Protecting CEACAM1 Expression Prevents Diet‐Induced Metabolic Dysfunction and Hepatic Fibrosis in Male Mice
Obesity, Volume 34, Issue 11, Page 2094-2108, November 2026.
#LiverFibrosis #LiverSky #Hepatology
https://doi.org/10.1002/oby.70302
Obesity, Volume 34, Issue 11, Page 2094-2108, November 2026.
#LiverFibrosis #LiverSky #Hepatology
https://doi.org/10.1002/oby.70302
Protecting CEACAM1 Expression Prevents Diet‐Induced Metabolic Dysfunction and Hepatic Fibrosis in Male Mice
Obesity, Volume 34, Issue 11, Page 2094-2108, November 2026.
doi.org
November 7, 2026 at 11:51 AM
Protecting CEACAM1 Expression Prevents Diet‐Induced Metabolic Dysfunction and Hepatic Fibrosis in Male Mice
Obesity, Volume 34, Issue 11, Page 2094-2108, November 2026.
#LiverFibrosis #LiverSky #Hepatology
https://doi.org/10.1002/oby.70302
Obesity, Volume 34, Issue 11, Page 2094-2108, November 2026.
#LiverFibrosis #LiverSky #Hepatology
https://doi.org/10.1002/oby.70302
GALE is a tumor-intrinsic checkpoint of Vγ9Vδ2 T cell-mediated killing
#gdTcells @natcancer.nature.com
#gdTcells @natcancer.nature.com
GALE is a tumor-intrinsic checkpoint of Vγ9Vδ2 T cell-mediated killing - Nature Cancer
Shan et al. identified UDP-galactose 4-epimerase as an immune checkpoint of Vγ9Vδ2 T cell-mediated cancer cell killing by enhancing interaction of CD155 and CEACAM1 with their receptors TIGIT and TIM3...
www.nature.com
October 31, 2026 at 11:16 AM
GALE is a tumor-intrinsic checkpoint of Vγ9Vδ2 T cell-mediated killing
#gdTcells @natcancer.nature.com
#gdTcells @natcancer.nature.com
The authors included RRIDs in their in Nature Communications paper! We value the author's support of reproducibility. #accelerateopenscience #reproducibility #ReproducibleResearch
CEACAM1 as a mediator of B-cell receptor signaling in mantle cell lymphoma - Nature Communications
Pathological B-cell receptor (BCR) signaling is a key driver of mantle cell lymphoma tumorigenesis. Here, the authors discover that CEACAM1, an immunoglobulin-like transmembrane protein, is essential for a subset of mantle cell lymphoma through activation of the BCR.
doi.org
October 30, 2026 at 7:03 AM
The authors included RRIDs in their in Nature Communications paper! We value the author's support of reproducibility. #accelerateopenscience #reproducibility #ReproducibleResearch
Jiongming He, Shan Liu, Lingying Wang & Fei Xiong report that #EsophagealCancer cells impair #NKcell function via the downregulation of #ZNF600 expression through the ligation of #CEACAM1 with #TIM3
Zinc finger protein 600 is essential for the cytotoxic function of esophageal cancer-associated natural killer cells
ZNF600 enhances the cytolytic activity of NK cells. EC cells downregulate ZNF600 expression in EC-associated NK cells via the ligation of CEACAM1 to TIM-3
doi.org
September 18, 2026 at 4:06 PM
Jiongming He, Shan Liu, Lingying Wang & Fei Xiong report that #EsophagealCancer cells impair #NKcell function via the downregulation of #ZNF600 expression through the ligation of #CEACAM1 with #TIM3
Could CEACAM1 represent a potential therapeutic target in mantle cell lymphoma? Tycel Phillips, MD, of @cityofhope.bsky.social breaks down preclinical findings and why future research and development could center around the glycoprotein #lymsm #oncology www.onclive.com/view/high-ce...
