BETHESDA, MD – When you step outside on a winter morning or pop a mint into your mouth, a tiny molecular sensor in your body springs into action, alerting your brain to the sensation of cold.…

A Bayesian perspective on orientation estimation in cryo-EM is presented, with the minimum mean-square error estimator outperforming standard cross-correlation-based approaches, particularly under challenging low signal-to-noise conditions. We demonstrate that improved orientation estimation has a decisive impact on 3D reconstruction quality and structural heterogeneity recovery.

Cryo-EM analysis of apoferritin exposed to an X-ray dose of 100 MGy confirms the potential for high-resolution correlative imaging workflows combining X-ray tomography and cryo-EM.

Cryo-EM sample preparation for high-resolution structure studies

Biohub and UC Berkeley show that the laser phase plate, a revolutionary device with a laser 100 million times brighter than the Sun, dramatically improves images obtained through cryo-electron microscopy, giving scientists a new window into the molecular underpinnings of disease BERKELEY, Calif. and REDWOOD CITY, Calif., June 11, 2026 /PRNewswire/ — In a landmark achievement in biological imaging, researchers at Biohub and the University of California, Berkeley today announced the successful demonstration of the laser phase plate, a novel device that dramatically improves the contrast of images produced by cryo-electron microscopes, opening up an entirely new view of human […]

F1F0-type ATPases catalyse both ATP-driven proton translocation and proton-gradient-driven ATP synthesis. Recent cryoelectronmicroscopy and low-resolution X-ray studies provide a first glimpse at the ...