An overview of the structure, activation, & regulation of EZH2 in human #Cancers and its role in #Tumorigenesis, while describing EZH2-targeting strategies to overcome therapy resistance and enhance #AntitumorImmunity.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
January 19, 2026 at 2:35 PM
An overview of the structure, activation, & regulation of EZH2 in human #Cancers and its role in #Tumorigenesis, while describing EZH2-targeting strategies to overcome therapy resistance and enhance #AntitumorImmunity.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Targeting #SRSF1 with TN2008 disrupts tumor cell metabolism and enhances CD8+ T cell #AntiTumorImmunity, improving glycolytic reprogramming, effector function, and adoptive #TCellTherapy efficacy. @fudan-university.bsky.social #medsky
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
October 26, 2025 at 12:30 AM
Targeting #SRSF1 with TN2008 disrupts tumor cell metabolism and enhances CD8+ T cell #AntiTumorImmunity, improving glycolytic reprogramming, effector function, and adoptive #TCellTherapy efficacy. @fudan-university.bsky.social #medsky
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
A #photoresponsive Nano‑PROTAC that reprograms #TumorMetabolism via HK2 degradation, enhances #AntitumorImmunity, achieves complete regression in #TNBC, and prevents #metastasis and recurrence through durable #photoimmunotherapy.
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
December 17, 2025 at 1:01 PM
A #photoresponsive Nano‑PROTAC that reprograms #TumorMetabolism via HK2 degradation, enhances #AntitumorImmunity, achieves complete regression in #TNBC, and prevents #metastasis and recurrence through durable #photoimmunotherapy.
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
Microbes can help or hinder cancer therapy.
This review shows how infection and the #microbiome shape #AntitumorImmunity, while highlighting #AI as a tool to improve patient stratification and treatment prediction.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
This review shows how infection and the #microbiome shape #AntitumorImmunity, while highlighting #AI as a tool to improve patient stratification and treatment prediction.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
September 3, 2026 at 2:54 PM
Microbes can help or hinder cancer therapy.
This review shows how infection and the #microbiome shape #AntitumorImmunity, while highlighting #AI as a tool to improve patient stratification and treatment prediction.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
This review shows how infection and the #microbiome shape #AntitumorImmunity, while highlighting #AI as a tool to improve patient stratification and treatment prediction.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
Researchers demonstrate that neutrophil-specific STAT3 targeting enhances cytotoxic CD8+ T-cell responses and inhibits tumor growth, identifying a potential new approach to strengthen #AntitumorImmunity. @unidue.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
June 8, 2026 at 10:30 AM
Researchers demonstrate that neutrophil-specific STAT3 targeting enhances cytotoxic CD8+ T-cell responses and inhibits tumor growth, identifying a potential new approach to strengthen #AntitumorImmunity. @unidue.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
Loss of #EHMT2 enhances #NKcell -driven #AntiTumorImmunity through #TGFβ1 suppression
by S. Chava, R. Gupta, N. Wajapeyee & colleagues
@uofalabama.bsky.social
doi.org/10.1038/s443...
by S. Chava, R. Gupta, N. Wajapeyee & colleagues
@uofalabama.bsky.social
doi.org/10.1038/s443...
December 10, 2025 at 4:10 PM
Loss of #EHMT2 enhances #NKcell -driven #AntiTumorImmunity through #TGFβ1 suppression
by S. Chava, R. Gupta, N. Wajapeyee & colleagues
@uofalabama.bsky.social
doi.org/10.1038/s443...
by S. Chava, R. Gupta, N. Wajapeyee & colleagues
@uofalabama.bsky.social
doi.org/10.1038/s443...
