Pretty cool. A neuron that releases norepinephrine (a catecholamine like dopamine) with a huge projection tree spanning many parts of the brain.
🧪 #neuroscience
🧪 #neuroscience
First off, these cells are gigantic. This one, for example, has >72 cm of axon! To our knowledge, it’s the longest neuron ever fully reconstructed. I leave it to the reader as an exercise to estimate the length of a human LC neuron. 5
September 16, 2026 at 11:41 PM
Pretty cool. A neuron that releases norepinephrine (a catecholamine like dopamine) with a huge projection tree spanning many parts of the brain.
🧪 #neuroscience
🧪 #neuroscience
For the love of all things holy….and really, can I please introduce you to the more evolved catecholamine
stop it with the dopamine speak pleaaaaaaaaaaaaase it’s not useful and dopamine ≠ addiction
August 1, 2026 at 10:23 AM
For the love of all things holy….and really, can I please introduce you to the more evolved catecholamine
A classic:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A Network Model of Catecholamine Effects: Gain, Signal-to-Noise Ratio, and Behavior
At the level of individual neurons, catecholamine release increases the responsivity of cells to excitatory and inhibitory inputs. A model of catecholamine effects in a network of neural-like elements...
www.science.org
December 7, 2024 at 6:24 PM
A classic:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
beta-blocker in sepsis trials continue to mystify me
you have patients on reasonable doses of pressor (0.5 mcg/kg/min norepi equivalent) with an average MAP ~80 (mean diastolic BP ~60!)
you're worried about catecholamine toxicity
instead of reducing the pressors you add a beta-blocker😳 #EMIMCC
you have patients on reasonable doses of pressor (0.5 mcg/kg/min norepi equivalent) with an average MAP ~80 (mean diastolic BP ~60!)
you're worried about catecholamine toxicity
instead of reducing the pressors you add a beta-blocker😳 #EMIMCC
June 14, 2025 at 12:21 PM
beta-blocker in sepsis trials continue to mystify me
you have patients on reasonable doses of pressor (0.5 mcg/kg/min norepi equivalent) with an average MAP ~80 (mean diastolic BP ~60!)
you're worried about catecholamine toxicity
instead of reducing the pressors you add a beta-blocker😳 #EMIMCC
you have patients on reasonable doses of pressor (0.5 mcg/kg/min norepi equivalent) with an average MAP ~80 (mean diastolic BP ~60!)
you're worried about catecholamine toxicity
instead of reducing the pressors you add a beta-blocker😳 #EMIMCC
The how and why of sleep: Motor theory and catecholamine hypothesis
The motor theory offers a unifying framework for sleep control, while the catecholamine hypothesis posits a core mechanism mediating sleep’s multifaceted benefits.
Open Access
www.cell.com/neuron/fullt...
The motor theory offers a unifying framework for sleep control, while the catecholamine hypothesis posits a core mechanism mediating sleep’s multifaceted benefits.
Open Access
www.cell.com/neuron/fullt...
September 18, 2025 at 8:53 AM
The how and why of sleep: Motor theory and catecholamine hypothesis
The motor theory offers a unifying framework for sleep control, while the catecholamine hypothesis posits a core mechanism mediating sleep’s multifaceted benefits.
Open Access
www.cell.com/neuron/fullt...
The motor theory offers a unifying framework for sleep control, while the catecholamine hypothesis posits a core mechanism mediating sleep’s multifaceted benefits.
Open Access
www.cell.com/neuron/fullt...
epinephrine drip for hyperkalemia with severe bradycardia and ecg toxicity sign
.
catecholamine will shift K intracellular while addressing bradycardia, obviously
taper slow, theoretical rebound hyperkalemia
good choice imo
#cccsky #emimcc #critcaresky
.
catecholamine will shift K intracellular while addressing bradycardia, obviously
taper slow, theoretical rebound hyperkalemia
good choice imo
#cccsky #emimcc #critcaresky
I don’t understand dopamine at all here. It amazes me every time I hear someone still uses it.
If hyperK, bradycardia and hypotensive, adrenaline is an elegant choice.
If hyperK, bradycardia and hypotensive, adrenaline is an elegant choice.
