Collective cell invasion: @yuritakahashi.bsky.social, @bensteventon.bsky.social et al establish EMT initiation as an upstream inducer of BMP pathway activation during vertebrate development
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reciprocal coupling between EMT and BMP morphogen signalling drives collective cell invasion - The EMBO Journal
During collective cell invasion, epithelial-to-mesenchymal transition (EMT) and morphogen signalling-mediated cell fate specification are traditionally viewed as a linear cascade: morphogens drive cel...
link.springer.com
October 14, 2026 at 10:00 AM
Collective cell invasion: @yuritakahashi.bsky.social, @bensteventon.bsky.social et al establish EMT initiation as an upstream inducer of BMP pathway activation during vertebrate development
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Which shocked the world when mad scientist Michael O'Connor revealed that these frightening phenotypes were associated with a common pathway:
Cytochrome P450.
This pathway turns cholesterol into steroid hormones, especially 'ecdysone', the hormone that controls molting & metamorphosis in insects.
Cytochrome P450.
This pathway turns cholesterol into steroid hormones, especially 'ecdysone', the hormone that controls molting & metamorphosis in insects.
October 3, 2026 at 3:09 PM
Which shocked the world when mad scientist Michael O'Connor revealed that these frightening phenotypes were associated with a common pathway:
Cytochrome P450.
This pathway turns cholesterol into steroid hormones, especially 'ecdysone', the hormone that controls molting & metamorphosis in insects.
Cytochrome P450.
This pathway turns cholesterol into steroid hormones, especially 'ecdysone', the hormone that controls molting & metamorphosis in insects.
In his seminal 1952 theoretical paper, Alan Turing proposed that partial differential equations, representing molecules (“morphogens”) that react with one another and diffuse through space, can encode spontaneous periodic pattern formation.
doi.org/10.1098/rstb...
doi.org/10.1098/rstb...
September 27, 2026 at 11:26 AM
In his seminal 1952 theoretical paper, Alan Turing proposed that partial differential equations, representing molecules (“morphogens”) that react with one another and diffuse through space, can encode spontaneous periodic pattern formation.
doi.org/10.1098/rstb...
doi.org/10.1098/rstb...
Intestinal and brain organoids run through the tutorial as contrasting prototypes. For example, in proliferative gut organoids, tuning growth factors enriches specific cell types. In brain organoids, timed morphogens pattern regional identity.
September 25, 2026 at 12:09 PM
Intestinal and brain organoids run through the tutorial as contrasting prototypes. For example, in proliferative gut organoids, tuning growth factors enriches specific cell types. In brain organoids, timed morphogens pattern regional identity.
How do uniform tissues become complex?
This review uses #SkinAppendages to show how #SymmetryBreaking—via morphogens, mechanics, and microenvironmental cues—drives patterning, stem cell regulation, and disease remodeling.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
This review uses #SkinAppendages to show how #SymmetryBreaking—via morphogens, mechanics, and microenvironmental cues—drives patterning, stem cell regulation, and disease remodeling.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
September 12, 2026 at 2:30 AM
How do uniform tissues become complex?
This review uses #SkinAppendages to show how #SymmetryBreaking—via morphogens, mechanics, and microenvironmental cues—drives patterning, stem cell regulation, and disease remodeling.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
This review uses #SkinAppendages to show how #SymmetryBreaking—via morphogens, mechanics, and microenvironmental cues—drives patterning, stem cell regulation, and disease remodeling.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
> A generative/procedural design or graphics tool — something that generates shapes, textures, layouts, or 3D forms using rules that "grow" or "differentiate" outputs from a small set of inputs, echoing how morphogens pattern biological tissue
but "Fluoddity" is 10x cooler than "morphogen".
but "Fluoddity" is 10x cooler than "morphogen".
August 30, 2026 at 1:54 AM
> A generative/procedural design or graphics tool — something that generates shapes, textures, layouts, or 3D forms using rules that "grow" or "differentiate" outputs from a small set of inputs, echoing how morphogens pattern biological tissue
but "Fluoddity" is 10x cooler than "morphogen".
but "Fluoddity" is 10x cooler than "morphogen".
