I see an icy microglia!
January 30, 2025 at 2:54 PM
I see an icy microglia!
We believe many neuro problems associated with #COVID come from the virus hijacking blood vessels to gain access to the brain. This is what it looks like for me, using super-resolution microscopy.
With thanks to @harryspoelstra.bsky.social, combining vascular and neuro to understand #NeuroCovid 💪
With thanks to @harryspoelstra.bsky.social, combining vascular and neuro to understand #NeuroCovid 💪
February 12, 2025 at 10:34 PM
We believe many neuro problems associated with #COVID come from the virus hijacking blood vessels to gain access to the brain. This is what it looks like for me, using super-resolution microscopy.
With thanks to @harryspoelstra.bsky.social, combining vascular and neuro to understand #NeuroCovid 💪
With thanks to @harryspoelstra.bsky.social, combining vascular and neuro to understand #NeuroCovid 💪
some great starter packs for the #glia, #astrocyte, #oligodendrocyte, #microglia, #neuro researcher: gliasky, astrocytesky, microglia
But if you also like interactions between celltypes, please help this starter pack get started. Maybe someone can connect all of us in a feed?
go.bsky.app/MHtJzeC
But if you also like interactions between celltypes, please help this starter pack get started. Maybe someone can connect all of us in a feed?
go.bsky.app/MHtJzeC
November 17, 2024 at 8:35 PM
some great starter packs for the #glia, #astrocyte, #oligodendrocyte, #microglia, #neuro researcher: gliasky, astrocytesky, microglia
But if you also like interactions between celltypes, please help this starter pack get started. Maybe someone can connect all of us in a feed?
go.bsky.app/MHtJzeC
But if you also like interactions between celltypes, please help this starter pack get started. Maybe someone can connect all of us in a feed?
go.bsky.app/MHtJzeC
Exquisite study characterizing morphological differences between plaque-associated microglia and coffin-like microglia and their association with astrocytes in AD 😳
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Microglia aggregates define distinct immune and neurodegenerative niches in Alzheimer's disease hippocampus - Acta Neuropathologica
In Alzheimer’s disease (AD), microglia form distinct cellular aggregates that play critical roles in disease progression, including Aβ plaque-associated microglia (PaM) and the newly identified coffin...
link.springer.com
February 18, 2025 at 12:23 AM
Exquisite study characterizing morphological differences between plaque-associated microglia and coffin-like microglia and their association with astrocytes in AD 😳
link.springer.com/article/10.1...
link.springer.com/article/10.1...
I spend my days in the microscope quantifying things like the images below. These photos show neurons 🔵 and microglia 🟣 (brain immune cells). Each #SARSCoV2 infected cell entering the brain generates this response in our Covid monkey model. #FluorescenceSaturday
#NeuroCovid
#NeuroCovid
April 5, 2025 at 5:02 PM
I spend my days in the microscope quantifying things like the images below. These photos show neurons 🔵 and microglia 🟣 (brain immune cells). Each #SARSCoV2 infected cell entering the brain generates this response in our Covid monkey model. #FluorescenceSaturday
#NeuroCovid
#NeuroCovid
I like microglia and I like electron microscopy. Today my new review on microglia ultrastructure came out on Open Biology.
doi.org/10.1098/rsob...
I tried to do a guide I wish I had on my PhD. Thankful for all the people that have taught me microglia EM
#microglia #electronmicroscopy
#tremblaylab
doi.org/10.1098/rsob...
I tried to do a guide I wish I had on my PhD. Thankful for all the people that have taught me microglia EM
#microglia #electronmicroscopy
#tremblaylab
November 20, 2024 at 5:38 PM
I like microglia and I like electron microscopy. Today my new review on microglia ultrastructure came out on Open Biology.
doi.org/10.1098/rsob...
I tried to do a guide I wish I had on my PhD. Thankful for all the people that have taught me microglia EM
#microglia #electronmicroscopy
#tremblaylab
doi.org/10.1098/rsob...
