#JACCBTS
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jaccjournals.bsky.social
Stay connected & share your insights with the JACC Journals community by using our hashtags & tagging @jaccjournals.bsky.social:
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🔬 #JACCBTS
💙 #JACCCardioOnc
🩺 #JACCCaseReports
⚡️ #JACCCEP
❤️ #JACCHF
🩻 #JACCIMG
🚀 #JACCINT
📚 #JACCJournals
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November 22, 2024 at 7:21 PM
cardioobdoc.bsky.social
Interesting study from Peter Stone group showing WSS Metrics Associate With Proinflammatory Pathways at Culprit Site of Coronary Erosion

#JACCBTS #CardioSky
@jaccjournals.bsky.social @accintouch.bsky.social
www.jacc.org/doi/10.1016/...
November 26, 2024 at 8:02 PM
cardioobdoc.bsky.social
Recent Pathophysiological Insights Are Advancing Treatment of Venous Thromboembolism #VTE

#CardioSky #JACCBTS
www.jacc.org/doi/10.1016/...
@jaccjournals.bsky.social @gbarnesmd.bsky.social @heatherlgornik.bsky.social
March 5, 2025 at 7:18 PM
cardiometabosci.bsky.social
Using a robust preclinical rat model of HFpEF, Dr. Andrew Gibb and colleagues identified disruptions in mitochondrial function and metabolism as key contributors to HFpEF pathophysiology. Check out the research manuscript and accompanying editorial out now in #JACCBTS. #cardiosky
August 19, 2025 at 4:34 AM
haoyin.bsky.social
#CircularRNA #Atherosclerosis

CircBTBD7-encoded 420 aa peptide ⏬#SmoothMuscleCell proliferation migration
via binding to &⏫ubiquitin-proteasome degradation of SLC3A2

Lentiviral CircBTBD7-420aa⏬plaque size in🐭#Atherosclerosis

#JACCBTS 2025
www.sciencedirect.com/science/arti...
March 27, 2025 at 11:50 AM
jaccjournals.bsky.social
Exciting news! 🎉

Matthias Nahrendorf, MD, PhD, has been named Editor-in-Chief of #JACCBTS! A leader in CV research, imaging & immunology, he brings a passion for collaboration & scientific excellence.

Please join us in welcoming him to this important role 👏👏 👏

📎: www.jacc.org/announcement...
May 5, 2025 at 6:48 PM
jaccjournals.bsky.social
🩸 New #JACCBTS study reveals estrogen’s dual effects on microvascular health differ by sex

⚖️ A balanced ceramide: S1P ratio is 🔑 to endothelial health
🧬 May explain why long-term hormone exposure can 📈 CV risk

🔗 https://bit.ly/43Ct5In

#APSSexDiff2025 #CardioSky #MedSky
October 25, 2025 at 11:05 PM
haoyin.bsky.social
#AortaEd
#Diabetes

⬆️HbA1c level (even in normal range) is associated with ⬇️asc/desc thoracic aortic diameter & ⬇️risk for Aneurysm/Dissection

Multi-omics #UKBiobank Mendelian Randomization analyses➡️a causal link b/w glycemic traits / #T2D & TAAD risk

#JACCBTS 2025
www.jacc.org/doi/10.1016/...
November 29, 2025 at 11:47 AM
haoyin.bsky.social
A workflow to optimize siRNA targeting SMILR #LncRNA & #SmoothMuscleCell proliferation/migration ex vivo

30 min siRNA exposure is sufficient to penetrate ~10 lamellar layers of explanted saphenous vein media

Polyethylenimine as siRNA delivery agent

#JACCBTS 2025
www.jacc.org/doi/10.1016/...
October 11, 2025 at 7:01 PM
jeffhsumd.bsky.social
Great summary of new #JACCBTS study on #LongCOVID inflammatory platelet activation

From STAR UCLA cardiology fellow & @jaccjournals.bsky.social SoMe Coordinator @michaelraddatz.bsky.social #bruinhearts

👇🏼
michaelraddatz.bsky.social Michael Raddatz @michaelraddatz.bsky.social · Jan 27
In this month’s issue of #JACCBTS, Brambilla, et al. explore the role of platelet function in long COVID. Read below ⬇️ to see what they found! 🧵
1/n
@jeffhsumd.bsky.social @jaccjournals.bsky.social @vascularimmuno.bsky.social @jeanwassenaar.bsky.social
Title page of paper entitled "Low-Grade Inflammation in Long COVID Syndrome Sustains a Persistent Platelet Activation Associated With Lung Impairment"
January 28, 2025 at 1:03 AM
michaelraddatz.bsky.social
In these uncertain times, celebrating novel science is one way to stay grounded and hopeful. In this month’s issue of #JACCBTS, Song, et al. investigate mitochondrial function in aortic valve calcification. Join me to see what they found! 🧵
1/10

