#FASEBJ
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soren.iodys.dev
The concept of sex as a spectrum is supported by biological, social, and educational research:
§ 01639625.2020.1735030
§ 00224499.2013.871691
§ fasebj.2022.36.s1.0i639

Read for yourself.
November 18, 2024 at 8:36 AM
haoyin.bsky.social
How does Genomic Instability cause #VascularCalcification?

A potential STING-STAT1-NLRP3 #Inflammasome cascade in #SmoothMuscleCell Osteogenesis #MedialArterialCacification

Which type of DNA lesions activates STING in calcifying SMC?🧐

#FASEBJ 2025
faseb.onlinelibrary.wiley.com/doi/10.1096/...
April 10, 2025 at 6:53 PM
haoyin.bsky.social
Trophoblast to Spiral Artery Communication

Trophoblast-derived IL-1β⏫#EndothelialCell MMP10 secretion (likely help periendothelial matrix decomposition)

MMP10⏬ in decidua of🤰with high risk of #Preeclampsia

#FASEBJ 2025
faseb.onlinelibrary.wiley.com/doi/full/10....
May 15, 2025 at 8:32 PM
haoyin.bsky.social
O-GlcNAcylation OGT (O-GlcNAc transferase)⏫ #SmoothMuscleCell #Osteogenesis

SM22-CreERT::Ogt f/f🐭
⏬#MedialArterialCalcification (VitaminD3, 5/6 Nephrectomy)

O-GlcNAcylated β-catenin is protected from degradation & ⬆️SMC calcification😎

#FASEBJ 2024
faseb.onlinelibrary.wiley.com/doi/10.1096/...
June 3, 2025 at 6:55 PM
haoyin.bsky.social
#FGF9 or FGF2/4/8 ⏫UCP1 in both Brown & White Preadipocytes

FGF-induced UCP1 can be artificially activated by TTNPB
But NOT enhance browning or adipocytic differentiation per se

Non-conventional anti-inflamm effect of UCP1 in preadipocyte

#FASEBJ 2025
faseb.onlinelibrary.wiley.com/doi/10.1096/...
December 19, 2025 at 8:33 PM
haoyin.bsky.social
#Piezo1 #YAP Bioenergetics

Human Umbilical Cord MSC

#CyclicStretch (10% strain, 0.5Hz, 7 d)
#Piezo➡️
YAP nuclear import➡️
⏫MFN1/2 ⏬DRP1➡️
⏫Mitochondrial fusion ⏫mtDNA-encoded genes➡️
⏫OXPHOS (⏫Glycolysis)➡️
⏫SMC contractile proteins

#FASEBJ 2025
faseb.onlinelibrary.wiley.com/doi/10.1096/...
February 15, 2025 at 12:10 PM
haoyin.bsky.social
YAP/TAZ as direct targets of Sirt6 deacetylase

Sirt6 ⏬YAP/TAZ-TEAD1 interaction ⏫VGLL4 (YAP/TAZ suppressor)-TEAD1 interaction

Both Lrat-Cre #HepaticStellateCell & Albumin-Cre Hepatocyte (or leaks to HSC?🤔) Sirt6 KO⏫Liver Fibrosis in MASH🐭

#FASEBJ 2022
faseb.onlinelibrary.wiley.com/doi/10.1096/...
February 25, 2026 at 8:13 PM
haoyin.bsky.social
#YAP #Ferroptosis #SmoothMuscleCell #Atherosclerosis

Ferrostatin-1 in Apoe-/-🐭
⏬ferroptotic markers: Iron 4HNE COX2 GPX4
⏫lesion stability: necrotic core SMC Mφ collagen

SMC YAP1 ⬆️in unstable lesion or by oxLDL
YAP1-Glutaminase 1 in vitro

#FASEBJ 2024
faseb.onlinelibrary.wiley.com/doi/10.1096/...
July 17, 2025 at 11:43 AM
haoyin.bsky.social
#MatrixStiffness & #PhosphatidicAcid enhance

