#Neointima
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idw-online.de
Researchers developed DeepNeo - an AI-powered algorithm that automates analyzing coronary stents after implantation. #HelmholtzMunich #TUM #AI...
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The bottom panel shows DeepNeo’s classification: blue indicates non-analyzable regions, green marks homogeneous neointima, orange denotes heterogeneous tissue, and red highlights neoatherosclerosis. - Copyright Helmholtz Munich / Valentin Koch
April 24, 2025 at 7:47 AM
idw-online.de
Forschende haben DeepNeo entwickelt – einen KI-basierten Algorithmus, der die Analyse von koronaren Stents nach der Implantation automatisiert. #HelmholtzMunich #TUM #TUMKlinikum #KI...
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Die untere Abbildung zeigt die Klassifizierung durch DeepNeo: Blau markiert nicht auswertbare Bereiche, Grün steht für homogene Neointima, Orange kennzeichnet heterogenes Gewebe, und Rot weist auf Neoatherosklerose hin. - Copyright Helmholtz Munich / Valentin Koch
April 24, 2025 at 7:43 AM
biorxiv-pathology.bsky.social
Repurpose of Ritlecitinib Reduces Neointima Formation and Enhances Endothelial Recovery Following Vascular Injury https://www.biorxiv.org/content/10.1101/2025.09.23.678172v1
September 25, 2025 at 7:00 PM
biorxiv-genomic.bsky.social
Integrative multiomics analysis of neointima proliferation in human saphenous vein: implications for bypass graft disease https://www.biorxiv.org/content/10.1101/2023.11.14.567053v1
Integrative multiomics analysis of neointima proliferation in human saphenous vein: implications for bypass graft disease https://www.biorxiv.org/content/10.1101/2023.11.14.567053v1
Introduction: Human saphenous veins (SV) are widely used as grafts in coronary artery bypass (CABG)
www.biorxiv.org
November 17, 2023 at 4:38 AM
moriartylab.bsky.social
A Novel Adipokine, FAM19A5, Inhibits Postinjury Neointima Formation through Sphingosine-1-Phosphate Receptor 2 http://circ.ahajournals.org/content/early/2018/02/14/CIRCULATIONAHA.117.032398
December 8, 2024 at 3:52 PM
appliedcvb.bsky.social
Member publication alert:

Deficiency of ZC3HC1 Modulates Vascular Smooth Muscle Cell Phenotype and Increases Neointima Formation

www.ahajournals.org/doi/10.1161/...
Deficiency of ZC3HC1 Modulates Vascular Smooth Muscle Cell Phenotype and Increases Neointima Formation | Arteriosclerosis, Thrombosis, and Vascular Biology
BACKGROUND: The ZC3HC1 (zinc finger C3HC-type containing 1) gene has been linked to various cardiovascular traits, including coronary artery disease, blood pressure, and carotid intima-media thickness...
www.ahajournals.org
March 16, 2026 at 3:13 AM
appliedcvb.bsky.social
Member publication alert:

Blockade of YAP Mechanoactivation Prevents Neointima Formation and Adverse Remodeling in Arterialized Vein Grafts

www.ahajournals.org/doi/10.1161/...
Blockade of YAP Mechanoactivation Prevents Neointima Formation and Adverse Remodeling in Arterialized Vein Grafts | Journal of the American Heart Association
www.ahajournals.org
March 23, 2025 at 7:08 PM
haoyin.bsky.social
Protein Arginine Methyltransferase 5 as a negative epigenetic regulator of SRF/Myocardin-mediated contractile phenotype of Smooth Muscle Cell

PRMT5 ⏫H3R8me2 H3R4me2

SMC Prmt5 KO🐭; Lenti-shPRMT5; EPZ015666 (PRMT5i)▶️
⏬Neointima in injured carotid

#CardiovascRes 2023
academic.oup.com/cardiovascre...
July 3, 2026 at 11:05 AM
haoyin.bsky.social
Nidogen-2, a basement membrane component, directly binds to & activates Jag1 & Notch3 in Smooth Muscle Cell➡️⏫Contractile phenotype

