First try at #FluorescenceFriday on this platform!
Mechanosensory fiber network in duodenal villi!
#mechanosensation #neuroscience
Mechanosensory fiber network in duodenal villi!
#mechanosensation #neuroscience
November 15, 2024 at 1:12 AM
First try at #FluorescenceFriday on this platform!
Mechanosensory fiber network in duodenal villi!
#mechanosensation #neuroscience
Mechanosensory fiber network in duodenal villi!
#mechanosensation #neuroscience
Mechanosensation and fast reorientation of ciliary structures: Marvin's work on the surprising locomotion capabilities of Trichoplax, an animal without neurons!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 27, 2025 at 10:50 AM
Mechanosensation and fast reorientation of ciliary structures: Marvin's work on the surprising locomotion capabilities of Trichoplax, an animal without neurons!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
2025 resolution: Dive deeper into mentoring and sharing the wonders of science! Whether it’s about mechanosensation or just embracing curiosity, let’s make science more accessible and exciting for everyone. Here’s to breakthroughs and inspiration ahead!
December 31, 2024 at 3:20 PM
2025 resolution: Dive deeper into mentoring and sharing the wonders of science! Whether it’s about mechanosensation or just embracing curiosity, let’s make science more accessible and exciting for everyone. Here’s to breakthroughs and inspiration ahead!
Wilhelmina Barns-Graham’s 1968 painting In Tension — yes, I’m eager to spot mechanosensation even in art!
January 13, 2025 at 6:44 AM
Wilhelmina Barns-Graham’s 1968 painting In Tension — yes, I’m eager to spot mechanosensation even in art!
Our story on mechanosensation in baroreceptor cells of the kidney is finally out! Well worth the wait on this project we began in 2020 that turned into a massive collaborative effort within the kidney field. 🫘 www.sciencedirect.com:5037/science/arti...
www.sciencedirect.com
December 4, 2025 at 4:42 PM
Our story on mechanosensation in baroreceptor cells of the kidney is finally out! Well worth the wait on this project we began in 2020 that turned into a massive collaborative effort within the kidney field. 🫘 www.sciencedirect.com:5037/science/arti...
you can reincarnate as anything. i'll find you as a butterfly's eyespot, a double fisherman's knot, the mechanosensation of hand-holding, a nonce-phoneme that died with its last speaker
February 6, 2026 at 6:04 AM
you can reincarnate as anything. i'll find you as a butterfly's eyespot, a double fisherman's knot, the mechanosensation of hand-holding, a nonce-phoneme that died with its last speaker
Flamingos, seen here in the Atacama Desert, feed by sweeping their heads underwater, using mechanosensation to detect tiny particles by touch. Their beaks are highly specialized to filter food from the salty water.
April 29, 2025 at 11:33 AM
Flamingos, seen here in the Atacama Desert, feed by sweeping their heads underwater, using mechanosensation to detect tiny particles by touch. Their beaks are highly specialized to filter food from the salty water.
… and we are very happy that our study on extrinsic control of melanocyte functions is published - kudos to @caroleluthold.bsky.social & co-authors! We found that distinct #ECM components impinge on #MITF, #melanocyte differentiation & #mechanosensation. Find out more here: doi.org/10.1038/s443...
September 22, 2025 at 2:01 PM
… and we are very happy that our study on extrinsic control of melanocyte functions is published - kudos to @caroleluthold.bsky.social & co-authors! We found that distinct #ECM components impinge on #MITF, #melanocyte differentiation & #mechanosensation. Find out more here: doi.org/10.1038/s443...
Proud of this collab! At first, we wondered—why would PIEZO2-positive neurons innervate soft tissue like fat? Turns out, mechanosensation plays a role in unexpected places. Studying PIEZOs keeps revealing surprises in biology and disease! 1/2
PIEZO2 ion channels come to the fore yet again, now as a key sensor for adipose tissue www.cell.com/cell-metabol... @ardemp.bskyverified.social @scripps.edu
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation
Wang et al. identified that the mechanoreceptor PIEZO2 is abundantly expressed in
fat-innervating sensory neurons and plays a crucial role in mediating the adipose
afferent pathway.