@jaccjournals.bsky.social
Title page of a paper titled Spermidine Enhances Mitochondrial Function and Mitigates Aortic Valve Calcification
March 24, 2025 at 3:35 PM
cardiometabosci.bsky.social
Congratulations to Dr. Gibb, an Assistant Professor in the Center, for being named as one of the 2025 Top Reviewers for #JACCBTS. We are proud of your accomplishments!
April 6, 2026 at 2:38 PM
jeanwassenaar.bsky.social
follow @michaelraddatz.bsky.social, @jeffhsumd.bsky.social, and @vascularimmuno.bsky.social and I for more exciting science from #JACCBTS!
March 3, 2025 at 10:30 PM
jaccjournals.bsky.social
New #JACCBTS issue dives into the overlooked cardiohepatic axis, highlighting heart-liver crosstalk in metabolic syndrome, #heartfailure, and cirrhosis. Explore how this interplay is reshaping our understanding of heart health: www.jacc.org/toc/basic-tr... #CardioSky #MedSky
July 29, 2025 at 6:23 PM
michaelraddatz.bsky.social
In this month’s issue of #JACCBTS, Brambilla, et al. explore the role of platelet function in long COVID. Read below ⬇️ to see what they found! 🧵
1/n
@jeffhsumd.bsky.social @jaccjournals.bsky.social @vascularimmuno.bsky.social @jeanwassenaar.bsky.social
Title page of paper entitled "Low-Grade Inflammation in Long COVID Syndrome Sustains a Persistent Platelet Activation Associated With Lung Impairment"
January 27, 2025 at 11:44 PM
michaelraddatz.bsky.social
In this month’s issue of #JACCBTS, Jønck, et al. explore the effects of cytokine inhibitors on cardiovascular adaptability in rheumatoid arthritis (RA). Read below to see what they found! 🧵
1/9
@jaccjournals.bsky.social
Title page of a paper titled IL-6 inhibitors and TNF inhibitors: Impact on Exercise-induced Cardiac Adaptations in Patients With Rheumatoid Arthritis
May 28, 2025 at 9:10 PM
jeanwassenaar.bsky.social
I’ll always remember the first congestive hepatopathy patient I took care of as an intern @vumc.bsky.social. The pathology was so different from anything else, so when I saw an article on this in this month’s #JACCBTS I couldn’t wait to learn more about it. (🧵: 1/10) @jaccjournals.bsky.social
May 1, 2025 at 1:44 AM
jaccjournals.bsky.social
🏃‍♀️💉 In RA pts, 12 weeks of HIIT ⬆️ cMRI-based LVM (cardiac remodeling) in those on TNFi—but not in those on IL-6i.

Yet, IL-6i vs TNFi didn’t significantly alter overall exercise-induced LVM change. www.jacc.org/doi/10.1016/... #JACCBTS #Arthritis
IL-6 Inhibitors and TNF Inhibitors: Impact on Exercise-induced Cardiac Adaptations in Patients With Rheumatoid Arthritis
www.jacc.org
May 29, 2025 at 8:05 PM
jeanwassenaar.bsky.social
Ever get back a genetic report and dread seeing the words “Variant of Unknown Significance (VUS)”😱? The # of VUSs are escalating as more patients get sequenced – join me in learning about how @spfisterer.bsky.social and colleagues are helping tackle the VUS problem 🧬 in this month's #JACCBTS🧵:1/9
March 3, 2025 at 10:14 PM
jaccjournals.bsky.social
For clinical use, miR-199a-3p should be given early after #cvMI using non-viral delivery. Synthetic #miRNA mimics via lipofection show promise, but more research is needed. www.jacc.org/doi/10.1016/... #JACCBTS
Delayed miR-199a Administration After Myocardial Infarction Precludes Pro-Regenerative Effects:
www.jacc.org
June 12, 2025 at 2:57 PM
jeanwassenaar.bsky.social
Obesity is a major risk factor for HFpEF. Join me in learning about a new HFpEF model that Valero-Munoz et al developed to study how adipose tissue changes in a 🐁 model and human patients🚶‍♂️in this month's #JACCBTS @jaccjournals.bsky.social . 🧵: 1/8
September 5, 2025 at 12:41 PM
jeanwassenaar.bsky.social
Balancing the risk for clotting and bleeding is constant challenge for cardiologists, so I was very excited to see in this month’s #JACCBTS work on targeting different parts of the coagulation cascade (Factor 11, FXI) to reduce bleeding risk while lowering risk for thrombosis. 🧵: 1/8
July 15, 2025 at 9:48 PM
jeanwassenaar.bsky.social
In summary, @spfisterer.bsky.social and co-authors created a semi-automated way to predict how variants in the LDLR gene will affect cholesterol and CVD risk, to tackle the ever-growing VUS problem! Read more in this month’s #JACCBTS! @jaccjournals.bsky.social 🧵:8/8
March 3, 2025 at 10:29 PM
michaelraddatz.bsky.social
2/
The authors previously showed in #JACCBTS that post-COVID pts have ⬆️ platelet activation: www.jacc.org/doi/10.1016/.... However, they looked to test this in Long COVID syndrome. Long COVID patients in this study were those who continued to have symptoms 6 mos post-infection. 🤒
Platelet and Endothelial Activation as Potential Mechanisms Behind the Thrombotic Complications of COVID-19 Patients:
Discover why JACC is the ultimate publishing partner for your cardiovascular research.
www.jacc.org
January 27, 2025 at 11:44 PM
michaelraddatz.bsky.social
9/9
In summary, CRP-rich plasma from Long COVID patients ⬆️ platelet activation, and platelet activation correlates with the severity of 🫁 damage. Platelet activation is reversible with aspirin or P2Y12. Read the paper in this month’s issue of #JACCBTS! doi.org/10.1016/j.ja...
January 27, 2025 at 11:44 PM