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New in JLR press| The monoacylglycerol acyltransferase 2 inhibitor VB-85387 reduces MASLD.
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Fig. 2. VB-85387 attenuates LMCD-induced hepatic steatosis and fibrosis in female mice.
September 25, 2026 at 9:58 PM
realbiomassspec.bsky.social
The Bioactive Sphingolipid Playbook. A Primer for the Uninitiated as well as Sphingolipidologists #JLipidRes #MassSpec www.jlr.org/article/S002...
The Bioactive Sphingolipid Playbook. A Primer for the Uninitiated as well as Sphingolipidologists
Sphingolipids and glycosphingolipids are among the most structurally diverse and complex compounds in the mammalian metabolome. They are well known to play important roles in biological architecture, ...
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April 19, 2025 at 6:59 AM
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Phosphatidylcholine synthesis and remodeling in #brain #endothelial #cells #JLipidRes #ThieleLab @unibonn.bsky.social #alkyne #tracer; #lipidomics; #lysophosphatdiylcholine; #phospholipase shorturl.at/NGLyE
Phosphatidylcholine synthesis and remodeling in brain endothelial cells
Mammalian cells synthesize hundreds of different variants of their prominent membrane lipid phosphatidylcholine (PC), all differing in the side chain …
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March 13, 2025 at 12:09 PM
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At the #JLipidRes session on #lipids in cell communication and metabolism, speakers will share new insights into signaling, inflammation, immunity and metabolic disease.
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☑️ Late-breaking abstracts open soon!
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#ASBMB26 #MakeItPossible
Promotional graphic for the 2026 ASBMB Annual Meeting scientific symposium on lipids in cell–cell communication and metabolism in health and disease. It features photos of organizers Nada Abumrad And Michele Alves-Bezerra.
November 25, 2025 at 3:05 AM
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Dysregulated metabolism of ceramides and glycosphingolipids in Parkinson’s Disease #JLipidRes #MassSpec www.jlr.org/article/S002...
Dysregulated metabolism of ceramides and glycosphingolipids in Parkinson’s Disease
Alterations in sphingolipid metabolism have been implicated in the pathogenesis of Parkinson's disease (PD), yet findings regarding peripheral sphingolipid changes remain inconsistent. This study aime...
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December 6, 2025 at 12:11 PM
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Chemical engineer–turned–biophysicist Matthew Mitsche uses curiosity, coding and creativity to tackle lipid biology, uncovering PNPLA3’s role in fatty liver disease and advancing mass spec tools for studying complex lipid systems.
www.asbmb.org/asbmb-... #JLipidRes
Building better tools to decipher the lipidome
Chemical engineer–turned–biophysicist Matthew Mitsche uses curiosity, coding and creativity to tackle lipid biology, uncovering PNPLA3’s role in fatty liver disease and advancing mass spectrometry tools for studying complex lipid systems.
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February 21, 2026 at 5:55 PM
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New JLR virtual issue: Lipids & Inflammation

Discover how lipids regulate inflammation, tissue repair and host defense through unique signaling pathways. All articles are free to read.

➡️ Access the collection: www.jlr.org/content/lipi...
#Immunology #JLipidRes #ASBMBJournals
Close-up of yellow lipid cells with red blood cells floating nearby, illustrating lipids and inflammation for the cover of a Journal of Lipid Research virtual issue.
June 23, 2026 at 10:34 PM
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No. 9 on ASBMB Today's 2025 most-read list: Butter, olive oil or coconut oil — what’s the healthiest choice?

Researchers at @mrcepid.bsky.social analyzed how various types of dietary fats may impact the health of adults and published their results in #JLipidRes: www.asbmb.org/asbmb-....
Butter, olive oil, coconut oil — what to choose?
Depending on the chain length and origin of the fat, regular fat consumption changes the specific makeup of fats in bloodstream and affect mild to severe cholesterol patterns. Read about this recent Journal of Lipid Research study.
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December 22, 2025 at 2:46 PM
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Introduction of a Lipidomics Scoring System for data quality assessment #JLipidRes #MassSpec www.jlr.org/article/S002...
Introduction of a Lipidomics Scoring System for data quality assessment
The scientific field of lipidomics has shown a constantly growing publication number in recent years, which is accompanied by an increasing need for quality standards. While the official shorthand nom...
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April 30, 2025 at 6:42 PM
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JLR Editorial Board member Paul Huang of Fudan University will present a UPMC (@news.upmc.com) seminar on Aug. 27 at 12 p.m. EDT:

