Bridging experimental curation & structural prediction to expand insight into complex composition and architecture.
#ComplexPortal #ProteinComplexes #StructuralBiology #huMAP30 #MuSIC #QSProteome
#ComplexPortal #ProteinComplexes #StructuralBiology #huMAP30 #MuSIC #QSProteome
February 16, 2026 at 11:20 AM
Bridging experimental curation & structural prediction to expand insight into complex composition and architecture.
#ComplexPortal #ProteinComplexes #StructuralBiology #huMAP30 #MuSIC #QSProteome
#ComplexPortal #ProteinComplexes #StructuralBiology #huMAP30 #MuSIC #QSProteome
🧬 Oncogenic KRAS mutations (pancreatic, colorectal, lung cancers) stabilize these complexes, sustaining growth signalling.
Explore RAS at the complex level → new therapeutic insights.
#RAS #KRAS #RASopathies #CancerBiology #ComplexPortal
Explore RAS at the complex level → new therapeutic insights.
#RAS #KRAS #RASopathies #CancerBiology #ComplexPortal
March 2, 2026 at 1:36 PM
🧬 Oncogenic KRAS mutations (pancreatic, colorectal, lung cancers) stabilize these complexes, sustaining growth signalling.
Explore RAS at the complex level → new therapeutic insights.
#RAS #KRAS #RASopathies #CancerBiology #ComplexPortal
Explore RAS at the complex level → new therapeutic insights.
#RAS #KRAS #RASopathies #CancerBiology #ComplexPortal
It is Skin Cancer awareness month! Explore manually curated interactomes of proteins associated with familial melanoma in IntAct. Access the network in IntAct (tinyurl.com/26tc7xtm). #IntAct-ebi, #ComplexPortal, #UniProt, #MelanomaAwareness, #HumanDisease, #SunSafety, #SpotSkinCancer,
May 21, 2025 at 9:38 AM
It is Skin Cancer awareness month! Explore manually curated interactomes of proteins associated with familial melanoma in IntAct. Access the network in IntAct (tinyurl.com/26tc7xtm). #IntAct-ebi, #ComplexPortal, #UniProt, #MelanomaAwareness, #HumanDisease, #SunSafety, #SpotSkinCancer,
May is skin cancer awareness month! We're highlighting Telomerase holoenzyme complex (CPX-265) featuring TERT(UniProt:O14746). ComplexPortal: tinyurl.com/mt7u4wbs & visit UniProt for all melanoma-linked proteins tinyurl.com/mryjvyu7 #MelanomaAwareness, #ComplexPortal, #IntAct-EBI, #UniProt
May 21, 2025 at 9:44 AM
May is skin cancer awareness month! We're highlighting Telomerase holoenzyme complex (CPX-265) featuring TERT(UniProt:O14746). ComplexPortal: tinyurl.com/mt7u4wbs & visit UniProt for all melanoma-linked proteins tinyurl.com/mryjvyu7 #MelanomaAwareness, #ComplexPortal, #IntAct-EBI, #UniProt
🔗 Explore CPX-6502 (tinyurl.com/wm9vz558) via the @emblebi Complex Portal - mapping all biologically functional protein complexes.
#GlobalPNHAwarenessDay #PNH #RareDisease #GPIAnchors #ComplementSystem #GpiGnT #ComplexPortal #EMBLEBI
#GlobalPNHAwarenessDay #PNH #RareDisease #GPIAnchors #ComplementSystem #GpiGnT #ComplexPortal #EMBLEBI
October 12, 2025 at 1:44 PM
🔗 Explore CPX-6502 (tinyurl.com/wm9vz558) via the @emblebi Complex Portal - mapping all biologically functional protein complexes.
#GlobalPNHAwarenessDay #PNH #RareDisease #GPIAnchors #ComplementSystem #GpiGnT #ComplexPortal #EMBLEBI
#GlobalPNHAwarenessDay #PNH #RareDisease #GPIAnchors #ComplementSystem #GpiGnT #ComplexPortal #EMBLEBI
academic.oup.com/nar/article/.... 🧪. Supported by my office The Complex Portal (www.ebi.ac.uk/complexportal) (1) serves as a unifying resource, linking information on protein complexes across multiple resources by providing summaries of the molecular composition, topology (when known) and function
Complex portal 2025: predicted human complexes and enhanced visualisation tools for the comparison of orthologous and paralogous complexes
Abstract. The Complex Portal (www.ebi.ac.uk/complexportal) is a manually curated reference database for molecular complexes. It is a unifying web resource
academic.oup.com
February 13, 2026 at 11:17 AM
academic.oup.com/nar/article/.... 🧪. Supported by my office The Complex Portal (www.ebi.ac.uk/complexportal) (1) serves as a unifying resource, linking information on protein complexes across multiple resources by providing summaries of the molecular composition, topology (when known) and function
🌉By integrating QSProteome, the Complex Portal bridges experiment-based curation & computational prediction, empowering exploration of alternative structural data.
