Now out in @narjournal.bsky.social - BAHCC1 promotes gene expression in neuronal cells by antagonizing SIN3A–HDAC1
July 19, 2025 at 8:17 PM
Now out in @narjournal.bsky.social - BAHCC1 promotes gene expression in neuronal cells by antagonizing SIN3A–HDAC1
New preprint 🖨️🚨 "BAHCC1 promotes gene expression in neuronal cells by antagonizing SIN3A-HDAC1" - part I of @alanmonziani.bsky.social 's PhD. How is the activity of the SIN3A complex that are supposed to be repressive (HDAC1) yet occupies active regions regulated? A🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
BAHCC1 promotes gene expression in neuronal cells by antagonizing SIN3A-HDAC1
Chromatin modifications play a key role in regulating gene expression during development and adult physiology. Histone acetylation, particularly H3K27ac, is associated with increased activity of gene ...
www.biorxiv.org
January 28, 2025 at 8:15 PM
New preprint 🖨️🚨 "BAHCC1 promotes gene expression in neuronal cells by antagonizing SIN3A-HDAC1" - part I of @alanmonziani.bsky.social 's PhD. How is the activity of the SIN3A complex that are supposed to be repressive (HDAC1) yet occupies active regions regulated? A🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Nature research paper: UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors
https://go.nature.com/3QdrVMq
https://go.nature.com/3QdrVMq
UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors - Nature
UM171 promotes corepressor degradation by acting as a molecular glue to induce KBTBD4–HDAC1/2 interactions with the help of inositol hexakisphosphate.
go.nature.com
February 13, 2025 at 8:48 AM
Nature research paper: UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors
https://go.nature.com/3QdrVMq
https://go.nature.com/3QdrVMq
Check out my new epigenetics blog for @activemotifusa.bsky.social!
#Epigenetics #Blogs #HDAC #Glioblastoma
www.activemotif.com/blog-hdac1-c...
#Epigenetics #Blogs #HDAC #Glioblastoma
www.activemotif.com/blog-hdac1-c...
HDAC1 Condensate Formation – A Critical Mediator of Chemotherapeutic Resistance in Glioblastoma
An exciting new study reveals that HDAC1 condensate formation underpins the temozolomide resistance observed during glioblastoma treatment. This previously unrecognized regulatory mechanism may highli...
www.activemotif.com
June 1, 2026 at 6:24 AM
Check out my new epigenetics blog for @activemotifusa.bsky.social!
#Epigenetics #Blogs #HDAC #Glioblastoma
www.activemotif.com/blog-hdac1-c...
#Epigenetics #Blogs #HDAC #Glioblastoma
www.activemotif.com/blog-hdac1-c...
#WeekendRead! #FungiPower! Kuchler, Penninger &co show @cellreports.bsky.social that HDAC1 tunes down the response of CD4+ Th17 cells that otherwise would produce excessive IL17A & GM-CSF with deleterious effects on structural kidney cells during invasive fungal infections!
HDAC1 fine-tunes Th17 polarization in vivo to restrain tissue damage in fungal infections
The mechanisms whereby histone deacetylases control effector functions of T helper subsets in antifungal immunity remain enigmatic. Penninger et al. utilize a T cell-specific deletion of murine histone deacetylase 1 to demonstrate that HDAC1 attenuates the inflammatory capacity of Th17 responses in invasive fungal infections to avoid immunopathology.
www.cell.com
December 29, 2024 at 3:42 PM
#WeekendRead! #FungiPower! Kuchler, Penninger &co show @cellreports.bsky.social that HDAC1 tunes down the response of CD4+ Th17 cells that otherwise would produce excessive IL17A & GM-CSF with deleterious effects on structural kidney cells during invasive fungal infections!