#Senescence
#Mitochondria-ER contact
#ERStress
#MitochondriaDysfunction (JC-1)
#ROS
in #SmoothMuscleCell

Seem to be rescued by Atorvastatin (How?)🧐

#FASEBJ 2023
faseb.onlinelibrary.wiley.com/doi/10.1096/...
December 15, 2023 at 12:26 PM
elbenhardt.bsky.social
Our new FASEBJ paper. We looked into mTOR Ser1261 phosphorylation in human and mouse muscle, proposed by Diane Fingar's lab to be first an Akt and then AMPK site regulating mTORC1 and 2 activity. Clearly AMPK site but impact on mTORC unclear in our hands faseb.onlinelibrary.wiley.com/doi/10.1096/...
mTOR Ser1261 is an AMPK‐dependent phosphosite in mouse and human skeletal muscle not required for mTORC2 activity
mTOR Ser1261 is an AMPK-dependent phosphosite in human and mouse skeletal muscle that responds to exercise but not insulin, plays an unclear role in mTORC1 regulation, and is not required for mTORC2 ....
faseb.onlinelibrary.wiley.com
January 21, 2025 at 7:06 PM
haoyin.bsky.social
Link b/w #LipidOxidation #Ferroptosis & #Calcification of #SmoothMuscleCell with #OxidizedPhospholipid POVPC

Ferrostatin-1 or mito-TEMPO⏬POVPC-induced SMC calcification

#FASEBJ 2024
faseb.onlinelibrary.wiley.com/doi/10.1096/...
April 8, 2024 at 7:52 PM
laurence1084.bsky.social
@cammsyn.net
Source: https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.31.1_supplement.788.24
January 6, 2025 at 6:58 AM
mattmuscleguy.bsky.social
Congrats to #NicolasDumant & colleagues for their new #FASEBJ paper: Transcriptomic and lipidomic profiling reveals distinct bioactive lipid signatures in slow and fast muscles and highlights the role of resolvin-D2 in fiber type determination during myogenesis. #MyoBlue tinyurl.com/3ht6nr66
Transcriptomic and lipidomic profiling reveals distinct bioactive lipid signatures in slow and fast muscles and highlights the role of resolvin‐D2 in fiber type determination during myogenesis
Transcriptomics (bulk and single-nuclei RNAseq) and lipidomics (mass spectrometry) analysis showed that slow-twitch muscle (soleus) is enriched in bioactive lipids derived from docosahexaenoic acid (...
tinyurl.com
December 19, 2024 at 7:25 PM
haoyin.bsky.social
#Senescence

E2F7 is methylated & stabilized (shunted away from ubiquitination) by Protein Arginine Methyltransferase 1

Sirt6 as a direct anti-senescent target gene in Smooth Muscle Cell

#FASEBJ 2025
faseb.onlinelibrary.wiley.com/doi/epdf/10....
February 5, 2026 at 8:15 PM
haoyin.bsky.social
IL1β serves as a possible link b/w Trophoblast invasion & Uterine Spiral Artery #SmoothMuscleCell contractile phenotypic dynamics

Are the myometrial SMCs also affected similarly? 🥸

#FASEBJ 2024
faseb.onlinelibrary.wiley.com/doi/10.1096/...
May 15, 2024 at 6:33 PM
haoyin.bsky.social
Ohh😀
Sirtuin 6 protects against hepatic fibrogenesis by suppressing the YAP and TAZ function

LRAT+ #HepaticStellateCell Sirt6 KO-> increased TGFβ-SMAD3 + #YAP/TAZ activity

Similar or opposite in SMC?

