#Caveolin-1
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rridrobot.bsky.social
RRIDs were included in this in PLOS Biology paper. RRIDs improve reproducibility in scientific research. #methodsmatter #RRID #OpenScience
Caveolin 1 is a conserved host factor mediating Bacillus cereus hemolysin BL toxin cytolytic toxicity
Bacillus cereus hemolysin BL (HBL) uses the host receptors LITAF and CDIP1 for cytotoxicity, but the loss of both only protects the host partly. This study shows that Caveolin 1 completes a three-factor host system whose combined loss confers full resistance to HBL.
doi.org
October 30, 2026 at 7:02 AM
rridrobot.bsky.social
The authors included RRIDs in their in Molecular Cancer Research paper! Thanks for making your methods matter! #accelerateopenscience #methodsmatter #BetterScience
The SNHG15/miR-451a/Caveolin-1 Axis Promotes Oxaliplatin Resistance in Gastric Cancer Cells by Regulating Fatty Acid β-oxidation
Read the full paper: The SNHG15/miR-451a/Caveolin-1 Axis Promotes Oxaliplatin Resistance in Gastric Cancer Cells by Regulating Fatty Acid β-oxidation
doi.org
October 25, 2026 at 7:00 AM
sigtrans-sttt.bsky.social
Can #GeneTherapy protect cognition in symptomatic #AlzheimersDisease?