In this study, researchers developed a conductive coordination #Nanozyme prodrug that triggers synergistic #Pyroptosis, #Cuproptosis, and #Ferroptosis to elicit potent in situ #CancerVaccination and systemic #AntitumorImmunity.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
March 28, 2026 at 4:15 PM
In this study, researchers developed a conductive coordination #Nanozyme prodrug that triggers synergistic #Pyroptosis, #Cuproptosis, and #Ferroptosis to elicit potent in situ #CancerVaccination and systemic #AntitumorImmunity.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
Researchers developed P8D NPs as a chemo-photothermal synergistic platform to ignite systemic #AntitumorImmunity via #Ferroptosis, providing a potent approach to enhance therapeutic efficacy against "cold" tumors.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
March 28, 2026 at 10:45 PM
Researchers developed P8D NPs as a chemo-photothermal synergistic platform to ignite systemic #AntitumorImmunity via #Ferroptosis, providing a potent approach to enhance therapeutic efficacy against "cold" tumors.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
This review outlines immune modulatory #Vaccines targeting #TumorMicroenvironment antigens, enhancing T-cell–mediated responses to overcome #Immunosuppression and improve #AntitumorImmunity.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
April 18, 2026 at 7:15 AM
This review outlines immune modulatory #Vaccines targeting #TumorMicroenvironment antigens, enhancing T-cell–mediated responses to overcome #Immunosuppression and improve #AntitumorImmunity.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
This study shows that targeting GPR34 in damage-associated macrophages enhances #antitumorimmunity and potentiates the efficacy of s#rufatinib, highlighting a promising therapeutic strategy for #PancreaticCancer.
#STTT #OpenAccess: doi.org/10.1038/s413...
#OncologyResearch #CancerResearch
#STTT #OpenAccess: doi.org/10.1038/s413...
#OncologyResearch #CancerResearch
June 29, 2026 at 12:40 PM
This study shows that targeting GPR34 in damage-associated macrophages enhances #antitumorimmunity and potentiates the efficacy of s#rufatinib, highlighting a promising therapeutic strategy for #PancreaticCancer.
#STTT #OpenAccess: doi.org/10.1038/s413...
#OncologyResearch #CancerResearch
#STTT #OpenAccess: doi.org/10.1038/s413...
#OncologyResearch #CancerResearch
#CancerCells evade #TCell attacks by removing #ReactiveOxygenSpecies from the #TumorMicroenvironment that are needed for #ImmuneSignaling, making this process a promising #immunotherapy target.
#AntitumorImmunity #Immunesuppression
#AntitumorImmunity #Immunesuppression
Cancer cells use antioxidant protein to suppress T cells and resist immunotherapy – BioNews Central
Cancer cells evade T cell attacks by removing reactive oxygen species from the tumor environment that are needed for immune signaling, making this process a promising immunotherapy target. ...
sbee.link
September 4, 2026 at 10:05 AM
#CancerCells evade #TCell attacks by removing #ReactiveOxygenSpecies from the #TumorMicroenvironment that are needed for #ImmuneSignaling, making this process a promising #immunotherapy target.
#AntitumorImmunity #Immunesuppression
#AntitumorImmunity #Immunesuppression
New research shows that the specialized #ImmuneCell #DendriticCell type 1 is crucial for forming and sustaining #TertiaryLymphoidStructures, which act as local immune hubs coordinating #AntitumorImmunity.
#ImmuneResponse #Immunotherapy
#ImmuneResponse #Immunotherapy
Researchers identify immune cell that builds cancer-fighting hubs inside tumors to enhance antitumor immunity – BioNews Central
New research shows that the specialized immune cell dendritic cell type 1 is crucial for forming and sustaining tertiary lymphoid structures, which act as local immune hubs coordinating antitumor immunity. ...
sbee.link
July 17, 2026 at 4:03 PM
New research shows that the specialized #ImmuneCell #DendriticCell type 1 is crucial for forming and sustaining #TertiaryLymphoidStructures, which act as local immune hubs coordinating #AntitumorImmunity.
#ImmuneResponse #Immunotherapy
#ImmuneResponse #Immunotherapy
Check out our latest review on lymphatic vessels in cancer ! @agostinislab.bsky.social #autophagy #lymphatics #immunotherapy #antitumorimmunity www.sciexplor.com/articles/EXO...