HDAC1 condensation is responsible for temozolomide resistance in glioblastoma by recruiting CCCTC-binding factor and remodeling chromatin in a deacetylase-independent manner
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Deacetylase-independent HDAC1 condensation defines temozolomide response in glioblastoma - Nature Chemical Biology
Zhang et al. found that histone deacetylase 1 (HDAC1) condensation is responsible for temozolomide resistance in glioblastoma by recruiting CCCTC-binding factor and remodeling chromatin in a deacetyla...
www.nature.com
January 16, 2026 at 8:44 PM
HDAC1 condensation is responsible for temozolomide resistance in glioblastoma by recruiting CCCTC-binding factor and remodeling chromatin in a deacetylase-independent manner
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Epigenetics Update - A Lactate–H4K12la–HDAC1 epigenetic axis governs microglial state transitions during experimental autoimmune encephalomyelitis in female mice u.epigenome.us/jLW1B75s
#Epigenetics #Chromatin #MultipleSclerosis #H4K12la #HDAC #Microglia
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Gain hi-res insight; epigenometech.com
#Epigenetics #Chromatin #MultipleSclerosis #H4K12la #HDAC #Microglia
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Gain hi-res insight; epigenometech.com
September 11, 2026 at 6:40 AM
Epigenetics Update - A Lactate–H4K12la–HDAC1 epigenetic axis governs microglial state transitions during experimental autoimmune encephalomyelitis in female mice u.epigenome.us/jLW1B75s
#Epigenetics #Chromatin #MultipleSclerosis #H4K12la #HDAC #Microglia
---
Gain hi-res insight; epigenometech.com
#Epigenetics #Chromatin #MultipleSclerosis #H4K12la #HDAC #Microglia
---
Gain hi-res insight; epigenometech.com
Nature research paper: Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations
https://go.nature.com/3WZ9ije
https://go.nature.com/3WZ9ije
Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations - Nature
We show that gain-of-function cancer mutations in the KBTBD4 E3 ligase promote neodegradation of substrates via a shape-complementarity-based mechanism, which converges with the mechanism of action of the UM171 molecular glue degrader and can be blocked by HDAC1/2 inhibitors.
go.nature.com
February 13, 2025 at 7:27 PM
Nature research paper: Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations
https://go.nature.com/3WZ9ije
https://go.nature.com/3WZ9ije
HDAC1 controls the generation and maintenance of effector-like CD8⁺ T cells during chronic viral infection, say Ramona Rica, Monika Waldherr, Emi Miyakoda, Shinya Sakaguchi and colleagues @meduniwien.ac.at: rupress.org/jem/article/...
#LymphocyteBiology
#LymphocyteBiology
June 11, 2025 at 1:54 PM
HDAC1 controls the generation and maintenance of effector-like CD8⁺ T cells during chronic viral infection, say Ramona Rica, Monika Waldherr, Emi Miyakoda, Shinya Sakaguchi and colleagues @meduniwien.ac.at: rupress.org/jem/article/...
#LymphocyteBiology
#LymphocyteBiology
Rica, Waldherr, Miyakoda, Sakaguchi et al. @meduniwien.ac.at demonstrate that HDAC1 promotes an open chromatin state at effector-like signature gene loci in exhausted T cell progenitors and thereby primes cell fate specification toward effector-like exhausted T cells rupress.org/jem/article/...
June 4, 2025 at 7:49 PM
Rica, Waldherr, Miyakoda, Sakaguchi et al. @meduniwien.ac.at demonstrate that HDAC1 promotes an open chromatin state at effector-like signature gene loci in exhausted T cell progenitors and thereby primes cell fate specification toward effector-like exhausted T cells rupress.org/jem/article/...
Nuclear cGAS inhibits stimulation-induced inflammatory gene transcription via HDAC1:
www.pnas.org/doi/10.1073/...
#cGAMP @pnas.org
www.pnas.org/doi/10.1073/...
#cGAMP @pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
September 29, 2026 at 4:29 PM
Nuclear cGAS inhibits stimulation-induced inflammatory gene transcription via HDAC1:
www.pnas.org/doi/10.1073/...
#cGAMP @pnas.org
www.pnas.org/doi/10.1073/...
