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A subpopulation of Higd1b+ lung capillary pericytes
👉Migrate to distal arteriole
👉Upregulate Vimentin
👉Acquire #SmoothMuscleCell identity (α-SMA, circumferential wrapping)
in🐭Hypoxic PH
#SciArt
Ke Yuan lab @embojournal.org 2025
www.embopress.org/doi/full/10....
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A subpopulation of Higd1b+ lung capillary pericytes
👉Migrate to distal arteriole
👉Upregulate Vimentin
👉Acquire #SmoothMuscleCell identity (α-SMA, circumferential wrapping)
in🐭Hypoxic PH
#SciArt
Ke Yuan lab @embojournal.org 2025
www.embopress.org/doi/full/10....
Any #PHpeeps here?
Is there anybooodyyy?? 😅
#ThePeoplesVentricle
Any #PHpeeps here?
Is there anybooodyyy?? 😅
#ThePeoplesVentricle
Welcome! 🎊🎉🎊🎉🎊🎉
@rjbernardomd.bsky.social @rrvdpool.bsky.social @khodrtello.bsky.social @albertaphdoc.bsky.social
Please feel free to tag those that I must have surely forgotten 😅
Welcome! 🎊🎉🎊🎉🎊🎉
@rjbernardomd.bsky.social @rrvdpool.bsky.social @khodrtello.bsky.social @albertaphdoc.bsky.social
Please feel free to tag those that I must have surely forgotten 😅
Here's new evidence for CA9 (+CA12) in human pulmonary arterial #SmoothMuscleCell & 🐭#PulmonaryHypertension (S4, CA9/CA12 dual inhibitor) 😎
#AJRCMB 2026
academic.oup.com/ajrcmb/advan...
Here's new evidence for CA9 (+CA12) in human pulmonary arterial #SmoothMuscleCell & 🐭#PulmonaryHypertension (S4, CA9/CA12 dual inhibitor) 😎
#AJRCMB 2026
academic.oup.com/ajrcmb/advan...
10 iPAH + 20 SSc-PAH + 4 chronic thromboembolic PH + 30 healthy Ctrl
5 Smooth muscle cell states
Contractile
VCAN-/APOE-hi
FLNA-/XIST-hi
ATF3-/SOCS3-hi
Cox4I2-/TMSB4X-hi
#ATVB 2026
www.ahajournals.org/doi/10.1161/...
10 iPAH + 20 SSc-PAH + 4 chronic thromboembolic PH + 30 healthy Ctrl
5 Smooth muscle cell states
Contractile
VCAN-/APOE-hi
FLNA-/XIST-hi
ATF3-/SOCS3-hi
Cox4I2-/TMSB4X-hi
#ATVB 2026
www.ahajournals.org/doi/10.1161/...
NK (Ncr-iCre) TGFβRII KO ▶️
Normal🫁
👉⏬Arteriolar vol
👉 #PulmonaryHypertension
👉Postnatal alveolar dilation ⏬Inflation compliance ♂️only
Hyperoxic 🫁 👉Rescue #BronchoPulmonaryDysplasia
TGFβ deficiency➡️
⏫senolytic NK➡️
⏬ #Senescence🫁
www.biorxiv.org/content/10.1...
NK (Ncr-iCre) TGFβRII KO ▶️
Normal🫁
👉⏬Arteriolar vol
👉 #PulmonaryHypertension
👉Postnatal alveolar dilation ⏬Inflation compliance ♂️only
Hyperoxic 🫁 👉Rescue #BronchoPulmonaryDysplasia
TGFβ deficiency➡️
⏫senolytic NK➡️
⏬ #Senescence🫁
www.biorxiv.org/content/10.1...
Difference is dosing. PH doses are smaller
Difference is dosing. PH doses are smaller
📈 #HFpEF is the dominant form of #HF, with morbidity and survival rates similar to #HFrEF.
Check out: #EchoFirst algorithm, #LeftAtrial dysfunction, #PulmonaryHypertension, #RV dysfunction.
Read more 👉 doi.org/10.1093/ehjc...
#CardioSky @jgrapsa.bsky.social
📈 #HFpEF is the dominant form of #HF, with morbidity and survival rates similar to #HFrEF.
Check out: #EchoFirst algorithm, #LeftAtrial dysfunction, #PulmonaryHypertension, #RV dysfunction.
