A safer intranasal vaccine could bolster preparedness against H5N1.
The engineered rVSV-based 6-9ΔGΔ51+S226R-H5N1 vaccine induces robust, durable humoral and mucosal immunity and provides 100% protection in mice.
#OpenAccess: doi.org/10.1038/s413...
#IntranasalVaccine | #MucosalImmunity
The engineered rVSV-based 6-9ΔGΔ51+S226R-H5N1 vaccine induces robust, durable humoral and mucosal immunity and provides 100% protection in mice.
#OpenAccess: doi.org/10.1038/s413...
#IntranasalVaccine | #MucosalImmunity
September 10, 2026 at 1:30 PM
A safer intranasal vaccine could bolster preparedness against H5N1.
The engineered rVSV-based 6-9ΔGΔ51+S226R-H5N1 vaccine induces robust, durable humoral and mucosal immunity and provides 100% protection in mice.
#OpenAccess: doi.org/10.1038/s413...
#IntranasalVaccine | #MucosalImmunity
The engineered rVSV-based 6-9ΔGΔ51+S226R-H5N1 vaccine induces robust, durable humoral and mucosal immunity and provides 100% protection in mice.
#OpenAccess: doi.org/10.1038/s413...
#IntranasalVaccine | #MucosalImmunity
University of North Carolina is hiring:
Post-Doc Research Associate in Sharma Lab
#postdoc #mucosalimmunity #inflammatoryboweldiseases
Post-Doc Research Associate in Sharma Lab
#postdoc #mucosalimmunity #inflammatoryboweldiseases
September 10, 2026 at 3:03 AM
University of North Carolina is hiring:
Post-Doc Research Associate in Sharma Lab
#postdoc #mucosalimmunity #inflammatoryboweldiseases
Post-Doc Research Associate in Sharma Lab
#postdoc #mucosalimmunity #inflammatoryboweldiseases
If both systemic and gut mucosal protection is desired, vaccines might need to target tonsils (for systemic immunity) as well as gut-associated lymphoid tissue (GALT) for #mucosalimmunity
July 29, 2026 at 11:53 AM
If both systemic and gut mucosal protection is desired, vaccines might need to target tonsils (for systemic immunity) as well as gut-associated lymphoid tissue (GALT) for #mucosalimmunity
University of North Carolina is hiring:
Post-Doc Research Associate - Malik Lab
#postdoc #mucosalimmunity #inflammatoryboweldiseases
Post-Doc Research Associate - Malik Lab
#postdoc #mucosalimmunity #inflammatoryboweldiseases
July 23, 2026 at 8:07 AM
University of North Carolina is hiring:
Post-Doc Research Associate - Malik Lab
#postdoc #mucosalimmunity #inflammatoryboweldiseases
Post-Doc Research Associate - Malik Lab
#postdoc #mucosalimmunity #inflammatoryboweldiseases
Read this recent paper from Lekbach and colleagues in Pathogens and Immunity: bit.ly/4bI9qe4 #SciComms #TEMCells #NKCells #Herpes #MucosalImmunity
July 15, 2026 at 7:26 PM
Read this recent paper from Lekbach and colleagues in Pathogens and Immunity: bit.ly/4bI9qe4 #SciComms #TEMCells #NKCells #Herpes #MucosalImmunity
#Medsky🧪 #immunosky #publichealth @cp-immunity.bsky.social
The study maps out a newly discovered diet-microbe-immune axis, demonstrating how eating soy during early life reshapes specific #gutbacteria to trigger targeted #mucosalimmunity and protect against infection www.cell.com/immunity/ful...
The study maps out a newly discovered diet-microbe-immune axis, demonstrating how eating soy during early life reshapes specific #gutbacteria to trigger targeted #mucosalimmunity and protect against infection www.cell.com/immunity/ful...