"When Immunity Redirects Lipids: Lipoprotein Transit Determines Psoriasis Comorbidities"

➡️Join virtually or in-person cim.pitt.edu/seminar-seri...
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Flyer for a University of Pittsburgh seminar by Paul Huang, Ph.D., of Fudan University, titled “When Immunity Redirects Lipids: Lipoprotein Transit Determines Psoriasis Comorbidities.” The seminar will be held Aug. 27, 2026, from 12–1 p.m. in BST 1095 and includes in-person and virtual attendance options.
August 24, 2026 at 10:35 PM
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Sphinganine as a potentially relevant metabolite in pulmonary involvement of primary Sjögren’s syndrome #JLipidRes #MassSpec www.jlr.org/article/S002...
Sphinganine as a potentially relevant metabolite in pulmonary involvement of primary Sjögren’s syndrome
Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by lymphocytic infiltration of exocrine glands and frequent extra-glandular manifestations, with pulmonary involvement b...
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December 12, 2025 at 5:12 PM
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JLR press| Scientists showed an intestinal trophic action of OCA that demonstrates a dual clinical benefit of NR1H4 agonism in the prevention of PNALD in pigs.
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October 9, 2025 at 9:46 PM
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Deep sphingolipidomic and metabolomic analyses of ceramide synthase 2 null mice reveal complex pathway-specific effects #JLipidRes #MassSpec www.jlr.org/article/S002...
Deep sphingolipidomic and metabolomic analyses of ceramide synthase 2 null mice reveal complex pathway-specific effects
The sphingolipidome contains thousands of structurally distinct sphingolipid (SL) species. This enormous diversity is generated by the combination of different long-chain-bases (LCBs), N-acyl chains a...
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May 30, 2025 at 6:25 PM
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Development and application of an LC-MS/MS method for the combined quantification of oxysterols and bile acids #JLipidRes www.jlr.org/article/S002...
Development and application of an LC-MS/MS method for the combined quantification of oxysterols and bile acids
Oxysterols and bile acids are interconnected bioactive lipids playing pivotal roles in diverse physiological and pathological processes. For this reason, they are increasingly studied together for the...
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November 18, 2024 at 11:18 AM
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New JLR press| Scientists' data highlights that CSN8/CSN is crucial for maintaining protein homeostasis in adipose tissue.
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Figure 3. Mice with adipose-specific deletion of CSN8 display insulin resistance and altered energy homeostasis.
January 28, 2026 at 11:28 PM
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Quantification of esterified oxylipins following HILIC-fractionation of lipid classes #JLipidRes #MassSpec www.jlr.org/article/S002...
Quantification of esterified oxylipins following HILIC-fractionation of lipid classes
Several oxylipins are lipid mediators derived from the oxidation of polyunsaturated fatty acids (PUFAs). The majority of oxylipins in biological samples occurs esterified in neutral lipids (nLs) and p...
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November 21, 2025 at 2:58 PM
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Spatial Lipidomic Combining DESI Imaging and LESA Mass Spectrometry to Evaluate Metabolic Alterations in Obese Zebrafish #JLipidRes www.jlr.org/article/S002...
Spatial Lipidomic Combining DESI Imaging and LESA Mass Spectrometry to Evaluate Metabolic Alterations in Obese Zebrafish
Mass Spectrometry Imaging (MSI) enables spatial mapping of metabolites but often lacks in-situ structural confirmation. To address this, we validated a workflow combining histological staining, Desorp...
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March 15, 2026 at 10:47 AM
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Integrated lipidomic and proteomic profiling reveals metabolic network disruption by SARS-CoV-2 variants #JLipidRes #MassSpec www.jlr.org/article/S002...
Integrated lipidomic and proteomic profiling reveals metabolic network disruption by SARS-CoV-2 variants
The rapid evolution of SARS-CoV-2 has produced myriad viral strains with increasing transmissibility and capacity for immune evasion. While effective vaccination campaigns have reduced the fatalities ...
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July 13, 2025 at 3:41 PM
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Circulating lipidome underpins gender differences in the pathogenesis of type 2 diabetes #JLipidRes #MassSpec www.jlr.org/article/S002...
Circulating lipidome underpins gender differences in the pathogenesis of type 2 diabetes
Metabolic alterations in human lipidome significantly impact various chronic diseases including type 2 diabetes (T2D). However, epidemiology and clinical studies have yet to identify clinically meanin...
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April 27, 2025 at 8:25 AM
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Influence of obesity and insulin resistance with hepatic steatosis on the human plasma lipidome #JLipidRes #MassSpec www.jlr.org/article/S002...
Influence of obesity and insulin resistance with hepatic steatosis on the human plasma lipidome
Insulin resistance accompanied by hepatic steatosis is a common complication of obesity. In an effort to identify plasma lipids that could be biomarkers or causes of insulin resistance with steatosis ...
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December 27, 2025 at 9:03 PM
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🧠 New research in JLR links early cognitive decline to reduced levels of protective omega-3-derived oxylipins in HDL, the so-called "good cholesterol."

