Single-cell and high-resolution spatial profiling of podocytopathies reveals core mechanisms of podocyte injury
Science Advances
www.science.org/doi/10.1126/...
Science Advances
www.science.org/doi/10.1126/...
Single-cell and high-resolution spatial profiling of podocytopathies reveals core mechanisms of podocyte injury
PDE4DIP emerges as a potential target for protecting podocytes and preserving kidney filtration.
www.science.org
July 25, 2026 at 5:41 AM
Single-cell and high-resolution spatial profiling of podocytopathies reveals core mechanisms of podocyte injury
Science Advances
www.science.org/doi/10.1126/...
Science Advances
www.science.org/doi/10.1126/...
Circular RNA Pde4dip regulates myogenesis by interacting with Zfp143 mRNA: A novel regulatory axis https://www.biorxiv.org/content/10.1101/2025.09.17.676975v1
September 20, 2025 at 4:18 PM
Circular RNA Pde4dip regulates myogenesis by interacting with Zfp143 mRNA: A novel regulatory axis https://www.biorxiv.org/content/10.1101/2025.09.17.676975v1
Expression Profile of Primary Microcephaly Genes Cdk5rap2, Cep63 and Their Paralogues Pde4dip, Ccdc67 in Mouse Embryonic and Adult Tissues https://www.biorxiv.org/content/10.1101/2023.12.16.571987v1
Expression Profile of Primary Microcephaly Genes Cdk5rap2, Cep63 and Their Paralogues Pde4dip, Ccdc67 in Mouse Embryonic and Adult Tissues https://www.biorxiv.org/content/10.1101/2023.12.16.571987v1
Autosomal recessive primary microcephaly (MCPH) is characterized by the prenatal reduction in the hu
www.biorxiv.org
December 17, 2023 at 2:32 AM
Expression Profile of Primary Microcephaly Genes Cdk5rap2, Cep63 and Their Paralogues Pde4dip, Ccdc67 in Mouse Embryonic and Adult Tissues https://www.biorxiv.org/content/10.1101/2023.12.16.571987v1
Circular RNA Pde4dip regulates myogenesis by interacting with Zfp143 mRNA: A novel regulatory axis https://www.biorxiv.org/content/10.1101/2025.09.17.676975v1
September 20, 2025 at 4:18 PM
Circular RNA Pde4dip regulates myogenesis by interacting with Zfp143 mRNA: A novel regulatory axis https://www.biorxiv.org/content/10.1101/2025.09.17.676975v1
Expression Profile of Primary Microcephaly Genes Cdk5rap2, Cep63 and Their Paralogues Pde4dip, Ccdc67 in Mouse Embryonic and Adult Tissues https://www.biorxiv.org/content/10.1101/2023.12.16.571987v1
Expression Profile of Primary Microcephaly Genes Cdk5rap2, Cep63 and Their Paralogues Pde4dip, Ccdc67 in Mouse Embryonic and Adult Tissues https://www.biorxiv.org/content/10.1101/2023.12.16.571987v1
Autosomal recessive primary microcephaly (MCPH) is characterized by the prenatal reduction in the hu
www.biorxiv.org
December 17, 2023 at 2:32 AM
Expression Profile of Primary Microcephaly Genes Cdk5rap2, Cep63 and Their Paralogues Pde4dip, Ccdc67 in Mouse Embryonic and Adult Tissues https://www.biorxiv.org/content/10.1101/2023.12.16.571987v1
#PDE4DIP upregulation disrupts #cytoskeleton, #CellPolarity, and mitochondrial energy metabolism via Rho-ROCK signaling, driving the progression of #LVNC and highlighting a potential therapeutic target.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
May 4, 2026 at 3:00 PM
#PDE4DIP upregulation disrupts #cytoskeleton, #CellPolarity, and mitochondrial energy metabolism via Rho-ROCK signaling, driving the progression of #LVNC and highlighting a potential therapeutic target.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
#PDE4DIP is identified as a driver of #LeftVentricularNoncompaction; its overexpression disrupts #cardiomyocyte polarity and energy metabolism, while knockdown restores #ATP and migration, highlighting new therapeutic targets for LVNC.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
January 8, 2026 at 12:45 AM
#PDE4DIP is identified as a driver of #LeftVentricularNoncompaction; its overexpression disrupts #cardiomyocyte polarity and energy metabolism, while knockdown restores #ATP and migration, highlighting new therapeutic targets for LVNC.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
PDE4DIP dysfunction contributes to the pathogenesis of left ventricular non-compaction (LVNC) by regulating cell polarity, cytoskeleton architecture, & energy metabolism through the Rho-ROCK pathway. #cardiomyopathy #medsky
#OpenAccess:
#OpenAccess:
www.sciencedirect.com
