ebola shot is on the market, and similar vaccines against other diseases are in development. The new data suggest they, too, could cause VITT, but they might be made safer by tinkering with the adenovirus."
Rare, dangerous side effects of some COVID-19 vaccines explained
“Groundbreaking” study uncovers why adenovirus-based shots caused life-threatening blood clots and bleeding in some people
www.science.org
February 13, 2026 at 1:03 PM
"Although [adenovirus-based] COVID-19 vaccines are out of the picture... an adenovirus-based Ebola shot is on the market, and similar vaccines against other diseases are in development. The new data suggest they, too, could cause VITT, but they might be made safer by tinkering with the adenovirus."
Early, non-mRNA Covid vaccines from AstraZeneca and J&J had rare side effects--deadly blood clots and bleeding--that led to their discontinuance and fed anti-vaxx beliefs. Now researchers have ID'd the cause, which may make safer future vaxxes of this type, esp. a new Ebola vaccine.
Rare, dangerous side effects of some COVID-19 vaccines explained
“Groundbreaking” study uncovers why adenovirus-based shots caused life-threatening blood clots and bleeding in some people
www.science.org
February 12, 2026 at 5:12 PM
Early, non-mRNA Covid vaccines from AstraZeneca and J&J had rare side effects--deadly blood clots and bleeding--that led to their discontinuance and fed anti-vaxx beliefs. Now researchers have ID'd the cause, which may make safer future vaxxes of this type, esp. a new Ebola vaccine.
Vaccines for #H5N1 based on either mRNA or an adenovirus vector can shield macaques from the virus when delivered via an intramuscular prime and a mucosal boost regimen, according to new experiments in #ScienceTranslationalMedicine. https://scim.ag/47aS1HR
An intramuscular prime and mucosal boost vaccine regimen protects against lethal clade 2.3.4.4b H5N1 challenge in cynomolgus macaques
Mucosal delivery of a rhesus adenovirus–vectored H5N1 influenza vaccine confers protection against lethal challenge in cynomolgus macaques.
scim.ag
October 20, 2025 at 6:00 PM
Vaccines for #H5N1 based on either mRNA or an adenovirus vector can shield macaques from the virus when delivered via an intramuscular prime and a mucosal boost regimen, according to new experiments in #ScienceTranslationalMedicine. https://scim.ag/47aS1HR
@biorxivpreprint.bsky.social Adenovirus-based vaccines transduce and activate human Langerhans cells
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 7, 2025 at 3:19 PM
@biorxivpreprint.bsky.social Adenovirus-based vaccines transduce and activate human Langerhans cells
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Fascinating stuff - the conundrum of why, in extremely rare cases, people ended up getting dangerous blood clotting after having received the adenovirus-based J&J (my first COVID-19 vaccine; Ad26-based) or AstraZeneca (ChAdOx1-based) vaccines has been solved.
Scientists Figured Out the Problem With Johnson & Johnson’s COVID Vaccine
Rare but dangerous blood clotting associated with that vaccine as well as AstraZeneca’s had a genetic cause, according to a new paper.
www.theatlantic.com
February 11, 2026 at 11:02 PM
Fascinating stuff - the conundrum of why, in extremely rare cases, people ended up getting dangerous blood clotting after having received the adenovirus-based J&J (my first COVID-19 vaccine; Ad26-based) or AstraZeneca (ChAdOx1-based) vaccines has been solved.
