A genome-wide atlas of human cell morphology https://www.nature.com/articles/s41592-024-02537-7 🧬🖥️🧪 https://github.com/broadinstitute/2022_PERISCOPE
January 27, 2025 at 7:30 PM
A genome-wide atlas of human cell morphology https://www.nature.com/articles/s41592-024-02537-7 🧬🖥️🧪 https://github.com/broadinstitute/2022_PERISCOPE
Online now! Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes by @d_ogasa, @brumelillo, @bencravatt, et al at @scrippsresearch @broadinstitute @harvardmed http://dlvr.it/TGFYHC
November 18, 2024 at 4:32 PM
Online now! Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes by @d_ogasa, @brumelillo, @bencravatt, et al at @scrippsresearch @broadinstitute @harvardmed http://dlvr.it/TGFYHC
#Technology Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes by @d_ogasa, @brumelillo, @bencravatt at @scrippsresearch @broadinstitute @harvardmed @MassGeneralNews http://dlvr.it/TGwBJt
December 20, 2024 at 7:01 PM
#Technology Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes by @d_ogasa, @brumelillo, @bencravatt at @scrippsresearch @broadinstitute @harvardmed @MassGeneralNews http://dlvr.it/TGwBJt
Another glorious sunny day in Kendall Square.
#MIT #BroadInstitute #Cambridge #Boston #Massachusetts #MondayAfternoon #Photography
#MIT #BroadInstitute #Cambridge #Boston #Massachusetts #MondayAfternoon #Photography
April 27, 2026 at 7:07 PM
Another glorious sunny day in Kendall Square.
#MIT #BroadInstitute #Cambridge #Boston #Massachusetts #MondayAfternoon #Photography
#MIT #BroadInstitute #Cambridge #Boston #Massachusetts #MondayAfternoon #Photography
No microscope? No problem! A new spatial transcriptomics method developed at the Broad lets you map gene expression with zero imaging needed. Perfect for big tissue samples and small labs! 🔬💡 #spatialtranscriptomics #bioinformatics #transcriptomics #genomics #biology #harvard #broadinstitute
April 4, 2025 at 6:40 PM
No microscope? No problem! A new spatial transcriptomics method developed at the Broad lets you map gene expression with zero imaging needed. Perfect for big tissue samples and small labs! 🔬💡 #spatialtranscriptomics #bioinformatics #transcriptomics #genomics #biology #harvard #broadinstitute
📄 Paper: www.nature.com/articles/s41...
📣 @broadinstitute news: www.broadinstitute.org/news/atlas-i...
🔎 Explore every molQTL, link, and cascade: cascade.finngen.fi
🧵 Preprint thread: bsky.app/profile/masa...
📣 @broadinstitute news: www.broadinstitute.org/news/atlas-i...
🔎 Explore every molQTL, link, and cascade: cascade.finngen.fi
🧵 Preprint thread: bsky.app/profile/masa...
September 30, 2026 at 5:27 PM
📄 Paper: www.nature.com/articles/s41...
📣 @broadinstitute news: www.broadinstitute.org/news/atlas-i...
🔎 Explore every molQTL, link, and cascade: cascade.finngen.fi
🧵 Preprint thread: bsky.app/profile/masa...
📣 @broadinstitute news: www.broadinstitute.org/news/atlas-i...
🔎 Explore every molQTL, link, and cascade: cascade.finngen.fi
🧵 Preprint thread: bsky.app/profile/masa...
Join our authors at the @broadinstitute on 30th October 2025
💻 Do bring your devices to explore these fascinating Macroscopes!
📚 Copies of Atlas of Macroscopes will be available for purchase at the event from the The MIT Press Bookstore.
@mitpress.bsky.social @broadinstitute.org
💻 Do bring your devices to explore these fascinating Macroscopes!
📚 Copies of Atlas of Macroscopes will be available for purchase at the event from the The MIT Press Bookstore.
@mitpress.bsky.social @broadinstitute.org
October 24, 2025 at 6:55 PM
Join our authors at the @broadinstitute on 30th October 2025
💻 Do bring your devices to explore these fascinating Macroscopes!
📚 Copies of Atlas of Macroscopes will be available for purchase at the event from the The MIT Press Bookstore.
@mitpress.bsky.social @broadinstitute.org
💻 Do bring your devices to explore these fascinating Macroscopes!
📚 Copies of Atlas of Macroscopes will be available for purchase at the event from the The MIT Press Bookstore.