I tried to do a guide I wish I had on my PhD. Thankful for all the people that have taught me microglia EM
#microglia #electronmicroscopy
#tremblaylab
APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
November 16, 2024 at 2:17 PM
APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
#fluorescencefriday Whole 🧠 microglia (cyan) distribution in an Alzheimer’s disease 🐁 model shows that microglia like amyloid plaques (magenta) but also enjoy clinging to blood vessels (yellow). Courtesy from the @mind-western.bsky.social team showing different levels of detail for the hippocampus
June 5, 2026 at 10:15 AM
#fluorescencefriday Whole 🧠 microglia (cyan) distribution in an Alzheimer’s disease 🐁 model shows that microglia like amyloid plaques (magenta) but also enjoy clinging to blood vessels (yellow). Courtesy from the @mind-western.bsky.social team showing different levels of detail for the hippocampus
Testing some new antibodies to identify oligodendrocytes 🟣, for me, the most difficult one to target in brain microscopy! Here I was able to identify its nuclei (oligo2 marker), not the whole cell body like neurons 🟡or microglia 🔵. Still, you can see oligos are everywhere! #Neuroscience #Microscopy
October 22, 2025 at 4:46 AM
Testing some new antibodies to identify oligodendrocytes 🟣, for me, the most difficult one to target in brain microscopy! Here I was able to identify its nuclei (oligo2 marker), not the whole cell body like neurons 🟡or microglia 🔵. Still, you can see oligos are everywhere! #Neuroscience #Microscopy
Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states: Cell www.cell.com/cell/fulltex...
April 21, 2026 at 3:02 PM
Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states: Cell www.cell.com/cell/fulltex...
Transplanted human microglia into mouse retina, completely integrating in, and responding just like the native microglia.
Verrrrrry cool work from NEI’s Wei Li and Janssen’s Wai T Wong: elifesciences.org/reviewed-pre...
Verrrrrry cool work from NEI’s Wei Li and Janssen’s Wai T Wong: elifesciences.org/reviewed-pre...
Human iPSC-derived Microglia Cells Integrated into Mouse Retina and Recapitulated Features of Endoge...
elifesciences.org
August 30, 2023 at 1:16 AM
Transplanted human microglia into mouse retina, completely integrating in, and responding just like the native microglia.
Verrrrrry cool work from NEI’s Wei Li and Janssen’s Wai T Wong: elifesciences.org/reviewed-pre...
Verrrrrry cool work from NEI’s Wei Li and Janssen’s Wai T Wong: elifesciences.org/reviewed-pre...
Most assume implants fail slowly over months. The moment an electrode enters the brain, microglia rush toward it within seconds, like fingers reaching for a splinter. Blood vessels leak. The BBB breaks. Inflammation starts instantly.
#BCI #NeuralEngineering #Neurotech
#BCI #NeuralEngineering #Neurotech
March 26, 2026 at 7:51 AM
Most assume implants fail slowly over months. The moment an electrode enters the brain, microglia rush toward it within seconds, like fingers reaching for a splinter. Blood vessels leak. The BBB breaks. Inflammation starts instantly.
#BCI #NeuralEngineering #Neurotech
#BCI #NeuralEngineering #Neurotech
Microglia? More like upset-o-glia!
Iba1 staining of sensorimotor organoids, awesome work by Dr. Anna Schreiber! @annaschreiber.bsky.social
Iba1 staining of sensorimotor organoids, awesome work by Dr. Anna Schreiber! @annaschreiber.bsky.social
April 2, 2025 at 3:11 PM
Microglia? More like upset-o-glia!
Iba1 staining of sensorimotor organoids, awesome work by Dr. Anna Schreiber! @annaschreiber.bsky.social
Iba1 staining of sensorimotor organoids, awesome work by Dr. Anna Schreiber! @annaschreiber.bsky.social
Astrocyte-microglia crosstalk through Hevin and Toll-like receptor signaling controls developmental thalamocortical synapse refinement: Neuron www.cell.com/neuron/fullt...
Astrocyte-microglia crosstalk through Hevin and Toll-like receptor signaling controls developmental thalamocortical synapse refinement
Microglia are key drivers of synapse refinement during development. Ramirez et al.
show that astrocytes instruct this process through the secreted synaptogenic protein
Hevin/Sparcl1. The proteolytical...
www.cell.com
February 19, 2026 at 9:16 PM
Astrocyte-microglia crosstalk through Hevin and Toll-like receptor signaling controls developmental thalamocortical synapse refinement: Neuron www.cell.com/neuron/fullt...