Phase ! trial of oral Norovirus vaccine candidate Here is the original manuscript published in Science translational Med. the vaccine candidate is a recombinant Adenovirus 5 based technology formulated for oral administration.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
March 6, 2025 at 7:07 PM
Phase ! trial of oral Norovirus vaccine candidate Here is the original manuscript published in Science translational Med. the vaccine candidate is a recombinant Adenovirus 5 based technology formulated for oral administration.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Wiederholte COVID-19-Impfung auf mRNA-Basis trägt zu neutralisierenden SARS-CoV-2-Antikörperreaktionen in der Schleimhaut bei
“Insgesamt zeigen diese Ergebnisse, dass die derzeit verwendeten COVID-19-mRNA-Impfstoffe, insbesondere bei wiederholter Impfung, mukosale neutralisierende Antikörper …
“Insgesamt zeigen diese Ergebnisse, dass die derzeit verwendeten COVID-19-mRNA-Impfstoffe, insbesondere bei wiederholter Impfung, mukosale neutralisierende Antikörper …
October 24, 2024 at 10:30 PM
Wiederholte COVID-19-Impfung auf mRNA-Basis trägt zu neutralisierenden SARS-CoV-2-Antikörperreaktionen in der Schleimhaut bei
“Insgesamt zeigen diese Ergebnisse, dass die derzeit verwendeten COVID-19-mRNA-Impfstoffe, insbesondere bei wiederholter Impfung, mukosale neutralisierende Antikörper …
“Insgesamt zeigen diese Ergebnisse, dass die derzeit verwendeten COVID-19-mRNA-Impfstoffe, insbesondere bei wiederholter Impfung, mukosale neutralisierende Antikörper …
Oh and read the story my colleague Gretchen Vogel and I wrote at Science. That is my dayjob... 😅
www.science.org/content/arti...
www.science.org/content/arti...
Rare, dangerous side effects of some COVID-19 vaccines explained
“Groundbreaking” study uncovers why adenovirus-based shots caused life-threatening blood clots and bleeding in some people
www.science.org
February 12, 2026 at 10:05 PM
Oh and read the story my colleague Gretchen Vogel and I wrote at Science. That is my dayjob... 😅
www.science.org/content/arti...
www.science.org/content/arti...
Brilliant work. This lethal side effect resulted from a confluence of bad luck-- for patients with a susceptible genetic background and prior adenoviral infection who received the adenovirus-based vaccine, and for creators of the vaccine who could not have anticipated cross-reactivity of pVII & PF4.
February 11, 2026 at 11:46 PM
Brilliant work. This lethal side effect resulted from a confluence of bad luck-- for patients with a susceptible genetic background and prior adenoviral infection who received the adenovirus-based vaccine, and for creators of the vaccine who could not have anticipated cross-reactivity of pVII & PF4.
Hugely important finding for the future of adenovirus-based vaccines. And also, quite honestly, it is satisfying to see this mystery solved.
Five years after the rollout of Covid-19 vaccines started, it seems the mystery of why the Astra-Zeneca and J&J vaccines led to a rare but deadly side effect of unusual blood clots and bleeding has finally been solved.
It's a fascinating case of molecular mimicry that may help make vaccine safer.🧪
It's a fascinating case of molecular mimicry that may help make vaccine safer.🧪
Rare, dangerous side effects of some COVID-19 vaccines explained
“Groundbreaking” study uncovers why adenovirus-based shots caused life-threatening blood clots and bleeding in some people
www.science.org
February 12, 2026 at 7:01 AM
Hugely important finding for the future of adenovirus-based vaccines. And also, quite honestly, it is satisfying to see this mystery solved.
Adenovirus and mRNA vaccines as well as mucosal boosting improve protective efficacy against influenza virus challenge in macaques | Science Translational Medicine www.science.org/doi/10.1126/... 🧪
Adenovirus and mRNA vaccines as well as mucosal boosting improve protective efficacy against influenza virus challenge in macaques
Mucosal delivery and gene-based vaccines can both enhance boost responses for influenza vaccination in cynomolgus macaques over available vaccines.
www.science.org
July 9, 2025 at 7:08 PM
Adenovirus and mRNA vaccines as well as mucosal boosting improve protective efficacy against influenza virus challenge in macaques | Science Translational Medicine www.science.org/doi/10.1126/... 🧪
Adenoviral Vaccines Including Adenovirus-Based COVID-19 Vaccines Are Linked to Red Blood Cell Damage and Clot Risks!
www.thailandmedical.news/news/adenovi...
www.thailandmedical.news/news/adenovi...
