This is huge news!
UBC has developed an enzyme that can convert donor organs to type O, making them universal.
Normally a using organs of the wrong blood type causes the recipient's immune system to attack the organ, leading to failure.
❤️🇨🇦⚕️
news.ubc.ca/2025/10/univ...
UBC has developed an enzyme that can convert donor organs to type O, making them universal.
Normally a using organs of the wrong blood type causes the recipient's immune system to attack the organ, leading to failure.
❤️🇨🇦⚕️
news.ubc.ca/2025/10/univ...
UBC enzyme technology clears first human test toward universal donor organs for transplantation - UBC News
UBC-developed enzymes successfully converted a kidney to universal type O for transplant, marking a major step toward faster, more compatible organ donations.
news.ubc.ca
October 15, 2025 at 3:54 AM
✨✨ It's #glycotime for #HIV Env ✨✨
N-linked glycans modulate flexibility & MPER epitope exposure #glycotime
Huge effort by @shehata92.bsky.social @lcasalino88.bsky.social with cryoET of Env in VLPs by @thevillalab.bsky.social & team 💪
Would love feedback!
www.biorxiv.org/content/10.1...
N-linked glycans modulate flexibility & MPER epitope exposure #glycotime
Huge effort by @shehata92.bsky.social @lcasalino88.bsky.social with cryoET of Env in VLPs by @thevillalab.bsky.social & team 💪
Would love feedback!
www.biorxiv.org/content/10.1...
March 28, 2025 at 4:23 AM
✨✨ It's #glycotime for #HIV Env ✨✨
N-linked glycans modulate flexibility & MPER epitope exposure #glycotime
Huge effort by @shehata92.bsky.social @lcasalino88.bsky.social with cryoET of Env in VLPs by @thevillalab.bsky.social & team 💪
Would love feedback!
www.biorxiv.org/content/10.1...
N-linked glycans modulate flexibility & MPER epitope exposure #glycotime
Huge effort by @shehata92.bsky.social @lcasalino88.bsky.social with cryoET of Env in VLPs by @thevillalab.bsky.social & team 💪
Would love feedback!
www.biorxiv.org/content/10.1...
The results of a study in Nature Metabolism establish hyperglycosylation as a pathological driver of Alzheimer’s disease and highlight glycan metabolism as an actionable target in the fight against the disease. #alzsky #Neuroskyence 🧪
Hyperglycosylation is a metabolic driver of Alzheimer’s disease - Nature Metabolism
Through spatial multiomics, spatial stable isotope tracing and retrospective cohort analyses, this study identifies hyperglycosylation as a driver of Alzheimer’s disease and a promising therapeutic target.
go.nature.com
June 20, 2026 at 1:53 AM
Playing with mucins for #glycotime. Trajectory from @fionachembot.bsky.social and @rommieamaro.bsky.social #b3d #MolecularNodes #GeometryNodes #SciArt
November 21, 2024 at 12:36 AM
Playing with mucins for #glycotime. Trajectory from @fionachembot.bsky.social and @rommieamaro.bsky.social #b3d #MolecularNodes #GeometryNodes #SciArt
Congratulations Chi-Huey!! #glycotime
Scripps Research professor Chi-Huey Wong will receive the 2027 American Chemical Society Alfred Bader Award for his work to understand carbohydrate chemistry and its roles in health and disease. He will be honored at the ACS Spring meeting in New Orleans.
More: https://ow.ly/3V1X50ZJFGv
More: https://ow.ly/3V1X50ZJFGv
September 5, 2026 at 12:02 AM
Congratulations Chi-Huey!! #glycotime
Thank you to the international #glycotime community for sharing our message of support for science @standupforscience.bsky.social !
Glycoscience Grenoble is supporting US colleaugrs @fionachembot.bsky.social @nmriley.bsky.social @carolynbertozzi.bskyverified.social
March 7, 2025 at 3:19 PM
Thank you to the international #glycotime community for sharing our message of support for science @standupforscience.bsky.social !