Nid2 KO🐭➡️⏫Neointima in wire-injured carotid artery

Nidogen-2
⬇️in SMC +PDGFBB
⬆️in SMC =TGFβ

#Circulation 2021
www.ahajournals.org/doi/10.1161/...
July 1, 2026 at 12:29 PM
haoyin.bsky.social
Hao's Preprint Reading List
December 10th, 2025

👉EphB4 in Lung Fibrosis
👉Mechanical Senescence of Endothelial Cell & Notch
👉Modeling tissue rupture by invading cells
👉Ovarian Aging
👉scBayesAge➡️single cell age
👉Connexin 43 & Neointima
👉Venous endothelial progenitor

docs.google.com/document/d/e...
December 10, 2025 at 12:36 PM
haoyin.bsky.social
#SmoothMuscleCell m6A Epitranscriptomics

METTL3-YTHDF3 ⏫Profilin-1 mRNA translation➡️
⏫SMC proliferation migration
⏬SMC contractile phenotype

METTL3 YTHDF3 PFN1 ⬆️in SMC+PDGFBB & injured carotid artery

SMC Mettl3 or Pfn1 KO🐭➡️
⏬carotid Neointima

#ATVB 2024
www.ahajournals.org/doi/10.1161/...
October 21, 2025 at 7:04 PM
haoyin.bsky.social
A biochemical XNOR gate (not (A ^ B)) in #IntimalHyperplasia & #SmoothMuscleCell Migration

Individual inhibitor everolimus (mTORi) or PAP-1 (Kv1.3i), but NOT a combination of these two, ⏬🐭👤 vascular neointima in vivo & SMC migration in vitro

#JAHA 2025
www.ahajournals.org/doi/10.1161/...
May 4, 2025 at 12:06 PM
haoyin.bsky.social
#CircularRNA #SmoothMuscleCell

Circ-Sirt6 (cyclized Sirt6 Ex3/4, ⏬by PDGFBB/arterial injury) & IGF2BP2 (as m6A reader)
⏫m6A modif+stabilize Sirt6 mRNA in SMCs➡️
⏫Contractile markers
⏬#Neointima in injured rat carotid artery

@faseborg.bsky.social 2025
faseb.onlinelibrary.wiley.com/doi/10.1096/...
February 28, 2025 at 8:15 PM
haoyin.bsky.social
#YAP/TAZ #SmoothMuscleCell phenotype

Rats with carotid artery balloon injury have extensive cerebral watershed infarction (so serious!?)🤯

Verteporin-eluting stent
⏬Carotid neointima (re-endothelialization OK) AND
⏬brain injury (How?🤔)

#MolCellBiochem 2024
link.springer.com/article/10.1...
December 12, 2024 at 12:45 PM
haoyin.bsky.social
#SpatialTranscriptomics #Visium #VeinGraft #Neointima

Late-stage Neointimal cells in grafted vessels are More Contractile & Synthetic than regenerated Medial cells

FHL1 CRISPR KO Rat▶️hyper-inflammatory, dysmorphic intima

Clin Transl Med 2024
onlinelibrary.wiley.com/doi/full/10....
December 11, 2024 at 12:13 PM
haoyin.bsky.social
Landmark revisit

Smooth muscle cells from the anastomosed artery are the major precursors for neointima formation in both artery (90%) & vein (60%) grafts

Wnt1-Cre reporter🐭

Minimal contribution from bone marrow (BMT)

#BasicResCardiol 2014
link.springer.com/article/10.1...
December 10, 2024 at 12:38 PM
haoyin.bsky.social
#ExtracellularAcidification #SmoothMuscleCell

pH-sensing, acidification-activated GPR68➡️
Ca2+/PKCα➡️
Rap1A/B (How?🧐)➡️
SMC proliferation/Neointima formation

