Open science for plant breeding 🌱
Researchers successfully used OpenCRISPR-1, and AI-designed open-source editing system, in soybean.
Tools with broader access could mean faster innovation 👇
www.biorxiv.org/content/10.6...
Researchers successfully used OpenCRISPR-1, and AI-designed open-source editing system, in soybean.
Tools with broader access could mean faster innovation 👇
www.biorxiv.org/content/10.6...
September 25, 2026 at 11:57 AM
Open science for plant breeding 🌱
Researchers successfully used OpenCRISPR-1, and AI-designed open-source editing system, in soybean.
Tools with broader access could mean faster innovation 👇
www.biorxiv.org/content/10.6...
Researchers successfully used OpenCRISPR-1, and AI-designed open-source editing system, in soybean.
Tools with broader access could mean faster innovation 👇
www.biorxiv.org/content/10.6...
✨ Paper spotlight ✨
(🧵 1/7) AI-designed OpenCRISPR-1 performs robust knock-out, base editing and prime editing in rice
nph.onlinelibrary.wiley.com/doi/10.1111/...
(🧵 1/7) AI-designed OpenCRISPR-1 performs robust knock-out, base editing and prime editing in rice
nph.onlinelibrary.wiley.com/doi/10.1111/...
May 22, 2026 at 2:35 PM
✨ Paper spotlight ✨
(🧵 1/7) AI-designed OpenCRISPR-1 performs robust knock-out, base editing and prime editing in rice
nph.onlinelibrary.wiley.com/doi/10.1111/...
(🧵 1/7) AI-designed OpenCRISPR-1 performs robust knock-out, base editing and prime editing in rice
nph.onlinelibrary.wiley.com/doi/10.1111/...
AI-designed OpenCRISPR-1 offers enhanced genome editing, outperforming Cas9 with h… PMID:42192532, Genome Med 2026, @GenomeMedicine @OTSociety @NAR_Open https://doi.org/10.1186/s13073-026-01682-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
High-fidelity genome and prime editing enabled by the AI-designed openCRISPR-1 | Genome Medicine | Springer Nature Link
RNA-guided nucleases such as CRISPR-Cas9 systems have revolutionized genome engineering by enabling programmable DNA modifications. Although structure-guid
doi.org
May 31, 2026 at 5:10 AM
AI-designed OpenCRISPR-1 performs robust knockout, base editing, and prime editing in rice
A #Letter by Molla et al.
👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience
A #Letter by Molla et al.
👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience
August 6, 2026 at 10:17 PM
AI-designed OpenCRISPR-1 performs robust knockout, base editing, and prime editing in rice
A #Letter by Molla et al.
👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience
A #Letter by Molla et al.
👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue #PlantScience
Vietnam Academy of Science and Technology researchers successfully deployed the AI-designed OpenCRISPR-1 nuclease in dicot plants, achieving 49.55% editing in soybean hairy roots and 75% T0 editing efficiency in tobacco. 🌿🤖 #OpenCRISPR #PlantGenomics #SoybeanEditing #CRISPR #bioRxiv2026 #AgBiotech
September 1, 2026 at 8:49 AM
Vietnam Academy of Science and Technology researchers successfully deployed the AI-designed OpenCRISPR-1 nuclease in dicot plants, achieving 49.55% editing in soybean hairy roots and 75% T0 editing efficiency in tobacco. 🌿🤖 #OpenCRISPR #PlantGenomics #SoybeanEditing #CRISPR #bioRxiv2026 #AgBiotech
"Alignment to NCBI-nr showed top hits to proteins from several Streptococcus spp. (Streptococcus cristatus, S. pyogenes and Streptococcus sanguinis), but none exceeding a sequence identity of 86.3%. Taken together, these three natural Cas9s yielded a cumulative identity of 98.3% for OpenCRISPR-1"
July 31, 2025 at 7:35 PM
"Alignment to NCBI-nr showed top hits to proteins from several Streptococcus spp. (Streptococcus cristatus, S. pyogenes and Streptococcus sanguinis), but none exceeding a sequence identity of 86.3%. Taken together, these three natural Cas9s yielded a cumulative identity of 98.3% for OpenCRISPR-1"
😱
The most extensive dataset of #CRISPR operons curated to-date (1,246,163)
Trained large language models (LLMs) of the dataset (ProGen2-base language model)
OpenCRISPR-1, a highly performant AI-generated gene editor that exhibits compatibility with base editing
www.biorxiv.org/content/10.1...