How does a brain with #Alzheimer look in the microscope? Neurons are dying, and I literally see holes in the tissue, like below. You can see microglia (🟡), brain immune cells, accumulating where the tissue disappears (hippocampus & entorhinal cortex). Additional markers: Astrocyte(🟣), pTau(🔵). 🧠🔬
March 8, 2025 at 10:04 PM
How does a brain with #Alzheimer look in the microscope? Neurons are dying, and I literally see holes in the tissue, like below. You can see microglia (🟡), brain immune cells, accumulating where the tissue disappears (hippocampus & entorhinal cortex). Additional markers: Astrocyte(🟣), pTau(🔵). 🧠🔬
How does #neuroinflammation trigger depressive-like behaviors?
Researchers in #ScienceSignaling show that #Orai1 sustains production of proinflammatory cytokines from microglia and that Orai1-deficient mice display less pronounced depressive-like behaviors. https://scim.ag/4rmJSZQ
Researchers in #ScienceSignaling show that #Orai1 sustains production of proinflammatory cytokines from microglia and that Orai1-deficient mice display less pronounced depressive-like behaviors. https://scim.ag/4rmJSZQ
Microglial reactivity and neuroinflammation-driven changes in motivational behaviors are regulated by Orai1 calcium channels
The Ca2+ channel Orai1 in microglia links systemic inflammation to depressive-like behaviors in mice.
scim.ag
March 4, 2026 at 8:29 PM
How does #neuroinflammation trigger depressive-like behaviors?
Researchers in #ScienceSignaling show that #Orai1 sustains production of proinflammatory cytokines from microglia and that Orai1-deficient mice display less pronounced depressive-like behaviors. https://scim.ag/4rmJSZQ
Researchers in #ScienceSignaling show that #Orai1 sustains production of proinflammatory cytokines from microglia and that Orai1-deficient mice display less pronounced depressive-like behaviors. https://scim.ag/4rmJSZQ
Microglia-like cells differentiated from iPSCs from patients with MS display similar gene signature as MS microglia, associated with immune receptor activation, antigen presentation, complement, secretion of inflammatory cytokines & chemokines & increased phagocytosis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Microglia from patients with multiple sclerosis display a cell-autonomous immune activation state
Aberrant and sustained activation of microglia is implicated in the progression and severity of multiple sclerosis (MS). However, whether intrinsic alterations in microglial function impact the pathog...
www.biorxiv.org
December 17, 2024 at 1:56 AM
Microglia-like cells differentiated from iPSCs from patients with MS display similar gene signature as MS microglia, associated with immune receptor activation, antigen presentation, complement, secretion of inflammatory cytokines & chemokines & increased phagocytosis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
#MicroscopyMonday is very much alive here and I'm loving it! My take for this week is Neuroinflammation! Under a microscope literally looks like the brain is on fire! 🔥🔬 Instead of gently touching the neurons, microglia changes shape, gets activated and start attacking them. How do we control this?
November 11, 2024 at 11:51 PM
#MicroscopyMonday is very much alive here and I'm loving it! My take for this week is Neuroinflammation! Under a microscope literally looks like the brain is on fire! 🔥🔬 Instead of gently touching the neurons, microglia changes shape, gets activated and start attacking them. How do we control this?
A calcium channel named Orai1 present in immune cells called #microglia may explain how neuroinflammation can induce depressive-like behaviors, according to new experiments in mice published in #ScienceSignaling. https://scim.ag/4rmJSZQ
Microglial reactivity and neuroinflammation-driven changes in motivational behaviors are regulated by Orai1 calcium channels
The Ca2+ channel Orai1 in microglia links systemic inflammation to depressive-like behaviors in mice.
scim.ag
February 18, 2026 at 4:46 PM
A calcium channel named Orai1 present in immune cells called #microglia may explain how neuroinflammation can induce depressive-like behaviors, according to new experiments in mice published in #ScienceSignaling. https://scim.ag/4rmJSZQ
Check out our latest preprint, this one led by PhD student extraordinaire, Khadijah Mazhar: "Satellite microglia-like cells in human dorsal root ganglia and changes with diabetic neuropathy" www.biorxiv.org/content/10.6...
www.biorxiv.org
May 15, 2026 at 7:00 PM
Check out our latest preprint, this one led by PhD student extraordinaire, Khadijah Mazhar: "Satellite microglia-like cells in human dorsal root ganglia and changes with diabetic neuropathy" www.biorxiv.org/content/10.6...