#ajpheartcirc 2024
journals.physiology.org/doi/abs/10.1...
October 30, 2024 at 6:41 PM
haoyin.bsky.social
SRF SUMOylation (SUMO1) prevents its (lysosomal) degradation & favors a pro-synthetic SRF-ELK1 transcriptional complex in #SmoothMuscleCell

SMC (SM22α-Cre) SENP1 (deSUMOylase) KO🐭->
Exacerbated Neointima, ⏬by AZD6244 MEK1/2 inhibitor

#NatureComms 2024
www.nature.com/articles/s41...
September 28, 2024 at 11:46 AM
haoyin.bsky.social

#PentosePhosphatePathway #SmoothMuscleCell

Inhibiting PhosphoGluconate Dehydrogenase/PGD (with local Hydrogel delivery of Physcion)⏬Neointima formation in injured rat carotid artery

Next, PGD in #Atherosclerosis?😆

Bowen Wang lab #JVS_VascSci 2024
jvsvs.org/article/S266...
September 26, 2024 at 11:57 AM
haoyin.bsky.social
PDGF/Arterial injury->
Glycolysis (PFKFB3, synergizing with HIF1α)->
de novo Lipogenesis (FASN/ACLY/ACACA/B)->
#SmoothMuscleCell proliferation, lipid loading, loss of contractile phenotype in #Neointima

SMC FASN KO🐭->⏬Neointima
J Pathol 2023
pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/...
August 19, 2024 at 7:01 PM
haoyin.bsky.social
#LongNonCodingRNA #SmoothMuscleCell

LncDACH1⏬SMC proliferation+migration & #Neointima of #ArterioVenousFistula, partially via ⏬HSP90 abundance & sequestrating SRPK1 in the nuclei

A similar pro-intimal role in #Atherosclerosis?

#NatureComms 2024
www.nature.com/articles/s41...
May 17, 2024 at 7:50 PM
haoyin.bsky.social
Single-cell transcriptomics of WKY vs SHR rat carotid artery, balloon injury

Hypertensive metabolic & phenotypic perturbations of Monocyte #EndothelialCell #SmoothMuscleCell

Targeting #MitochondrialRespiration ⏬Neointima in SHR but not WKY

#Hypertension 2024
www.ahajournals.org/doi/10.1161/...
March 15, 2024 at 1:11 AM
haoyin.bsky.social
Designing an N-cadherin-blocking peptide that⏬migration, not proliferation/apoptosis, of #SmoothMuscleCell

Infusion of this peptide⏬#Neointima, not re-endothelialization/EC barrier, of injured carotid artery

Michelle Bendeck lab #ATVB 2023
www.ahajournals.org/doi/10.1161/...
September 25, 2023 at 7:20 PM
jiliang-zhou.bsky.social
Actually mir15/16 can inhibit YAP1, thereby reducing cell proliferation. Not sure whether YAP1 is upregulated in MiR 15/16 KO and is functionally involved in these settings as a down-stream target of miR15/16. Check out our publication in ATVB.

www.ahajournals.org/doi/10.1161/...
MicroRNA-15b/16 Attenuates Vascular Neointima Formation by Promoting the Contractile Phenotype of Vascular Smooth Muscle Through Targeting YAP | Arteriosclerosis, Thrombosis, and Vascular Biology
Objective—To investigate the functional role of the microRNA (miR)-15b/16 in vascular smooth muscle (SM) phenotypic modulation. Approach and Results—We found that miR-15b/16 is one of the most abundan...
www.ahajournals.org
June 19, 2025 at 3:36 AM
biorxiv-molbio.bsky.social
CircSMAD3 represses VSMC phenotype switching and neointima formation via promoting hnRNPA1 ubiquitination degradation https://www.biorxiv.org/content/10.1101/2023.09.17.558158v1
CircSMAD3 represses VSMC phenotype switching and neointima formation via promoting hnRNPA1 ubiquitination degradation https://www.biorxiv.org/content/10.1101/2023.09.17.558158v1
Aims: Circular RNAs (circRNAs) are novel regulatory RNAs with high evolutionary conservation and sta
www.biorxiv.org
September 29, 2023 at 2:18 PM