#BMP9
LightNews LightNews
haoyin.bsky.social
CDK4/6
Endothelial Cell Cycle
#ArterioVenousMalformation
#HereditaryHemorrhagicTelangiectasia

Evidence from
👉🐭Retina +BMP9/10 blocking Ab +Palbociclib Ribociclib
👉🐭EC Eng KO Retina 🧠 +Palbociclib
👉🐭EC Cdk6 KO Retina +BMP9/10 Ab
👉👤HHT2 (ALK1) Skin

#NatureCVR 2024
www.nature.com/articles/s44...
June 8, 2026 at 6:08 PM
haoyin.bsky.social
How BMP9/10 induces Endothelial Cell Quiescence?

#Phosphoproteome HUVEC+BMP9/10
>3k phosphoproteins (289 DpP)
>12k phosphosites (419 DpPs)

Cell cycle kinases inferred
CDK4/6⬇️
CDC7⬇️
PLK3⬇️(BMP9 only)
CHK1⬆️

#CellCommunSignal 2024
link.springer.com/article/10.1...
June 2, 2026 at 11:39 AM
haoyin.bsky.social
Liver #EndothelialCell Zonation
#SciArt

Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction (by Hepatocytic BMP9)

@cp-cellstemcell.bsky.social 2022
www.cell.com/cell-stem-ce...
February 28, 2025 at 12:21 PM
haoyin.bsky.social
BMP10 KO alone, but not BMP9 KO alone, induces #ArterioVenousMalformation in 🐭Retina Brain wounded Skin

ROSA26-CreER; Bmp10 f/f vs Bmp9-/- vs compound KO
B6/129 strain

Exogenous BMP10, not BMP9, rescues retinal vascularization in BMP9/10 dKO🐭

#Angiogenesis 2023
link.springer.com/article/10.1...
May 31, 2026 at 12:46 PM
haoyin.bsky.social
#ArterioVenousMalformation
#HereditaryHemorrhagicTelangiectasia

Endothelial Cell KLF4 hyperactivation➡️
⏫EC Proliferation
⏬EC PDGFB➡️
⏬NG2+PDGFRβ+ Pericyte investment on AVM lesion

Evidence from
1⃣🐭 Retina +BMP9/10 Ab +EC Alk1 or Smad4 KO
2⃣HHT2👤 Nasal mucosa

#THNO 2026
www.thno.org/v16p4905.htm
June 9, 2026 at 12:30 PM
ats-pc.bsky.social
On Lombard St B19 - Cellular Pathophysiology of Pulmonary Vascular Disease: From epigenetic and molecular drivers to treatment targets. Featuring
@navneetsinghmd.bsky.social from @brownpvd.bsky.social discussing his work with hepatic inflammation, BMP9 and PAH 🧬
May 19, 2025 at 6:03 PM
torilhol.bsky.social
It is still possible to sign up for the conference on Bone Morphogenetic Proteins in May! 🧬🧶🧪🩸🔬👩‍🔬🦴🩺🤗 #BMP #activin #SMAD #ACVR1 #BMPR2 #BMP9 #ACVRL1
www.14thbmpconference2025.com
University of Pennsylvania | 14th International BMP Conference
It is our great pleasure to welcome you to the 14th International Bone Morphogenetic Protein (BMP) Conference, held at the University of Pennsylvania's Smilow Center for Translational Research in Phil...
www.14thbmpconference2025.com
March 11, 2025 at 6:59 AM
haoyin.bsky.social
CDK4/6
Endothelial Cell Cycle
#ArterioVenousMalformation
#HereditaryHemorrhagicTelangiectasia

Evidence from
👉Fucci2🐭 (fluorescent cell cycle reporter) Retina +BMP9/10 blocking Ab
+Palbociclib CDK4/6i

👉🐭EC ALK1 KO👁️🧠
+Palbociclib
👉👤HHT2 Skin biopsy

#CircAHA 2024
www.ahajournals.org/doi/full/10....
June 11, 2026 at 12:08 PM
genesndiseases.bsky.social
LGR4 enhances #BMP9-induced #osteogenesis in #MesenchymalStemCells via mTORC1/Stat3 signaling, promoting bone formation while its inhibition shifts differentiation toward #adipogenesis, highlighting LGR4 as a key target in #BoneTissueEngineering.

#OpenAccess: doi.org/10.1016/j.ge...
BMP9 induces osteogenic differentiation through up-regulating LGR4 via the mTORC1/Stat3 pathway in mesenchymal stem cells
April 9, 2026 at 3:00 PM
torilhol.bsky.social
Our preprint is out! We induced apoptosis in myeloma cells with BMP9 and did a whole genome KO screen to find regulators of apoptosis (and BMP-SMAD signaling). ID3 induced by SMAD activity inhibited TCF3 and induced apoptosis.
This was the main work in Clara Andersson-Rusch's PhD. Have a look! 👇
biorxiv-cancer.bsky.social bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · Sep 13
Whole genome CRISPR knockout screen reveals ID3 as a key regulator of myeloma cell survival via TCF3 and c-MYC https://www.biorxiv.org/content/10.1101/2025.09.09.675036v1
September 17, 2025 at 7:47 PM
jlroberson.bsky.social
A completely unintentional, but now rather weirdly timely, fable from Syd www.youtube.com/watch?v=bMp9...
Effervescing elephant-Syd Barrett
YouTube video by Zhu Ming
www.youtube.com
September 16, 2025 at 12:42 AM
armaturesmusic.bandcamp.com
Its BC friday, here's some codes for 4 different albums

