Richard so deserves this - a legend in bioinformatics and computational biology - work genome, human genome, Pfam, 1,000 genomes, Sam/bam format, bwa, vcf, psmc… and so many more
Congratulations to Richard Durbin on being awarded our Genetics Society Medal!
November 14, 2025 at 1:37 PM
Richard so deserves this - a legend in bioinformatics and computational biology - work genome, human genome, Pfam, 1,000 genomes, Sam/bam format, bwa, vcf, psmc… and so many more
Fission yeast doing the splits— Microtubule push nucleus from inside, while cell membrane finishes the party. Shout-out @pasteur.fr and #PFAM course for the science vibes! #FluorescenceFriday #Microscopy #CellBiology @pasteuredu.bsky.social
April 4, 2025 at 10:24 AM
Fission yeast doing the splits— Microtubule push nucleus from inside, while cell membrane finishes the party. Shout-out @pasteur.fr and #PFAM course for the science vibes! #FluorescenceFriday #Microscopy #CellBiology @pasteuredu.bsky.social
HMMER, Pfam, and Rfam are critical to so many Bioinformatics pipelines. This is absolutely crazy
This is awful to hear, describing how Sean Eddy (HMMER, infernal, pfam, rfam) has been defunded. The letter said his work
"had been determined to be of absolutely no value to the US taxpayer, and therefore it was being specifically terminated,"
www.npr.org/2026/05/21/n...
"had been determined to be of absolutely no value to the US taxpayer, and therefore it was being specifically terminated,"
www.npr.org/2026/05/21/n...
Researchers say the Trump administration is finding new ways to punish science
Even with federal grants largely restored, scientists say the Trump administration is still preventing those funds from reaching them. The consequences, they say, are already becoming clear.
www.npr.org
May 26, 2026 at 3:34 PM
HMMER, Pfam, and Rfam are critical to so many Bioinformatics pipelines. This is absolutely crazy
This is terrible news, HMMER & Infernal are at the heart of DBs like Pfam, Rfam & Dfam. And vital pipelines such as AlphaFold.
May 29, 2025 at 7:00 AM
This is terrible news, HMMER & Infernal are at the heart of DBs like Pfam, Rfam & Dfam. And vital pipelines such as AlphaFold.
The Pfam protein families database: embracing AI/ML. #Pfam #ProteinDomains #GenomeAnnotation #AI #NAR #Bioinformatics 🧬 🖥️
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
The Pfam protein families database: embracing AI/ML
Abstract. The Pfam protein families database is a comprehensive collection of protein domains and families used for genome annotation and protein structure
academic.oup.com
November 26, 2024 at 12:07 AM
The Pfam protein families database: embracing AI/ML. #Pfam #ProteinDomains #GenomeAnnotation #AI #NAR #Bioinformatics 🧬 🖥️
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
Introducing PhyloDig: a small command-line tool I am developing to make comparative phylogenetic analyses easier.
github.com/davidjhoey/P...
github.com/davidjhoey/P...
GitHub - davidjhoey/PhyloDig: PhyloDig is a command line pipeline for automated homology mining across collections of protein and coding sequence databases. It combines HMMER searches, optional Pfam d...
PhyloDig is a command line pipeline for automated homology mining across collections of protein and coding sequence databases. It combines HMMER searches, optional Pfam domain filtering, and sequen...
github.com
September 16, 2026 at 5:01 PM
Introducing PhyloDig: a small command-line tool I am developing to make comparative phylogenetic analyses easier.
github.com/davidjhoey/P...
github.com/davidjhoey/P...
🧬 What's new in Pfam? Beta propellers uncovered through smart deduplication, fresh perspectives on haloarchaeal proteins, and more! Dive into our latest blog: xfam.wordpress.com/2024/12/09/p...
Pfam 37.1 release
Pfam 37.1 release is now out and accessible through the InterPro website and Pfam ftp. More frequent Pfam updates Historically, Pfam releases occurred approximately once per year. With the de…
xfam.wordpress.com
December 9, 2024 at 9:58 AM
🧬 What's new in Pfam? Beta propellers uncovered through smart deduplication, fresh perspectives on haloarchaeal proteins, and more! Dive into our latest blog: xfam.wordpress.com/2024/12/09/p...