The most extensive dataset of #CRISPR operons curated to-date (1,246,163)
Trained large language models (LLMs) of the dataset (ProGen2-base language model)
OpenCRISPR-1, a highly performant AI-generated gene editor that exhibits compatibility with base editing
www.biorxiv.org/content/10.1...
Design of highly functional genome editors by modeling the universe of CRISPR-Cas sequences
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
April 23, 2024 at 9:28 AM
😱
The most extensive dataset of #CRISPR operons curated to-date (1,246,163)
Trained large language models (LLMs) of the dataset (ProGen2-base language model)
OpenCRISPR-1, a highly performant AI-generated gene editor that exhibits compatibility with base editing
www.biorxiv.org/content/10.1...
The most extensive dataset of #CRISPR operons curated to-date (1,246,163)
Trained large language models (LLMs) of the dataset (ProGen2-base language model)
OpenCRISPR-1, a highly performant AI-generated gene editor that exhibits compatibility with base editing
www.biorxiv.org/content/10.1...
We note the 86% identity to S. cristatus Cas9 in the paper, but importantly found that OpenCRISPR-1 was <80% identity to anything in our database of patented sequences.
April 26, 2024 at 1:28 AM
We note the 86% identity to S. cristatus Cas9 in the paper, but importantly found that OpenCRISPR-1 was <80% identity to anything in our database of patented sequences.
Plant Science Research Weekly -- Letter. OpenCRISPR-1 in rice: when AI meets plant genome editing (New Phytologist) (Summary by Ching Chan @ntnuchanlab.bsky.social) buff.ly/LojGmez
#PlantaePSRW
#PlantaePSRW
Letter. OpenCRISPR-1 in rice: when AI meets plant genome editing | Plantae
Genome editing has rapidly transformed biology, and Cas9 remains the most widely used tool for making targeted changes in DNA. Recently, a new AI-designed editor called OpenCRISPR-1 (OC1) which…
buff.ly
June 12, 2026 at 10:15 AM
Plant Science Research Weekly -- Letter. OpenCRISPR-1 in rice: when AI meets plant genome editing (New Phytologist) (Summary by Ching Chan @ntnuchanlab.bsky.social) buff.ly/LojGmez
#PlantaePSRW
#PlantaePSRW
RRIDs were included in this in aBIOTECH paper. Thanks for making your methods matter! #OpenScience #accelerateopenscience #methodsmatter
AI-Designed OpenCRISPR-1 Enables Efficient Targeted Mutagenesis and Prime Editing in Rice
Read the full paper: AI-Designed OpenCRISPR-1 Enables Efficient Targeted Mutagenesis and Prime Editing in Rice
doi.org
May 29, 2026 at 7:01 AM
RRIDs were included in this in aBIOTECH paper. Thanks for making your methods matter! #OpenScience #accelerateopenscience #methodsmatter
The authors included RRIDs in their in Genome Medicine paper! Thanks for making your methods matter! #ReproducibleResearch #OpenResearch #reproducibility
High-fidelity genome and prime editing enabled by the AI-designed openCRISPR-1
Read the full paper: High-fidelity genome and prime editing enabled by the AI-designed openCRISPR-1
doi.org
August 10, 2026 at 7:00 AM
The authors included RRIDs in their in Genome Medicine paper! Thanks for making your methods matter! #ReproducibleResearch #OpenResearch #reproducibility
What if 𝗔𝗜 could design 𝗯𝗲𝘁𝘁𝗲𝗿 𝗴𝗲𝗻𝗲 𝗲𝗱𝗶𝘁𝗼𝗿𝘀 than what evolution gave us? 𝗢𝗽𝗲𝗻𝗖𝗥𝗜𝗦𝗣𝗥-𝟭 - the first AI-designed genome editing enzyme - might be exactly that.