#cGAMP @pnas.org
Nzf2 promotes oligodendrocyte differentiation and regeneration via repressing HDAC1-mediated histone deacetylation
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Nzf2 promotes oligodendrocyte differentiation and regeneration via repressing HDAC1-mediated histone deacetylation
Nzf2 promotes oligodendrocyte differentiation and regeneration via repressing histone deacetylation.
www.science.org
December 18, 2024 at 9:59 AM
Nzf2 promotes oligodendrocyte differentiation and regeneration via repressing HDAC1-mediated histone deacetylation
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
HDAC1 modulates sepsis-induced immunosuppression by driving the exhaustion of CD8+ T cells @insight.jci.org
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
February 24, 2026 at 5:49 PM
HDAC1 modulates sepsis-induced immunosuppression by driving the exhaustion of CD8+ T cells @insight.jci.org
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
David has done fantastic work with Shaun Cowley employing our dTAG system for interrogating transcriptional complexes including HDACs.
David's latest work:
academic.oup.com/nar/advance-...
David's latest work:
academic.oup.com/nar/advance-...
Rapid degradation of histone deacetylase 1 (HDAC1) reveals essential roles in both gene repression and active transcription
Abstract. Histone Deacetylase 1 (HDAC1) removes acetyl groups from lysine residues on core histones, a critical step in regulating chromatin accessibility.
academic.oup.com
December 21, 2024 at 12:52 AM
David has done fantastic work with Shaun Cowley employing our dTAG system for interrogating transcriptional complexes including HDACs.
David's latest work:
academic.oup.com/nar/advance-...
David's latest work:
academic.oup.com/nar/advance-...
🎯 Target for #immunotherapy:
A #MedUniVienna study shows #HDAC1 supports antiviral #Tcells under chronic infection & exhaustion. Published in @jem.org, findings may aid development of therapies for #chronicinfections like #HIV, #HepatitisB & #HepatitisC. ⬇️
A #MedUniVienna study shows #HDAC1 supports antiviral #Tcells under chronic infection & exhaustion. Published in @jem.org, findings may aid development of therapies for #chronicinfections like #HIV, #HepatitisB & #HepatitisC. ⬇️
New target identified for the development of specific immunotherapies
Find out more!
www.meduniwien.ac.at
June 10, 2025 at 12:07 PM
🎯 Target for #immunotherapy:
A #MedUniVienna study shows #HDAC1 supports antiviral #Tcells under chronic infection & exhaustion. Published in @jem.org, findings may aid development of therapies for #chronicinfections like #HIV, #HepatitisB & #HepatitisC. ⬇️
A #MedUniVienna study shows #HDAC1 supports antiviral #Tcells under chronic infection & exhaustion. Published in @jem.org, findings may aid development of therapies for #chronicinfections like #HIV, #HepatitisB & #HepatitisC. ⬇️
These data are in agreement with www.nature.com/articles/s41... from @dremilygoldberg.bsky.social showing that HDAC1-3 can acylate proteins using fatty acids rather than their acyl-CoA derivatives as substrates. This raises many questions about epigenomic regulation via changes in metabolism.
Reversible histone deacetylase activity catalyzes lysine acylation - Nature Chemical Biology
Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...
www.nature.com
May 30, 2025 at 8:03 PM
These data are in agreement with www.nature.com/articles/s41... from @dremilygoldberg.bsky.social showing that HDAC1-3 can acylate proteins using fatty acids rather than their acyl-CoA derivatives as substrates. This raises many questions about epigenomic regulation via changes in metabolism.
If you missed our April Variant Effects Seminars, they're now on our YouTube channel. Olivia Zhang (Liau Lab, Harvard University) spoke about her work on how KBTBD4 cancer hotspot mutations drive neomorphic degradation of HDAC1/2 corepressor complexes.
Watch now: youtu.be/K3Nk6_ecH5U?...
Watch now: youtu.be/K3Nk6_ecH5U?...
KBTBD4 Cancer Hotspot Mutations Drive Neomorphic Degradation of HDAC1/2 Corepressor Complexes
YouTube video by Variant Effects
www.youtube.com
April 16, 2026 at 7:45 AM
If you missed our April Variant Effects Seminars, they're now on our YouTube channel. Olivia Zhang (Liau Lab, Harvard University) spoke about her work on how KBTBD4 cancer hotspot mutations drive neomorphic degradation of HDAC1/2 corepressor complexes.
Watch now: youtu.be/K3Nk6_ecH5U?...
Watch now: youtu.be/K3Nk6_ecH5U?...
HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection
@jem.org
rupress.org/jem/article/...