🚀 HUGE NEWS: Pfam 37.4 is LIVE!
318 brand-new protein families + 4 new clans! 🧬
Total collection now: 24,736 entries! 📈
Get exploring via InterPro website, API & Pfam FTP!
💻🧪
318 brand-new protein families + 4 new clans! 🧬
Total collection now: 24,736 entries! 📈
Get exploring via InterPro website, API & Pfam FTP!
💻🧪
June 20, 2025 at 8:47 AM
🚀 HUGE NEWS: Pfam 37.4 is LIVE!
318 brand-new protein families + 4 new clans! 🧬
Total collection now: 24,736 entries! 📈
Get exploring via InterPro website, API & Pfam FTP!
💻🧪
318 brand-new protein families + 4 new clans! 🧬
Total collection now: 24,736 entries! 📈
Get exploring via InterPro website, API & Pfam FTP!
💻🧪
📢InterPro release 105.0 is live!
✨Update to Pfam 37.3, PROSITE patterns 2025_01
PROSITE profiles 2025_01 and HAMAP 2025_01
✨342 new entries
✨Addition of InterPro-N annotations
✨Addition of BFVD structure predictions from @martinsteinegger.bsky.social's lab
Have a look: ebi.ac.uk/interpro/htt...
💻🧪🆕
✨Update to Pfam 37.3, PROSITE patterns 2025_01
PROSITE profiles 2025_01 and HAMAP 2025_01
✨342 new entries
✨Addition of InterPro-N annotations
✨Addition of BFVD structure predictions from @martinsteinegger.bsky.social's lab
Have a look: ebi.ac.uk/interpro/htt...
💻🧪🆕
April 24, 2025 at 4:07 PM
📢InterPro release 105.0 is live!
✨Update to Pfam 37.3, PROSITE patterns 2025_01
PROSITE profiles 2025_01 and HAMAP 2025_01
✨342 new entries
✨Addition of InterPro-N annotations
✨Addition of BFVD structure predictions from @martinsteinegger.bsky.social's lab
Have a look: ebi.ac.uk/interpro/htt...
💻🧪🆕
✨Update to Pfam 37.3, PROSITE patterns 2025_01
PROSITE profiles 2025_01 and HAMAP 2025_01
✨342 new entries
✨Addition of InterPro-N annotations
✨Addition of BFVD structure predictions from @martinsteinegger.bsky.social's lab
Have a look: ebi.ac.uk/interpro/htt...
💻🧪🆕
🚀 InterPro 106.0 is now live!
✨ Updated to Pfam 37.4
✨ 683 new entries added
✨ Enhanced protein classification coverage
Explore the latest annotations and discover new protein insights.
Explore it now: interpro.ebi.ac.uk 💻🧪🧬
#Bioinformatics #ProteinScience #Pfam #EMBLEBI
✨ Updated to Pfam 37.4
✨ 683 new entries added
✨ Enhanced protein classification coverage
Explore the latest annotations and discover new protein insights.
Explore it now: interpro.ebi.ac.uk 💻🧪🧬
#Bioinformatics #ProteinScience #Pfam #EMBLEBI
June 20, 2025 at 8:23 AM
🚀 InterPro 106.0 is now live!
✨ Updated to Pfam 37.4
✨ 683 new entries added
✨ Enhanced protein classification coverage
Explore the latest annotations and discover new protein insights.
Explore it now: interpro.ebi.ac.uk 💻🧪🧬
#Bioinformatics #ProteinScience #Pfam #EMBLEBI
✨ Updated to Pfam 37.4
✨ 683 new entries added
✨ Enhanced protein classification coverage
Explore the latest annotations and discover new protein insights.
Explore it now: interpro.ebi.ac.uk 💻🧪🧬
#Bioinformatics #ProteinScience #Pfam #EMBLEBI
Another feature adding to my terminal plasmid editor is a transcriptome browser. Helps you quickly build blast databases from a heap of transcripts in a single fasta file. Gonna add HMM/Pfam detection and Pfam search. I really love this current rabbit hole of bespoke biovibeware.
