In this story, a bunch of guys called The Axons turn up. That's them, all with golden haircuts. They've all dressed exactly the same, which is probably embarrassing for them. They should have co-ordi...

The authors combined whole-brain developmental projection maps with single-cell transcriptomics to work out how serotonin neurons wire the forebrain after…

Piezo1 acts as a molecular sensor helping oligodendrocytes measure axon size to set myelin sheath length.

Read the full paper: Local translation of endosome-associated lc3b mRNA in axons contributes to endosomal clearance

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Afferent nerve fibers are axons (nerve fibers) of sensory neurons that carry sensory information

Axon myelination can tune neuronal circuits through placement and modulation of different patterns of myelin sheaths on distinct types of axons. How myelin formation is coordinated on distinct axon classes remains largely unknown. Recent work indicates neuronal activity and vesicle release promote myelin formation, and myelin-producing oligodendrocytes express canonical postsynaptic factors that potentially facilitate oligodendrocyte-axon interaction for myelin ensheathment. Here, we examined whether the inhibitory postsynaptic scaffold protein Gephyrin (Gphn) mediates selective myelination of specific axon classes in the larval zebrafish. Consistent with this possibility, Gphn was enriched in myelin on GABAergic and glycinergic axons. In gphnb deficient larval oligodendrocytes, myelin sheaths were longer and the frequency of myelin placement on GABAergic axons was reduced. Collectively, our results indicate that oligodendrocyte lineage cells use Gphn to promote myelin formation on GAB

Nucleoside analogs show protective and therapeutic effects in a mouse model of multiple sclerosis (MS) and association with reduced MS risk in humans.

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