#MedSky #IDSky #ImmunoSky This study sheds light on the complex immune response in #COVID particularly within 🫁 -associated lymph nodes where Bcl6 expression seems to influence immune organization and activity.
The clustering of B &TFH cells in Bcl6 (journals.aai.org/jimmunol/art... ) -high nodes
The clustering of B &TFH cells in Bcl6 (journals.aai.org/jimmunol/art... ) -high nodes
A Bcl6 Intronic Element Regulates T Follicular Helper Cell Differentiation
Key Points. TFH cell differentiation is regulated by FOXO1 via intronic elements in the Bcl6 gene.Deletion of the FOXO1 binding sites changes the proportio
journals.aai.org
November 9, 2024 at 6:33 AM
#MedSky #IDSky #ImmunoSky This study sheds light on the complex immune response in #COVID particularly within 🫁 -associated lymph nodes where Bcl6 expression seems to influence immune organization and activity.
The clustering of B &TFH cells in Bcl6 (journals.aai.org/jimmunol/art... ) -high nodes
The clustering of B &TFH cells in Bcl6 (journals.aai.org/jimmunol/art... ) -high nodes
@biorxivpreprint.bsky.social BCL6 is required for the development of functionally responsive IgM+ GC-independent Memory B Cells @marionpepper.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 6, 2025 at 4:28 AM
@biorxivpreprint.bsky.social BCL6 is required for the development of functionally responsive IgM+ GC-independent Memory B Cells @marionpepper.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
BLIMP1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4 @cp-cellreports.bsky.social @luoweicool.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
July 13, 2025 at 4:17 PM
BLIMP1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4 @cp-cellreports.bsky.social @luoweicool.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Herein, she reveals that the differentiation of these important memory B cells depends upon the expression of BCL6, but does not depend on BCL6-expressing Germinal Center T Follicular Helper cells, suggesting GC-independence. ⤵️
June 11, 2026 at 2:17 PM
Herein, she reveals that the differentiation of these important memory B cells depends upon the expression of BCL6, but does not depend on BCL6-expressing Germinal Center T Follicular Helper cells, suggesting GC-independence. ⤵️
BCL6 in T cells promotes type 1 diabetes by redirecting fates of insulin-autoreactive B lymphocytes https://www.biorxiv.org/content/10.1101/2025.08.25.671997v1
August 29, 2025 at 12:17 AM
BCL6 in T cells promotes type 1 diabetes by redirecting fates of insulin-autoreactive B lymphocytes https://www.biorxiv.org/content/10.1101/2025.08.25.671997v1
This week in #Science #Immunology: Peng Shao, Noah Butler, & colleagues at University of Iowa show that TRAF3 is critical for early #TFollicularHelper ( #Tfh ) cell differentiation!
TRAF3 is critical for initial T follicular helper cell specification via coordination of the IL-6R/IL-2R–BCL6 signaling nexus
TRAF3 integrates early cell-intrinsic and cell-extrinsic signals to initiate TFH cell differentiation.
www.science.org
February 15, 2025 at 10:31 AM
This week in #Science #Immunology: Peng Shao, Noah Butler, & colleagues at University of Iowa show that TRAF3 is critical for early #TFollicularHelper ( #Tfh ) cell differentiation!
📽️ New video summary of a study "BCL6 is required for the development of functionally responsive IgM+ GC Tfh–independent memory B cells" from the @marionpepper.bsky.social lab (rupress.org/jem/article/...)
Video by the first author, Gretchen Harms Pritchard:
Video by the first author, Gretchen Harms Pritchard:
BCL6 is required for development of functionally responsive IgM+ GC Tfh independent Memory B Cells
Original paper: https://rupress.org/jem/article/223/8/e20252336/282726/BCL6-is-required-for-the-development-of
Video summary by Gretchen Harms Pritchard (Marion Pepper lab, University of Washington)…
youtu.be
June 11, 2026 at 2:45 PM
📽️ New video summary of a study "BCL6 is required for the development of functionally responsive IgM+ GC Tfh–independent memory B cells" from the @marionpepper.bsky.social lab (rupress.org/jem/article/...)
Video by the first author, Gretchen Harms Pritchard:
Video by the first author, Gretchen Harms Pritchard:
Many cancers have multiple oncogenes. Does it matter if they are in the same cell or not?
-- Anand Jeyesekaran kicking off the Immuno-Oncology session for #multiomics2024 🧵 1/
-- Anand Jeyesekaran kicking off the Immuno-Oncology session for #multiomics2024 🧵 1/
December 1, 2024 at 4:10 AM
Many cancers have multiple oncogenes. Does it matter if they are in the same cell or not?