High Rates of Expression Paint CEACAM1 as a Potential Therapeutic Target in Mantle Cell Lymphoma | OncLive
Data from a retrospective study showed high levels of CEACAM1 expression in patients with mantle cell lymphoma.
www.onclive.com
September 16, 2026 at 2:30 PM
Could CEACAM1 represent a potential therapeutic target in mantle cell lymphoma? Tycel Phillips, MD, of @cityofhope.bsky.social breaks down preclinical findings and why future research and development could center around the glycoprotein #lymsm #oncology www.onclive.com/view/high-ce...
Israeli Study Finds That Immunity Gene CEACAM1 Shows Potential Against Respiratory Viruses Including HMPV
www.thailandmedical.news/news/israeli...
www.thailandmedical.news/news/israeli...
Israeli Study Finds That Immunity Gene CEACAM1 Shows Potential Against Respiratory Viruses Including HMPV - Thailand Medical News
www.thailandmedical.news
January 12, 2025 at 6:45 AM
Israeli Study Finds That Immunity Gene CEACAM1 Shows Potential Against Respiratory Viruses Including HMPV
www.thailandmedical.news/news/israeli...
www.thailandmedical.news/news/israeli...
In a phase 2 trial, an investigational antibody--CM24, anti-CEACAM1--shows very encouraging activity against pancreatic cancer, @curetoday.bsky.social www.curetoday.com/view/cm24-co... #AACR25 #PancreaticCancer
CM24 Combo With Biomarker Targeting Improves Survival in Pancreatic Cancer
CM24 plus Opdivo and chemo improved survival in pancreatic cancer with CEACAM1 biomarkers, supporting a biomarker-driven phase 2b study.
www.curetoday.com
April 30, 2025 at 5:52 PM
In a phase 2 trial, an investigational antibody--CM24, anti-CEACAM1--shows very encouraging activity against pancreatic cancer, @curetoday.bsky.social www.curetoday.com/view/cm24-co... #AACR25 #PancreaticCancer
Binding of Fusobacterium nucleatum autotransporter adhesin CbpF to human CEACAM1 and CEACAM5: A Velcro model for bacterium adhesion www.pnas.org/doi/10....
September 25, 2025 at 11:37 AM
Binding of Fusobacterium nucleatum autotransporter adhesin CbpF to human CEACAM1 and CEACAM5: A Velcro model for bacterium adhesion www.pnas.org/doi/10....
RRIDs were included in this in Advanced Science paper. RRIDs improve reproducibility in scientific research. #OpenResearch #STMpublishing #OpenScience
Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti-TIM3 Immunotherapy
Read the full paper: Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti-TIM3 Immunotherapy
doi.org
August 19, 2026 at 7:00 AM
RRIDs were included in this in Advanced Science paper. RRIDs improve reproducibility in scientific research. #OpenResearch #STMpublishing #OpenScience
The authors included RRIDs in their in Molecular Oncology paper! RRIDs improve reproducibility in scientific research. #OpenResearch #RRID #ReproducibleResearch
CEACAM1 participation in breast cancer progression
Read the full paper: CEACAM1 participation in breast cancer progression
doi.org
July 12, 2026 at 7:00 AM
The authors included RRIDs in their in Molecular Oncology paper! RRIDs improve reproducibility in scientific research. #OpenResearch #RRID #ReproducibleResearch
Failure of Hepatic Insulin Clearance via CEACAM1-Mediated Endocytosis: The Missing Physiological Link Between Proinsulin Misfolding, Hyperinsulinemia, and Metabolic Complications in Type 2 Diabetes, Obesity, and NAFLD pubmed.ncbi.nlm.nih.gov/42227093/ #cryoem
June 4, 2026 at 2:33 AM
Failure of Hepatic Insulin Clearance via CEACAM1-Mediated Endocytosis: The Missing Physiological Link Between Proinsulin Misfolding, Hyperinsulinemia, and Metabolic Complications in Type 2 Diabetes, Obesity, and NAFLD pubmed.ncbi.nlm.nih.gov/42227093/ #cryoem
Among all the bad news about science, I had to share some beautiful new imaging of the mouse liver from @hannahhrncir.bsky.social in my lab. CEACAM1 (red) and Sox9EGFP (green).