-Osprey
yelz-wvxw
jnbc-yjw9
c28w-ucbk
plz4-jxd9
8ctq-y5wt

-Limitation
v8v5-yayl
fkb9-772j
pydn-7gam
zrg5-u2j5
bg55-bmp9

-Remixes
v6wp-w784
7yhg-ce7m
x2e3-w3p6
9byh-jsaf
yxuj-ys3a

-Coplanar
7eej-exnt
5vfb-52ea
b9al-bcfb
52fq-xhex
rva7-e52p
August 7, 2026 at 11:15 AM
osteoporosis-nl.bsky.social
BMP9 enhances osteogenic differentiation in rheumatoid arthritis. BMP9 is down-regulated in synovial tissue of RA patients. In arthritis mice model BMP9 enhances osteogenic differentiation of synovial cells. Han Zhang et al. J Transl Med 2025 Feb 28 tinyurl.com/y65xbekk
March 3, 2025 at 9:12 AM
haoyin.bsky.social
A complex role of #EndopthelialCell mTORC1 in 🐭retinal #ArterioVenousMalformation
inducible EC Endoglin KO

👉mTORC1⬆️in AVM only
👉Rapamycin⏬AVM
👉EC Raptor (mTORC1 adaptor) KO mildly⏬AVM
👉EC TSC1 (mTORC1 suppressor) KO⏬AVM induced by BMP9/10 Ab

#Angiogenesis 2024
link.springer.com/article/10.1...
January 30, 2025 at 8:25 PM
genesndiseases.bsky.social
This study shows that LGR4 augments the osteoblastic potential of BMP9 in #MesenchymalStemCells, and BMP9 may up-regulate LGR4 via activating the mTORC1/Stat3 signal pathway. #osteogenesis #BoneRegeneration #TissueEngineering #medsky

#OpenAccess:
May 25, 2025 at 12:30 PM
biorxivpreprint.bsky.social
Exogenous BMP9 therapy ameliorates primary graft dysfunction post lung transplantation https://www.biorxiv.org/content/10.1101/2025.09.30.679530v1
October 2, 2025 at 2:16 AM
genesndiseases.bsky.social
This study reveals that #BMP9 regulates tooth root development by modulating cell proliferation and intercellular junctions in HERS, highlighting BMP9 signaling as a promising target for regenerative dental therapies.
#OpenAccess: doi.org/10.1016/j.ge...
May 30, 2026 at 1:31 PM
haoyin.bsky.social
#BMP9 #MyocardialInfarction

BMP9 expressed by #EndothelialCell #CardiacFibroblast Not #Cardiomyocyte

BMP9 KO🐭post-MI->
⏬Survival
⏫TGFβ signal, #CardiacFibrosis, MMP9

How about #Angiogenesis/#EndMT?🧐

Navin Kapur lab #JACCBTS 2023
www.sciencedirect.com/science/arti...
November 10, 2023 at 4:59 PM
haoyin.bsky.social
Germline Bmp9 KO🐭, Not Bmp10 KO🐭or BMP9-neutralizing Ab

Normoxia
⏬muscularized pulmonary arterioles

Normoxia + Tamoxifen (Not Cre off-target effects)
Cardiomegaly
Splenomegaly
⏬alveolar space
⏫🫁iron-loaded Mφ

#Angiogenesis 2025
link.springer.com/article/10.1...
November 14, 2025 at 7:59 PM
rridrobot.bsky.social
@thermofishersci.bsky.social's resource, RRID:AB_2536183, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #OpenResearch #reproducibility #RRID
Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe
Read the full paper: Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe
doi.org
February 7, 2026 at 8:00 AM
jeromejatzlau.bsky.social
Within our study, where we used Halo-tagged BMP/TGFβ receptors for quantification of cell surface ligand binding, we compared BMP9 binding to different Teleost ALK1 receptors. Interestingly, BMP9 binding was not similar, but signaling was.
#science #DALLE3
nature.com/articles/s4200…
November 18, 2023 at 11:30 AM
rridrobot.bsky.social
The authors included RRIDs in their Structure paper! We value the author's support of reproducibility. #reproducibility #accelerateopenscience #reproducibility
Unprocessed BMP9 precursor is an intrinsic antagonist for its active growth factor
doi.org
June 1, 2025 at 7:00 AM
rridrobot.bsky.social
RRID:AB_11145462 was used by the authors of the Journal of Translational Medicine paper "BMP9 enhances osteogenic differentiation in rheumatoid arthritis: a potential therapeutic approach". Thank you for making your methods matter! #ReproducibleResearch #OpenScience
doi.org
March 30, 2025 at 7:00 AM
haoyin.bsky.social
Microvascular dysmorphogenesis in BMP9 KO 129/Ola🐭

👉Liver 25~30 wk
⬆️Proliferation of hepatocytes & non-parenchymal cells

👉Kidney 17 wk
⬆️Glomerular capillary size
⬆️Renal fibrosis
⬇️Podocyte

👉 #ArterioVenousMalformation in Liver/Intestine/Uterus

#CardiovascRes 2024
academic.oup.com/cardiovascre...
June 1, 2026 at 11:06 AM
aitechnews-247.bsky.social
Trump and Obama Share Unexpectedly Friendly Moment at Jimmy Carter’s Funeral

www.youtube.com/watch?v=BMP9...

#TrumpAndObama #JimmyCarterFuneral #PresidentialUnity #StateFuneral #USPresidents #HistoricalMoment #Politics #HumanitarianLegacy #DonaldTrump #BarackObama
Trump and Obama Share Unexpectedly Friendly Moment at Jimmy Carter’s Funeral #TrumpAndObama #Carter
YouTube video by Quick Global News
www.youtube.com
January 10, 2025 at 2:19 PM