In our 𝗹𝗮𝘁𝗲𝘀𝘁 𝗯𝗹𝗼𝗴, we explain:
✔What OpenCRISPR-1 is & how it was created
✔Why developers should care
👉Read the 𝗯𝗹𝗼𝗴: hubs.li/Q03YjfQp0
In our 𝗹𝗮𝘁𝗲𝘀𝘁 𝗯𝗹𝗼𝗴, we explain:
✔What OpenCRISPR-1 is & how it was created
✔Why developers should care
👉Read the 𝗯𝗹𝗼𝗴: hubs.li/Q03YjfQp0
December 17, 2025 at 10:50 AM
What if 𝗔𝗜 could design 𝗯𝗲𝘁𝘁𝗲𝗿 𝗴𝗲𝗻𝗲 𝗲𝗱𝗶𝘁𝗼𝗿𝘀 than what evolution gave us? 𝗢𝗽𝗲𝗻𝗖𝗥𝗜𝗦𝗣𝗥-𝟭 - the first AI-designed genome editing enzyme - might be exactly that.
In our 𝗹𝗮𝘁𝗲𝘀𝘁 𝗯𝗹𝗼𝗴, we explain:
✔What OpenCRISPR-1 is & how it was created
✔Why developers should care
👉Read the 𝗯𝗹𝗼𝗴: hubs.li/Q03YjfQp0
In our 𝗹𝗮𝘁𝗲𝘀𝘁 𝗯𝗹𝗼𝗴, we explain:
✔What OpenCRISPR-1 is & how it was created
✔Why developers should care
👉Read the 𝗯𝗹𝗼𝗴: hubs.li/Q03YjfQp0
OpenCRISPR-1, Profluent's AI-designed gene editor, is now published in Nature!
@thisismadani.bsky.social emphasizes the need to move away from random discovery and into bespoke design using AI. 1/
Read more at GEN:
www.genengnews.com/topics/artif...
@thisismadani.bsky.social emphasizes the need to move away from random discovery and into bespoke design using AI. 1/
Read more at GEN:
www.genengnews.com/topics/artif...
Profluent’s AI-Designed Gene Editor Provides Glimpse Into Generalizable Platform
OpenCRISPR-1, an AI-generated custom gene editor capable of precision editing of the human genome. is just the beginning of Profluent’s AI applications.
www.genengnews.com
July 30, 2025 at 3:51 PM
OpenCRISPR-1, Profluent's AI-designed gene editor, is now published in Nature!
@thisismadani.bsky.social emphasizes the need to move away from random discovery and into bespoke design using AI. 1/
Read more at GEN:
www.genengnews.com/topics/artif...
@thisismadani.bsky.social emphasizes the need to move away from random discovery and into bespoke design using AI. 1/
Read more at GEN:
www.genengnews.com/topics/artif...
Hey, happy to provide more info here! We did find other generated sequences with activity further from naturals (including S. cristatus), but for OpenCRISPR-1 we wanted a sequence that’d be viable as a drop-in for SpCas9 (high activity, NGG PAM), which ended up bringing us closer to a few naturals.
April 26, 2024 at 1:27 AM
Hey, happy to provide more info here! We did find other generated sequences with activity further from naturals (including S. cristatus), but for OpenCRISPR-1 we wanted a sequence that’d be viable as a drop-in for SpCas9 (high activity, NGG PAM), which ended up bringing us closer to a few naturals.
This study validates rice-tailored AI-designed open-source OpenCRISPR-1 matching SpCas9 in editing efficiency, generating blight-resistant lines, compatible with OpsgRNA and high-fidelity OpenPE6c as an open precision crop breeding platform. doi.org/10.1016/j.ab...
