Just a teensy more fat-derived extracellular matrix should fix this
November 14, 2024 at 12:16 PM
Just a teensy more fat-derived extracellular matrix should fix this
Extracellular vesicles inside cells wait a minute
April 24, 2025 at 7:47 AM
Extracellular vesicles inside cells wait a minute
Extracellular ATP is an environmental cue in bacteria
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
Extracellular ATP is an environmental cue in bacteria
Extracellular ATP acts as a signal regulating physiology and immunity in eukaryotes
and is elevated during intestinal infection or damage. Tronnet et al. show that extracellular
ATP reprograms the tra...
www.cell.com
October 11, 2025 at 11:59 AM
Extracellular ATP is an environmental cue in bacteria
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
A TurboID-based proximity labelling method for detecting extracellular protein interactions in plants https://www.biorxiv.org/content/10.64898/2026.09.22.753433v1
September 23, 2026 at 8:00 AM
A TurboID-based proximity labelling method for detecting extracellular protein interactions in plants https://www.biorxiv.org/content/10.64898/2026.09.22.753433v1
What do you get when #NationalProteinDay and #NationalPokémonDay meet? Pikachurin. ⚡
A 2023 #ScienceSignaling study solved the structure of this extracellular protein that plays an essential role in vision. Learn more: scim.ag/4gZdRRI
A 2023 #ScienceSignaling study solved the structure of this extracellular protein that plays an essential role in vision. Learn more: scim.ag/4gZdRRI
Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179
The structure of the orphan GPCR GPR179 bound to the extracellular matrix component pikachurin is solved.
scim.ag
February 27, 2025 at 5:25 PM
What do you get when #NationalProteinDay and #NationalPokémonDay meet? Pikachurin. ⚡
A 2023 #ScienceSignaling study solved the structure of this extracellular protein that plays an essential role in vision. Learn more: scim.ag/4gZdRRI
A 2023 #ScienceSignaling study solved the structure of this extracellular protein that plays an essential role in vision. Learn more: scim.ag/4gZdRRI
Study: Possible long COVID biomarker: identification of SARC-CoV-2 related protein(s) in Serum Extracellular Vesicles
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Possible long COVID biomarker: identification of SARC-CoV-2 related protein(s) in Serum Extracellular Vesicles - Infection
Infection -
link.springer.com
August 13, 2025 at 4:49 AM
Study: Possible long COVID biomarker: identification of SARC-CoV-2 related protein(s) in Serum Extracellular Vesicles
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Can small extracellular vesicles guide growing axons?🧪
Our new preprint provides evidence that small extracellular vesicle (sEV) secretion regulates axon guidance at a key ventral midline choice point during spinal cord development.
www.biorxiv.org/content/10.6...
#neuroscience #EVs #axon
Our new preprint provides evidence that small extracellular vesicle (sEV) secretion regulates axon guidance at a key ventral midline choice point during spinal cord development.
www.biorxiv.org/content/10.6...
#neuroscience #EVs #axon
September 12, 2026 at 10:45 AM
Can small extracellular vesicles guide growing axons?🧪
Our new preprint provides evidence that small extracellular vesicle (sEV) secretion regulates axon guidance at a key ventral midline choice point during spinal cord development.
www.biorxiv.org/content/10.6...
#neuroscience #EVs #axon
Our new preprint provides evidence that small extracellular vesicle (sEV) secretion regulates axon guidance at a key ventral midline choice point during spinal cord development.
www.biorxiv.org/content/10.6...
#neuroscience #EVs #axon
In a new #ScienceSignaling study, researchers introduce extracellular #TurboID, a refinement of the popular proteomics tool that interrogates #ProteinProteinInteractions on the exterior cell membrane, and characterize interactions between #EGFR and #LDLR. scim.ag/3DgfJr9
Extracellular proximal interaction profiling by cell surface–targeted TurboID reveals LDLR as a partner of liganded EGFR
A modified form of TurboID identifies extracellular interactions between transmembrane proteins.
www.science.org
December 13, 2024 at 5:22 PM
In a new #ScienceSignaling study, researchers introduce extracellular #TurboID, a refinement of the popular proteomics tool that interrogates #ProteinProteinInteractions on the exterior cell membrane, and characterize interactions between #EGFR and #LDLR. scim.ag/3DgfJr9
Check it out, powerful new method for optical imaging of the live ECM, from @hhmijanelia.bsky.social Group Leader Kayvon Pedram #proudofalumni #glycotime
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Live imaging of the extracellular matrix with a glycan-binding fluorophore - Nature Methods
Rhobo6 is a cell-impermeable small-molecule fluorophore that displays reversible fluorogenic binding to glycans, making it a general, wash-free, and non-perturbative label for the extracellular matrix...
www.nature.com
February 6, 2025 at 10:59 PM
Check it out, powerful new method for optical imaging of the live ECM, from @hhmijanelia.bsky.social Group Leader Kayvon Pedram #proudofalumni #glycotime
www.nature.com/articles/s41...
www.nature.com/articles/s41...
