#JakStat
Neu als Open-Access-Publikation auf ART-Books:
Baumbauer, Benno, Feist, Marie-Therese und Jakstat, Sven (Hrsg.): Nürnberg GLOBAL 1300-1600, Heidelberg: arthistoricum.net, 2025.
👉 books.ub.uni-heidelberg.de//arthistoric...

#Openaccess #Ausstellungskatalog #Nürnberg #GNM
October 20, 2025 at 8:39 AM
“When one organ is wounded, how does the rest of the body know to protect itself?”
We explored exactly this question in our latest preprint 👇

🔗 www.biorxiv.org/content/10.1...
#Preprint #JAKSTAT #Regeneration #Drosophila #ImmuneSignaling #GutHomeostasis
www.biorxiv.org
October 16, 2025 at 4:20 AM
An amazing 7 year journey now finally materialising! So proud of our whole team! Special thanks to @nikfortelny.bsky.social, who went with me through several highs and lows; M. Müller, T. Decker and @bocklab.bsky.social, and the institutions including the @FWF_at for their support! #JakStat forever!
📖 Full story at Nature Immunology: www.nature.com/articles/s41... (#OpenAccess). Joint work with Vienna JAK-STAT consortium led by M. Müller (Vetmed) & T. Decker (Max Perutz Labs). Analysis led by Nikolaus Fortelny (@nikfortelny.bsky.social). Experiments led by Matthias Farlik (@mfarlik.bsky.social)
April 24, 2024 at 1:51 PM
Irgendwie ein krasses Gefühl seinen Namen so ganz offiziell unter Autor*innen zu lesen.
Samstag fahr ich gucken, was aus meinen Texten geworden ist. War schon bei einer Probe und da war es schon ergreifend Schauspieler*innen den eigenen Text spielen zu sehen.
July 1, 2025 at 8:54 PM
March 13, 2026 at 2:27 AM
Is #JAKSTAT a friend or foe in #SolidTumors?
This review reveals paradoxical roles, showing how direct inhibition fuels immune exhaustion and resistance, and proposes system‑level targeting to overcome the impasse.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
September 5, 2026 at 12:13 PM
Double strike today with our paper in @NatImmunol www.nature.com/articles/s41... and our paper together with T. Deckers lab of the @maxperutzlabs.bsky.social @MUW in @embojournal www.embopress.org/doi/full/10.... - a companion published as part of the @FWF funded SFB consortium. #JakStat forever!
Dynamic control of gene expression by ISGF3 and IRF1 during IFNβ and IFNγ signaling | The EMBO Journal
imageimageType I interferons (IFN) and IFNγ have different immunological activities. This study finds that although their signals and transcriptome changes early after receptor engagement are very sim...
www.embopress.org
April 24, 2024 at 7:08 PM
📚MedChemExpress Digest | #JAKSTAT in #AutoimmuneTreatment
🔹JAK #inhibitors: Tofacitinib, Baricitinib, Ruxolitinib; Upadacitinib 🔹Cytokine #antibodies: daclizumab, anti-IL-5, tocilizumab, siltuximab 🔹Emerging modalities: #Peptide , #oligos , #siRNAs
🔗https://ow.ly/b8Gx50Xmfqy
November 5, 2025 at 7:45 PM
📚MedChemExpress Digest | #JAKSTAT in #AutoimmuneDiseases
💊JAK inhibitors & cytokine antibodies offer safer, long-lasting remission vs. broad immunosuppressants.
🔹Cytokine → STAT: #IL12→#STAT4 | #IL4→#STAT6 | #IL6/#IL23→#STAT3 | #IL2→#STAT5
🔗https://ow.ly/eaHu50Xmfho
November 4, 2025 at 3:52 AM