Dietary soy shapes the microbiome to induce commensal-specific T follicular helper cells and IgA production
Diet impacts gut microbes and, subsequently, host immunity, but our understanding
of the mechanisms driving this axis remains incomplete. Hattori-Muroi, Maruta, Takahashi,
et al. show that dietary soy...
www.cell.com
May 20, 2026 at 9:14 AM
#Medsky🧪 #immunosky #publichealth @cp-immunity.bsky.social
The study maps out a newly discovered diet-microbe-immune axis, demonstrating how eating soy during early life reshapes specific #gutbacteria to trigger targeted #mucosalimmunity and protect against infection www.cell.com/immunity/ful...
The study maps out a newly discovered diet-microbe-immune axis, demonstrating how eating soy during early life reshapes specific #gutbacteria to trigger targeted #mucosalimmunity and protect against infection www.cell.com/immunity/ful...
This review highlights respiratory #MucosalImmunity as a frontline defense integrating barrier protection and immune memory, and advances #IntranasalVaccine strategies and inhalable therapies to enhance protection against #RespiratoryPathogens.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
April 28, 2026 at 1:30 PM
This review highlights respiratory #MucosalImmunity as a frontline defense integrating barrier protection and immune memory, and advances #IntranasalVaccine strategies and inhalable therapies to enhance protection against #RespiratoryPathogens.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Mucosal immune responses are central to host defense, disease prevention, and treatment, linking barrier immunity with systemic inflammatory control.
doi.org/10.1038/s413...
#MucosalImmunity #HostDefense #ImmuneHomeostasis #DiseasePrevention
doi.org/10.1038/s413...
#MucosalImmunity #HostDefense #ImmuneHomeostasis #DiseasePrevention
February 17, 2026 at 4:44 PM
Mucosal immune responses are central to host defense, disease prevention, and treatment, linking barrier immunity with systemic inflammatory control.
doi.org/10.1038/s413...
#MucosalImmunity #HostDefense #ImmuneHomeostasis #DiseasePrevention
doi.org/10.1038/s413...
#MucosalImmunity #HostDefense #ImmuneHomeostasis #DiseasePrevention
GPR15 shapes how cigarette smoke exposure differentially impacts Crohn’s disease and ulcerative colitis, revealing disease-specific immune pathways.
doi.org/10.1038/s413...
#CrohnsDisease #UlcerativeColitis #GPR15 #MucosalImmunity #EnvironmentalExposure
doi.org/10.1038/s413...
#CrohnsDisease #UlcerativeColitis #GPR15 #MucosalImmunity #EnvironmentalExposure
February 17, 2026 at 4:43 PM
GPR15 shapes how cigarette smoke exposure differentially impacts Crohn’s disease and ulcerative colitis, revealing disease-specific immune pathways.
doi.org/10.1038/s413...
#CrohnsDisease #UlcerativeColitis #GPR15 #MucosalImmunity #EnvironmentalExposure
doi.org/10.1038/s413...
#CrohnsDisease #UlcerativeColitis #GPR15 #MucosalImmunity #EnvironmentalExposure
Gut microbiota have multifaceted effects on the immune system of the intestinal mucosa strengthening barrier defense, modulating inflammation and guiding immune tolerance. 🦠
Join us at GMC 2026|Boston |June 15–16
🔗 microbiomecongress.org
#Microbiome #Immunity #GMC2026 #MucosalImmunity #GutMicrobiota
Join us at GMC 2026|Boston |June 15–16
🔗 microbiomecongress.org
#Microbiome #Immunity #GMC2026 #MucosalImmunity #GutMicrobiota
January 6, 2026 at 4:00 AM
Gut microbiota have multifaceted effects on the immune system of the intestinal mucosa strengthening barrier defense, modulating inflammation and guiding immune tolerance. 🦠
Join us at GMC 2026|Boston |June 15–16
🔗 microbiomecongress.org
#Microbiome #Immunity #GMC2026 #MucosalImmunity #GutMicrobiota
Join us at GMC 2026|Boston |June 15–16
🔗 microbiomecongress.org
#Microbiome #Immunity #GMC2026 #MucosalImmunity #GutMicrobiota
I am excited to share that our latest work is now available as a preprint on BioRxiv.