Dive into Wnt morphogens: Cryo-EM structures reveal how Wntless (WLS) transports lipid-modified Wnts from ER to PM for secretion. Development & disease link explored! PMID:42321207, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74521-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Conformational cycling of the Wntless transporter drives trafficking and secretion of Wnt morphogens | Nature Communications
Wnt proteins are lipid-modified morphogens fundamental in development and disease. During Wnt biogenesis, the G-protein-coupled receptor (GPCR)-like transporter Wntless (WLS) escorts lipidated Wnts from the endoplasmic reticulum to the plasma membrane, then transfers them to extracellular carriers, forming active and soluble morphogen-carrier complexes. To dissect the mechanisms involved, we solve cryo-EM structures of Wnt-bound WLS and unliganded WLS, and perform structure-guided functional experiments. Wnts engage WLS via three conserved hairpins, which are all required for Wnt trafficking to the cell surface and carrier-mediated secretion. Wnt release from cells is driven by dramatic conformational changes in the WLS transmembrane domain, reminiscent of GPCR activation, together with WLS extracellular rearrangements. Unexpectedly, we find that Wnt5a bound to WLS forms dimers, with implications for Wnt signaling. These findings define the mechanism of WLS conformational cycling that
doi.org
August 24, 2026 at 9:00 PM
Rambaud, B., Joseph, M., Tsai, F. C., ...., Bassereau, P., Hipfner, D. R., Carreno, S. (2025). Slik sculpts the plasma membrane into cytonemes to control cell-cell communication.. Embo j, 44(8):2186-2210 link.springer.com/article/10.1...
Slik sculpts the plasma membrane into cytonemes to control cell-cell communication - The EMBO Journal
Cytonemes are signaling filopodia that facilitate long-range cell–cell communication by forming synapses between cells. Initially discovered in Drosophila for transporting morphogens during embryogene...
link.springer.com
August 19, 2026 at 10:34 PM
Rambaud, B., Joseph, M., Tsai, F. C., ...., Bassereau, P., Hipfner, D. R., Carreno, S. (2025). Slik sculpts the plasma membrane into cytonemes to control cell-cell communication.. Embo j, 44(8):2186-2210 link.springer.com/article/10.1...
Rambaud, B., Joseph, M., Tsai, F. C., ..., Bassereau, P., Hipfner, D. R., Carreno, S. (2025). Slik sculpts the plasma membrane into cytonemes to control cell-cell communication.. Embo j, 44(8):2186-2210 link.springer.com/article/10.1...
Slik sculpts the plasma membrane into cytonemes to control cell-cell communication - The EMBO Journal
Cytonemes are signaling filopodia that facilitate long-range cell–cell communication by forming synapses between cells. Initially discovered in Drosophila for transporting morphogens during embryogene...
link.springer.com
August 18, 2026 at 6:34 PM
Rambaud, B., Joseph, M., Tsai, F. C., ..., Bassereau, P., Hipfner, D. R., Carreno, S. (2025). Slik sculpts the plasma membrane into cytonemes to control cell-cell communication.. Embo j, 44(8):2186-2210 link.springer.com/article/10.1...
New preprint published showing how the feedback between morphogens and cell growth can drive the emergence of tissue shapes. Check out these stable Turing patterns.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
February 26, 2025 at 6:41 PM
New preprint published showing how the feedback between morphogens and cell growth can drive the emergence of tissue shapes. Check out these stable Turing patterns.
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Insect wings arose with a genetic circuit that extends the useful range of a BMP morphogen
Congratulations @jpvincentlab.bsky.social. Your #PaperThemeTune is "Further than we've gone" by Captain Beefheart & His Magic Band
www.biorxiv.org/content/10.1...
Congratulations @jpvincentlab.bsky.social. Your #PaperThemeTune is "Further than we've gone" by Captain Beefheart & His Magic Band
www.biorxiv.org/content/10.1...
