#NGMJournal🆕🔥
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rajansingh.bsky.social
🆕🔥The Path Forward: Assessing a Pilot Competency-Based Curriculum on #DGBIs for Gastroenterology Trainees‼️ #NGMJournal 👉 onlinelibrary.wiley.com/doi/10.1111/nm… ✅DGBI education curriculum ✅Pre-&Post-individual knowledge scores 🎯Attitudes in managing DGBIs#ANMSocietyt#ESNMNM
June 12, 2025 at 4:14 PM
rajansingh.bsky.social
🆕🔥Classification of #IBS using Brain #FunctionalConnectivityStrength & #MachineLearning‼️ #NGMJournal
🎯A unique pattern of #FCS alterations in brain areas governs #Pain regulation & #Emotional processing in IBS patients
👉 onlinelibrary.wiley.com/doi/10.1111/...
#GutBrain🧠Axis #fMRI
#ANMS #ESNM
Summary The research employs resting-state functional mag- netic resonance imaging (fMRI) to assess brain function in Irritable Bowel Syndrome (IBS) patients noninvasively. A unique pattern of FCS alterations in brain areas govern pain regulation and emotional processing in IBS patients The identified abnormal FCS features have the potential to serve as effective biomarkers for IBS classification.
January 9, 2025 at 2:31 PM
rajansingh.bsky.social
Genome-Wide DNA #Methylation identifies potential disease-specific #biomarkers & #pathophysiologic mechanisms in #IBS #IBD & #CeliacDisease‼️ #NGMJournal🆕🔥
🎯#CellAdhesion & #Neuronal pathways ⏩IBS
🎯#Inflammation ⏩IBD
🎯MHC class II pathways ⏩CeD
👉https://onlinelibrary.wiley.com/doi/10.1111/nmo.14980👏
1. Blood-based DNA methylation biomarkers show promise in distinguishing between gastrointestinal (GI) disorders with overlapping symptoms, such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and celiac disease, and in differentiating these conditions from healthy individuals, thus offering a novel diagnostic approach for these GI disorders. 2. Gene ontology analysis identified distinct pathways associated with each disorder, such as cell adhesion and neuronal pathways for IBS, inflammation for IBD, and MHC class II pathways for celiac disease, underscoring the biological relevance of these biomarkers.
December 15, 2024 at 5:20 PM
rajansingh.bsky.social
🆕🔥Elevated #FecalBiomarkers of colo‐rectal #EpithelialCell activity in #IBS‼️ #NGMJournal
🎯Activity of #GutEpithelialCells rather than #inflammation driven by #neutrophils and/or #eosinophils, is a key #pathogenetic mechanism in #IBS👏
👉https://onlinelibrary.wiley.com/doi/full/10.1111/nmo.14984
✅The measurement in feces of a panel of biomarkers reflecting inflammatory and epithelial cell activities is important for understanding the underlying pathophysiology of IBS. ✅The absence of signs of involvement of neutrophils and eosinophils in IBS suggests that increased activity of intestinal epithelial cells rather than inflammation is a major determinant of the disease. ✅The negative correlation between the novel biomarker human phospholipase BII-precursor (HPLBII-P) and bloating and the presence of this biomarker in intestinal epithelial cells suggest a physiological role of HPLBII-P in intestinal activities.
December 17, 2024 at 2:40 PM
rajansingh.bsky.social
🆕🔥Global epidemiology study shows symptom differences within 5 most common #DGBIs based on #sex #menopause #age & #menses‼️ #NGMJournal
🎯Sex hormone-mediated effects may contribute to ⏫symptom burden in women than men with #DGBI👏
👉 onlinelibrary.wiley.com/doi/epdf/10....
#ANMS #ESNM
Our global epidemiological study showed sex differences in individual disorders of gut–brain interaction(DGBI) symptoms, where women experienced higher prevalence in the vast majority of symptoms. This may indicate sex-specific abnormal regulation in women that increases symptoms compared to men. We found that both premenopausal women and comparably aged younger men tended to have greater symptom burden compared to their older counter-parts, which supports that there is an age effect on DGBI symptoms that is possibly independent of sex. Some indicators of visceral perception were increased in premenopausal women compared to postmenopausal women, and others of outlet dysfunction were increased in postmenopausal compared to premenopausal women, both of which differences were not shared by men. This, together with our finding that menses-related symptoms tend to be most bothersome and most co-morbid in pain-predominant DGBI (irritable bowel syndrome and functional dyspepsia), suggests that sex hormone-mediated effects on visceral perception and GI function may contribute to a greater symptom burden in women than men with DGBI.
January 4, 2025 at 5:04 AM
rajansingh.bsky.social
🆕🔥 #NGMJournal
✳️Changes in the #Pannexin Channel in Ileum Myenteric Plexus & Intestinal Motility Following Ischemia & Reperfusion‼️
🎯Pannexin channel blockage by probenecid is effective in attenuating the effects of I/R damage👏
👉 onlinelibrary.wiley.com/doi/full/10....
#ANMS #ESNM
Summary Intestinal ischemia and reperfusion causes intestinal damage as a whole. Here, we demonstrate that this condition also affects enteric neurons that control intestinal motility. The pannexin-1 channel is a membrane protein important in cellular communication and also in controlling ATP levels. In this work, we treated animals subjected to ischemia and reperfusion with probenecid, a pannexin-1 inhibitor. PB was able to attenuate the harmful effects of I/R, recovering the number of enteric neurons and improving intestinal motility.
January 8, 2025 at 2:44 PM