GLYCO-BUILD, an entirely enzymatic approach for the production of N-glycans and N-glycopeptides.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Client Challenge
www.nature.com
January 15, 2026 at 3:44 AM
Another epic #glycotime accomplishment from @rommieamaro.bsky.social and coworkers @UCSD
✨✨ It's #glycotime for #HIV Env ✨✨
N-linked glycans modulate flexibility & MPER epitope exposure #glycotime
Huge effort by @shehata92.bsky.social @lcasalino88.bsky.social with cryoET of Env in VLPs by @thevillalab.bsky.social & team 💪
Would love feedback!
www.biorxiv.org/content/10.1...
N-linked glycans modulate flexibility & MPER epitope exposure #glycotime
Huge effort by @shehata92.bsky.social @lcasalino88.bsky.social with cryoET of Env in VLPs by @thevillalab.bsky.social & team 💪
Would love feedback!
www.biorxiv.org/content/10.1...
March 29, 2025 at 1:10 AM
Another epic #glycotime accomplishment from @rommieamaro.bsky.social and coworkers @UCSD
Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry
Mammalian cells present RNA-binding proteins on the cell surface that form clustered
domains containing glycoRNAs.
www.cell.com
February 28, 2025 at 3:43 AM
My PhD work is (finally) published in Science Signaling! And it made the cover!
Here’s what we found 🧵⬇️
www.science.org/doi/10.1126/...
Here’s what we found 🧵⬇️
www.science.org/doi/10.1126/...
November 8, 2025 at 9:13 PM
Great to see #glycotime on BlueSky!
#glycotime people, if you’re already around here, I’m re-advertising my postdoc position in my group, so if you are keen on finding the golden path between biology and computing with me, come join us at CCG!
Postdoc at the Copenhagen Center for Glycomics (CCG), Department of Cellular and Molecular Medicine
We are looking for a highly motivated and dynamic scientist for a 2-year postdoctoral position to commence 1 October 2023 or after agreement. The ...
www.nature.com
November 12, 2024 at 3:43 PM
Great to see #glycotime on BlueSky!
The anomeric effect is well known to chemistry students. But do we need to be more subtle when we think about what causes it?
Anomeric effect cannot be explained by hyperconjugation alone
Computational studies suggest this textbook principle is governed by a range of factors
www.chemistryworld.com
January 12, 2026 at 4:23 PM
More discoveries around #glycoRNA #glycotime
New method for detecting cell surface RNAs highlights Y RNAs as having a role for modulating extracellular histone binding
Exciting overlap between #glycoRNA transcripts and those characterized here
www.biorxiv.org/content/10.1...
Exciting overlap between #glycoRNA transcripts and those characterized here
www.biorxiv.org/content/10.1...
www.biorxiv.org
April 14, 2025 at 2:06 PM
More discoveries around #glycoRNA #glycotime
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬
The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy
www.biorxiv.org/content/10.1...
The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy
www.biorxiv.org/content/10.1...
February 10, 2025 at 8:21 AM
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬
The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy
www.biorxiv.org/content/10.1...
The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy
www.biorxiv.org/content/10.1...
Welcome #glycotime prof Lara Mahal @glycocode.bsky.social!
November 23, 2024 at 12:31 AM
Welcome #glycotime prof Lara Mahal @glycocode.bsky.social!
Looks like #glycotime is seeing a major uptick this month! 💜
As someone who has gained a lot of knowledge and career advice from fellow glycobiologists, I wanted to recreate a space for discussion on Bluesky. Here's a starter pack with some glycobiology users to get started. Please comment/DM me to get added to the #glycotime starter pack
go.bsky.app/CN9pS3u
go.bsky.app/CN9pS3u
November 18, 2024 at 5:49 AM
Looks like #glycotime is seeing a major uptick this month! 💜
Beautiful #glycotime work showing MD simulation of Siglec6 binding to glycolipids, membrane interactions contribute to specificity!
When glycan recognition is linked to immune response, you need fine tuning! 😎
Here ⬇️ we show how human Siglecs act as molecular precision tools, recognising the glycan and also the biological environment (or context) these glycans are found in. A 1/5 #glycotime🧵 ⬇️
doi.org/10.1101/2025...