Insect wings arose with a genetic circuit that extends the useful range of a BMP morphogen
Morphogens are produced by a subset of cells to trigger a signalling gradient that provides positional information to surrounding tissues. At increasing distances from the source, the dwindling number...
www.biorxiv.org
February 10, 2025 at 8:53 AM
Insect wings arose with a genetic circuit that extends the useful range of a BMP morphogen
Congratulations @jpvincentlab.bsky.social. Your #PaperThemeTune is "Further than we've gone" by Captain Beefheart & His Magic Band
www.biorxiv.org/content/10.1...
Congratulations @jpvincentlab.bsky.social. Your #PaperThemeTune is "Further than we've gone" by Captain Beefheart & His Magic Band
www.biorxiv.org/content/10.1...
I should have a shirt with, I ❤️ Morphogens.
January 21, 2025 at 2:34 PM
I should have a shirt with, I ❤️ Morphogens.
1/2
Morphogens. According to Alan Turing, morphogens are “chemical mechanisms for biological pattern formation.” I mention this to introduce the idea of patterns in biology, and how to this day, patterns are essential to life, not only to the formation of life,
Morphogens. According to Alan Turing, morphogens are “chemical mechanisms for biological pattern formation.” I mention this to introduce the idea of patterns in biology, and how to this day, patterns are essential to life, not only to the formation of life,
December 5, 2024 at 11:17 PM
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Morphogens. According to Alan Turing, morphogens are “chemical mechanisms for biological pattern formation.” I mention this to introduce the idea of patterns in biology, and how to this day, patterns are essential to life, not only to the formation of life,
Morphogens. According to Alan Turing, morphogens are “chemical mechanisms for biological pattern formation.” I mention this to introduce the idea of patterns in biology, and how to this day, patterns are essential to life, not only to the formation of life,
Alan Turing y el desarrollo embrionario temprano. Interesante inmersión en la biología de un enorme matemático.
The chemical basis of morphogenesis | Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences royalsocietypublishing.org/doi/10.1098/...
The chemical basis of morphogenesis | Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences royalsocietypublishing.org/doi/10.1098/...
The chemical basis of morphogenesis | Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
It is suggested that a system of chemical substances, called morphogens, reacting
together and diffusing through a tissue, is adequate to account for the main phenomena
of morphogenesis. Such a system...
royalsocietypublishing.org
September 3, 2025 at 7:22 AM
Alan Turing y el desarrollo embrionario temprano. Interesante inmersión en la biología de un enorme matemático.
The chemical basis of morphogenesis | Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences royalsocietypublishing.org/doi/10.1098/...
The chemical basis of morphogenesis | Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences royalsocietypublishing.org/doi/10.1098/...
Meet this week's✨ #TraineeTuesday: Soraya Scuderi, PhD!👩🔬✨
Soraya is an Associate Research Scientist in the Vaccarino Lab & recently published a @cp-cellstemcell.bsky.social study introducing DuoMAPS —a revolutionary brain-on-a-chip platform 🧠💻 that better models neural tube regionalization. [1/5]
Soraya is an Associate Research Scientist in the Vaccarino Lab & recently published a @cp-cellstemcell.bsky.social study introducing DuoMAPS —a revolutionary brain-on-a-chip platform 🧠💻 that better models neural tube regionalization. [1/5]
Specification of human brain regions with orthogonal gradients of WNT and SHH in organoids reveals patterning variations across cell lines
Vaccarino and colleagues show that simultaneous orthogonal gradients of posteriorizing
and ventralizing morphogens trigger gene regulatory programs in human stem cells,
recreating forebrain, midbrain,...
www.cell.com
June 17, 2025 at 2:20 PM
Meet this week's✨ #TraineeTuesday: Soraya Scuderi, PhD!👩🔬✨
Soraya is an Associate Research Scientist in the Vaccarino Lab & recently published a @cp-cellstemcell.bsky.social study introducing DuoMAPS —a revolutionary brain-on-a-chip platform 🧠💻 that better models neural tube regionalization. [1/5]
Soraya is an Associate Research Scientist in the Vaccarino Lab & recently published a @cp-cellstemcell.bsky.social study introducing DuoMAPS —a revolutionary brain-on-a-chip platform 🧠💻 that better models neural tube regionalization. [1/5]
We love to see the impact of our seed grants! Congratulations to the @yale.edu Vaccarino & Levchenko labs, 2020 #Kavli Innovative Award recipients, for their new paper offering new insight into how morphogens help regulate the development of stem cells into specialized brain cells.