📖Edward Catoiu et al.,PMID: 41163446 👉 tinyurl.com/4578uktz
#ComplexPortal #QSProteome #ProteinComplexes #StructuralBiology #PalssonLab
📖Edward Catoiu et al.,PMID: 41163446 👉 tinyurl.com/4578uktz
#ComplexPortal #QSProteome #ProteinComplexes #StructuralBiology #PalssonLab
February 9, 2026 at 10:08 AM
🌉By integrating QSProteome, the Complex Portal bridges experiment-based curation & computational prediction, empowering exploration of alternative structural data.
📖Edward Catoiu et al.,PMID: 41163446 👉 tinyurl.com/4578uktz
#ComplexPortal #QSProteome #ProteinComplexes #StructuralBiology #PalssonLab
📖Edward Catoiu et al.,PMID: 41163446 👉 tinyurl.com/4578uktz
#ComplexPortal #QSProteome #ProteinComplexes #StructuralBiology #PalssonLab
👩🔬 𝐒𝐨 𝐭𝐡𝐢𝐬 𝐍𝐞𝐰 𝐘𝐞𝐚𝐫, let’s resolve not just to feel healthier, but to understand how our biology really works - guided by evidence, tools, and data that are openly accessible and citable. 🧠✨
#COMPLEXPORTAL #IntAct #UniProt #EMBLEBI #NEWYEAR2026
#COMPLEXPORTAL #IntAct #UniProt #EMBLEBI #NEWYEAR2026
January 6, 2026 at 11:19 AM
👩🔬 𝐒𝐨 𝐭𝐡𝐢𝐬 𝐍𝐞𝐰 𝐘𝐞𝐚𝐫, let’s resolve not just to feel healthier, but to understand how our biology really works - guided by evidence, tools, and data that are openly accessible and citable. 🧠✨
#COMPLEXPORTAL #IntAct #UniProt #EMBLEBI #NEWYEAR2026
#COMPLEXPORTAL #IntAct #UniProt #EMBLEBI #NEWYEAR2026
🧠 Alzheimer’s research meets precision medicine
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...
#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...
#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety
September 8, 2025 at 1:11 PM
🧠 Alzheimer’s research meets precision medicine
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...
#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...
#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety
🧠 Today is #WorldAlzheimersDay.
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
September 22, 2025 at 10:31 AM
🧠 Today is #WorldAlzheimersDay.
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
#CotM: we now have #cullin E3 ligases from 6 species (#human, #mouse, @wormbase #arath @yeastgenome @PomBase). Find them all with GO:0031461.
Here's one with its #crystalStructure from @PDBeurope #4a0k:
ebi.ac.uk/complexportal/…
Here's one with its #crystalStructure from @PDBeurope #4a0k:
ebi.ac.uk/complexportal/…
December 3, 2024 at 10:37 AM
#CotM: we now have #cullin E3 ligases from 6 species (#human, #mouse, @wormbase #arath @yeastgenome @PomBase). Find them all with GO:0031461.
Here's one with its #crystalStructure from @PDBeurope #4a0k:
ebi.ac.uk/complexportal/…
Here's one with its #crystalStructure from @PDBeurope #4a0k:
ebi.ac.uk/complexportal/…
#CotM: In the spirit of #Easter we proudly present the #EggComplex:
Egg-3/4/5 MBK-2 complexPseudophosphatase complex required for oocyte-to-zygote transition that sequesters and modulates the kinase activity of mbk-2 before and during meiosis.
ebi.ac.uk/complexportal/…
Egg-3/4/5 MBK-2 complexPseudophosphatase complex required for oocyte-to-zygote transition that sequesters and modulates the kinase activity of mbk-2 before and during meiosis.
ebi.ac.uk/complexportal/…
December 3, 2024 at 10:39 AM
#CotM: In the spirit of #Easter we proudly present the #EggComplex:
Egg-3/4/5 MBK-2 complexPseudophosphatase complex required for oocyte-to-zygote transition that sequesters and modulates the kinase activity of mbk-2 before and during meiosis.
ebi.ac.uk/complexportal/…
Egg-3/4/5 MBK-2 complexPseudophosphatase complex required for oocyte-to-zygote transition that sequesters and modulates the kinase activity of mbk-2 before and during meiosis.
ebi.ac.uk/complexportal/…
How can GO be used by your group/team? Appasamy et al. just released a fantastic paper in Scientific Data that uses GO (+ ComplexPortal & UniProt) to accurately describe and contextualise macromolecular complexes within their biological settings. 🧪
community.alliancegenome.org/t/protein-da...
community.alliancegenome.org/t/protein-da...
