December 4, 2024 at 7:28 PM
Nature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis
https://go.nature.com/46c474I
https://go.nature.com/46c474I
Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature
A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabilities.
go.nature.com
June 25, 2025 at 11:01 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Peng Bai Marichal &co show @ Science Immunology that endothelial cells produce TGFb to differentiate monocytes into #lung interstitial macrophages preventing aging & fibrosis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Endothelial-driven TGFβ signaling supports lung interstitial macrophage development from monocytes
Endothelial Tgfβ1 shapes the development and functional identity of lung interstitial macrophages.
www.science.org
April 27, 2025 at 2:59 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Peng Bai Marichal &co show @ Science Immunology that endothelial cells produce TGFb to differentiate monocytes into #lung interstitial macrophages preventing aging & fibrosis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Excited to share this “Insight” @jem.org about an amazing new finding by Zhou, Zhang, Ye, Staeheli &co showing that type III interferons #IFNL also signal in #fibroblasts driving renal #fibrosis! #InterferonPower! #EveryCellIsAnImmuneCell! #FriendsOrFoes!
IFNλ works at mucosal surfaces by signaling in epithelial cells and selected immune cells. Zhou, Zhang et al. (rupress.org/jem/article/...) demonstrate that IFNλ also signals in kidney fibroblasts sustaining renal #fibrosis. @lozanzi.bsky.social highlights the findings: rupress.org/jem/article/...
July 7, 2026 at 9:24 PM
Excited to share this “Insight” @jem.org about an amazing new finding by Zhou, Zhang, Ye, Staeheli &co showing that type III interferons #IFNL also signal in #fibroblasts driving renal #fibrosis! #InterferonPower! #EveryCellIsAnImmuneCell! #FriendsOrFoes!
#WeekendRead! #EveryCellisAnImmuneCell! Park, Ahn & Barber show @sciimmunology.bsky.social that DNA-damaged cells activate cGAS-STING secreting factors & induce endosomal vesicles that activate in antigen-presenting cells cGAS-STING inducing immune activation! www.science.org/doi/10.1126/...
Antigen-presenting cell activation requires intrinsic and extrinsic STING signaling after the phagocytosis of DNA-damaged cells
Both cytosolic DNA species and innate immune STING signaling are required for stressed cells to activate phagocytes.
www.science.org
December 22, 2024 at 4:27 PM
#WeekendRead! #EveryCellisAnImmuneCell! Park, Ahn & Barber show @sciimmunology.bsky.social that DNA-damaged cells activate cGAS-STING secreting factors & induce endosomal vesicles that activate in antigen-presenting cells cGAS-STING inducing immune activation! www.science.org/doi/10.1126/...
#WeekendRead! #EveryCellIsAnImmuneCell! A new paper @ Immunity shows that stress increases gut permeability, leading to IL1b secretion driving Th17-dependent IL22 production! IL22 suppresses brain #neuron activation dampening stress-induced anxiety! doi.org/10.1016/j.im...
Redirecting
doi.org
December 7, 2024 at 5:53 PM
#WeekendRead! #EveryCellIsAnImmuneCell! A new paper @ Immunity shows that stress increases gut permeability, leading to IL1b secretion driving Th17-dependent IL22 production! IL22 suppresses brain #neuron activation dampening stress-induced anxiety! doi.org/10.1016/j.im...
#WeekendRead! #EveryCellIsAnImmuneCell! Brown, Yipp &co show @science.org that platelet cathelicidin initiates antibacterial neutrophil-platelet lung aggregates amplified by LTB4, driving lethal immunothrombi during sepsis! LTB4 blockade maintains antibacterial functions preventing immunopathology!
doi.org
June 6, 2026 at 3:05 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Brown, Yipp &co show @science.org that platelet cathelicidin initiates antibacterial neutrophil-platelet lung aggregates amplified by LTB4, driving lethal immunothrombi during sepsis! LTB4 blockade maintains antibacterial functions preventing immunopathology!
#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...
Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair
Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.
www.cell.com
December 26, 2024 at 5:24 PM
#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...