More hope for Long Covid🌈 from Stellenbosch University;
“identified the most predictive biomarker combinations, enhancing diagnostic reliability and paving the way for personalized medicine approaches.
www.su.ac.za/en/faculties...
“identified the most predictive biomarker combinations, enhancing diagnostic reliability and paving the way for personalized medicine approaches.
www.su.ac.za/en/faculties...
Scientists reveal another piece in Long COVID puzzle
New study reveals a structural association between circulating microclots and neutrophil extracellular traps (NETs) in patients with Long COVID. When dysregulated, this interaction may become pathogen...
www.su.ac.za
November 15, 2025 at 1:46 AM
More hope for Long Covid🌈 from Stellenbosch University;
“identified the most predictive biomarker combinations, enhancing diagnostic reliability and paving the way for personalized medicine approaches.
www.su.ac.za/en/faculties...
“identified the most predictive biomarker combinations, enhancing diagnostic reliability and paving the way for personalized medicine approaches.
www.su.ac.za/en/faculties...
protease-activated receptors (PARs) are a subfamily of G protein-coupled receptors that are activated by cleavage of their extracellular domain
December 5, 2024 at 3:09 PM
protease-activated receptors (PARs) are a subfamily of G protein-coupled receptors that are activated by cleavage of their extracellular domain
Our group's latest preprint shows TurboID can be adapted for studying extracellular elicitor-receptor interactions in plants. Hopefully useful for the apoplastic MPMI community
www.biorxiv.org/content/10.6...
Led by former PhD @abdelrahmanqutb.bsky.social
www.biorxiv.org/content/10.6...
Led by former PhD @abdelrahmanqutb.bsky.social
A TurboID-based proximity labelling method for detecting extracellular protein interactions in plants
The apoplast is a primary location for interactions between plants and invasive pathogens and is the site where many pathogen-secreted effectors are perceived by cell surface immune receptors to activ...
www.biorxiv.org
September 23, 2026 at 3:25 PM
Our group's latest preprint shows TurboID can be adapted for studying extracellular elicitor-receptor interactions in plants. Hopefully useful for the apoplastic MPMI community
www.biorxiv.org/content/10.6...
Led by former PhD @abdelrahmanqutb.bsky.social
www.biorxiv.org/content/10.6...
Led by former PhD @abdelrahmanqutb.bsky.social
Thrilled to share our new review article!
“The role of extracellular matrix viscoelasticity in development and disease” written together with Olivia Courbot is now published in npj Biological Physics and Mechanics. www.nature.com/articles/s44...
#ECM #Mechanobiology #DevelopmentalBiology
“The role of extracellular matrix viscoelasticity in development and disease” written together with Olivia Courbot is now published in npj Biological Physics and Mechanics. www.nature.com/articles/s44...
#ECM #Mechanobiology #DevelopmentalBiology
The role of extracellular matrix viscoelasticity in development and disease - npj Biological Physics and Mechanics
npj Biological Physics and Mechanics - The role of extracellular matrix viscoelasticity in development and disease
www.nature.com
April 7, 2025 at 8:42 AM
Thrilled to share our new review article!
“The role of extracellular matrix viscoelasticity in development and disease” written together with Olivia Courbot is now published in npj Biological Physics and Mechanics. www.nature.com/articles/s44...
#ECM #Mechanobiology #DevelopmentalBiology
“The role of extracellular matrix viscoelasticity in development and disease” written together with Olivia Courbot is now published in npj Biological Physics and Mechanics. www.nature.com/articles/s44...
#ECM #Mechanobiology #DevelopmentalBiology
What do you get when #NationalProteinDay and #NationalPokémonDay meet? Pikachurin. ⚡
A 2023 #ScienceSignaling study solved the structure of this extracellular protein that plays an essential role in vision.
Learn more: https://scim.ag/4s82e0N
A 2023 #ScienceSignaling study solved the structure of this extracellular protein that plays an essential role in vision.
Learn more: https://scim.ag/4s82e0N
Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179
The structure of the orphan GPCR GPR179 bound to the extracellular matrix component pikachurin is solved.
scim.ag
February 27, 2026 at 2:31 PM
What do you get when #NationalProteinDay and #NationalPokémonDay meet? Pikachurin. ⚡
A 2023 #ScienceSignaling study solved the structure of this extracellular protein that plays an essential role in vision.
Learn more: https://scim.ag/4s82e0N
A 2023 #ScienceSignaling study solved the structure of this extracellular protein that plays an essential role in vision.