December 8, 2024 at 2:37 PM
epinephrine drip for hyperkalemia with severe bradycardia and ecg toxicity sign
.
catecholamine will shift K intracellular while addressing bradycardia, obviously
taper slow, theoretical rebound hyperkalemia
good choice imo
#cccsky #emimcc #critcaresky
.
catecholamine will shift K intracellular while addressing bradycardia, obviously
taper slow, theoretical rebound hyperkalemia
good choice imo
#cccsky #emimcc #critcaresky
LC-NE neurons correlating with RPE turned out to project to the cortex. This is fascinating, because of a classic finding in neuroscience about another catecholamine: dopamine. 12
April 13, 2026 at 4:51 AM
LC-NE neurons correlating with RPE turned out to project to the cortex. This is fascinating, because of a classic finding in neuroscience about another catecholamine: dopamine. 12
#Phaeochromocytomas and #paragangliomas (PPGLs) release #catecholamines leading to catecholamine-induced hypertensive (CIH) crises, with blood pressure greater than or equal to 180/120 mm Hg thelancet.com/journals/lan...
#PPGLs #hypertension
#MedSky #EndoSky #CardioSky #OncSky
#PPGLs #hypertension
#MedSky #EndoSky #CardioSky #OncSky
Catecholamine-induced hypertensive crises: current insights and management
Phaeochromocytomas and paragangliomas (PPGLs) release catecholamines leading to catecholamine-induced
hypertensive (CIH) crises, with blood pressure greater than or equal to 180/120 mm
Hg. CIH crises ...
thelancet.com
March 18, 2025 at 3:43 PM
#Phaeochromocytomas and #paragangliomas (PPGLs) release #catecholamines leading to catecholamine-induced hypertensive (CIH) crises, with blood pressure greater than or equal to 180/120 mm Hg thelancet.com/journals/lan...
#PPGLs #hypertension
#MedSky #EndoSky #CardioSky #OncSky
#PPGLs #hypertension
#MedSky #EndoSky #CardioSky #OncSky
A genetic zebrafish model that is deficient for all catecholamines still displays normal development of catecholamine neuron somata and projections, but develops specific abnormalities in hatching, heart rate regulation, and motor behavior 🐟
www.nature.com/articles/s42...
www.nature.com/articles/s42...
A genetic model for development, physiology and behavior of catecholamine-deficient zebrafish larvae - Communications Biology
A genetic zebrafish model that is deficient for all catecholamines still displays normal development of catecholamine neuron somata and projections, but develops specific abnormalities in hatching, he...
www.nature.com
August 24, 2026 at 8:43 PM
A genetic zebrafish model that is deficient for all catecholamines still displays normal development of catecholamine neuron somata and projections, but develops specific abnormalities in hatching, heart rate regulation, and motor behavior 🐟
www.nature.com/articles/s42...
www.nature.com/articles/s42...
RESEARCH |
@schellerlab.bsky.social
(WUSTL, US)
Stable adipocytes resist lipolysis in healthy states but are highly susceptible to a catecholamine-independent, neurosystemic pathway-driven catabolic state🧪
@schellerlab.bsky.social
(WUSTL, US)
Stable adipocytes resist lipolysis in healthy states but are highly susceptible to a catecholamine-independent, neurosystemic pathway-driven catabolic state🧪
A catecholamine-independent pathway controlling adaptive adipocyte lipolysis - Nature Metabolism
Stable adipocytes resist lipolysis in healthy states but are highly susceptible to a catecholamine-independent, neurosystemic pathway-driven catabolic state.
dlvr.it
February 11, 2026 at 4:52 PM
RESEARCH |
@schellerlab.bsky.social
(WUSTL, US)
Stable adipocytes resist lipolysis in healthy states but are highly susceptible to a catecholamine-independent, neurosystemic pathway-driven catabolic state🧪
@schellerlab.bsky.social
(WUSTL, US)
Stable adipocytes resist lipolysis in healthy states but are highly susceptible to a catecholamine-independent, neurosystemic pathway-driven catabolic state🧪
💔 Broken Heart Syndrome isn't poetry - it's cardiology.
Broken heart syndrome: the biology explained | Psyll
Takotsubo cardiomyopathy mimics a heart attack but stems from a catecholamine storm overwhelming the heart. Learn the biology, risks and recovery path.
psyll.com
July 20, 2026 at 3:16 PM
💔 Broken Heart Syndrome isn't poetry - it's cardiology.
Thrilled to share our recent research with Laetitia Davidovic, investigating how p-cresol contributes to social deficits by modulating host catecholamine-biosynthesizing enzymes. A huge thank-you to the entire team for their exceptional work. Hope you enjoy it!
www.nature.com/articles/s42...
www.nature.com/articles/s42...