April 1, 2026 at 3:35 PM
Another feature adding to my terminal plasmid editor is a transcriptome browser. Helps you quickly build blast databases from a heap of transcripts in a single fasta file. Gonna add HMM/Pfam detection and Pfam search. I really love this current rabbit hole of bespoke biovibeware.
Amazing how far you can push vibecoding if you know what you need and the general theory behind the tool chains needed to get your result. I can now load a transcriptome dataset, find the pfam associated with that transcript, find the CDS that contains said pfam, and check NCBI.
April 2, 2026 at 2:37 AM
Amazing how far you can push vibecoding if you know what you need and the general theory behind the tool chains needed to get your result. I can now load a transcriptome dataset, find the pfam associated with that transcript, find the CDS that contains said pfam, and check NCBI.
🧬 New @EMBL course: "Protein Domains: Structure, Classification & Evolution" - free & online now. CATH, SCOP, Pfam, IDRs + more.
🔗 www.ebi.ac.uk/training/onl...
#StructuralBiology #Bioinformatics #Domains
🔗 www.ebi.ac.uk/training/onl...
#StructuralBiology #Bioinformatics #Domains
July 1, 2026 at 9:09 AM
🧬 New @EMBL course: "Protein Domains: Structure, Classification & Evolution" - free & online now. CATH, SCOP, Pfam, IDRs + more.
🔗 www.ebi.ac.uk/training/onl...
#StructuralBiology #Bioinformatics #Domains
🔗 www.ebi.ac.uk/training/onl...
#StructuralBiology #Bioinformatics #Domains
This is awful to hear, describing how Sean Eddy (HMMER, infernal, pfam, rfam) has been defunded. The letter said his work
"had been determined to be of absolutely no value to the US taxpayer, and therefore it was being specifically terminated,"
www.npr.org/2026/05/21/n...
"had been determined to be of absolutely no value to the US taxpayer, and therefore it was being specifically terminated,"
www.npr.org/2026/05/21/n...
Researchers say the Trump administration is finding new ways to punish science
Even with federal grants largely restored, scientists say the Trump administration is still preventing those funds from reaching them. The consequences, they say, are already becoming clear.
www.npr.org
May 25, 2026 at 5:53 PM
This is awful to hear, describing how Sean Eddy (HMMER, infernal, pfam, rfam) has been defunded. The letter said his work
"had been determined to be of absolutely no value to the US taxpayer, and therefore it was being specifically terminated,"
www.npr.org/2026/05/21/n...
"had been determined to be of absolutely no value to the US taxpayer, and therefore it was being specifically terminated,"
www.npr.org/2026/05/21/n...
Order of amino acid recruitment into the genetic code resolved by last universal common ancestor’s protein domains 🧪
www.pnas.org/doi/10.1073/...
Argues current understanding of how the code evolved is flawed because it relies on misleading laboratory experiments rather than evolutionary evidence.
www.pnas.org/doi/10.1073/...
Argues current understanding of how the code evolved is flawed because it relies on misleading laboratory experiments rather than evolutionary evidence.
December 24, 2024 at 3:32 PM
Order of amino acid recruitment into the genetic code resolved by last universal common ancestor’s protein domains 🧪
www.pnas.org/doi/10.1073/...
Argues current understanding of how the code evolved is flawed because it relies on misleading laboratory experiments rather than evolutionary evidence.
www.pnas.org/doi/10.1073/...
Argues current understanding of how the code evolved is flawed because it relies on misleading laboratory experiments rather than evolutionary evidence.
