#MLL2
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radaiglesiaslab.bsky.social
#Preprint alert! 📣

We are thrilled to share the work led by Lara Zorro-Shahidian and Lucio di Filippo, in which we show that #MLL2 controls gene expression in both #ESC and upon #differentiation by facilitating the #enhancer like activity of #LINE1 elements

www.biorxiv.org/cgi/content/...
MLL2 facilitates long-range gene regulation through LINE1 elements
Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 d...
www.biorxiv.org
August 13, 2025 at 5:54 AM
srinjan.bsky.social
New #preprint from the Basu & Stewart labs! We discover a non-catalytic role for H3K4me3 methyltransferase MLL2 in modulating 3D chromatin organisation and mobility as pluripotent cells are primed for differentiation.

www.biorxiv.org/content/10.1...
February 26, 2025 at 6:07 PM
pradeepmadapura.bsky.social
Check out this preprint on MLL2 by Srinjan Basu's lab @srinjan.bsky.social; I am happy to contribute a bit to this tour de force work
www.biorxiv.org/content/10.1...
February 25, 2025 at 10:41 AM
cp-molcell.bsky.social
H2AK119ub1-MLL2 counteraction underlies heritable H3K27me3 formation in oocytes
H2AK119ub1-MLL2 counteraction underlies heritable H3K27me3 formation in oocytes
Mei et al. reveal that the Polycomb mark H2AK119ub1 maintains gene silencing in mouse oocytes by opposing MLL2 activity, enabling the establishment of heritable H3K27me3. They uncover how the balance between repressive and activating chromatin mechanisms shapes the maternal epigenome.
dlvr.it
May 7, 2026 at 7:14 PM
cp-molcell.bsky.social
Online Now: H2AK119ub1-MLL2 counteraction underlies heritable H3K27me3 formation in oocytes Online now:
H2AK119ub1-MLL2 counteraction underlies heritable H3K27me3 formation in oocytes
Mei et al. reveal that the Polycomb mark H2AK119ub1 maintains gene silencing in mouse oocytes by opposing MLL2 activity, enabling the establishment of heritable H3K27me3. They uncover how the balance between repressive and activating chromatin mechanisms shapes the maternal epigenome.
dlvr.it
April 13, 2026 at 3:19 PM
srinjan.bsky.social
Using single-molecule imaging, we find that MLL2 acts like a tether, restricting chromatin mobility genome-wide and at the Mll2-dependent gene Sox2. This suggests a model where MLL2 tethering increases enhancer-promoter mixing at key neuroectoderm genes to drive differentiation.
February 26, 2025 at 6:07 PM
radaiglesiaslab.bsky.social
In agreement with this possibility, Micro-C experiments revealed that MLL2-bound L1 elements engaged into physical contacts with the promoters of nearby MLL2 target genes and such interactions were slightly decreased in the absence of MLL2
August 13, 2025 at 5:54 AM
embojournal.org
Histone methyltransferases MLL2 and SETD1A/B play distinct roles in H3K4me3 deposition during the transition from totipotency to pluripotency
www.embopress.org/doi/full/10....
December 6, 2024 at 12:48 PM
radaiglesiaslab.bsky.social
Moreover, although MLL2 was bound to many bivalent promoters where it controlled H3K4me3 levels, the loss of MLL2 barely increased PRC1 or PRC2 levels at those promoters
August 13, 2025 at 5:54 AM
plamofigure.com
001_ポリニアン MLL2-V2エルマー

DMM通販で予約受付中！
販売価格:7,148円

#ダイバディプロダクション
#フィギュア

https://plamofigure.com/article/24916
001_ポリニアン MLL2-V2エルマー｜プラモ・フィギュア情報
001_ポリニアン MLL2-V2エルマーの在庫復活、予約受付情報の記事
plamofigure.com
September 30, 2026 at 5:06 AM
chromatinhaiku.bsky.social
For mature oocytes
H2A.Z is needed
With MLL2

#ChromatinHaiku @natsmb.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Model figure from Mei et al., Figure legend: Small growing oocytes show canonical distributions of H3K4me3 and H2A.Z at active and bivalent gene promoters. In wild-type FGOs, H3K4me3 and H2A.Z form non-canonical broad domains across intergenic regions, whereas H2A.Z is displaced at bivalent gene promoters. In H2A.Z-DKO FGOs, non-canonical H3K4me3 at intergenic regions and H2AK119ub1 at active gene promoters are partially reduced. In Mll2-KO FGOs, ncH2A.Z is partially reduced. The distributions of H3K27me3 and H2AK119ub1 were not investigated in the Mll2-KO FGOs (marked with question marks). H2AK119ub1 at bivalent gene promoters is not shown. Model figure from Xu et al., Figure legend: Maternal depletion of H2A.Z results in aberrant meiosis resumption. Only a few FGOs survived to MII oocytes, with abnormal chromosome alignment. H2A.Z is acetylated (red) at active promoters and enhancers in mouse FGOs. Genes with low CG densities are preferentially downregulated in H2A.ZmKO FGOs. In mESCs, growing oocytes, and early embryos, in addition to active promoters and enhancers, H2A.Z and H2A.Zac are also present at inactive promoters with high CG densities, including Polycomb-target genes.
June 15, 2025 at 12:52 PM
embojournal.org
Issue 2:
Rhythmic astrocytic GABA production in the suprachiasmatic nucleus
Structural insight into Okazaki fragment maturation
Distinct MLL2 & SETD1A/B roles in H3K4me3 deposition
Assembly of pentameric IgM immunoglobulin
Cover by Takako Kikkawa, Noriko Osumi et al
www.embopress.org/toc/14602075...
January 14, 2025 at 12:04 PM
srinjan.bsky.social
Micro-C reveals that MLL2’s effect on chromatin architecture is more substantial, stabilising enhancer-promoter loops associated with bivalent genes in primed pluripotent cells. Interestingly, MLL2’s catalytic activity is not required for loop formation or differentiation.
February 26, 2025 at 6:07 PM
figuretimes.bsky.social
本日Amazon、あみあみなどで予約開始✨
amzn.to/4lZeuik