Learn more: https://scim.ag/4s82e0N
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
December 4, 2024 at 4:05 PM
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
Check out our latest preprint! We show that the same antibacterial toxin requires different immunity proteins depending whether it’s intra or extracellular
Distinct immunity protein families mediate compartment-specificneutralisation of a bacterial toxin https://www.biorxiv.org/content/10.1101/2025.05.31.657152v1
June 1, 2025 at 7:37 AM
Check out our latest preprint! We show that the same antibacterial toxin requires different immunity proteins depending whether it’s intra or extracellular
New discoveries are reshaping how scientists understand the molecular connections between the extracellular matrix and lysosomes—and the resulting implications for research and therapeutics for neurodegenerative disorders.
Learn more in this #ScienceSignaling Review: https://scim.ag/3Yi2sFS
Learn more in this #ScienceSignaling Review: https://scim.ag/3Yi2sFS
Decoding extracellular matrix–lysosome cross-talk and its implications for neurodegenerative diseases
Reciprocal signaling between intracellular lysosomes and the extracellular matrix supports brain health.
scim.ag
January 2, 2026 at 4:14 PM
New discoveries are reshaping how scientists understand the molecular connections between the extracellular matrix and lysosomes—and the resulting implications for research and therapeutics for neurodegenerative disorders.
Learn more in this #ScienceSignaling Review: https://scim.ag/3Yi2sFS
Learn more in this #ScienceSignaling Review: https://scim.ag/3Yi2sFS
Tumor extracellular vesicle–derived PD-L1 promotes T cell senescence through lipid metabolism reprogramming
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Tumor extracellular vesicle–derived PD-L1 promotes T cell senescence through lipid metabolism reprogramming
PD-L1 from tumor extracellular vesicles induces T cell senescence through lipid metabolism.
www.science.org
February 26, 2025 at 3:35 AM
Tumor extracellular vesicle–derived PD-L1 promotes T cell senescence through lipid metabolism reprogramming
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
extracellular matrix hydrogels and dental stem cells (for bone regeneration)
March 10, 2026 at 6:31 PM
extracellular matrix hydrogels and dental stem cells (for bone regeneration)
Study: Unveiling alternate pathways for SARS-CoV-2 infection via extracellular vesicle-mediated transfer of ACE2 and TMPRSS2
Published: 10 April 2026
www.nature.com/articles/s41...
Published: 10 April 2026
www.nature.com/articles/s41...
Unveiling alternate pathways for SARS-CoV-2 infection via extracellular vesicle-mediated transfer of ACE2 and TMPRSS2 - Nature Communications
Extracellular vesicles from lung epithelial cells deliver ACE2 and TMPRSS2 to recipient cells, enabling SARS-CoV-2 infection beyond receptor-expressing cells and expanding viral tropism.
www.nature.com
April 13, 2026 at 5:01 AM
Study: Unveiling alternate pathways for SARS-CoV-2 infection via extracellular vesicle-mediated transfer of ACE2 and TMPRSS2
Published: 10 April 2026
www.nature.com/articles/s41...
Published: 10 April 2026
www.nature.com/articles/s41...
Extracellular vesicles are the main contributor to the non-viral protected extracellular sequence space www.nature.com/articles/s43... #jcampubs
Extracellular vesicles are the main contributor to the non-viral protected extracellular sequence sp...
ISME Communications - Extracellular vesicles are the main contributor to the non-viral protected extracellular sequence space
www.nature.com
October 18, 2023 at 1:31 PM
Extracellular vesicles are the main contributor to the non-viral protected extracellular sequence space www.nature.com/articles/s43... #jcampubs
neurons, but when it undergoes a process called phosphorylation, it deforms and is ejected from neurons into the extracellular space, creating the tangles that are characteristic of Alzheimer’s and other neurodegenerative diseases. In their recent study published in Alzheimer’s & Dementia: The
May 5, 2025 at 4:04 PM
neurons, but when it undergoes a process called phosphorylation, it deforms and is ejected from neurons into the extracellular space, creating the tangles that are characteristic of Alzheimer’s and other neurodegenerative diseases. In their recent study published in Alzheimer’s & Dementia: The
The production and accumulation of aberrant proteins can have serious pathological consequences.
In a new #ScienceReview, researchers explore how organisms maintain the extracellular proteome. https://scim.ag/4tdEB7B
In a new #ScienceReview, researchers explore how organisms maintain the extracellular proteome. https://scim.ag/4tdEB7B
Systems-level organization of extracellular proteostasis
One defining feature of complex organisms is the ability to maintain protein homeostasis beyond cellular boundaries. We review how extracellular proteostasis is organized as a hierarchical network spa...
scim.ag
April 1, 2026 at 7:24 PM
The production and accumulation of aberrant proteins can have serious pathological consequences.
In a new #ScienceReview, researchers explore how organisms maintain the extracellular proteome. https://scim.ag/4tdEB7B
In a new #ScienceReview, researchers explore how organisms maintain the extracellular proteome. https://scim.ag/4tdEB7B