www.cell.com
March 6, 2025 at 7:12 PM
Proud of this collab! At first, we wondered—why would PIEZO2-positive neurons innervate soft tissue like fat? Turns out, mechanosensation plays a role in unexpected places. Studying PIEZOs keeps revealing surprises in biology and disease! 1/2
Preprint dropped! Excited about this study by Yu Wang, a PhD student from Li Ye's lab and mine, now a postdoc in @deisseroth.bsky.social lab. It unveils an unexpected role for PIEZO2/mechanosensation in sensory neurons that innervate fat! What is it sensing in fat?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 20, 2024 at 2:40 AM
Preprint dropped! Excited about this study by Yu Wang, a PhD student from Li Ye's lab and mine, now a postdoc in @deisseroth.bsky.social lab. It unveils an unexpected role for PIEZO2/mechanosensation in sensory neurons that innervate fat! What is it sensing in fat?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Latest work from the lab driven by our talented student @yannis-reignier.bsky.social , in which we characterize mechanisms coupling surface mechanosensation and cell polarity that promote the dynamic repair of Cell Wall damages. @ijmonod.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
April 24, 2026 at 1:46 PM
Latest work from the lab driven by our talented student @yannis-reignier.bsky.social , in which we characterize mechanisms coupling surface mechanosensation and cell polarity that promote the dynamic repair of Cell Wall damages. @ijmonod.bsky.social
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Dyk:
The lateral line picks up mechanosensation vibrational stimuli
...but...
It's not the only mechanosensation based receptor in #chondrichthyans! There are also other cell types that pick up pressure and stretch that are also mechanosensory stimuli!
#sharks #rays #skates #chimaeras 🦈
The lateral line picks up mechanosensation vibrational stimuli
...but...
It's not the only mechanosensation based receptor in #chondrichthyans! There are also other cell types that pick up pressure and stretch that are also mechanosensory stimuli!
#sharks #rays #skates #chimaeras 🦈
July 29, 2026 at 12:36 AM
Dyk:
The lateral line picks up mechanosensation vibrational stimuli
...but...
It's not the only mechanosensation based receptor in #chondrichthyans! There are also other cell types that pick up pressure and stretch that are also mechanosensory stimuli!
#sharks #rays #skates #chimaeras 🦈
The lateral line picks up mechanosensation vibrational stimuli
...but...
It's not the only mechanosensation based receptor in #chondrichthyans! There are also other cell types that pick up pressure and stretch that are also mechanosensory stimuli!
#sharks #rays #skates #chimaeras 🦈
✍️ New preprint from the @minclab.bsky.social
📃 Mechanosensation Promotes Local Cell Wall Repair
🔗 www.biorxiv.org/content/10.6...
📃 Mechanosensation Promotes Local Cell Wall Repair
🔗 www.biorxiv.org/content/10.6...
April 27, 2026 at 12:29 PM
✍️ New preprint from the @minclab.bsky.social
📃 Mechanosensation Promotes Local Cell Wall Repair
🔗 www.biorxiv.org/content/10.6...
📃 Mechanosensation Promotes Local Cell Wall Repair
🔗 www.biorxiv.org/content/10.6...
Great to be at #CeNeuro to hear about great science and to present today my poster on #mechanosensation in P. pacificus
July 1, 2026 at 3:48 PM
Great to be at #CeNeuro to hear about great science and to present today my poster on #mechanosensation in P. pacificus
Sandra Iden @sandraiden.bsky.social @idenlab.bsky.social @uni-saarland.de @pharmascihub.bsky.social and co-workers show that #melanocyte #differentiation and #mechanosensation are differentially modulated by distinct extracellular matrix proteins. #ECM #MITF
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
September 19, 2025 at 9:16 AM
Sandra Iden @sandraiden.bsky.social @idenlab.bsky.social @uni-saarland.de @pharmascihub.bsky.social and co-workers show that #melanocyte #differentiation and #mechanosensation are differentially modulated by distinct extracellular matrix proteins. #ECM #MITF
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Documenting this for the imposter in me: 2nd place award at the 31st Annual Cooley Neuroscience Poster Session. Grateful for all the support, encouragement, and great discussions! #Aging #bladder #mechanosensation 🧠⚙️🚽
December 6, 2025 at 11:13 PM
Documenting this for the imposter in me: 2nd place award at the 31st Annual Cooley Neuroscience Poster Session. Grateful for all the support, encouragement, and great discussions! #Aging #bladder #mechanosensation 🧠⚙️🚽
✨New issue!✨
Check out the latest in #metabolism research from across all disciplines.
Read about #EVs, #Exercise, #GlucoseMonitoring, #LiverMetabolism , #Mechanosensation, #Neurometabolism - and many more topics!
www.nature.com/natmetab/vol...