In this study, we describe and characterize a Pglyrp1-Cre mouse model and uncover previously unappreciated heterogeneity among Pglyrp1-expressing cells across mucosal lymphoid tissues.
#MucosalImmunity #MouseModels
In this study, we describe and characterize a Pglyrp1-Cre mouse model and uncover previously unappreciated heterogeneity among Pglyrp1-expressing cells across mucosal lymphoid tissues.
#MucosalImmunity #MouseModels
Pglyrp1-Cre Marks Distinct Epithelial and Immune Lineages Across Mucosal Sites https://www.biorxiv.org/content/10.64898/2025.12.22.696025v1
December 28, 2025 at 12:40 AM
I am excited to share that our latest work is now available as a preprint on BioRxiv.
In this study, we describe and characterize a Pglyrp1-Cre mouse model and uncover previously unappreciated heterogeneity among Pglyrp1-expressing cells across mucosal lymphoid tissues.
#MucosalImmunity #MouseModels
In this study, we describe and characterize a Pglyrp1-Cre mouse model and uncover previously unappreciated heterogeneity among Pglyrp1-expressing cells across mucosal lymphoid tissues.
#MucosalImmunity #MouseModels
Intranasal circRNA vaccination triggers strong T cell responses against lung cancer—highlighting a needle-free path for future immunotherapies.
#circRNA #LungCancer #TCellResponse #CancerVaccine #MucosalImmunity
www.nature.com/articles/s41...
#circRNA #LungCancer #TCellResponse #CancerVaccine #MucosalImmunity
www.nature.com/articles/s41...
December 9, 2025 at 4:21 PM
Intranasal circRNA vaccination triggers strong T cell responses against lung cancer—highlighting a needle-free path for future immunotherapies.
#circRNA #LungCancer #TCellResponse #CancerVaccine #MucosalImmunity
www.nature.com/articles/s41...
#circRNA #LungCancer #TCellResponse #CancerVaccine #MucosalImmunity
www.nature.com/articles/s41...
Induction & Maintenance of Mucosal IgA Responses :
- #Mucosalimmunity is primarily➡️ secretory IgA (sIgA) & tissue-resident memory T (TRM) cells. sIgA neutralizes viral particles at the site of infection through immune exclusion, antigen excretion, & intracellular neutralization.
- #Mucosalimmunity is primarily➡️ secretory IgA (sIgA) & tissue-resident memory T (TRM) cells. sIgA neutralizes viral particles at the site of infection through immune exclusion, antigen excretion, & intracellular neutralization.
December 2, 2025 at 9:07 AM
Induction & Maintenance of Mucosal IgA Responses :
- #Mucosalimmunity is primarily➡️ secretory IgA (sIgA) & tissue-resident memory T (TRM) cells. sIgA neutralizes viral particles at the site of infection through immune exclusion, antigen excretion, & intracellular neutralization.
- #Mucosalimmunity is primarily➡️ secretory IgA (sIgA) & tissue-resident memory T (TRM) cells. sIgA neutralizes viral particles at the site of infection through immune exclusion, antigen excretion, & intracellular neutralization.
#Medsky🧪 #IDsky #immunosky #publichealth Challenges & Considerations for Long-Term #MucosalImmunity from mucosal viral infections elicit long-lived IgA responses through type 1 follicular helper T cells, particularly in the context of #COVID19vaccination
#Medsky🧪 #IDsky #immunosky #pedsky #mucosalimmunity #virosky #publichealth Mucosal viral infections elicit long-lived IgA responses through mechanisms that critically depend on type 1 follicular helper T (Tfh1) cells, with site-specific requirements for B cell MHC class II & IFNγ signaling.
December 2, 2025 at 8:56 AM
#Medsky🧪 #IDsky #immunosky #publichealth Challenges & Considerations for Long-Term #MucosalImmunity from mucosal viral infections elicit long-lived IgA responses through type 1 follicular helper T cells, particularly in the context of #COVID19vaccination
#Medsky🧪 #IDsky #immunosky #pedsky #mucosalimmunity #virosky #publichealth Mucosal viral infections elicit long-lived IgA responses through mechanisms that critically depend on type 1 follicular helper T (Tfh1) cells, with site-specific requirements for B cell MHC class II & IFNγ signaling.