ダイバディプロダクション、『ポリニアン』の『MLL2-V2エルマー』が可動フィギュア化！2026年11月発売予定
figure-times.com?p=291750

#フィギュア #ポリニアン
ダイバディプロダクション、『ポリニアン』の『MLL2-V2エルマー』が可動フィギュア化！2026年11月発売予定
どうも、みなさんこんにちは！ ダイバディプロダクションより、 『ポリニアン』の『MLL2-V2エルマー』が可動フィギュア化！ 価格は7,370円(税込)、発売日は2026年11月発売予定となります。
figure-times.com
March 30, 2026 at 3:49 AM
hobyyinfo.bsky.social
001_ポリニアン MLL2-V2エルマー

DMMで予約受付中🌈

販売価格:7,148円
発売日:2026年11月末までに発売予定

#フィギュア
#PR

https://al.dmm.com/?lurl=https%3A%2F%2Fwww.dmm.com%2Fmono%2Fhobby%2F-%2Fdetail%2F%3D%2Fcid%3Dc260307231%2F&af_id=minami096-010&ch=toolbar&ch_id=link
001_ポリニアン MLL2-V2エルマー
al.dmm.com
September 30, 2026 at 5:06 AM
epigenometech.bsky.social
Epigenetics Update - H2AK119ub1-MLL2 counteraction underlies heritable H3K27me3 formation in oocytes bit.ly/4ctnKqx

Hailiang Mei and Azusa Inoue from RIKEN in Mol Cell

#Epigenetics #H3K27me3 #Oocytes #Chromatin
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Empower your research with high-res epigenetic insights at epigenometech.com
April 15, 2026 at 8:40 AM
radaiglesiaslab.bsky.social
Lastly, by deleting a few MLL2-bound L1 elements, we demonstrated that these elements act as enhancers of MLL2 target genes in both ESC and upon differentiation
August 13, 2025 at 5:54 AM
srinjan.bsky.social
We build on previous studies that show a requirement for MLL2 in neuroectoderm differentiation. Using conditional knockouts, we reveal that this requirement occurs during pluripotent cell priming, days before differentiation is impaired.
February 26, 2025 at 6:07 PM
radaiglesiaslab.bsky.social
Interestingly, the genes downregulated in the absence of MLL2 were significantly closer to MLL2-bound L1 elements than to either upregulated or unaffected genes (especially upon ESC differentiation)
August 13, 2025 at 5:54 AM
radaiglesiaslab.bsky.social
So, how can MLL2 control gene expression then?

Upon inspection of our MLL2 ChIP-seq data, we were surprised to find out that, in addition to many CpG-rich promoters, MLL2 was also bound to a large number of distal CpG-poor regions, where it also controlled H3K4me3 levels
August 13, 2025 at 5:54 AM
srinjan.bsky.social
However, single-cell transcriptomics and quantitative immunofluorescence of the priming transition reveal that MLL2 has only a subtle change on transcription, increasing the expression of a few important neuroectodermal transcription factors such as SOX2.
February 26, 2025 at 6:07 PM
dproychan.bsky.social
www.youtube.com/watch?v=Mll2...
Fire Emblem: Fortune's Weave - Fabio gameplay via Nintendo Today
YouTube video by princereyson
www.youtube.com
July 21, 2026 at 4:34 AM
rridrobot.bsky.social
@activemotifusa.bsky.social's resource, RRID:AB_2614987, was just reported to be used in the paper. Thanks for making your methods matter! #OpenScience #OpenResearch #STMpublishing
H2AK119ub1-MLL2 counteraction underlies heritable H3K27me3 formation in oocytes
Read the full paper: H2AK119ub1-MLL2 counteraction underlies heritable H3K27me3 formation in oocytes
doi.org
April 18, 2026 at 7:01 AM
biorxiv-genomic.bsky.social
MLL2 facilitates long-range gene regulation through LINE1 elements https://www.biorxiv.org/content/10.1101/2025.08.10.669526v1
August 12, 2025 at 9:32 PM
radaiglesiaslab.bsky.social
However, by combining conditional MLL1/2 KO cell lines with ChIP-seq and RNA-seq, we found that, in the absence of MLL2, only a small fraction of the differentially expressed genes in either pluripotent or differentiating cells corresponded to developmental genes with bivalent promoters
August 13, 2025 at 5:54 AM