🔍 Lost in Pfam data? Our redesigned Help page has you covered! From quick answers to deep dives into protein families, find exactly what you need at www.ebi.ac.uk/interpro/help/ 💻🧪
January 24, 2025 at 11:04 AM
🔍 Lost in Pfam data? Our redesigned Help page has you covered! From quick answers to deep dives into protein families, find exactly what you need at www.ebi.ac.uk/interpro/help/ 💻🧪
Pfam protein families database: embracing AI/ML academic.oup.com/nar/advance-... #jcampubs
The Pfam protein families database: embracing AI/ML
Abstract. The Pfam protein families database is a comprehensive collection of protein domains and families used for genome annotation and protein structure
academic.oup.com
November 14, 2024 at 2:15 PM
Pfam protein families database: embracing AI/ML academic.oup.com/nar/advance-... #jcampubs
InterPro release 103.0 is live! 💻🧪
✨Update to Pfam 37.1
✨1029 new entries, including 1019 signatures from the Pfam (1008), NCBIfam (2), PIRSF (1), PANTHER (1), CDD (7) databases.
Have a look: ebi.ac.uk/interpro/
✨Update to Pfam 37.1
✨1029 new entries, including 1019 signatures from the Pfam (1008), NCBIfam (2), PIRSF (1), PANTHER (1), CDD (7) databases.
Have a look: ebi.ac.uk/interpro/
November 29, 2024 at 8:29 AM
InterPro release 103.0 is live! 💻🧪
✨Update to Pfam 37.1
✨1029 new entries, including 1019 signatures from the Pfam (1008), NCBIfam (2), PIRSF (1), PANTHER (1), CDD (7) databases.
Have a look: ebi.ac.uk/interpro/
✨Update to Pfam 37.1
✨1029 new entries, including 1019 signatures from the Pfam (1008), NCBIfam (2), PIRSF (1), PANTHER (1), CDD (7) databases.
Have a look: ebi.ac.uk/interpro/
🔈InterPro release 104.0 is live!
✨Update to Pfam 37.2, NCBIfam 17.0, CDD 3.21.
✨661 new entries, including 682 signatures from the Pfam (663), NCBIfam (5), PANTHER (5), CDD (9) databases. Have a look: ebi.ac.uk/interpro/ 💻🧪
✨Update to Pfam 37.2, NCBIfam 17.0, CDD 3.21.
✨661 new entries, including 682 signatures from the Pfam (663), NCBIfam (5), PANTHER (5), CDD (9) databases. Have a look: ebi.ac.uk/interpro/ 💻🧪
February 6, 2025 at 2:19 PM
🔈InterPro release 104.0 is live!
✨Update to Pfam 37.2, NCBIfam 17.0, CDD 3.21.
✨661 new entries, including 682 signatures from the Pfam (663), NCBIfam (5), PANTHER (5), CDD (9) databases. Have a look: ebi.ac.uk/interpro/ 💻🧪
✨Update to Pfam 37.2, NCBIfam 17.0, CDD 3.21.
✨661 new entries, including 682 signatures from the Pfam (663), NCBIfam (5), PANTHER (5), CDD (9) databases. Have a look: ebi.ac.uk/interpro/ 💻🧪
For the latest Pfam updates, have a look at our recently published paper: The Pfam protein families database: embracing AI/ML
t.co/8auCxw3mdj
t.co/8auCxw3mdj
November 29, 2024 at 9:59 AM
For the latest Pfam updates, have a look at our recently published paper: The Pfam protein families database: embracing AI/ML
t.co/8auCxw3mdj
t.co/8auCxw3mdj
🚀 InterPro 108.0 is live!
✨ Updated to Pfam 38.1 and NCBIFam 18.0
✨ 1,911 InterPro entries
Explore the latest annotations and discover new protein insights.
Explore it now: www.ebi.ac.uk/interpro/
✨ Updated to Pfam 38.1 and NCBIFam 18.0
✨ 1,911 InterPro entries
Explore the latest annotations and discover new protein insights.
Explore it now: www.ebi.ac.uk/interpro/
January 30, 2026 at 7:10 AM
🚀 InterPro 108.0 is live!
✨ Updated to Pfam 38.1 and NCBIFam 18.0
✨ 1,911 InterPro entries
Explore the latest annotations and discover new protein insights.
Explore it now: www.ebi.ac.uk/interpro/
✨ Updated to Pfam 38.1 and NCBIFam 18.0
✨ 1,911 InterPro entries
Explore the latest annotations and discover new protein insights.
Explore it now: www.ebi.ac.uk/interpro/