Neuron-targeted #Caveolin-1 delivery preserves memory in mouse models, with synaptic signaling and PAC1R–ADNP implicated in #Neuroprotection. @uofcalifornia.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...
Neuron-targeted caveolin-1 overexpression attenuates cognitive loss and pathological transcriptome changes in symptomatic Alzheimer’s disease models
October 24, 2026 at 7:00 AM
biomedicines.bsky.social
🧠This study found that sorting nexin 19 contains caveolin-1 and flotillin-1 binding motifs that are essential for dopamine D1 receptor signaling and endocytosis. These findings provide new insight into the regulation of dopamine pathways.🔬 #Neuroscience
brnw.ch/21x6xIK
October 21, 2026 at 12:38 PM
rridrobot.bsky.social
RRIDs were included in this in Experimental Neurology paper. Thanks for making your methods matter! #OpenResearch #reproducibility #OpenScience
Intravenous administration of a PHP.eB vector overexpressing neuronal Caveolin-1 delays motor neuron and neuromuscular degeneration in a TDP-43 mouse model of ALS
Read the full paper: Intravenous administration of a PHP.eB vector overexpressing neuronal Caveolin-1 delays motor neuron and neuromuscular degeneration in a TDP-43 mouse model of ALS
doi.org
October 16, 2026 at 7:03 AM
biorxiv-cancer.bsky.social
Low-dose doxorubicin drives caveolin-1 depended re-epithelialization of breast cancer cells as a mechanism of cancer plasticity https://www.biorxiv.org/content/10.64898/2026.09.28.754929v1
September 29, 2026 at 3:49 PM
biorxivpreprint.bsky.social
Low-dose doxorubicin drives caveolin-1 depended re-epithelialization of breast cancer cells as a mechanism of cancer plasticity https://www.biorxiv.org/content/10.64898/2026.09.28.754929v1
September 29, 2026 at 3:49 PM
biorxiv-biophys.bsky.social
Atomistic Insights into TRPC6/Caveolin-1 Interactions Interface via All- Atom Molecular Dynamics Simulations: Structural and Energetic Basis for Selective Modulation https://www.biorxiv.org/content/10.64898/2026.09.09.750526v1
September 10, 2026 at 6:47 PM
biorxivpreprint.bsky.social
Atomistic Insights into TRPC6/Caveolin-1 Interactions Interface via All- Atom Molecular Dynamics Simulations: Structural and Energetic Basis for Selective Modulation https://www.biorxiv.org/content/10.64898/2026.09.09.750526v1
September 10, 2026 at 6:47 PM
thebiotechtimes.bsky.social
Rein Therapeutics' inhaled Caveolin-1 peptide LTI-03 has secured FDA Fast Track status for idiopathic pulmonary fibrosis. Phase 2 interim readout targeted for H2 2026.
Rein Therapeutics wins FDA Fast Track for LTI-03 in IPF
The Austin-based biotech said the designation supports its inhaled Caveolin-1 peptide, with Phase 2 interim data expected in the second half of 2026.
biotech.disruptsmedia.com
August 25, 2026 at 2:00 PM
plosbiology.org
Bacillus cereus #hemolysin BL (HBL) uses host receptors LITAF & CDIP1 for #cytotoxicity, but the loss of both only partially protects the host. This study shows that Caveolin 1 completes a 3-factor host system whose combined loss confers full resistance to HBL @plosbiology.org 🧪 plos.io/4xTXe2A
Left: Co-localization (yellow) of HBL-B (green) and CAV1 (red) on HT1080 cell surface. HT1080-WT, HT1080-dKO, and HT1080-tKO cells bound with HBL-B were stained with an anti-HBL-B antiserum (green) and an anti-CAV1 antibody (red). Merge images highlight co-localization (yellow) of HBL-B and CAV1. DAPI-stained nuclei (blue). Scale bar = 25 μm. Representative of three independent experiments with similar results. Right: In vivo role of CAV1 in HBL pathogenesis. Mice with indicated genotypes (WT, Cav1−/−, Litaf−/−/Cdip1−/− (dKO), Litaf−/−/Cdip1−/−/Cav1−/− (tKO)) were challenged with 2 µg HBL toxin (I.P. route) daily as indicated by red arrows. Of note, while all the Litaf−/−/Cdip1−/− (dKO) mice succumbed to 2-3 doses of HBL, the Litaf−/−/Cdip1−/−/Cav1−/− (tKO) mice were completely resistant to the HBL challenge that all the mice survived even with 5 doses of 2 µg HBL toxin challenge.
August 25, 2026 at 12:55 PM
plosbiology.org
Bacillus cereus #hemolysin BL (HBL) uses host receptors LITAF and CDIP1 for #cytotoxicity, but the loss of both only partially protects the host. This study shows that Caveolin 1 completes a 3-factor host system whose combined loss confers full resistance to HBL @plosbiology.org 🧪 plos.io/4xTXe2A
Left: Co-localization (yellow) of HBL-B (green) and CAV1 (red) on HT1080 cell surface. HT1080-WT, HT1080-dKO, and HT1080-tKO cells bound with HBL-B were stained with an anti-HBL-B antiserum (green) and an anti-CAV1 antibody (red). Merge images highlight co-localization (yellow) of HBL-B and CAV1. DAPI-stained nuclei (blue). Scale bar = 25 μm. Representative of three independent experiments with similar results. Right: In vivo role of CAV1 in HBL pathogenesis. Mice with indicated genotypes (WT, Cav1−/−, Litaf−/−/Cdip1−/− (dKO), Litaf−/−/Cdip1−/−/Cav1−/− (tKO)) were challenged with 2 µg HBL toxin (I.P. route) daily as indicated by red arrows. Of note, while all the Litaf−/−/Cdip1−/− (dKO) mice succumbed to 2-3 doses of HBL, the Litaf−/−/Cdip1−/−/Cav1−/− (tKO) mice were completely resistant to the HBL challenge that all the mice survived even with 5 doses of 2 µg HBL toxin challenge.
August 24, 2026 at 4:25 PM
plosbiology.org
Bacillus cereus #hemolysin BL (HBL) uses host receptors LITAF & CDIP1 for #cytotoxicity, but the loss of both only partially protects the host. This study shows that Caveolin 1 completes a 3-factor host system whose combined loss confers full resistance to HBL @plosbiology.org 🧪 plos.io/4xTXe2A
Left: Co-localization (yellow) of HBL-B (green) and CAV1 (red) on HT1080 cell surface. HT1080-WT, HT1080-dKO, and HT1080-tKO cells bound with HBL-B were stained with an anti-HBL-B antiserum (green) and an anti-CAV1 antibody (red). Merge images highlight co-localization (yellow) of HBL-B and CAV1. DAPI-stained nuclei (blue). Scale bar = 25 μm. Representative of three independent experiments with similar results. Right: In vivo role of CAV1 in HBL pathogenesis. Mice with indicated genotypes (WT, Cav1−/−, Litaf−/−/Cdip1−/− (dKO), Litaf−/−/Cdip1−/−/Cav1−/− (tKO)) were challenged with 2 µg HBL toxin (I.P. route) daily as indicated by red arrows. Of note, while all the Litaf−/−/Cdip1−/− (dKO) mice succumbed to 2-3 doses of HBL, the Litaf−/−/Cdip1−/−/Cav1−/− (tKO) mice were completely resistant to the HBL challenge that all the mice survived even with 5 doses of 2 µg HBL toxin challenge.
August 24, 2026 at 8:05 AM
biorxiv-physio.bsky.social
AKAP5 and Caveolin-1 organize opposing nanodomains that regulate smooth muscle contraction and blood pressure https://www.biorxiv.org/content/10.64898/2026.08.13.744495v1
August 22, 2026 at 3:10 AM
biorxivpreprint.bsky.social
AKAP5 and Caveolin-1 organize opposing nanodomains that regulate smooth muscle contraction and blood pressure https://www.biorxiv.org/content/10.64898/2026.08.13.744495v1
August 22, 2026 at 3:10 AM
haoyin.bsky.social
SIRT6 physically binds to PPARγ & suppress its transcriptional activity on Fatty acid metabolic genes (CD36, caveolin-1, FATP1, FABP3, VLDLR)

⬇️PPARγ occupancy at target gene promoters, independent of H3K9 and H3K56 acetylation