@mitpress.bsky.social @broadinstitute.org
Perspective! Emerging biochemical, microbial and immunological evidence in the search for why HLA-B∗27 confers risk for spondyloarthritis by Eric Brown, Phuong Nguyen, and Ramnik Xavier @TheXavierLab at @broadinstitute http://dlvr.it/THQ9LV
January 17, 2025 at 1:02 PM
Perspective! Emerging biochemical, microbial and immunological evidence in the search for why HLA-B∗27 confers risk for spondyloarthritis by Eric Brown, Phuong Nguyen, and Ramnik Xavier @TheXavierLab at @broadinstitute http://dlvr.it/THQ9LV
Fixed in GATK 4.6.0.0! github.com/broadinstitu...
Release 4.6.0.0 · broadinstitute/gatk
Download release: gatk-4.6.0.0.zip
Docker image: https://hub.docker.com/r/broadinstitute/gatk/
Highlights of the 4.6.0.0 release:
We've fixed a serious CRAM writing bug that affects GATK versions...
github.com
August 28, 2024 at 5:30 PM
Fixed in GATK 4.6.0.0! github.com/broadinstitu...
Fresh out on biorxiv - me getting to brag about the stupendous, brilliant, AMAZING folks who have been kind enough to come hang out with us at the
@broadinstitute
to do our Postdoctoral Training Program in #BioimageAnalysis . Into the🧵 for story!
www.biorxiv.org/content/10.1... (1/x)
@broadinstitute
to do our Postdoctoral Training Program in #BioimageAnalysis . Into the🧵 for story!
www.biorxiv.org/content/10.1... (1/x)
| bioRxiv
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
May 16, 2024 at 2:00 PM
Fresh out on biorxiv - me getting to brag about the stupendous, brilliant, AMAZING folks who have been kind enough to come hang out with us at the
@broadinstitute
to do our Postdoctoral Training Program in #BioimageAnalysis . Into the🧵 for story!
www.biorxiv.org/content/10.1... (1/x)
@broadinstitute
to do our Postdoctoral Training Program in #BioimageAnalysis . Into the🧵 for story!
www.biorxiv.org/content/10.1... (1/x)
Wei Zhou from the @bmneale lab giving an #ASHG23 standout talk on SAIGE-QTL (github.com/weizhou0/qtl), which improves on pseudobulked eQTL studies.
Setting up her own lab at the @broadinstitute, great training opportunities with an exceptional early stage investigator.
Setting up her own lab at the @broadinstitute, great training opportunities with an exceptional early stage investigator.
GitHub - weizhou0/qtl
Contribute to weizhou0/qtl development by creating an account on GitHub.
github.com
November 4, 2023 at 3:33 PM
Wei Zhou from the @bmneale lab giving an #ASHG23 standout talk on SAIGE-QTL (github.com/weizhou0/qtl), which improves on pseudobulked eQTL studies.
Setting up her own lab at the @broadinstitute, great training opportunities with an exceptional early stage investigator.
Setting up her own lab at the @broadinstitute, great training opportunities with an exceptional early stage investigator.
7/
CellBender (from the Broad Institute):
Uses Bayesian inference to estimate and subtract ambient RNA.
Best for 10x Genomics data with raw counts.
github.com/broadinstit...
CellBender (from the Broad Institute):
Uses Bayesian inference to estimate and subtract ambient RNA.
Best for 10x Genomics data with raw counts.
github.com/broadinstit...
GitHub - broadinstitute/CellBender: CellBender is a software package for eliminating technical artifacts from high-throughput single-cell RNA sequencing (scRNA-seq) data.
CellBender is a software package for eliminating technical artifacts from high-throughput single-cell RNA sequencing (scRNA-seq) data. - broadinstitute/CellBender
github.com
July 19, 2025 at 1:45 PM
7/
CellBender (from the Broad Institute):
Uses Bayesian inference to estimate and subtract ambient RNA.
Best for 10x Genomics data with raw counts.
github.com/broadinstit...
CellBender (from the Broad Institute):
Uses Bayesian inference to estimate and subtract ambient RNA.
Best for 10x Genomics data with raw counts.
github.com/broadinstit...
