The authors developed spatial NT-seq to map the landscape of RNA turnover and stability regulation in the mouse brain, identifying the dentate gyrus as a turnover hotspot and revealing region-specific...

OpenAI teamed up with PerturbAI and Scripps Research to deploy thousands of AI agents that analyzed biological data from millions of mouse cells. The article OpenAI agents analyze mouse brain data in...

Knowledge of the brain’s immune system has come a long way since scientists thought the brain was completely cut off from the body’s defenses. Now, using a technique called mass cytometry, researchers have characterized the diverse populations of immune cells in the mouse brain—and there are a lot of them. Scientists led by Asya Rolls, Israel Institute of Technology, Haifa, report in the July 24 Nature Neuroscience that microglia keep company with B cells, T cells, and natural killer cells. Some were expected in the normal brain, but others were a complete surprise. This study catalogues which immune cells inhabit the healthy mouse brain, where they reside, and where they originated. It provides the basis for similar future analyses in models of stress, infection, or neurodegeneration, to see how immune cells factor in to those conditions.