#CellRep 2021
www.sciencedirect.com/science/arti...
August 21, 2026 at 12:27 PM
biorxivpreprint.bsky.social
AKAP5 and Caveolin-1 organize opposing nanodomains that regulate smooth muscle contraction and blood pressure https://www.biorxiv.org/content/10.64898/2026.08.13.744495v1
August 19, 2026 at 3:04 AM
biorxiv-physio.bsky.social
AKAP5 and Caveolin-1 organize opposing nanodomains that regulate smooth muscle contraction and blood pressure https://www.biorxiv.org/content/10.64898/2026.08.13.744495v1
August 19, 2026 at 3:04 AM
norionakatsuji.bsky.social
元論文→ Wang, Ta, Wang, et al. Systemic delivery of synapsin-promoted caveolin-1 overexpression ameliorates pathological TDP-43–induced cognitive decline and neurodegenerative changes. Alzheimers Dement. 2026;22(5):e71450. doi: 10.1002/alz.71450

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Systemic delivery of synapsin‐promoted caveolin‐1 overexpression ameliorates pathological TDP‐43–induced cognitive decline and neurodegenerative changes
INTRODUCTION Transactive response DNA-binding protein 43 (TDP-43) proteinopathy is associated with frontotemporal dementia and Alzheimer's disease (AD). We previously demonstrated that synapsin-prom...
alz-journals.onlinelibrary.wiley.com
May 28, 2026 at 10:42 PM
prepub-singlecell.bsky.social
Mammary gland metabolism and its relevance to the fetoplacental expression of cytokine signaling in Caveolin-1 null mice #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.04.13.648647v1
April 19, 2025 at 7:00 AM
alexludwig.bsky.social
2) Using time-resolved proximity proteomics with APEX2 we have identified a membrane tension-sensitive caveolin-1 interactome that is likely to be important for the function of caveolae at the rear of migrating cells. elifesciences.org/articles/85601.
Time-resolved proximity proteomics uncovers a membrane tension-sensitive caveolin-1 interactome at the rear of migrating cells
Membrane tension controls the dynamic assembly and disassembly of caveolae and their association with the F-actin cortex in migrating cells.
elifesciences.org
November 13, 2024 at 6:15 AM
medcomm.bsky.social
#Article in #MedComm
CD36 Inhibits Triple-Negative Breast Cancer Progression by Transcriptionally Upregulating Caveolin-1 and Promoting Lipid-Reactive Oxygen Species-Related Ferroptosis doi.org/10.1002/mco2...

#caveolin_1 #CD36 #ferroptosis #TNBC #CAV1
CD36 Inhibits Triple‐Negative Breast Cancer Progression by Transcriptionally Upregulating Caveolin‐1 and Promoting Lipid‐Reactive Oxygen Species‐Related Ferroptosis
CD36 is identified as a key suppressor in triple-negative breast cancer (TNBC). It inhibits tumor metastasis by promoting ferroptosis via the CD36–CAV1–lipid peroxidation axis. Multiomics and metasta...
doi.org
November 20, 2025 at 9:37 AM
castltrastondrs.medsky.network
Neuroinflammation and vascular dysfunction
are directly related in PASC
www.biorxiv.org/content/10.1...
Caveolin-1 mediates neuroinflammation and cognitive impairment in SARS-CoV-2 infection

www.biorxiv.org/content/10.1...
Figure 1 legend: Figure 1A: Example slices through sagittal (×=3), coronal (y=-7), and axial (z=10) sections of the 12 PASC > 43 control group-level unpaired (between-groups) comparison, showing the pattern of increased ["C]PBR28 signal (shown in neurological convention). Color bar: threshold min. Z score of 2 and max. 3.54. Figure 1B: PET signal data extracted from individual study participants, depicted from the primary whole-brain analysis and across five example bilateral brain regions. Y-axis data points represent the mean SUVR values of significant voxels within each significant cluster region, with each structure's data normalized to the control average. PASC participants hospitalized during their acute COVID-19 illness are indicated with an open circle. Brain regions are anatomically defined by the Harvard-Oxford Atlas (thalamus, ACC, striatum) or CC by the Jüelich Atlas at >70% probability threshold. In the case of the pMCC, we used the Harvard-Oxford posterior cingulate anato Vascular factors
October 21, 2023 at 4:50 AM
ajrcmb.bsky.social
Caveolin-1 Scaffolding Domain Peptide (CSP7): A Novel Target for Idiopathic Pulmonary Fibrosis
@atscommunity.bsky.social #medsky

🔓 Open Access

🔗 tinyurl.com/ywj4vxj3
Caveolin-1 Scaffolding Domain Peptide (CSP7): A Novel Target for Idiopathic Pulmonary Fibrosis | American Journal of Respiratory Cell and Molecular Biology
tinyurl.com
January 24, 2025 at 7:12 PM
ajrcmb.bsky.social
Caveolin-1 Scaffolding Domain Peptide (CSP7): A Novel Target for Idiopathic Pulmonary Fibrosis
@atscommunity.bsky.social #medsky

🔓 Open Access

🔗 tinyurl.com/ywj4vxj3
Caveolin-1 Scaffolding Domain Peptide (CSP7): A Novel Target for Idiopathic Pulmonary Fibrosis | American Journal of Respiratory Cell and Molecular Biology
tinyurl.com
January 9, 2025 at 9:13 PM