#LocationLocationLocation & #EveryCellIsAnImmuneCell!! Check out the final version just out today of our Trends in Immunology review on the regionalization of the immune response along the respiratory tract!! dlvr.it/TG3Qzc
Regional specialization within the mammalian respiratory immune system
The respiratory tract is exposed to infection from inhaled pathogens, including viruses,
bacteria, and fungi. So far, a comprehensive assessment that integrates common and
distinct aspects of the immu...
dlvr.it
November 17, 2024 at 3:33 PM
#LocationLocationLocation & #EveryCellIsAnImmuneCell!! Check out the final version just out today of our Trends in Immunology review on the regionalization of the immune response along the respiratory tract!! dlvr.it/TG3Qzc
Nice CELLebration during Cytokines 2024 for our new Cell paper!! 👇#EveryCellIsAnImmuneCell! We show that, during #IBD, type III #interferons delay gut repair by inducing #pyroptosis in intestinal epithelial cells via #gasdermin C upon ZBP1 activation! authors.elsevier.com/a/1k2OAL7PXqSL5
November 17, 2024 at 3:36 PM
Nice CELLebration during Cytokines 2024 for our new Cell paper!! 👇#EveryCellIsAnImmuneCell! We show that, during #IBD, type III #interferons delay gut repair by inducing #pyroptosis in intestinal epithelial cells via #gasdermin C upon ZBP1 activation! authors.elsevier.com/a/1k2OAL7PXqSL5
#WeekendRead! #EveryCellIsAnImmuneCell! #MysterySolved! Clevers &co reveal @nature the differentiation trajectory of human intestinal M cells & show they respond to GM-CSF, express PRRs, & present antigen via MHC-II as dendritic cells, contributing to anti-gluten responses!
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Human gut M cells resemble dendritic cells and present gluten antigen - Nature
An intestinal organoid model recapitulates human microfold (M) cell function and transcriptomic profiling and biochemical assays demonstrate that M cells uptake and present antigens to the immune syst...
doi.org
December 13, 2025 at 3:57 PM
#WeekendRead! #EveryCellIsAnImmuneCell! #MysterySolved! Clevers &co reveal @nature the differentiation trajectory of human intestinal M cells & show they respond to GM-CSF, express PRRs, & present antigen via MHC-II as dendritic cells, contributing to anti-gluten responses!
doi.org/10.1038/s415...
doi.org/10.1038/s415...
#EveryCellIsAnImmuneCell! @jieyang437.bsky.social @roychoudhurilab.bsky.social &co show @nature.com that platelet-derived thromboxane A2 suppresses T cell effector functions favoring melanoma metastases! Aspirin or COX1 inhibition or deletion in platelets reduce metastasis!
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - Nature
Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.
doi.org
March 5, 2025 at 6:59 PM
#EveryCellIsAnImmuneCell! @jieyang437.bsky.social @roychoudhurilab.bsky.social &co show @nature.com that platelet-derived thromboxane A2 suppresses T cell effector functions favoring melanoma metastases! Aspirin or COX1 inhibition or deletion in platelets reduce metastasis!
#WeekendRead! #EveryCellIsAnImmuneCell! Cao &co show @cp-cellmetabolism.bsky.social that the sweetener aspartame aggravates atherosclerosis by inducing insulin which acts on arterial endothelial cells to drive a chemokine that recruit inflammatory myeloid cells. #ScienceSavesLives
www.cell.com
February 23, 2025 at 7:14 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Cao &co show @cp-cellmetabolism.bsky.social that the sweetener aspartame aggravates atherosclerosis by inducing insulin which acts on arterial endothelial cells to drive a chemokine that recruit inflammatory myeloid cells. #ScienceSavesLives
#EveryCellIsAnImmuneCell! Rakoff-Nahoum & Chatila labs @bostonchildrens.bsky.social @harvardmed.bsky.social show @nature.com that in food #allergy intestinal goblet cells produce RELMb which depletes #microbiota producing indole metabolites necessary to activate AHR & drive Tregs!
RELMβ sets the threshold for microbiome-dependent oral tolerance - Nature
RELMβ mediates a gut immune–epithelial circuit regulating tolerance to food antigens, offering targetable candidates for the prevention and treatment of food allergies.
www.nature.com
January 22, 2025 at 9:36 PM
#EveryCellIsAnImmuneCell! Rakoff-Nahoum & Chatila labs @bostonchildrens.bsky.social @harvardmed.bsky.social show @nature.com that in food #allergy intestinal goblet cells produce RELMb which depletes #microbiota producing indole metabolites necessary to activate AHR & drive Tregs!