July 29, 2025 at 12:56 PM
PDE4DIP dysfunction contributes to the pathogenesis of left ventricular non-compaction (LVNC) by regulating cell polarity, cytoskeleton architecture, & energy metabolism through the Rho-ROCK pathway. #cardiomyopathy #medsky
#OpenAccess:
#OpenAccess:
PDE4DIP dysfunction contributes to the pathogenesis of left ventricular non-compaction (LVNC) by regulating cell polarity, cytoskeleton architecture, & energy metabolism through the Rho-ROCK pathway. #cardiomyopathy #medsky
#OpenAccess:
#OpenAccess:
www.sciencedirect.com
July 29, 2025 at 12:30 AM
PDE4DIP dysfunction contributes to the pathogenesis of left ventricular non-compaction (LVNC) by regulating cell polarity, cytoskeleton architecture, & energy metabolism through the Rho-ROCK pathway. #cardiomyopathy #medsky
#OpenAccess:
#OpenAccess:
#PDE4DIP activation plays a critical role in #LeftVentricularNoncompaction development by regulating #cellpolarity, skeleton, and energy metabolism via the Rho-ROCK pathway, thereby offering potential targets and therapeutic strategies. #medsky
#OpenAccess:
#OpenAccess:
www.sciencedirect.com
July 4, 2025 at 5:56 PM
#PDE4DIP activation plays a critical role in #LeftVentricularNoncompaction development by regulating #cellpolarity, skeleton, and energy metabolism via the Rho-ROCK pathway, thereby offering potential targets and therapeutic strategies. #medsky
#OpenAccess:
#OpenAccess:
This study identifies #PDE4DIP as a key player in #LeftVentricularNoncompaction development by regulating #cellpolarity, skeleton, and energy metabolism via the Rho-ROCK pathway. #LVNC
Dysfunction of PDE4DIP contributes to LVNC development by regulating cell polarity, skeleton ec1
This study demonstrates that dysfunction of PDE4DIP contributes to the development of left ventricular non-compaction (LVNC) cardiomyopathy by disrupting cel...
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June 25, 2025 at 5:18 AM
This study identifies #PDE4DIP as a key player in #LeftVentricularNoncompaction development by regulating #cellpolarity, skeleton, and energy metabolism via the Rho-ROCK pathway. #LVNC
Mechanistic insights into how PDE4DIP contributes to the #pathogenesis of left ventricular non-compaction (#LVNC) by regulating #CellPolarity, cytoskeleton architecture, & energy metabolism through the Rho-ROCK pathway. #cardiomyopathy #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
April 7, 2025 at 2:00 PM
Mechanistic insights into how PDE4DIP contributes to the #pathogenesis of left ventricular non-compaction (#LVNC) by regulating #CellPolarity, cytoskeleton architecture, & energy metabolism through the Rho-ROCK pathway. #cardiomyopathy #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
Mechanistic insights into how PDE4DIP contributes to the #pathogenesis of left ventricular non-compaction (#LVNC) by regulating #CellPolarity, cytoskeleton architecture, & energy metabolism through the Rho-ROCK pathway. #cardiomyopathy #medsky
#OpenAccess: www.sciencedirect.co...
#OpenAccess: www.sciencedirect.co...
March 4, 2025 at 2:00 PM
Mechanistic insights into how PDE4DIP contributes to the #pathogenesis of left ventricular non-compaction (#LVNC) by regulating #CellPolarity, cytoskeleton architecture, & energy metabolism through the Rho-ROCK pathway. #cardiomyopathy #medsky
#OpenAccess: www.sciencedirect.co...
#OpenAccess: www.sciencedirect.co...
Mechanistic exploration of PDE4DIP in the progression of non-small cell lung cancer (NSCLC) demonstrates that PDE4DIP coordinates with AKAP9 to promotes NSCLC growth via regulating PKA/CREB signalling pathway.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
The PDE4DIP-AKAP9 axis promotes lung cancer growth through modulation of PKA signalling - Communications Biology
Mechanistic exploration of PDE4DIP in the progression of non-small cell lung cancer (NSCLC) demonstrates that PDE4DIP coordinates with AKAP9 to promotes NSCLC growth via regulating PKA/CREB signaling ...
www.nature.com
February 5, 2025 at 11:23 AM
Mechanistic exploration of PDE4DIP in the progression of non-small cell lung cancer (NSCLC) demonstrates that PDE4DIP coordinates with AKAP9 to promotes NSCLC growth via regulating PKA/CREB signalling pathway.
www.nature.com/articles/s42...
www.nature.com/articles/s42...