February 11, 2025 at 1:41 AM
Among all the bad news about science, I had to share some beautiful new imaging of the mouse liver from @hannahhrncir.bsky.social in my lab. CEACAM1 (red) and Sox9EGFP (green).
CEACAM1 Drives B-Cell Signaling in Mantle Cell Lymphoma
In the relentless battle against mantle cell lymphoma (MCL), a rare yet aggressive form of non-Hodgkin's lymphoma, scientists continue to unravel the complex molecular mechanisms that drive the disease’s progression. A groundbreaking study…
In the relentless battle against mantle cell lymphoma (MCL), a rare yet aggressive form of non-Hodgkin's lymphoma, scientists continue to unravel the complex molecular mechanisms that drive the disease’s progression. A groundbreaking study…
CEACAM1 Drives B-Cell Signaling in Mantle Cell Lymphoma
In the relentless battle against mantle cell lymphoma (MCL), a rare yet aggressive form of non-Hodgkin's lymphoma, scientists continue to unravel the complex molecular mechanisms that drive the disease’s progression. A groundbreaking study published recently in Nature Communications has unveiled a novel player that may redefine our understanding of B-cell receptor (BCR) signaling in MCL. This key molecule, known as carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), emerges as an essential mediator in the signaling pathways that empower malignant B cells, a discovery that could pave the way for innovative therapeutic strategies.
scienmag.com
May 28, 2025 at 11:13 PM
CEACAM1 Drives B-Cell Signaling in Mantle Cell Lymphoma
In the relentless battle against mantle cell lymphoma (MCL), a rare yet aggressive form of non-Hodgkin's lymphoma, scientists continue to unravel the complex molecular mechanisms that drive the disease’s progression. A groundbreaking study…
In the relentless battle against mantle cell lymphoma (MCL), a rare yet aggressive form of non-Hodgkin's lymphoma, scientists continue to unravel the complex molecular mechanisms that drive the disease’s progression. A groundbreaking study…
Direct interactions of CEACAM1 and CD36 with LPS and each other https://www.biorxiv.org/content/10.64898/2026.02.01.703119v1
February 4, 2026 at 12:45 AM
Direct interactions of CEACAM1 and CD36 with LPS and each other https://www.biorxiv.org/content/10.64898/2026.02.01.703119v1
Cross-species insights into CEACAM1 autoantibodies as diagnostic biomarkers for mammary cancer. www.sciencedirect.com/science/arti...
Cross-species insights into CEACAM1 autoantibodies as diagnostic biomarkers for mammary cancer
Identifying reliable serological biomarkers for cancer is crucial for improving diagnosis, prognosis, and treatment outcomes. This study evaluates car…
www.sciencedirect.com
October 18, 2025 at 2:33 AM
Cross-species insights into CEACAM1 autoantibodies as diagnostic biomarkers for mammary cancer. www.sciencedirect.com/science/arti...