Learn more: www.asbmb.org/asbmb-today/...
#Cholesterol #LipidResearch #JLipidRes #ASBMBJournals | @asbmb.bsky.social
Changes in HDL lipids linked to early cognitive decline
A targeted lipidomics study finds that the anti-inflammatory oxylipin cargo of HDL is depleted in men and Hispanic adults with mild cognitive impairment, independent of cholesterol levels.
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September 10, 2026 at 6:09 PM
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Comparison of the capillary and venous blood plasma lipidomes- validation of self-collected blood for plasma lipidomics #JLipidRes #MassSpec www.jlr.org/article/S002...
Comparison of the capillary and venous blood plasma lipidomes- validation of self-collected blood for plasma lipidomics
Venipuncture of the upper extremities is commonly used to collect blood for plasma lipidomics. However, self-administered blood collection devices such as the Tasso+TM system for capillary blood sampl...
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February 12, 2025 at 7:01 PM
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Chemical engineer–turned–biophysicist Matthew Mitsche uses curiosity, coding and creativity to tackle lipid biology, uncovering PNPLA3’s role in fatty liver disease and advancing mass spec tools for studying complex lipid systems.
www.asbmb.org/asbmb-... #JLipidRes
Building better tools to decipher the lipidome
Chemical engineer–turned–biophysicist Matthew Mitsche uses curiosity, coding and creativity to tackle lipid biology, uncovering PNPLA3’s role in fatty liver disease and advancing mass spectrometry tools for studying complex lipid systems.
www.asbmb.org
February 20, 2026 at 11:42 PM
asbmb.bsky.social
In a recent study in Journal of Lipid Research, scientists used a new imaging approach to map fentanyl’s effects on brain immune cells. Their findings could transform how addiction is assessed and lead to new diagnostic and therapeutic tools: www.asbmb.org/asbmb-.... #ASBMBJournals #JlipidRes
Mapping fentanyl’s cellular footprint
Using a new imaging method, researchers at State University of New York at Buffalo traced fentanyl’s effects inside brain immune cells, revealing how the drug alters lipid droplets, pointing to new paths for addiction diagnostics.
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December 5, 2025 at 6:03 PM
asbmb.bsky.social
X-linked adrenoleukodystrophy is a rare disorder where early diagnosis is critical.

In #JLipidRes, researchers at Teikyo University identified the enzyme that produces C26:0-LPC, a key diagnostic biomarker — advancing precision in rare disease detection.

www.teikyo-u.ac.jp/en/topics/20...
Spatial configuration of the choline group of PC in LPLAT10. A: Multiple sequence alignment of human LPLAT8–10 and docking simulations of LPLAT10 and C26:0-PC. The AGPAT motif 4 and loop domain are represented in a box, whereas the W-X-W motif is represented in a neon-green box. Conserved residues are highlighted in yellow.
February 14, 2026 at 12:15 AM