-- Anand Jeyesekaran kicking off the Immuno-Oncology session for #multiomics2024 🧵 1/
-- Anand Jeyesekaran kicking off the Immuno-Oncology session for #multiomics2024 🧵 1/
Pillars of Immunology @jimmunol.bsky.social
Identifying the master regulator Bcl6 and its archrival Blimp1 for T follicular helper lineage differentiation
academic.oup.com/jimmunol/art...
2009 paper in @science.org
www.science.org/doi/10.1126/....
Identifying the master regulator Bcl6 and its archrival Blimp1 for T follicular helper lineage differentiation
academic.oup.com/jimmunol/art...
2009 paper in @science.org
www.science.org/doi/10.1126/....
April 28, 2026 at 2:02 AM
Pillars of Immunology @jimmunol.bsky.social
Identifying the master regulator Bcl6 and its archrival Blimp1 for T follicular helper lineage differentiation
academic.oup.com/jimmunol/art...
2009 paper in @science.org
www.science.org/doi/10.1126/....
Identifying the master regulator Bcl6 and its archrival Blimp1 for T follicular helper lineage differentiation
academic.oup.com/jimmunol/art...
2009 paper in @science.org
www.science.org/doi/10.1126/....
'Here, we showed that IL-4 cytokine signaling in GC B cells directly downregulated the transcription factor BCL6 via negative autoregulation to release cells from the GC program and to promote MBC formation.'
#Immunology
www.cell.com/immunity/abs...
#Immunology
www.cell.com/immunity/abs...
March 24, 2024 at 8:26 AM
'Here, we showed that IL-4 cytokine signaling in GC B cells directly downregulated the transcription factor BCL6 via negative autoregulation to release cells from the GC program and to promote MBC formation.'
#Immunology
www.cell.com/immunity/abs...
#Immunology
www.cell.com/immunity/abs...
This work is also important as it reveals that like BCL6, SIPR2 is expressed on activated B cells prior to GC entry and marks cells that will go on to become optimally responsive IgM+ MBCs. It also reveals that CD4-Cre BCL6-floxed CD4+ T cells are still capable of migrating to the T-B border. ⤵️
June 11, 2026 at 2:17 PM
This work is also important as it reveals that like BCL6, SIPR2 is expressed on activated B cells prior to GC entry and marks cells that will go on to become optimally responsive IgM+ MBCs. It also reveals that CD4-Cre BCL6-floxed CD4+ T cells are still capable of migrating to the T-B border. ⤵️
Looking forward to speak at the 2nd Biophysics for Drug Discovery Summit (ter.li/39kb11) about the integrated biophysical approaches used in our BCL6 project. Collaborative drug discovery with Swen Hoelder, @chemb.bsky.social and @temt-icr.bsky.social at @icrlondon.bsky.social.
January 31, 2025 at 11:54 AM
Looking forward to speak at the 2nd Biophysics for Drug Discovery Summit (ter.li/39kb11) about the integrated biophysical approaches used in our BCL6 project. Collaborative drug discovery with Swen Hoelder, @chemb.bsky.social and @temt-icr.bsky.social at @icrlondon.bsky.social.
The many roads to B cell memory | Science Immunology www.science.org/doi/10.1126/... 🧪
The many roads to B cell memory
Germinal center–experienced IgM memory B cells require BCL6 but not TFH cells.
www.science.org
September 7, 2026 at 6:34 PM
The many roads to B cell memory | Science Immunology www.science.org/doi/10.1126/... 🧪
Bcl6 reactivity is associated with a distinct immune landscape and spatial transcriptome in COVID-19 @jci-insight.bsky.social
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
September 9, 2025 at 5:47 PM
Bcl6 reactivity is associated with a distinct immune landscape and spatial transcriptome in COVID-19 @jci-insight.bsky.social
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
Lack of Bcl6 promotes anti-tumor immunity by activating glycolysis to rescue CD8 T cell function https://www.biorxiv.org/content/10.1101/2025.04.01.646721v1
April 7, 2025 at 6:16 AM
Lack of Bcl6 promotes anti-tumor immunity by activating glycolysis to rescue CD8 T cell function https://www.biorxiv.org/content/10.1101/2025.04.01.646721v1
BCL6 is required for the development of functionally responsive IgM⁺ GC Tfh–independent memory #Bcells. New study from Gretchen Harms Pritchard, Marion Pepper @marionpepper.bsky.social and colleagues (University of Washington):
rupress.org/jem/article/...
📽️ See video summary: youtu.be/1VhyIx03UMs
rupress.org/jem/article/...