How molecular traffic cops guide development of the human brain
A new Yale study offers new insight into how morphogens help regulate the development of stem cells into specialized brain cells.
news.yale.edu
May 6, 2025 at 6:14 PM
Turing morphogens are so cool, you can actually find the programs he wrote to simulate em.
August 7, 2024 at 2:05 AM
Turing morphogens are so cool, you can actually find the programs he wrote to simulate em.
One example of morphogens is the melanocytes on cats. All their melanin-producing cells start out on their backs, and ooze away. Cats have white feet when the ink runs out before it reaches the feetsies.
July 20, 2024 at 3:35 PM
One example of morphogens is the melanocytes on cats. All their melanin-producing cells start out on their backs, and ooze away. Cats have white feet when the ink runs out before it reaches the feetsies.
The reason it's symmetrical is the same reason your face is, why you have two eyes and two nostrils, etc:
Diffusion of Wnt morphogens from the center
en.m.wikipedia.org/wiki/Wnt_sig...
Diffusion of Wnt morphogens from the center
en.m.wikipedia.org/wiki/Wnt_sig...
Wnt signaling pathway - Wikipedia
en.m.wikipedia.org
July 20, 2024 at 3:33 PM
The reason it's symmetrical is the same reason your face is, why you have two eyes and two nostrils, etc:
Diffusion of Wnt morphogens from the center
en.m.wikipedia.org/wiki/Wnt_sig...
Diffusion of Wnt morphogens from the center
en.m.wikipedia.org/wiki/Wnt_sig...
One example of morphogens is the melanocytes on cats. All their melanin-producing cells start out on their backs, and ooze away. Cats have white feet when the ink runs out before it reaches the feetsies.
April 11, 2024 at 4:08 AM
One example of morphogens is the melanocytes on cats. All their melanin-producing cells start out on their backs, and ooze away. Cats have white feet when the ink runs out before it reaches the feetsies.
Morphogens are why you are probably bilaterally symmetrical, way you probably only have one face and not two, why your eyes are probably the same size, etc
April 11, 2024 at 4:06 AM
Morphogens are why you are probably bilaterally symmetrical, way you probably only have one face and not two, why your eyes are probably the same size, etc
Our latest @crick.ac.uk @ucllifesciences.bsky.social @ucl-ipls.bsky.social fresh @currentbiology.bsky.social 💥. How can morphogens specify cell fate at single cell precision? A little help from Notch, ERK and glia can go a long way! A collab with the wonderful Vil Fernandes 🪰📈
How do cells build complex tissues? 🧬 New research from UCL shows how morphogens and other signalling systems collaborate to guide individual cell identities, revealing how tissues create precise patterns during development.
Read more: www.ucl.ac.uk/life-science...
Read more: www.ucl.ac.uk/life-science...
How cells build complex tissues one decision at a time.
Scientists discover how morphogens and other signalling systems collaborate to guide individual cell identities, revealing how tissues create precise patterns during development.
www.ucl.ac.uk
July 13, 2026 at 1:53 PM
Our latest @crick.ac.uk @ucllifesciences.bsky.social @ucl-ipls.bsky.social fresh @currentbiology.bsky.social 💥. How can morphogens specify cell fate at single cell precision? A little help from Notch, ERK and glia can go a long way! A collab with the wonderful Vil Fernandes 🪰📈
So juxtacrine and temporally dynamic signals can themselves carry and refine positional information, augmenting that provided by morphogens to enable robust, fine-grained patterning.
September 22, 2025 at 9:14 PM
So juxtacrine and temporally dynamic signals can themselves carry and refine positional information, augmenting that provided by morphogens to enable robust, fine-grained patterning.