July 5, 2026 at 10:47 AM
This study validates rice-tailored AI-designed open-source OpenCRISPR-1 matching SpCas9 in editing efficiency, generating blight-resistant lines, compatible with OpsgRNA and high-fidelity OpenPE6c as an open precision crop breeding platform. doi.org/10.1016/j.ab...
Beijing Institute of Technology researchers synthesized CRISPR engineering into a DBTL framework, showing how structural tuning, DMS, and generative AI (OpenCRISPR-1) are overcoming PAM and size bottlenecks. 🧬🤖 #CRISPR #GeneEditing #ACSSynBio2026 #GenerativeAI #SyntheticBiology #AgBiotech
August 19, 2026 at 8:03 AM
Beijing Institute of Technology researchers synthesized CRISPR engineering into a DBTL framework, showing how structural tuning, DMS, and generative AI (OpenCRISPR-1) are overcoming PAM and size bottlenecks. 🧬🤖 #CRISPR #GeneEditing #ACSSynBio2026 #GenerativeAI #SyntheticBiology #AgBiotech
AI設計によるゲノム編集ツールOpenCRISPR-1
大規模なゲノムデータから言語モデルを用いて、自然界には存在しないゲノムエディターを設計。そのうちOpenCRISPR-1は従来のspCas9と同等またはそれ以上の活性と特異性を示し、さらに免疫原性が低い可能性
すごすぎてクラクラしてきます、
www.nature.com/articles/s41...
大規模なゲノムデータから言語モデルを用いて、自然界には存在しないゲノムエディターを設計。そのうちOpenCRISPR-1は従来のspCas9と同等またはそれ以上の活性と特異性を示し、さらに免疫原性が低い可能性
すごすぎてクラクラしてきます、
www.nature.com/articles/s41...
Design of highly functional genome editors by modelling CRISPR–Cas sequences - Nature
Gene editors designed using artificial intelligence can undertake precision editing of the human genome.
www.nature.com
July 31, 2025 at 10:00 AM
AI設計によるゲノム編集ツールOpenCRISPR-1
大規模なゲノムデータから言語モデルを用いて、自然界には存在しないゲノムエディターを設計。そのうちOpenCRISPR-1は従来のspCas9と同等またはそれ以上の活性と特異性を示し、さらに免疫原性が低い可能性
すごすぎてクラクラしてきます、
www.nature.com/articles/s41...
大規模なゲノムデータから言語モデルを用いて、自然界には存在しないゲノムエディターを設計。そのうちOpenCRISPR-1は従来のspCas9と同等またはそれ以上の活性と特異性を示し、さらに免疫原性が低い可能性
すごすぎてクラクラしてきます、
www.nature.com/articles/s41...
#AI #Biotech #CRISPR #MLSky AI has generated OpenCRISPR-1, a novel gene-editing protein. rivals natural CRISPR efficiency, offers significantly higher specificity, paving the way for safer, bespoke gene therapies. Read the Nature paper: www.nature.com/articles/s41...
Design of highly functional genome editors by modelling CRISPR–Cas sequences - Nature
Gene editors designed using artificial intelligence can undertake precision editing of the human genome.
www.nature.com
January 4, 2026 at 3:06 PM
#AI #Biotech #CRISPR #MLSky AI has generated OpenCRISPR-1, a novel gene-editing protein. rivals natural CRISPR efficiency, offers significantly higher specificity, paving the way for safer, bespoke gene therapies. Read the Nature paper: www.nature.com/articles/s41...
