#EpithelialCell
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immunoeditor.bsky.social
In #Science #Immunology, researchers at @stanfordmedicine.bsky.social studied #IFNs in human #fetal #thymus development. They found type I & II IFNs play distinct but critical roles in cortical & medullary thymic #EpithelialCell differentiation!
Distinct type I and II interferon responses direct cortical and medullary thymic epithelial cell development
Single-cell transcriptomics identifies type I and II interferons as regulators of cortical and medullary thymic epithelial differentiation.
www.science.org
May 26, 2025 at 10:06 PM
genesndiseases.bsky.social
This recent review dives into how #Circadian cycles, #CellCycle regulation, and key #Intestinal signaling pathways work together to guide #StemCell and #EpithelialCell behavior, opening new avenues for advanced intestinal health. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...
August 26, 2025 at 5:30 PM
currentmedscience.bsky.social
This review highlights #intestinal #EpithelialCell #Ferroptosis hallmarks in #UlcerativeColitis (UC), outlines regulatory pathways and therapeutic strategies shaping stage specific paradigms for UC management. #medsky

#OpenAccess: doi.org/10.1007/s115...

#currentmedicalscience #GutHealth
Intestinal Epithelial Cell Ferroptosis in Ulcerative Colitis: Pathogenesis, Signaling Networks, and Therapeutic Implications
July 10, 2026 at 3:45 AM
currentmedscience.bsky.social
This study identifies #EpithelialCell transforming sequence 2 (ECT2) as a potential driver of #fibrosis, a common pathological alteration in #ChronicKidneyDisease (CKD), which holds significance for the diagnosis and treatment of #CKD. #medsky

To read: link.springer.com/article/10.1...
Contribution of ECT2 to Tubulointerstitial Fibrosis in the Progression of Chronic Kidney Disease
August 15, 2025 at 12:05 PM
rajansingh.bsky.social
🆕🔥Elevated #FecalBiomarkers of colo‐rectal #EpithelialCell activity in #IBS‼️ #NGMJournal
🎯Activity of #GutEpithelialCells rather than #inflammation driven by #neutrophils and/or #eosinophils, is a key #pathogenetic mechanism in #IBS👏
👉https://onlinelibrary.wiley.com/doi/full/10.1111/nmo.14984
✅The measurement in feces of a panel of biomarkers reflecting inflammatory and epithelial cell activities is important for understanding the underlying pathophysiology of IBS. ✅The absence of signs of involvement of neutrophils and eosinophils in IBS suggests that increased activity of intestinal epithelial cells rather than inflammation is a major determinant of the disease. ✅The negative correlation between the novel biomarker human phospholipase BII-precursor (HPLBII-P) and bloating and the presence of this biomarker in intestinal epithelial cells suggest a physiological role of HPLBII-P in intestinal activities.
December 17, 2024 at 2:40 PM
medcomm.bsky.social
#Review in #MedComm
Idiopathic Pulmonary Fibrosis: Cellular Heterogeneity, Mechanisms, and Therapeutic Implications doi.org/10.1002/mco2...

#EpithelialCell #fibroblast #ImmuneCell #IPF #scRNA_seq #SpatialTranscriptomics
Idiopathic Pulmonary Fibrosis: Cellular Heterogeneity, Mechanisms, and Therapeutic Implications
Single-cell sequencing has elucidated cell-type-specific transcriptional alterations, activated signaling pathways, metabolic reprogramming, immune infiltration, and chromatin-associated genetic mech...
doi.org
December 26, 2025 at 2:43 AM