#FASEBJ 2022
faseb.onlinelibrary.wiley.com/doi/full/10....
February 24, 2024 at 8:20 PM
realbiomassspec.bsky.social
Spatial Metabolism of Primary Limited Cutaneous Amyloidosis Based on Mass Spectrometry Imaging #FASEBJ faseb.onlinelibrary.wiley.com/doi/10.1096/...
Spatial Metabolism of Primary Limited Cutaneous Amyloidosis Based on Mass Spectrometry Imaging
In this study, metabolomic profiling was performed on skin tissues from patients with primary localized cutaneous amyloidosis (PLCA) and healthy controls (HC). The analysis identified several differe...
faseb.onlinelibrary.wiley.com
September 16, 2025 at 3:06 PM
realbiomassspec.bsky.social
Metabolome Atlas of Brain Reveals Regional Shared and Unique Metabolic Drifts in Response to Type 2 Diabetes in Male Mice #FASEBJ #MassSpec faseb.onlinelibrary.wiley.com/doi/10.1096/...
Metabolome Atlas of Brain Reveals Regional Shared and Unique Metabolic Drifts in Response to Type 2 Diabetes in Male Mice
A detailed metabolome atlas of the male mouse brain was established, incorporating metabolomic and lipidomic profiling of seven anatomical regions. T2D induced marked metabolic alterations, which wer...
faseb.onlinelibrary.wiley.com
January 20, 2026 at 3:38 PM
realbiomassspec.bsky.social
Spatial Metabolomics Reveals GLA‐Mediated Imbalance of Gal2Cer/GalCer as a Therapeutic Target in Myocardial Ischemia–Reperfusion Injury #FASEBJ #MassSpec faseb.onlinelibrary.wiley.com/doi/10.1096/...
faseb.onlinelibrary.wiley.com
December 29, 2025 at 8:22 PM
realbiomassspec.bsky.social
Altered Lipid Metabolism in the Vaginal Wall of Women With Pelvic Organ Prolapse: A Targeted Lipidomics Study #FASEBJ #MassSpec faseb.onlinelibrary.wiley.com/doi/10.1096/...
Altered Lipid Metabolism in the Vaginal Wall of Women With Pelvic Organ Prolapse: A Targeted Lipidomics Study
This graphical abstract illustrates the association between pelvic organ prolapse (POP) and obesity. Vaginal anterior wall tissues were collected for targeted lipidomics analysis, revealing significa....
faseb.onlinelibrary.wiley.com
November 28, 2025 at 9:31 PM
realbiomassspec.bsky.social
Multi-omics analysis reveals alterations of breastmilk metabolites and proteins in Hong Kong lactating mothers #FASEBJ #MassSpec faseb.onlinelibrary.wiley.com/doi/10.1096/...
Multi‐omics analysis reveals alterations of breastmilk metabolites and proteins in Hong Kong lactating mothers
Multi-omics analysis was applied in Hong Kong lactating mothers over the 12 months. The altered metabolic pathways included biotin/amino acid/fatty acid metabolism. The accumulation/remodeling of lip...
faseb.onlinelibrary.wiley.com
December 10, 2024 at 7:12 PM
scholarai.bsky.social
A study titled "Space travel directly induces skeletal muscle atrophy" explains that muscle loss occurs rapidly in space, with potential countermeasures being essential https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.13.9.1031
December 10, 2025 at 12:16 AM
moriartylab.bsky.social
https://www.fasebj.org/doi/abs/10.1096/fj.201800605?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=fasebj#.XBgdp3Bqu54.twitter
December 8, 2024 at 12:32 AM
haoyin.bsky.social
#SmoothMuscleCell NRF2 KO🐭are susceptible to Angiotensin II-induced #AbdominalAorticAneurysm

NRF2-miR-145 cascade

scRNAseq👤AAA▶️7 SMC clusters
Contractile 1/2
Fibroblast-like
Macrophage-like
Stem cell-like
T cell-like
Plasma cell-like

#FASEBJ 2024
faseb.onlinelibrary.wiley.com/doi/10.1096/...
July 18, 2024 at 7:03 PM
jenrm.bsky.social
Holy shit. You think Tylenol causes DNA damage?! Just hearing you make that claim is the biggest update I've made in a while, and lead to some double-checking.

Does this research jive, or not jive, with your model here?
https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2020.34.s1.09021
faseb.onlinelibrary.wiley.com
May 22, 2023 at 7:20 PM