Read more 👉 doi.org/10.1093/ehjc...
#CardioSky @jgrapsa.bsky.social
Personally I'd like to talk about #PulmonaryHypertension, #RightVentricle aka #ThePeoplesVentricle & #PulmonaryEmbolism
Also #vaccines, #HealthcareIsAHumanRight, #ReproductiveHealth, #TransRights, #BLM & the #ClimateEmergency as public health issues
& the broken publishing industry
Personally I'd like to talk about #PulmonaryHypertension, #RightVentricle aka #ThePeoplesVentricle & #PulmonaryEmbolism
Also #vaccines, #HealthcareIsAHumanRight, #ReproductiveHealth, #TransRights, #BLM & the #ClimateEmergency as public health issues
& the broken publishing industry
#EndMT
#Atherosclerosis
#VascularCalcification
#PeripheralArteryDisease
#PulmonaryHypertension
#ValvularHeartDisease
#MyocardialInfarction
#CardiacFibrosis
Krishna Singh lab #IJMS_MDPI 2024
www.mdpi.com/1422-0067/25...
#EndMT
#Atherosclerosis
#VascularCalcification
#PeripheralArteryDisease
#PulmonaryHypertension
#ValvularHeartDisease
#MyocardialInfarction
#CardiacFibrosis
Krishna Singh lab #IJMS_MDPI 2024
www.mdpi.com/1422-0067/25...
Welcome! 🎊🎉🎊🎉🎊🎉
@rjbernardomd.bsky.social @rrvdpool.bsky.social @khodrtello.bsky.social @albertaphdoc.bsky.social
Please feel free to tag those that I must have surely forgotten 😅
I'll join Hall Skaara from phaeurope.org, Mona Lichtblau & @simonoxfphys.com to discuss what's #ClimateChange & how it affects #patients and #carers with #PH
🗓️ 7 May 2025
⏰ 6 pm CET
🌐 Register to belaircenter.info & join
I'll join Hall Skaara from phaeurope.org, Mona Lichtblau & @simonoxfphys.com to discuss what's #ClimateChange & how it affects #patients and #carers with #PH
🗓️ 7 May 2025
⏰ 6 pm CET
🌐 Register to belaircenter.info & join
www.scilifelab.se/news/combini...
www.scilifelab.se/news/combini...
- Group 1 - Pulmonary Arterial Hypertension- genetic or congenital/early onset heart diseases or lupus
- Group 2 - caused by left-sided #heart failure
- Group 3 - caused by lung disease (including OSA)
- Group 1 - Pulmonary Arterial Hypertension- genetic or congenital/early onset heart diseases or lupus
- Group 2 - caused by left-sided #heart failure
- Group 3 - caused by lung disease (including OSA)
#DisabilitySolidarity
Join #PHA’s “PH Plus” Facebook support group to connect with others and find support.
Join now: buff.ly/mvPrZQV
#DisabilitySolidarity
In this podcast, discover how Sheffield’s doctors and engineers helped change that. Their work in the 1800s led to treatments that save lives today.
🎧 Listen here: bit.ly/3GBGdFl
#MedicalHistory #Sheffield #PulmonaryHypertension
In this podcast, discover how Sheffield’s doctors and engineers helped change that. Their work in the 1800s led to treatments that save lives today.
🎧 Listen here: bit.ly/3GBGdFl
#MedicalHistory #Sheffield #PulmonaryHypertension
@atscommunity.bsky.social #PulmonaryHypertension
www.atsjournals.org/doi/full/10....
@atscommunity.bsky.social #PulmonaryHypertension
www.atsjournals.org/doi/full/10....
Check out this fascinating paper: publications.ersnet.org/content/erj/...
We will be discussing it Thursday during the #PVRI Community call at 10am EST
Register here 👇
pvrinstitute.org/learning-hub...
#PCCM #CardioSky
Check out this fascinating paper: publications.ersnet.org/content/erj/...
We will be discussing it Thursday during the #PVRI Community call at 10am EST
Register here 👇
pvrinstitute.org/learning-hub...
#PCCM #CardioSky
Parameters related to the #PulmonaryArtery stiffness-right ventricular interplay may be significant predictors of mortality in patients with #PulmonaryHypertension. #PulmSky
Parameters related to the #PulmonaryArtery stiffness-right ventricular interplay may be significant predictors of mortality in patients with #PulmonaryHypertension. #PulmSky