Application of AI-Designed OpenCRISPR-1 for Highly Efficient Gene Editing in Soybean and Nicotiana benthamiana https://www.biorxiv.org/content/10.64898/2026.08.27.747635v1
August 28, 2026 at 4:00 PM
Application of AI-Designed OpenCRISPR-1 for Highly Efficient Gene Editing in Soybean and Nicotiana benthamiana https://www.biorxiv.org/content/10.64898/2026.08.27.747635v1
Application of AI-Designed OpenCRISPR-1 for Highly Efficient Gene Editing in Soybean and Nicotiana benthamiana https://www.biorxiv.org/content/10.64898/2026.08.27.747635v1
August 28, 2026 at 4:00 PM
Application of AI-Designed OpenCRISPR-1 for Highly Efficient Gene Editing in Soybean and Nicotiana benthamiana https://www.biorxiv.org/content/10.64898/2026.08.27.747635v1
Se ha presentado OPENCRISPR-1, una herramienta de edición de genes creada mediante modelos de lenguaje de IA. Este diseño sintético es mas preciso que los métodos naturales y reduce los errores de edición ADN.
December 18, 2025 at 4:30 PM
Se ha presentado OPENCRISPR-1, una herramienta de edición de genes creada mediante modelos de lenguaje de IA. Este diseño sintético es mas preciso que los métodos naturales y reduce los errores de edición ADN.
Científicos han lanzado OPENCRISPR-1, una herramienta de edición genética creada mediante modelos de lenguaje de IA. A diferencia de los métodos naturales, este diseño sintético ofrece una precisión mucho mayor y reduce efectos secundarios.
December 18, 2025 at 12:30 AM
Científicos han lanzado OPENCRISPR-1, una herramienta de edición genética creada mediante modelos de lenguaje de IA. A diferencia de los métodos naturales, este diseño sintético ofrece una precisión mucho mayor y reduce efectos secundarios.
Profluent bearbeitet erfolgreich das menschliche Genom mit OpenCRISPR-1, dem weltweit ersten KI-erstellten und Open-Source-Gen-Editor
https://www.bytesde.com/100472/
Profluent bearbeitet erfolgreich das menschliche Genom mit OpenCRISPR-1, dem weltweit ersten KI-erstellten und …
https://www.bytesde.com/100472/
Profluent bearbeitet erfolgreich das menschliche Genom mit OpenCRISPR-1, dem weltweit ersten KI-erstellten und …
Profluent bearbeitet erfolgreich das menschliche Genom mit OpenCRISPR-1, dem weltweit ersten KI-erstellten und Open-Source-Gen-Editor
Profluent bearbeitet erfolgreich das menschliche Genom mit OpenCRISPR-1, dem weltweit ersten KI-erstellten und Open-Source-Gen-Editorhttps://www.businesswire.com/news/home/20240422399482/en/Profluent-Successfully-Edits-Human-Genome-with-OpenCRISPR-1-the-World%E2%80%99s-First-AI-Created-and-Open-Source-Gene-Editor
www.bytesde.com
April 23, 2024 at 12:15 PM
Profluent bearbeitet erfolgreich das menschliche Genom mit OpenCRISPR-1, dem weltweit ersten KI-erstellten und Open-Source-Gen-Editor
https://www.bytesde.com/100472/
Profluent bearbeitet erfolgreich das menschliche Genom mit OpenCRISPR-1, dem weltweit ersten KI-erstellten und …
https://www.bytesde.com/100472/
Profluent bearbeitet erfolgreich das menschliche Genom mit OpenCRISPR-1, dem weltweit ersten KI-erstellten und …
prompt: "modify eye structure and function. increase rod cells for night vision, add a tapetum lucidum for light amplification, shift cone cells to dichromatic vision for contrast, optimize for motion detection, enhance depth perception with narrower field of view for stealth and tracking"
News: OpenCRISPR-1: Generative AI Meets CRISPR - CRISPR Medicine
Researchers used large language models (LLMs) to expand the sequence diversity of CRISPR-Cas proteins and generate novel, functional genome editors with improved properties compared to natural systems...
crisprmedicinenews.com
November 26, 2024 at 1:42 PM
prompt: "modify eye structure and function. increase rod cells for night vision, add a tapetum lucidum for light amplification, shift cone cells to dichromatic vision for contrast, optimize for motion detection, enhance depth perception with narrower field of view for stealth and tracking"