The autism-linked gut microbial metabolite p-cresol inhibits host catecholamine biosynthesizing enzymes to elicit social deficits - Communications Biology
The microbial metabolite p-cresol and p-cresol sulfate accumulate in brainstem and inhibit TH and DBH, key enzymes in catecholamine synthesis. This disruption alters brain function and behavior, ...
www.nature.com
November 22, 2025 at 7:05 PM
Thrilled to share our recent research with Laetitia Davidovic, investigating how p-cresol contributes to social deficits by modulating host catecholamine-biosynthesizing enzymes. A huge thank-you to the entire team for their exceptional work. Hope you enjoy it!
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Different skillsets for different times, I think. No Riefenstahl imagery, but amazing skill at projecting irreality into today's framing. Time will tell if that translates into any staying power; my guess would be "nope", the catecholamine cycle is too fleeting for that.
September 7, 2025 at 7:44 PM
Different skillsets for different times, I think. No Riefenstahl imagery, but amazing skill at projecting irreality into today's framing. Time will tell if that translates into any staying power; my guess would be "nope", the catecholamine cycle is too fleeting for that.
Had a case where we were running epi at 40 mcg/min & norepi at 30-40 mcg/min post-arrest...barely keeping HR, BP & MAP up. One thing I always check is to make sure we're administering bicarb separately from pressors. Bicarb inactivates catecholamine-based pressors such as norepi, epi, & dopamine
January 10, 2025 at 12:10 AM
Had a case where we were running epi at 40 mcg/min & norepi at 30-40 mcg/min post-arrest...barely keeping HR, BP & MAP up. One thing I always check is to make sure we're administering bicarb separately from pressors. Bicarb inactivates catecholamine-based pressors such as norepi, epi, & dopamine
Big day for our team: our pheochromocytoma and paraganglioma (PPGL) organoid paper is now up on bioRxiv!
This was a tour de force across 6 institutions, 37 authors, building patient-derived organoids from 35 PPGL patients /🧵
🔗 www.biorxiv.org/content/10.1...
This was a tour de force across 6 institutions, 37 authors, building patient-derived organoids from 35 PPGL patients /🧵
🔗 www.biorxiv.org/content/10.1...
Patient-derived organoids reveal hypoxia-driven plasticity and therapeutic vulnerabilities in pheochromocytomas and paragangliomas
Pheochromocytomas and paragangliomas (PPGLs) are rare chromaffin cell-derived neuroendocrine tumors of sympathetic (catecholamine-producing) or parasympathetic (nonsecretory) origin, frequently driven...
www.biorxiv.org
August 26, 2025 at 8:34 PM
Big day for our team: our pheochromocytoma and paraganglioma (PPGL) organoid paper is now up on bioRxiv!
This was a tour de force across 6 institutions, 37 authors, building patient-derived organoids from 35 PPGL patients /🧵
🔗 www.biorxiv.org/content/10.1...
This was a tour de force across 6 institutions, 37 authors, building patient-derived organoids from 35 PPGL patients /🧵
🔗 www.biorxiv.org/content/10.1...
New paper:
Nanopore-enabled time-resolved monitoring of catecholamine-related phenylalanine metabolism.
"An engineered MspA #nanopore tracks #catecholamine biosynthesis at the #singlemolecule level, revealing pathway dynamics and enzymatic dysfunction."
www.nature.com/articles/s41...
Nanopore-enabled time-resolved monitoring of catecholamine-related phenylalanine metabolism.
"An engineered MspA #nanopore tracks #catecholamine biosynthesis at the #singlemolecule level, revealing pathway dynamics and enzymatic dysfunction."
www.nature.com/articles/s41...
Nanopore-enabled time-resolved monitoring of catecholamine-related phenylalanine metabolism - Nature Nanotechnology
An engineered bionanopore enables single-molecule tracking of catecholamine biosynthesis from phenylalanine to adrenaline, revealing time-resolved pathway dynamics and showing how impaired dehalogenas...
www.nature.com
September 1, 2026 at 9:52 AM
New paper:
Nanopore-enabled time-resolved monitoring of catecholamine-related phenylalanine metabolism.
"An engineered MspA #nanopore tracks #catecholamine biosynthesis at the #singlemolecule level, revealing pathway dynamics and enzymatic dysfunction."
www.nature.com/articles/s41...
Nanopore-enabled time-resolved monitoring of catecholamine-related phenylalanine metabolism.