The lymphatic endothelial-immune dialogue in cancer and immunotherapy
Lymphatic endothelial cells (LECs) and the lymphatic vasculature have evolved from being viewed as passive conduits for fluid drainage and metastatic dissemination to active, dynamic regulators of inf...
www.sciexplor.com
April 24, 2026 at 5:47 AM
Check out our latest review on lymphatic vessels in cancer ! @agostinislab.bsky.social #autophagy #lymphatics #immunotherapy #antitumorimmunity www.sciexplor.com/articles/EXO...
Preclinical study shows that #prostate -targeted engineered amorphous #SilicaNanoparticles effectively kill aggressive #ProstateCancer cells and enhance #AntitumorImmunity, supporting further clinical investigation.
Engineered silica nanoparticles directly kill prostate cancer cells while reactivating antitumor immunity – BioNews Central
Preclinical mouse models showed that prostate-targeted engineered amorphous silica nanoparticles effectively kill aggressive prostate cancer tumors and enhance anti-tumor immunity, supporting further clinical investigation. ...
sbee.link
June 15, 2026 at 6:40 PM
Preclinical study shows that #prostate -targeted engineered amorphous #SilicaNanoparticles effectively kill aggressive #ProstateCancer cells and enhance #AntitumorImmunity, supporting further clinical investigation.
Research shows that the #AminoAcid #cysteine promotes the production of the #antioxidant #glutathione, which regulates #TCellActivity, and also supports #TCell proliferation and maintenance of their #CancerFighting function.
#AntiTumorImmunity
#AntiTumorImmunity
Amino acid cysteine fuels cancer-fighting T cells – BioNews Central
Research shows that the amino acid cysteine promotes the production of the antioxidant glutathione, which regulates T-cell activity, and also supports T-cell proliferation and maintenance of their cancer-fighting function. ...
sbee.link
April 1, 2026 at 1:57 AM
Research shows that the #AminoAcid #cysteine promotes the production of the #antioxidant #glutathione, which regulates #TCellActivity, and also supports #TCell proliferation and maintenance of their #CancerFighting function.
#AntiTumorImmunity
#AntiTumorImmunity
#Zeaxanthin — a #PlantDerived #carotenoid best known for protecting #vision — may also strengthen #ImmuneResponses by increasing the #CancerFighting activity of #ImmuneCells.
#AntiTumorImmunity
#AntiTumorImmunity
Plant-derived nutrient zeaxanthin improves immune cells’ ability to fight cancer – BioNews Central
Zeaxanthin — a plant-derived carotenoid best known for protecting vision — may also strengthen immune responses by increasing the cancer-fighting activity of immune cells. ..
sbee.link
September 3, 2025 at 3:50 PM
#Zeaxanthin — a #PlantDerived #carotenoid best known for protecting #vision — may also strengthen #ImmuneResponses by increasing the #CancerFighting activity of #ImmuneCells.
#AntiTumorImmunity
#AntiTumorImmunity
A decade-long study shows that #HighFatDiets rich in #AnimalFats like #lard, #BeefTallow, or #butter impair #AntiTumorImmunity and promote #CancerGrowth in obese mice, unlike #PlantBasedFats.
#Obesity
#Obesity
Influence of animal and plant-based dietary fats on cancer growth in obese mice – BioNews Central
A decade-long study shows that high-fat diets rich in animal fats like lard, beef tallow, or butter impair anti-tumor immunity and promote cancer growth in obese mice, unlike plant-based fats. ...
sbee.link
August 1, 2025 at 9:55 PM
A decade-long study shows that #HighFatDiets rich in #AnimalFats like #lard, #BeefTallow, or #butter impair #AntiTumorImmunity and promote #CancerGrowth in obese mice, unlike #PlantBasedFats.
#Obesity
#Obesity
Researchers have discovered a fat uptake mechanism in #ImmuneCells within #tumors that blocks #AntiTumorImmunity and have developed an #AntibodyDrug to overcome this barrier in #CancerImmunotherapy.