Adenoviral Vaccines Including Adenovirus-Based COVID-19 Vaccines Are Linked to Red Blood Cell Damage and Clot Risks! - Thailand Medical News
www.thailandmedical.news
November 30, 2025 at 7:13 AM
Adenoviral Vaccines Including Adenovirus-Based COVID-19 Vaccines Are Linked to Red Blood Cell Damage and Clot Risks!
www.thailandmedical.news/news/adenovi...
www.thailandmedical.news/news/adenovi...
What this gives us is a clear explanation for why this clotting happened in some people and not most others. It also gives vaccine researchers a clearer target to avoid when designing future adenovirus-based vaccines.
April 22, 2026 at 2:19 PM
What this gives us is a clear explanation for why this clotting happened in some people and not most others. It also gives vaccine researchers a clearer target to avoid when designing future adenovirus-based vaccines.
Nice explainer by Gretchen Vogel and @kakape.bsky.social on #adenovirus vaccines' rare side effect of clots and bleeding
www.science.org/content/arti...
www.science.org/content/arti...
Rare, dangerous side effects of some COVID-19 vaccines explained
“Groundbreaking” study uncovers why adenovirus-based shots caused life-threatening blood clots and bleeding in some people
www.science.org
February 21, 2026 at 10:31 PM
Nice explainer by Gretchen Vogel and @kakape.bsky.social on #adenovirus vaccines' rare side effect of clots and bleeding
www.science.org/content/arti...
www.science.org/content/arti...
🧪The authors enhanced the anti-tumor response in recurrent high grade glioma patients by combining the oncolytic adenovirus Delta-24-RGD with IFN-𝛾 to activate immune cells. Peripheral blood analysis distinguished a small number of patients with longer-term survival.
aacrjournals.org/clincancerre...
aacrjournals.org/clincancerre...
Systemic immune correlates of long-term survival after Delta-24-RGD based on the Therapeutic Adenovirus for Recurrent Glioblastoma Effect Trial (TARGET)
Abstract. Purpose: To evaluate the combination of intra-tumoral Delta-24-RGD and subcutaneous interferon gamma (IFN-g) in patients with high grade glioma (HGG), based on the rationale that augmenting ...
aacrjournals.org
February 2, 2026 at 12:07 AM
🧪The authors enhanced the anti-tumor response in recurrent high grade glioma patients by combining the oncolytic adenovirus Delta-24-RGD with IFN-𝛾 to activate immune cells. Peripheral blood analysis distinguished a small number of patients with longer-term survival.
aacrjournals.org/clincancerre...
aacrjournals.org/clincancerre...
Cross reactive antibodies produced by people with rare genetic variants explain the very rare clotting disorders in people receiving adenovirus-based COVID vaccines Gift🔗 www.theatlantic.com/science/2026...
Scientists Figured Out the Problem With Johnson & Johnson’s COVID Vaccine
Rare but dangerous blood clotting associated with that vaccine as well as AstraZeneca’s had a genetic cause, according to a new paper.
www.theatlantic.com
February 12, 2026 at 3:26 PM
Cross reactive antibodies produced by people with rare genetic variants explain the very rare clotting disorders in people receiving adenovirus-based COVID vaccines Gift🔗 www.theatlantic.com/science/2026...
So upset about the mischaracterization of the coronavirus though, ruining a great burn (it's not a DNA virus! not a retrovirus! the only people who got new DNA from it in their system got one of the adenovirus-based vaccines, and those were transient!)
August 6, 2023 at 6:20 AM
So upset about the mischaracterization of the coronavirus though, ruining a great burn (it's not a DNA virus! not a retrovirus! the only people who got new DNA from it in their system got one of the adenovirus-based vaccines, and those were transient!)
There's currently no licensed vaccine for nipah virus but this stockpile will support a ph II study of a chimp adenovirus vector based vaccine candidate for this deadly infection by building a stockpile of 100k doses Outbreaks primarily in South East Asia have had case fatality as high as 70%.
October 30, 2025 at 10:19 PM
There's currently no licensed vaccine for nipah virus but this stockpile will support a ph II study of a chimp adenovirus vector based vaccine candidate for this deadly infection by building a stockpile of 100k doses Outbreaks primarily in South East Asia have had case fatality as high as 70%.