Here ⬇️ we show how human Siglecs act as molecular precision tools, recognising the glycan and also the biological environment (or context) these glycans are found in. A 1/5 #glycotime🧵 ⬇️
doi.org/10.1101/2025...
June 22, 2025 at 2:42 PM
Beautiful #glycotime work showing MD simulation of Siglec6 binding to glycolipids, membrane interactions contribute to specificity!
It’s #glycotime for phage infecting pathogenic E. coli strains
New Preprint 🥳
Here we wondered how phages that have been extensively studied in laboratory E. coli strains actually behave when they encounter a real pathogen such as O157:H7 strain...one with a far more complex cell surface & one of the most consequential foodborne pathogens in the United States.
Here we wondered how phages that have been extensively studied in laboratory E. coli strains actually behave when they encounter a real pathogen such as O157:H7 strain...one with a far more complex cell surface & one of the most consequential foodborne pathogens in the United States.
Animated E. coli Bacteria Drawing
Alt: Animated E. coli Bacteria Drawing
static.klipy.com
July 25, 2026 at 2:56 PM
It’s #glycotime for phage infecting pathogenic E. coli strains
Cool new study showing glycoRNAs on circulating extracellular vesicles may have diagnostic utility #glycotime
Advancing #glycoRNA imaging with FRET-based detection and expanding the scope of their presentation to extracellular vesicles - interestingly high levels of sialoglycoRNAs on blood EVs can be predictive of having cancer @naturecomms.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com
April 11, 2025 at 3:16 PM
Cool new study showing glycoRNAs on circulating extracellular vesicles may have diagnostic utility #glycotime
Exciting new #glycotime work from the Woo lab @harvard.edu 👏
Roses are red, GlcNAc is blue, sugar is sweet, and we want YOU to read our latest in @natcomms.nature.com — where we identify small-molecules that disrupt OGlcNAc homeostasis via RNA splicing. Congrats Steven (@scheng23.bsky.social) and all the authors! 🟦🍭❤️ www.nature.com/articles/s41...
Small molecule splicing modulators that disrupt O-GlcNAc homeostasis - Nature Communications
Authors report drug repurposing screens against O-GlcNAc cycling enzymes, finding kinase inhibitors that act as splicing modulators to disrupt O-GlcNAc homeostasis and downregulate OGT and OGA. These ...
www.nature.com
February 11, 2026 at 8:52 PM
Exciting new #glycotime work from the Woo lab @harvard.edu 👏
Stacy Malaker @yalepress.bsky.social representing #glycotime and #massspec @onoinitiative.bsky.social chem bio symposium @stanford-chemh.bsky.social
June 25, 2026 at 8:56 PM
Stacy Malaker @yalepress.bsky.social representing #glycotime and #massspec @onoinitiative.bsky.social chem bio symposium @stanford-chemh.bsky.social
Linking the glycome and transcriptome at the single cell level #glycotime
Online now! Online now! Single-cell glycome and transcriptome profiling enabled by a library of anti-glycan antibodies #chembiol
Single-cell glycome and transcriptome profiling enabled by a library of anti-glycan antibodies
Marglous et al. generated a database of anti-glycan antibody sequences, expressed and characterized a library of 154 antibodies, and generated DNA-barcoded antibodies for single-cell transcriptome and glycome profiling. Glycans associated with cancer stem cells and metastasis were uncovered, demonstrating utility for basic and clinical research.
dlvr.it
December 15, 2025 at 4:54 PM
Linking the glycome and transcriptome at the single cell level #glycotime
April 22, 2025 at 4:36 PM
Our lab works on various aspects of hormone regulation by O-GlcNAcylation, including pituitary hormones @aknier.bsky.social and placental hormones(Lily Massman).
So we wrote a review, "O-GlcNAcylation in Endocrinology: The Sweet Link".
Check it out!
academic.oup.com/endo/article...
So we wrote a review, "O-GlcNAcylation in Endocrinology: The Sweet Link".
Check it out!
academic.oup.com/endo/article...
January 17, 2026 at 1:01 AM