#WeekendRead! #ImmunometabolismPower! #EveryCellIsAnImmuneCell! Ji, Zhang, Lu, Liu &co show @nature.com that infection, irradiation, or lupus #SLE induce a mevalonate intermediates that drives IL6 & CCL20 by #keratinocytes via NFAT to potentate antibody production!
A metabolic alarmin from keratinocytes potentiates systemic humoral immunity - Nature
Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20.
www.nature.com
March 14, 2026 at 3:01 PM
#WeekendRead! #ImmunometabolismPower! #EveryCellIsAnImmuneCell! Ji, Zhang, Lu, Liu &co show @nature.com that infection, irradiation, or lupus #SLE induce a mevalonate intermediates that drives IL6 & CCL20 by #keratinocytes via NFAT to potentate antibody production!
#EveryCellIsAnImmuneCell! June Round &friends show @science.org that in early life bacteria & fungi cooperate to expand insulin producing β islets via macrophage infiltration & that recognition of commensal yeast cell wall can protects against diabetes in adults! www.science.org/doi/10.1126/...
Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development
Loss of early-life microbial diversity is correlated with diabetes, yet mechanisms by which microbes influence disease remain elusive. We report a critical neonatal window in mice when microbiota disr...
www.science.org
March 12, 2025 at 5:12 PM
#EveryCellIsAnImmuneCell! June Round &friends show @science.org that in early life bacteria & fungi cooperate to expand insulin producing β islets via macrophage infiltration & that recognition of commensal yeast cell wall can protects against diabetes in adults! www.science.org/doi/10.1126/...
#MyMostPopularFromTheOtherside! #EveryCellIsAnImmuneCell! Srivastava, Alexanian &co show @Nature that BRD4 controls IL-1 in Cx3cr1+ #macrophages that infiltrate the scompensated heart, activating MEOX1 in #fibroblasts & driving fibrosis! Blocking IL1 protects against heart failure! t.co/31VokwVNij
https://www.nature.com/articles/s41586-024-08085-6
t.co
November 23, 2024 at 7:38 PM
#MyMostPopularFromTheOtherside! #EveryCellIsAnImmuneCell! Srivastava, Alexanian &co show @Nature that BRD4 controls IL-1 in Cx3cr1+ #macrophages that infiltrate the scompensated heart, activating MEOX1 in #fibroblasts & driving fibrosis! Blocking IL1 protects against heart failure! t.co/31VokwVNij
#WeekendRead! #EveryCellIsAnImmuneCell! Kolter, Doring, Henneke &co show @cp-immunity.bsky.social that during development or after injury, skin sensory neurons provide TGFb & CGRP to macrophages which become neuron-associated macrophages helping nerve regeneration! doi.org/10.1016/j.im...
Redirecting
doi.org
October 18, 2025 at 7:33 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Kolter, Doring, Henneke &co show @cp-immunity.bsky.social that during development or after injury, skin sensory neurons provide TGFb & CGRP to macrophages which become neuron-associated macrophages helping nerve regeneration! doi.org/10.1016/j.im...
#EveryCellIsAnImmuneCell! Luchetti @rauchlab.bksy.social Dixit &co show @nature.com that enteropathogenic bacteria evolved a virulence factor that degrades non-canonical #inflammasome & targets ROCKs necessary for luminal extrusion of infected intestinal #epithelial cells, favoring bacterial growth!
Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature
The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...
doi.org
October 22, 2025 at 9:40 PM
#EveryCellIsAnImmuneCell! Luchetti @rauchlab.bksy.social Dixit &co show @nature.com that enteropathogenic bacteria evolved a virulence factor that degrades non-canonical #inflammasome & targets ROCKs necessary for luminal extrusion of infected intestinal #epithelial cells, favoring bacterial growth!
#EveryCellIsAnImmuneCell! @merbllan.bsky.social Goldberg &co show @nature.com that antimicrobial peptides can be produced in a cell-autonomous manner by e.g. lung epithelial cells via proteasome degradation of host proteins, protecting against lung or systemic pseudomonas infections!
Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature
Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...
www.nature.com
March 6, 2025 at 6:48 PM
#EveryCellIsAnImmuneCell! @merbllan.bsky.social Goldberg &co show @nature.com that antimicrobial peptides can be produced in a cell-autonomous manner by e.g. lung epithelial cells via proteasome degradation of host proteins, protecting against lung or systemic pseudomonas infections!