Check out the latest in #metabolism research from across all disciplines.
Read about #EVs, #Exercise, #GlucoseMonitoring, #LiverMetabolism , #Mechanosensation, #Neurometabolism - and many more topics!
www.nature.com/natmetab/vol...
February 26, 2025 at 2:53 PM
✨New issue!✨
Check out the latest in #metabolism research from across all disciplines.
Read about #EVs, #Exercise, #GlucoseMonitoring, #LiverMetabolism , #Mechanosensation, #Neurometabolism - and many more topics!
www.nature.com/natmetab/vol...
Check out the latest in #metabolism research from across all disciplines.
Read about #EVs, #Exercise, #GlucoseMonitoring, #LiverMetabolism , #Mechanosensation, #Neurometabolism - and many more topics!
www.nature.com/natmetab/vol...
How does mechanosensation work? Nerves are critical, but recent work from Gary Lewin, Patrik Ernfors et al (nature.com/articles/s41...) builds on findings a few years ago that Schwann cells are involved in nociception (science.org/doi/10.1126/...) #neuroscience #touch #pain 🧪
February 10, 2024 at 4:14 PM
How does mechanosensation work? Nerves are critical, but recent work from Gary Lewin, Patrik Ernfors et al (nature.com/articles/s41...) builds on findings a few years ago that Schwann cells are involved in nociception (science.org/doi/10.1126/...) #neuroscience #touch #pain 🧪
Excessive mechanosensation via PIEZO1 in bladder epithelium, driven by IL-6 during E. coli infection, boosts nociceptive pathways and chronic pain via SLC7A11-glutamate. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5
No description available
www.cell.com
October 5, 2026 at 12:00 AM
Mechanosensation isn't just at the cell surface. In gut smooth muscle, we found that Piezo1 is mostly intracellular, <40 nm from RyR and BK channels. Activating it hyperpolarizes cells and weakens contraction- like a molecular brake. Stay tuned for more to come! J Physiol: doi.org/10.1113/JP29...
Intracellular mechanosensation in intestinal smooth muscle: Piezo1 complexes amplify signalling beyond the surface
Abstract figure legend Mechanosensation is not confined to the cell surface. In intestinal smooth muscle Piezo1 is predominantly intracellular (86%), where it forms a nanoscale (<40 nm) complex at th...
doi.org
September 10, 2026 at 2:08 PM
Mechanosensation isn't just at the cell surface. In gut smooth muscle, we found that Piezo1 is mostly intracellular, <40 nm from RyR and BK channels. Activating it hyperpolarizes cells and weakens contraction- like a molecular brake. Stay tuned for more to come! J Physiol: doi.org/10.1113/JP29...
Curious about how the cannibalistic nematode Pristionchus pacificus hunts its prey? Check out our preprint on BioRxiv, where we explore the roles of mechanosensation and chemosensation, using behaviour tracking among other methods!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
March 26, 2025 at 10:01 AM
Curious about how the cannibalistic nematode Pristionchus pacificus hunts its prey? Check out our preprint on BioRxiv, where we explore the roles of mechanosensation and chemosensation, using behaviour tracking among other methods!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Mechanosensation promotes broad-spectrum antiviral defense through membrane remodeling
Mechanosensation promotes broad-spectrum antiviral defense through membrane remodeling
Huang et al. define the mechano-antiviral response system (MARS) and reveal that mechanical force triggers Piezo1-dependent membrane stiffening. This establishes a broad-spectrum, interferon-independent antiviral defense that can be exploited by small-molecule agonists or vibration.
dlvr.it
March 19, 2026 at 6:30 PM
Mechanosensation promotes broad-spectrum antiviral defense through membrane remodeling
Mechanosensation induces persistent bacterial growth during bacteriophage predation
mBio journal from Rojas Lab
journals.asm.org/doi/10.1128/...
mBio journal from Rojas Lab
journals.asm.org/doi/10.1128/...
November 1, 2023 at 6:55 PM
Mechanosensation induces persistent bacterial growth during bacteriophage predation
mBio journal from Rojas Lab
journals.asm.org/doi/10.1128/...
mBio journal from Rojas Lab
journals.asm.org/doi/10.1128/...
Excessive mechanosensation via PIEZO1 in bladder epithelial cells drives nociceptive innervation and chronic pain during uropathogenic E. coli infection through IL-6 signaling. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5
No description available
www.cell.com
October 2, 2026 at 12:00 AM