January 17, 2024 at 1:38 AM
How can GO be used by your group/team? Appasamy et al. just released a fantastic paper in Scientific Data that uses GO (+ ComplexPortal & UniProt) to accurately describe and contextualise macromolecular complexes within their biological settings. 🧪
community.alliancegenome.org/t/protein-da...
community.alliancegenome.org/t/protein-da...
👏 Thanks to our collaborators and the Complex Portal community!
🔗 Explore: www.ebi.ac.uk/complexporta...
#ComplexPortal #ProteinComplexes #IntAct #UniProt #OpenScience #FAIRdata #EMBL_EBI 🎊
🔗 Explore: www.ebi.ac.uk/complexporta...
#ComplexPortal #ProteinComplexes #IntAct #UniProt #OpenScience #FAIRdata #EMBL_EBI 🎊
January 19, 2026 at 6:18 AM
👏 Thanks to our collaborators and the Complex Portal community!
🔗 Explore: www.ebi.ac.uk/complexporta...
#ComplexPortal #ProteinComplexes #IntAct #UniProt #OpenScience #FAIRdata #EMBL_EBI 🎊
🔗 Explore: www.ebi.ac.uk/complexporta...
#ComplexPortal #ProteinComplexes #IntAct #UniProt #OpenScience #FAIRdata #EMBL_EBI 🎊
Complex Portal release 250 is out! 5,049 manually curated biological complexes. www.ebi.ac.uk/complexportal (in sync with UniProt release 2025_02). Come explore our high quality manually-curated complexes!!
April 10, 2025 at 4:55 PM
Complex Portal release 250 is out! 5,049 manually curated biological complexes. www.ebi.ac.uk/complexportal (in sync with UniProt release 2025_02). Come explore our high quality manually-curated complexes!!
Our #CotM on #InternationalWomensDay #IWD2021 celebrates @KowaEva's team @EMBL for solving the @yeastgenome cytoplasmic exosome complex:The cytoplasmic exosome is a 3' to 5' exo- and endoribonuclease that is involved in RNA maturation & degradation
ebi.ac.uk/complexportal/…
ebi.ac.uk/complexportal/…
December 3, 2024 at 10:42 AM
Our #CotM on #InternationalWomensDay #IWD2021 celebrates @KowaEva's team @EMBL for solving the @yeastgenome cytoplasmic exosome complex:The cytoplasmic exosome is a 3' to 5' exo- and endoribonuclease that is involved in RNA maturation & degradation
ebi.ac.uk/complexportal/…
ebi.ac.uk/complexportal/…
#CotM: Mitochondrial succinyl-CoA synthetase complex which catalyzes the reversible phosphorylation/dephosphorylation of Succinyl-CoA in the #Krebscycle
ebi.ac.uk/complexportal/…
ebi.ac.uk/complexportal/…
December 3, 2024 at 10:42 AM
#CotM: Mitochondrial succinyl-CoA synthetase complex which catalyzes the reversible phosphorylation/dephosphorylation of Succinyl-CoA in the #Krebscycle
ebi.ac.uk/complexportal/…
ebi.ac.uk/complexportal/…
We've updated the #ComplexTab file:
- filename = NCBI Taxon ID
- Stoichiometry consistently collapsed
- New column: all protein participants identified with @uniprot IDs even if these are members of subcomplexes or protein sets
- Readme file updated
ebi.ac.uk/complexportal/…
- filename = NCBI Taxon ID
- Stoichiometry consistently collapsed
- New column: all protein participants identified with @uniprot IDs even if these are members of subcomplexes or protein sets
- Readme file updated
ebi.ac.uk/complexportal/…
December 3, 2024 at 10:42 AM
We've updated the #ComplexTab file:
- filename = NCBI Taxon ID
- Stoichiometry consistently collapsed
- New column: all protein participants identified with @uniprot IDs even if these are members of subcomplexes or protein sets
- Readme file updated
ebi.ac.uk/complexportal/…
- filename = NCBI Taxon ID
- Stoichiometry consistently collapsed
- New column: all protein participants identified with @uniprot IDs even if these are members of subcomplexes or protein sets
- Readme file updated
ebi.ac.uk/complexportal/…
#CotM: the Membane Attack Complex is the final complex of all 3 #complementPathways of the #innateImmuneSystem. All complexes of the classical, alternative and lectin pathway are now available for #human.Activated by most pathogens 🦠, incl. #SARSCoV2
ebi.ac.uk/complexportal/…
ebi.ac.uk/complexportal/…
December 3, 2024 at 10:41 AM
#CotM: the Membane Attack Complex is the final complex of all 3 #complementPathways of the #innateImmuneSystem. All complexes of the classical, alternative and lectin pathway are now available for #human.Activated by most pathogens 🦠, incl. #SARSCoV2
ebi.ac.uk/complexportal/…
ebi.ac.uk/complexportal/…