December 2, 2025 at 6:03 AM
#Medsky🧪 #IDsky #immunosky #pedsky #mucosalimmunity #virosky #publichealth Mucosal viral infections elicit long-lived IgA responses through mechanisms that critically depend on type 1 follicular helper T (Tfh1) cells, with site-specific requirements for B cell MHC class II & IFNγ signaling.
Studies indicate that IgA subtype dynamics differ between the upper (nasal) and lower (sputum) respiratory tracts, highlighting the complexity of #mucosalimmunity
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
October 20, 2025 at 5:46 AM
Studies indicate that IgA subtype dynamics differ between the upper (nasal) and lower (sputum) respiratory tracts, highlighting the complexity of #mucosalimmunity
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
#Medsky🧪 #IDsky #virosky #immunosky #mucosalimmunity #publicheath Recent studies on mucosal #COVID vaccines have shown that they induce rapid, but often transient, IgA responses in respiratory secretions,
October 20, 2025 at 5:12 AM
#Medsky🧪 #IDsky #virosky #immunosky #mucosalimmunity #publicheath Recent studies on mucosal #COVID vaccines have shown that they induce rapid, but often transient, IgA responses in respiratory secretions,
Researchers highlight the vital role of #MucosalImmunity, detailing its #lymphoid structures, regulatory mechanisms, and emerging therapies, including #MucosalVaccines and inhalable antibodies. #SARSCoV2 #medsky
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
October 10, 2025 at 3:04 PM
Researchers highlight the vital role of #MucosalImmunity, detailing its #lymphoid structures, regulatory mechanisms, and emerging therapies, including #MucosalVaccines and inhalable antibodies. #SARSCoV2 #medsky
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
On one side: scientists engineering a nasal COVID vaccine that blocks Omicron transmission and boosts mucosal immunity
On the other: people still yelling “just a cold.”
Follow for science > vibes
#COVID19 #MucosalImmunity #VaccinesWork #PublicHealth #NextGenVaccines #MedSky
On the other: people still yelling “just a cold.”
Follow for science > vibes
#COVID19 #MucosalImmunity #VaccinesWork #PublicHealth #NextGenVaccines #MedSky
Intranasal vaccine combining adenovirus and trimeric subunit protein provides superior immunity against SARS-CoV-2 Omicron variant - Nature Biomedical Engineering
A combination of adenovirus-vectored and subunit protein intranasal vaccine enhances immune response against SARS-CoV-2 variants in animal models and humans.
www.nature.com
September 23, 2025 at 3:27 PM
On one side: scientists engineering a nasal COVID vaccine that blocks Omicron transmission and boosts mucosal immunity
On the other: people still yelling “just a cold.”
Follow for science > vibes
#COVID19 #MucosalImmunity #VaccinesWork #PublicHealth #NextGenVaccines #MedSky
On the other: people still yelling “just a cold.”
Follow for science > vibes
#COVID19 #MucosalImmunity #VaccinesWork #PublicHealth #NextGenVaccines #MedSky
NanoSTING‑SN: Houston’s intranasal pan‑coronavirus vaccine aims for sterilizing immunity + no transmission.
Strong animal data. Human trials pending funding.
This could be the endgame for COVID spread.
🔗 www.uh.edu/news-events/... #NextGenVaccines #MucosalImmunity
Strong animal data. Human trials pending funding.
This could be the endgame for COVID spread.
🔗 www.uh.edu/news-events/... #NextGenVaccines #MucosalImmunity
University of Houston Researchers Create New Treatment and Vaccine for Flu and Various Coronaviruses
Two new nasal sprays to fight coronavirus and flu developed @UHouston: one, a vaccine and one an immune activator.
www.uh.edu
September 3, 2025 at 5:20 PM
NanoSTING‑SN: Houston’s intranasal pan‑coronavirus vaccine aims for sterilizing immunity + no transmission.