🚨Urgent appeal for Lito Sousa, fighting Creutzfeldt-Jakob disease. Pls share/tag these institutions who could include him in life-saving trials:
@ionis_pharma - Ionis Pharmaceuticals - ION717 trial @broadinstitute - PRISM trial (NCT07444580)
@mayoclinic.org
@harvard.edu
@ionis_pharma - Ionis Pharmaceuticals - ION717 trial @broadinstitute - PRISM trial (NCT07444580)
@mayoclinic.org
@harvard.edu
August 23, 2026 at 7:14 PM
🚨Urgent appeal for Lito Sousa, fighting Creutzfeldt-Jakob disease. Pls share/tag these institutions who could include him in life-saving trials:
@ionis_pharma - Ionis Pharmaceuticals - ION717 trial @broadinstitute - PRISM trial (NCT07444580)
@mayoclinic.org
@harvard.edu
@ionis_pharma - Ionis Pharmaceuticals - ION717 trial @broadinstitute - PRISM trial (NCT07444580)
@mayoclinic.org
@harvard.edu
Online now! The cyclimids: Degron-inspired cereblon binders for targeted protein degradation by Saki Ichikawa, @Chemist_Payne, @mazit, @drcmwoo, and colleagues at @HarvardChanSPH @HarvardCCB @MGHCSB @broadinstitute
February 5, 2024 at 4:30 PM
Online now! The cyclimids: Degron-inspired cereblon binders for targeted protein degradation by Saki Ichikawa, @Chemist_Payne, @mazit, @drcmwoo, and colleagues at @HarvardChanSPH @HarvardCCB @MGHCSB @broadinstitute
This research will impact millions. 🧠
#BroadInstitute #Harvard #BiologyOfAdversityProject #trauma #biology #psychology
#BroadInstitute #Harvard #BiologyOfAdversityProject #trauma #biology #psychology
Biology of Adversity Project launches at Broad Institute
New research collaboration aims to understand how adverse life experiences affect human biology and increase risk of health disorders.
www.broadinstitute.org
November 4, 2025 at 5:25 PM
This research will impact millions. 🧠
#BroadInstitute #Harvard #BiologyOfAdversityProject #trauma #biology #psychology
#BroadInstitute #Harvard #BiologyOfAdversityProject #trauma #biology #psychology
GENCODE 2025 boosts gene annotation with advanced tech! 🎉 Long-read sequencing elevates human & mouse models—massive lncRNA catalog revamp at EMBL-EBI, UK. #GenomicsRevolution PMID:39565199, Nucleic Acids Res 2025, @NAR_Open @broadinstitute https://doi.org/10.1093/nar/gkae1078 🧪
March 1, 2025 at 7:20 AM
GENCODE 2025 boosts gene annotation with advanced tech! 🎉 Long-read sequencing elevates human & mouse models—massive lncRNA catalog revamp at EMBL-EBI, UK. #GenomicsRevolution PMID:39565199, Nucleic Acids Res 2025, @NAR_Open @broadinstitute https://doi.org/10.1093/nar/gkae1078 🧪
Tangram is now available on GenePattern! 🎉 Map sc-RNA-seq data onto spatial gene expression data. GPU & CPU compatible for flexible workflows.
📷 GitHub: t.ly/07w-M
👉 CPU: t.ly/9G2lJ
👉GPU: t.ly/XO8qA
#nciitcr
@broadinstitute.org
📷 GitHub: t.ly/07w-M
👉 CPU: t.ly/9G2lJ
👉GPU: t.ly/XO8qA
#nciitcr
@broadinstitute.org
GitHub - broadinstitute/Tangram: Spatial alignment of single cell transcriptomic data.
Spatial alignment of single cell transcriptomic data. - GitHub - broadinstitute/Tangram: Spatial alignment of single cell transcriptomic data.
t.ly
December 12, 2024 at 8:39 PM
Tangram is now available on GenePattern! 🎉 Map sc-RNA-seq data onto spatial gene expression data. GPU & CPU compatible for flexible workflows.