@jem.org
rupress.org/jem/article/...
June 5, 2025 at 1:07 AM
HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection
@jem.org
rupress.org/jem/article/...
@jem.org
rupress.org/jem/article/...
🧬 New study reveals: The enzyme HDAC1 acts as a tumour suppressor in T-cell lymphomas
Researchers from #MedUniVienna and international partners identified HDAC1 as a key protective factor against the growth of #ALCL, an aggressive #lymphoma subtype.
🔗 Published in Leukemia
Researchers from #MedUniVienna and international partners identified HDAC1 as a key protective factor against the growth of #ALCL, an aggressive #lymphoma subtype.
🔗 Published in Leukemia
Enzyme identified as a tumour inhibitor in T-cell lymphomas
Read more about the study!
www.meduniwien.ac.at
May 19, 2025 at 1:06 PM
🧬 New study reveals: The enzyme HDAC1 acts as a tumour suppressor in T-cell lymphomas
Researchers from #MedUniVienna and international partners identified HDAC1 as a key protective factor against the growth of #ALCL, an aggressive #lymphoma subtype.
🔗 Published in Leukemia
Researchers from #MedUniVienna and international partners identified HDAC1 as a key protective factor against the growth of #ALCL, an aggressive #lymphoma subtype.
🔗 Published in Leukemia
A Collaboration Paper with Philipp:
“HDAC1 Fine-Tunes Th17 Polarization In Vivo to Restrain Tissue Damage in Fungal Infections”
www.cell.com/cell-reports...
“HDAC1 Fine-Tunes Th17 Polarization In Vivo to Restrain Tissue Damage in Fungal Infections”
www.cell.com/cell-reports...
December 1, 2024 at 11:53 AM
A Collaboration Paper with Philipp:
“HDAC1 Fine-Tunes Th17 Polarization In Vivo to Restrain Tissue Damage in Fungal Infections”
www.cell.com/cell-reports...
“HDAC1 Fine-Tunes Th17 Polarization In Vivo to Restrain Tissue Damage in Fungal Infections”
www.cell.com/cell-reports...
Personalized Medicine for Meningiomas: Drug Screening on Tumor Organoids Exposes Therapeutic Vulnerabilities to HDAC1/2i Panobinostat https://www.biorxiv.org/content/10.1101/2024.11.26.625347v1
Personalized Medicine for Meningiomas: Drug Screening on Tumor Organoids Exposes Therapeutic Vulnerabilities to HDAC1/2i Panobinostat https://www.biorxiv.org/content/10.1101/2024.11.26.625347v1
Managing aggressive meningiomas remains challenging due to limited treatment options besides surgica
www.biorxiv.org
December 1, 2024 at 8:48 AM
Personalized Medicine for Meningiomas: Drug Screening on Tumor Organoids Exposes Therapeutic Vulnerabilities to HDAC1/2i Panobinostat https://www.biorxiv.org/content/10.1101/2024.11.26.625347v1
Bu süreçte FXR’yi aktifleştirmek, HDAC1’i baskılamak veya safra asidi taşıyan BSEP’i artırmak, hasarı azaltabiliyormuş. Bulgular, FXR'yi hedef alan ilaçlara dair umut verici bir yol açmış.
April 30, 2025 at 3:40 PM
Bu süreçte FXR’yi aktifleştirmek, HDAC1’i baskılamak veya safra asidi taşıyan BSEP’i artırmak, hasarı azaltabiliyormuş. Bulgular, FXR'yi hedef alan ilaçlara dair umut verici bir yol açmış.
TOMORROW: PIN PhD candidate Mikah Greene will present his thesis proposal from the Lobo Lab - CRISPR epigenome editing of Hdac1 in D1-MSNs during fentanyl abstinence. Come show your support at 10:00 in the HSF II auditorium! @marykaylobo.bsky.social
April 29, 2026 at 5:38 PM
TOMORROW: PIN PhD candidate Mikah Greene will present his thesis proposal from the Lobo Lab - CRISPR epigenome editing of Hdac1 in D1-MSNs during fentanyl abstinence. Come show your support at 10:00 in the HSF II auditorium! @marykaylobo.bsky.social