Strong animal data. Human trials pending funding.
This could be the endgame for COVID spread.
🔗 www.uh.edu/news-events/... #NextGenVaccines #MucosalImmunity
Strong animal data. Human trials pending funding.
This could be the endgame for COVID spread.
🔗 www.uh.edu/news-events/... #NextGenVaccines #MucosalImmunity
This review focuses on the multifaceted dimensions of #MucosalImmunity, highlighting its pivotal roles in countering mucosal-related diseases & conditions and underscoring its importance in the development of novel therapeutic approaches. #SARSCoV2 #medsky
Read in #STTT #OpenAccess: buff.ly/cDI6LaK
Read in #STTT #OpenAccess: buff.ly/cDI6LaK
August 11, 2025 at 8:02 PM
This review focuses on the multifaceted dimensions of #MucosalImmunity, highlighting its pivotal roles in countering mucosal-related diseases & conditions and underscoring its importance in the development of novel therapeutic approaches. #SARSCoV2 #medsky
Read in #STTT #OpenAccess: buff.ly/cDI6LaK
Read in #STTT #OpenAccess: buff.ly/cDI6LaK
#Medsky🧪 #IDsky #immunosky #oncosky #publichealth #Immunoglobulin (Ig) A antibodies are involved in #mucosalimmunity and eliminate pathogens immediately at the point of entry.
July 3, 2025 at 1:15 PM
#Medsky🧪 #IDsky #immunosky #oncosky #publichealth #Immunoglobulin (Ig) A antibodies are involved in #mucosalimmunity and eliminate pathogens immediately at the point of entry.
These findings highlight the potential role of boosters or alternative strategies to sustain #mucosalimmunity in Cancer patients with on going Cancer therapy . cancer patients who received dual-dose BNT162b2 vaccination
June 28, 2025 at 5:53 AM
These findings highlight the potential role of boosters or alternative strategies to sustain #mucosalimmunity in Cancer patients with on going Cancer therapy . cancer patients who received dual-dose BNT162b2 vaccination
Don’t miss Dr. Ana Caetano Faria at SMI's 2025 Principles of Mucosal Immunology Virtual Course as she presents “Oral tolerance: past and present insights.” 🧬
Join 250+ immunologists already registered!
www.socmucimm.org/meetings-eve...
#Immunology #MucosalImmunity #SMICourse2025
Join 250+ immunologists already registered!
www.socmucimm.org/meetings-eve...
#Immunology #MucosalImmunity #SMICourse2025
June 2, 2025 at 3:33 PM
Don’t miss Dr. Ana Caetano Faria at SMI's 2025 Principles of Mucosal Immunology Virtual Course as she presents “Oral tolerance: past and present insights.” 🧬
Join 250+ immunologists already registered!
www.socmucimm.org/meetings-eve...
#Immunology #MucosalImmunity #SMICourse2025
Join 250+ immunologists already registered!
www.socmucimm.org/meetings-eve...
#Immunology #MucosalImmunity #SMICourse2025
#mucosalimmunity
link.springer.com/article/10.1...
www.mdpi.com/2218-273X/15...
onlinelibrary.wiley.com/doi/full/10....
pmc.ncbi.nlm.nih.gov/articles/PMC...
papers.ssrn.com/sol3/papers....
link.springer.com/article/10.1...
www.mdpi.com/2218-273X/15...
onlinelibrary.wiley.com/doi/full/10....
pmc.ncbi.nlm.nih.gov/articles/PMC...
papers.ssrn.com/sol3/papers....
Viruses and neurodegeneration: a growing concern - Journal of Translational Medicine
Neurodegenerative diseases (NDDs) cause a progressive loss of neurons. Since NDDs are multifactorial, the precise etiology varies on the basis of the type of disease and patient history. Cohort studie...
link.springer.com
May 31, 2025 at 4:13 AM