How does a white matter lesion look like under the confocal microscope 🤓? You can see a blood vessel going bad in the left corner. These lesions are often associated with age and cardiovascular risk factors, but can also be found in young adults. Neurons🔵, astrocytes🔴, microglia🟡 #FluorescenceFriday
May 23, 2025 at 10:02 PM
How does a white matter lesion look like under the confocal microscope 🤓? You can see a blood vessel going bad in the left corner. These lesions are often associated with age and cardiovascular risk factors, but can also be found in young adults. Neurons🔵, astrocytes🔴, microglia🟡 #FluorescenceFriday
Excited to share our new paper in Immunity! 🧠
Circumventricular organs are tiny brain border-like regions without a blood-brain barrier, where the brain directly samples signals from the blood. We wondered what macrophages live in these border-like niches?
www.cell.com/immunity/ful...
Circumventricular organs are tiny brain border-like regions without a blood-brain barrier, where the brain directly samples signals from the blood. We wondered what macrophages live in these border-like niches?
www.cell.com/immunity/ful...
Microglia with distinct origins and non-canonical phenotypes coexist within the border-like niche of the brain’s circumventricular organs
Circumventricular organs are specialized brain regions lacking a blood-brain barrier.
Van Hove et al. reveal that these regions harbor unique microglia and border-associated
macrophage populations tha...
www.cell.com
September 30, 2026 at 11:57 AM
Excited to share our new paper in Immunity! 🧠
Circumventricular organs are tiny brain border-like regions without a blood-brain barrier, where the brain directly samples signals from the blood. We wondered what macrophages live in these border-like niches?
www.cell.com/immunity/ful...
Circumventricular organs are tiny brain border-like regions without a blood-brain barrier, where the brain directly samples signals from the blood. We wondered what macrophages live in these border-like niches?
www.cell.com/immunity/ful...
Who knew #microglia could be like starfish (extruding stomached to digest stuff outside their bodies)? Check out Microglial lysosomal synapses in murine #Alzheimers disease model. #neuroinflammation #neurodegeneration #neurosky
New publication on Cell Reports! We describe a mechanism by which #microglia degrade amyloid-beta deposits that they can't phagocytose.
Collaboration between the Tremblay lab and Rudy Jacquet, Santiago Solé-Domènech and Frederick Maxfield at Weill Cornell.
www.sciencedirect.com/science/arti...
Collaboration between the Tremblay lab and Rudy Jacquet, Santiago Solé-Domènech and Frederick Maxfield at Weill Cornell.
www.sciencedirect.com/science/arti...
Microglia degrade Alzheimer’s amyloid-beta deposits extracellularly via digestive exophagy
How microglia digest Alzheimer’s fibrillar amyloid-beta (Aβ) plaques that are too large to be phagocytosed is not well understood. Here, we show that …
www.sciencedirect.com
December 9, 2024 at 9:16 PM
Who knew #microglia could be like starfish (extruding stomached to digest stuff outside their bodies)? Check out Microglial lysosomal synapses in murine #Alzheimers disease model. #neuroinflammation #neurodegeneration #neurosky
This is important in two ways.
1. COVID looks like any severe viral infection vs having atypical brain injury behavior.
2. Mechanism for how viral infections accelerate brain aging by IL action on microglia mitochondria
1. COVID looks like any severe viral infection vs having atypical brain injury behavior.
2. Mechanism for how viral infections accelerate brain aging by IL action on microglia mitochondria
The data argues against a primarily neurotropic spread of SARS-CoV-2, in line with most neuropathological findings. It suggests systemic inflammation, possibly worsened by chronic inflammatory comorbidities, promote the risk of poor clinical outcome in COVID-19 cases.
March 7, 2025 at 8:15 PM
This is important in two ways.
1. COVID looks like any severe viral infection vs having atypical brain injury behavior.
2. Mechanism for how viral infections accelerate brain aging by IL action on microglia mitochondria
1. COVID looks like any severe viral infection vs having atypical brain injury behavior.
2. Mechanism for how viral infections accelerate brain aging by IL action on microglia mitochondria
Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution
@cellcellpress.bsky.social
www.cell.com/cell/fulltex...
@cellcellpress.bsky.social
www.cell.com/cell/fulltex...
April 8, 2025 at 1:06 PM
Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution
@cellcellpress.bsky.social
www.cell.com/cell/fulltex...
@cellcellpress.bsky.social
www.cell.com/cell/fulltex...