#WeekendRead! #EveryCellIsAnImmuneCell! Mills @fungalspore.bsky.social &co show @ Science Immunology that during lung fungal infections, lung epithelial cells independently respond to IL-1 & type III #interferons by producing GM-CSF which potentiates fungal killing by neutrophils!
GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus
During mold infection, epithelial-derived GM-CSF licenses neutrophil killing of fungal cells, leading to improved survival.
www.science.org
March 23, 2025 at 3:32 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Mills @fungalspore.bsky.social &co show @ Science Immunology that during lung fungal infections, lung epithelial cells independently respond to IL-1 & type III #interferons by producing GM-CSF which potentiates fungal killing by neutrophils!
#WeekendRead! #EveryCellIsAnImmuneCell! Artis @jazib.bsky.social &co show @natimmunol.nature.com that enteric neurons produce the neuropeptide ADM2 which acts directly on ILC2s limiting intestinal damage/#IBDs via amphiregulin production!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CGRP-related neuropeptide adrenomedullin 2 promotes tissue-protective ILC2 responses and limits intestinal inflammation - Nature Immunology
Artis and colleagues show that enteric neurons produce CGRP-related ADM2 to promote intestinal tissue-protective functions in ILC2s.
www.nature.com
August 23, 2025 at 4:25 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Artis @jazib.bsky.social &co show @natimmunol.nature.com that enteric neurons produce the neuropeptide ADM2 which acts directly on ILC2s limiting intestinal damage/#IBDs via amphiregulin production!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
#EveryCellIsAnImmuneCell! @ikinglab.bsky.social @susanwestfall.bsky.social show @cp-cell.bsky.social that during elminth infections CD8 T cells sense #microbiota via MYD88 (not TCR) producing #interferon-g which signals on stromal cells recruiting neutrophils & on muscle cells avoiding dysmotility!
A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection
Type 1 immunity mediates host defense through pathogen elimination, but whether this pathway also impacts tissue function is unknown. Here, we demonst…
www.sciencedirect.com
April 22, 2025 at 7:23 PM
#EveryCellIsAnImmuneCell! @ikinglab.bsky.social @susanwestfall.bsky.social show @cp-cell.bsky.social that during elminth infections CD8 T cells sense #microbiota via MYD88 (not TCR) producing #interferon-g which signals on stromal cells recruiting neutrophils & on muscle cells avoiding dysmotility!
#WeekendRead! #MomIsAlwaysMom! #EveryCellIsAnImmuneCell! Serhan, Gaudenzio &co show @nature.com that elevated corticosterone in stressed moms alters #skin mast cells & mechanosensing #neurons causing fetal immunedysregulation & eczema after birth. doi.org/10.1038/s415...
Maternal stress triggers early-life eczema through fetal mast cell programming - Nature
Prenatal stress triggers molecular dysregulations in fetal neuroimmune circuits, leading to altered mast cell and sensory neuron function, which predisposes offspring to develop eczema in response to otherwise harmless mechanical friction after birth.
doi.org
October 11, 2025 at 3:09 PM
#WeekendRead! #MomIsAlwaysMom! #EveryCellIsAnImmuneCell! Serhan, Gaudenzio &co show @nature.com that elevated corticosterone in stressed moms alters #skin mast cells & mechanosensing #neurons causing fetal immunedysregulation & eczema after birth. doi.org/10.1038/s415...
#EveryCellIsAnImmuneCell! Ugolini, Roger &co show @cp-immunity.bsky.social that herpes simplex virus #HSV1 activates sensory #neurons that produce the neuropeptide SP to limit neutrophil influx, & TAFA4 that drives IL-10 by macrophages, overall fostering disease tolerance!
Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection
Neuroimmune interactions shape host responses to infection, but the molecular role
of sensory neurons during viral infection remains unclear. Roger et al. show that
HSV-1-activated sensory neurons pro...
www.cell.com
February 25, 2026 at 8:18 PM
#EveryCellIsAnImmuneCell! Ugolini, Roger &co show @cp-immunity.bsky.social that herpes simplex virus #HSV1 activates sensory #neurons that produce the neuropeptide SP to limit neutrophil influx, & TAFA4 that drives IL-10 by macrophages, overall fostering disease tolerance!