October 30, 2024 at 5:00 AM
CEACAM1 Targets ABCA1 to Mediate Atrial Fibrillation via Lipophagy-Dependent Ferroptosis https://www.biorxiv.org/content/10.1101/2024.11.26.625561v1
CEACAM1 Targets ABCA1 to Mediate Atrial Fibrillation via Lipophagy-Dependent Ferroptosis https://www.biorxiv.org/content/10.1101/2024.11.26.625561v1
Atrial fibrillation (AF) is one of the most common arrhythmias, imposing a significant burden on ind
www.biorxiv.org
December 2, 2024 at 5:48 PM
CEACAM1 Targets ABCA1 to Mediate Atrial Fibrillation via Lipophagy-Dependent Ferroptosis https://www.biorxiv.org/content/10.1101/2024.11.26.625561v1
Conditional deletion of CEACAM1 causes hepatic stellate cell activation https://www.biorxiv.org/content/10.1101/2024.04.02.586238v1
Conditional deletion of CEACAM1 causes hepatic stellate cell activation https://www.biorxiv.org/content/10.1101/2024.04.02.586238v1
Objectives: Hepatic CEACAM1 expression declines with advanced hepatic fibrosis stage in patients wit
www.biorxiv.org
April 3, 2024 at 11:02 PM
Conditional deletion of CEACAM1 causes hepatic stellate cell activation https://www.biorxiv.org/content/10.1101/2024.04.02.586238v1
Direct interactions of CEACAM1 and CD36 with LPS and each other https://www.biorxiv.org/content/10.64898/2026.02.01.703119v1
February 4, 2026 at 12:45 AM
Direct interactions of CEACAM1 and CD36 with LPS and each other https://www.biorxiv.org/content/10.64898/2026.02.01.703119v1
CEACAM1 Targets ABCA1 to Mediate Atrial Fibrillation via Lipophagy-Dependent Ferroptosis https://www.biorxiv.org/content/10.1101/2024.11.26.625561v1
CEACAM1 Targets ABCA1 to Mediate Atrial Fibrillation via Lipophagy-Dependent Ferroptosis https://www.biorxiv.org/content/10.1101/2024.11.26.625561v1
Atrial fibrillation (AF) is one of the most common arrhythmias, imposing a significant burden on ind
www.biorxiv.org
December 2, 2024 at 5:48 PM
CEACAM1 Targets ABCA1 to Mediate Atrial Fibrillation via Lipophagy-Dependent Ferroptosis https://www.biorxiv.org/content/10.1101/2024.11.26.625561v1
Conditional deletion of CEACAM1 causes hepatic stellate cell activation https://www.biorxiv.org/content/10.1101/2024.04.02.586238v1
Conditional deletion of CEACAM1 causes hepatic stellate cell activation https://www.biorxiv.org/content/10.1101/2024.04.02.586238v1
Objectives: Hepatic CEACAM1 expression declines with advanced hepatic fibrosis stage in patients wit
www.biorxiv.org
April 3, 2024 at 11:02 PM
Conditional deletion of CEACAM1 causes hepatic stellate cell activation https://www.biorxiv.org/content/10.1101/2024.04.02.586238v1
High-dimensional mapping reveals human CEACAM1's unique expression on immune cells, linking it to melanoma drug resistance. Understanding CEACAM1 may help tackle treatment challenges. #MelanomaResearch PMID:38956268, Commun Med (Lond) 2024 https://doi.org/10.1038/s43856-024-00525-8
February 4, 2025 at 12:10 PM
High-dimensional mapping reveals human CEACAM1's unique expression on immune cells, linking it to melanoma drug resistance. Understanding CEACAM1 may help tackle treatment challenges. #MelanomaResearch PMID:38956268, Commun Med (Lond) 2024 https://doi.org/10.1038/s43856-024-00525-8
#VitaminADeficiency from #pregnancy reduces #SCFA-producing #GutMicrobes, lowering SCFA levels and suppressing colonic CEACAM1, impairing epithelial integrity; timely postnatal VA supplementation restores SCFAs, and protects colonic barrier function.
Read: doi.org/10.1016/j.ge...
Read: doi.org/10.1016/j.ge...
April 18, 2026 at 6:45 AM
#VitaminADeficiency from #pregnancy reduces #SCFA-producing #GutMicrobes, lowering SCFA levels and suppressing colonic CEACAM1, impairing epithelial integrity; timely postnatal VA supplementation restores SCFAs, and protects colonic barrier function.
Read: doi.org/10.1016/j.ge...
Read: doi.org/10.1016/j.ge...