"An engineered MspA #nanopore tracks #catecholamine biosynthesis at the #singlemolecule level, revealing pathway dynamics and enzymatic dysfunction."
www.nature.com/articles/s41...
🧠✨ Exciting new research alert! ✨🧠
Did you know that catecholamines can reduce choice history biases in perceptual decision-making? 🧐🔍
Paper: journals.plos.org/plosbiology/...
With @donnerlab.bsky.social and @swammerdamuva.bsky.social
Did you know that catecholamines can reduce choice history biases in perceptual decision-making? 🧐🔍
Paper: journals.plos.org/plosbiology/...
With @donnerlab.bsky.social and @swammerdamuva.bsky.social
September 5, 2025 at 8:05 AM
🧠✨ Exciting new research alert! ✨🧠
Did you know that catecholamines can reduce choice history biases in perceptual decision-making? 🧐🔍
Paper: journals.plos.org/plosbiology/...
With @donnerlab.bsky.social and @swammerdamuva.bsky.social
Did you know that catecholamines can reduce choice history biases in perceptual decision-making? 🧐🔍
Paper: journals.plos.org/plosbiology/...
With @donnerlab.bsky.social and @swammerdamuva.bsky.social
Increasingly, no, if what you mean is stimulate wakefulness without like catecholamine surges
August 22, 2026 at 12:24 AM
Increasingly, no, if what you mean is stimulate wakefulness without like catecholamine surges
She also talked about what individuals can do other than screaming "what are YOU doing." She's a great communicator, and I'd encourage people to watch her IG lives. Not for nothing, they also have a slight calming effect for those of us whose catecholamine levels are at nonsustainable highs
February 4, 2025 at 3:50 PM
She also talked about what individuals can do other than screaming "what are YOU doing." She's a great communicator, and I'd encourage people to watch her IG lives. Not for nothing, they also have a slight calming effect for those of us whose catecholamine levels are at nonsustainable highs
Brilliant!😀👍 Sounds like you've discovered a cornerstone of Joshual Leisk's (BornFree) disease model.
Zinc depleted by chronic pathogen acetaldehyde production & DMT-1 transporter blockade.
Zinc a cofactor for methylation, all histamine/catecholamine, etc, degradation, activating B-vits, etc.
1/2
Zinc depleted by chronic pathogen acetaldehyde production & DMT-1 transporter blockade.
Zinc a cofactor for methylation, all histamine/catecholamine, etc, degradation, activating B-vits, etc.
1/2
August 2, 2025 at 10:36 PM
Brilliant!😀👍 Sounds like you've discovered a cornerstone of Joshual Leisk's (BornFree) disease model.
Zinc depleted by chronic pathogen acetaldehyde production & DMT-1 transporter blockade.
Zinc a cofactor for methylation, all histamine/catecholamine, etc, degradation, activating B-vits, etc.
1/2
Zinc depleted by chronic pathogen acetaldehyde production & DMT-1 transporter blockade.
Zinc a cofactor for methylation, all histamine/catecholamine, etc, degradation, activating B-vits, etc.
1/2
Pathogens sense #stress hormones in the gut and use them to regulate motility and virulence. Weston Whitaker explores a new @PLOSBiology.org study which transfers this pathway to a #probiotic bacterium, redesigns it to drive programmable outputs 🧪
Article plos.io/4zI6itm
Primer plos.io/4qE1npb
Article plos.io/4zI6itm
Primer plos.io/4qE1npb
August 30, 2026 at 4:15 PM
Pathogens sense #stress hormones in the gut and use them to regulate motility and virulence. Weston Whitaker explores a new @PLOSBiology.org study which transfers this pathway to a #probiotic bacterium, redesigns it to drive programmable outputs 🧪
Article plos.io/4zI6itm
Primer plos.io/4qE1npb
Article plos.io/4zI6itm
Primer plos.io/4qE1npb
Elisa Caetano-Silva presents beautiful data showing that stress potentiates IBD by altering catecholamine and ROS activity ! 😍👏
June 10, 2025 at 9:43 AM
Elisa Caetano-Silva presents beautiful data showing that stress potentiates IBD by altering catecholamine and ROS activity ! 😍👏
these is my daughter marijuana catecholamine+this is my daughter arena
could sum1pls draw them
could sum1pls draw them
December 14, 2024 at 6:39 AM
these is my daughter marijuana catecholamine+this is my daughter arena
could sum1pls draw them
could sum1pls draw them