📽️ See video summary: youtu.be/1VhyIx03UMs
June 17, 2026 at 8:03 PM
BCL6 is required for the development of functionally responsive IgM⁺ GC Tfh–independent memory #Bcells. New study from Gretchen Harms Pritchard, Marion Pepper @marionpepper.bsky.social and colleagues (University of Washington):
rupress.org/jem/article/...
📽️ See video summary: youtu.be/1VhyIx03UMs
rupress.org/jem/article/...
📽️ See video summary: youtu.be/1VhyIx03UMs
I am certain there is a really good evolutionary reason probably related to autoimmune disease that BLIMP1 and BCL6 are mutually repressive but it would be super cool if we could make them… not. In some circumstances.
March 9, 2024 at 9:37 PM
I am certain there is a really good evolutionary reason probably related to autoimmune disease that BLIMP1 and BCL6 are mutually repressive but it would be super cool if we could make them… not. In some circumstances.
Follicular Bcl6 reactivity is associated with a unique immune landscape and spatial transcriptome in COVID-19 https://www.biorxiv.org/content/10.1101/2024.11.07.622471v1
Follicular Bcl6 reactivity is associated with a unique immune landscape and spatial transcriptome in COVID-19 https://www.biorxiv.org/content/10.1101/2024.11.07.622471v1
The regulation of follicular (F) and germinal center (GC) immune reactivity in human lymph nodes (LN
www.biorxiv.org
November 9, 2024 at 2:15 AM
Follicular Bcl6 reactivity is associated with a unique immune landscape and spatial transcriptome in COVID-19 https://www.biorxiv.org/content/10.1101/2024.11.07.622471v1
#Bcl6 inhibition destabilizes #TregCells by reducing H3K4me3, enhancing #AntiTumor immunity, delaying #HeadandNeckSquamousCellCarcinoma progression, and synergizing with immune checkpoint therapy, highlighting Bcl6 as a promising target.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
March 31, 2026 at 4:45 PM
#Bcl6 inhibition destabilizes #TregCells by reducing H3K4me3, enhancing #AntiTumor immunity, delaying #HeadandNeckSquamousCellCarcinoma progression, and synergizing with immune checkpoint therapy, highlighting Bcl6 as a promising target.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Thrilled to share that our manuscript is now published in Cell Reports! Our findings support a model in which BLIMP1 intrinsically regulates GC B cell fate through transcriptional control.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
BLIMP1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4
BLIMP1 is expressed in a subset of GCBCs. Conter et al. have shown that BLIMP1 intrinsically
regulates multiple key processes in GCBCs, including positive selection, cell-cycle
progression, isotype sw...
www.cell.com
July 14, 2025 at 5:23 PM
Thrilled to share that our manuscript is now published in Cell Reports! Our findings support a model in which BLIMP1 intrinsically regulates GC B cell fate through transcriptional control.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
This review highlights #BCL6 overexpression in #GlioblastomaMultiforme as a driver of proliferation and poor prognosis; its inhibition induces #apoptosis, and YK01 suppresses GBM growth and synergizes with temozolomide as a promising therapy.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
May 13, 2026 at 4:30 AM
This review highlights #BCL6 overexpression in #GlioblastomaMultiforme as a driver of proliferation and poor prognosis; its inhibition induces #apoptosis, and YK01 suppresses GBM growth and synergizes with temozolomide as a promising therapy.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
My favorite thing about T cell biology is how it’s so tractable and finite. Anyway, here’s a preprint showing that there are TFH cells that don’t express BCL6, express BLIMP1, and they seem to be important for plasma cells:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 10, 2024 at 5:02 AM
My favorite thing about T cell biology is how it’s so tractable and finite. Anyway, here’s a preprint showing that there are TFH cells that don’t express BCL6, express BLIMP1, and they seem to be important for plasma cells:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The project started when Zosia was a summer student, & we discussed the great paper by Słabicki et al. The ubiquitylation of BCL6 by SIAH1 is boosted when BCL6 gets multimerised by a small molecule. We reasoned that SIAH1 might also be a multimer & preferentially recognise multimers through avidity.
Small-molecule-induced polymerization triggers degradation of BCL6 - Nature
Binding of the small molecule BI-3802 to the oncogenic transcription factor B cell lymphoma 6 (BCL6) induces polymerization of BCL6, leading to its ubiquitination by SIAH1 and proteasomal de...
www.nature.com
February 6, 2025 at 9:42 AM
The project started when Zosia was a summer student, & we discussed the great paper by Słabicki et al. The ubiquitylation of BCL6 by SIAH1 is boosted when BCL6 gets multimerised by a small molecule. We reasoned that SIAH1 might also be a multimer & preferentially recognise multimers through avidity.