An antibody drug dismantles a metabolic barrier to anti-tumor immunity – BioNews Central
Researchers have discovered a fat uptake mechanism in immune cells within tumors that blocks anti-tumor immunity and have developed a humanized antibody to overcome this barrier in cancer immunotherapy. ...
sbee.link
April 29, 2025 at 5:07 AM
Researchers have discovered a fat uptake mechanism in #ImmuneCells within #tumors that blocks #AntiTumorImmunity and have developed an #AntibodyDrug to overcome this barrier in #CancerImmunotherapy.
##Aging specifically impairs the generation of CD8+ tissue-resident ##memoryTcells and thus compromises ##AntitumorImmunity.
##ImmuneResponse ##ImmuneAging
##ImmuneResponse ##ImmuneAging
Study reveals how aging impairs antitumor immunity – BioNews Central
Aging specifically impairs the generation of CD8+ tissue-resident memory T cells and thus compromises antitumor immunity. ...
sbee.link
November 28, 2024 at 2:49 PM
##Aging specifically impairs the generation of CD8+ tissue-resident ##memoryTcells and thus compromises ##AntitumorImmunity.
##ImmuneResponse ##ImmuneAging
##ImmuneResponse ##ImmuneAging
CCL19+ reticular cells help shape fibroblastic niches that drive anti-tumor immunity in lung cancer. New insights into the tumor microenvironment may inform future therapies.
www.nature.com/articles/s41...
#LungCancer #TumorMicroenvironment #CancerImmunology #Fibroblasts #AntiTumorImmunity
www.nature.com/articles/s41...
#LungCancer #TumorMicroenvironment #CancerImmunology #Fibroblasts #AntiTumorImmunity
June 23, 2026 at 11:36 AM
CCL19+ reticular cells help shape fibroblastic niches that drive anti-tumor immunity in lung cancer. New insights into the tumor microenvironment may inform future therapies.
www.nature.com/articles/s41...
#LungCancer #TumorMicroenvironment #CancerImmunology #Fibroblasts #AntiTumorImmunity
www.nature.com/articles/s41...
#LungCancer #TumorMicroenvironment #CancerImmunology #Fibroblasts #AntiTumorImmunity
A heterogenic fusion membrane #TumorVaccine (EV–CM) enhanced with a Pt‑porphyrin #nanoplatform was developed, showing ultrasound‑augmented immunogenic cell death, stronger #AntitumorImmunity, and #antimetastatic effects.
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
December 7, 2025 at 1:01 PM
A heterogenic fusion membrane #TumorVaccine (EV–CM) enhanced with a Pt‑porphyrin #nanoplatform was developed, showing ultrasound‑augmented immunogenic cell death, stronger #AntitumorImmunity, and #antimetastatic effects.
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
An overview of how cell cycle proteins modulate #AntitumorImmunity and progression by shaping the tumor immune microenvironment, highlighting that targeting these pathways offers new immunotherapeutic strategies for #PrecisionOncology.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
May 27, 2026 at 3:30 PM
An overview of how cell cycle proteins modulate #AntitumorImmunity and progression by shaping the tumor immune microenvironment, highlighting that targeting these pathways offers new immunotherapeutic strategies for #PrecisionOncology.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Scientists show #CSF1R correlates with poor prognosis in #OvarianCancer, and blocking it with PLX3397 enhances #paclitaxel efficacy, reprograms #macrophages, boosts #AntitumorImmunity, and reduces #angiogenesis, highlighting it as a promising target.
Read: doi.org/10.1016/j.ge...
Read: doi.org/10.1016/j.ge...
April 7, 2026 at 1:41 PM
Scientists show #CSF1R correlates with poor prognosis in #OvarianCancer, and blocking it with PLX3397 enhances #paclitaxel efficacy, reprograms #macrophages, boosts #AntitumorImmunity, and reduces #angiogenesis, highlighting it as a promising target.
Read: doi.org/10.1016/j.ge...
Read: doi.org/10.1016/j.ge...