📷 GitHub: t.ly/07w-M
👉 CPU: t.ly/9G2lJ
👉GPU: t.ly/XO8qA
#nciitcr
@broadinstitute.org
📷 GitHub: t.ly/07w-M
👉 CPU: t.ly/9G2lJ
👉GPU: t.ly/XO8qA
#nciitcr
@broadinstitute.org
Fine-mapping 64 loci IDs 17 causal SNPs linked to bipolar disorder, refining risk genes & function. #BipolarResearch PMID:40562893, Nat Neurosci 2025, @NatureNeuro @broadinstitute https://doi.org/10.1038/s41593-025-01998-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Fine-mapping genomic loci refines bipolar disorder risk genes | Nature Neuroscience
Bipolar disorder is a heritable mental illness with complex etiology. While the largest published genome-wide association study identified 64 bipolar disorder risk loci, the causal SNPs and genes within these loci remain unknown. We applied a suite of statistical and functional fine-mapping methods to these loci and prioritized 17 likely causal SNPs for bipolar disorder. We mapped these SNPs to genes and investigated their likely functional consequences by integrating variant annotations, brain cell-type epigenomic annotations, brain quantitative trait loci and results from rare variant exome sequencing in bipolar disorder. Convergent lines of evidence supported the roles of genes involved in neurotransmission and neurodevelopment, including SCN2A, TRANK1, DCLK3, INSYN2B, SYNE1, THSD7A, CACNA1B, TUBBP5, FKBP2, RASGRP1, FURIN, FES, MED24 and THRA among others in bipolar disorder. These represent promising candidates for functional experiments to understand biological mechanisms and ther
doi.org
August 7, 2025 at 1:10 AM
Fine-mapping 64 loci IDs 17 causal SNPs linked to bipolar disorder, refining risk genes & function. #BipolarResearch PMID:40562893, Nat Neurosci 2025, @NatureNeuro @broadinstitute https://doi.org/10.1038/s41593-025-01998-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
I like to think of myself as someone with a fairly high set of moral and interpersonal standards but they’re evidently not high enough for the Broad since I would have just given this guy a warning, a lecture about Inside Thoughts, and a recommendation to talk to his prescriber about the bupropion
September 13, 2025 at 1:29 PM
I like to think of myself as someone with a fairly high set of moral and interpersonal standards but they’re evidently not high enough for the Broad since I would have just given this guy a warning, a lecture about Inside Thoughts, and a recommendation to talk to his prescriber about the bupropion
Our latest work, with Mika Kivimaki's lab, now online @alzdemjournals.bsky.social: we used single-cell and GWAS data to uncover genes in peripheral blood immune cells associated with Alzheimer’s disease.
doi.org/10.1002/alz....
@broadinstitute
@MGHMolBio
@MGBResearchNews
#Alzheimers
doi.org/10.1002/alz....
@broadinstitute
@MGHMolBio
@MGBResearchNews
#Alzheimers
Population and single‐cell analyses reveal immune cell‐specific expression profiles associated with Alzheimer's disease risk
INTRODUCTION Dysregulation of the peripheral immune system may increase Alzheimer's disease (AD) risk, but the underlying cell type-specific mechanisms remain unclear. METHODS We conducted Mendeli...
doi.org
March 23, 2026 at 3:34 PM
Our latest work, with Mika Kivimaki's lab, now online @alzdemjournals.bsky.social: we used single-cell and GWAS data to uncover genes in peripheral blood immune cells associated with Alzheimer’s disease.
doi.org/10.1002/alz....
@broadinstitute
@MGHMolBio
@MGBResearchNews
#Alzheimers
doi.org/10.1002/alz....
@broadinstitute
@MGHMolBio
@MGBResearchNews
#Alzheimers
MS challenges with CNS glial cells like astrocytes, microglia, oligodendrocytes resisting. Targeting divergent functions emerges as key. #NeuroImmunology PMID:42236914, Nat Rev Immunol 2026, @NatRevImmunol @broadinstitute https://doi.org/10.1038/s41577-026-01313-2 #Medsky #Pharmsky #RNA #ASHG 🧪
Glial cells in chronic inflammation: diversity, dysfunction and therapeutic targeting | Nature Reviews Immunology
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Current therapies for relapsing MS primarily target the peripheral immune system but have consistently failed to address mechanisms underlying disease progression, which are thought to involve CNS-resident glial cells such as astrocytes, microglia and oligodendrocytes. Recent technological advances have revealed the functional heterogeneity of these glial cells, highlighting their crucial roles in inflammation, demyelination, remyelination and neurodegeneration. In this Review, we summarize emerging insights into the diversity, function and regulation of glial cells in MS and inflammation in general, highlight their interactions with immune cells and non-immune cells in the CNS, and discuss potential strategies for their therapeutic modulation. A growing appreciation of the diversity of glial cells, including astrocytes, microglia and oligodendrocytes, is providing new insights into their rol
doi.org
July 5, 2026 at 2:00 PM
MS challenges with CNS glial cells like astrocytes, microglia, oligodendrocytes resisting. Targeting divergent functions emerges as key. #NeuroImmunology PMID:42236914, Nat Rev Immunol 2026, @NatRevImmunol @broadinstitute https://doi.org/10.1038/s41577-026-01313-2 #Medsky #Pharmsky #RNA #ASHG 🧪