Join us for the ISPG Members' Meetup on March 26th!
Dr. Oliver Pain will present his groundbreaking research on polygenic scores and the innovative GenoPred pipeline.
Don't miss out: us06web.zoom.us/meeting/regi...
#ISPG #Genetics #PolygenicScores #Bioinformatics
Dr. Oliver Pain will present his groundbreaking research on polygenic scores and the innovative GenoPred pipeline.
Don't miss out: us06web.zoom.us/meeting/regi...
#ISPG #Genetics #PolygenicScores #Bioinformatics
March 23, 2025 at 1:25 AM
Join us for the ISPG Members' Meetup on March 26th!
Dr. Oliver Pain will present his groundbreaking research on polygenic scores and the innovative GenoPred pipeline.
Don't miss out: us06web.zoom.us/meeting/regi...
#ISPG #Genetics #PolygenicScores #Bioinformatics
Dr. Oliver Pain will present his groundbreaking research on polygenic scores and the innovative GenoPred pipeline.
Don't miss out: us06web.zoom.us/meeting/regi...
#ISPG #Genetics #PolygenicScores #Bioinformatics
6/n SNP-based #heritability of depression was comparable to previous studies (h2=8.4%).
#Polygenicscores for depression showed higher predictive accuracies than before (R2=5.8%), esp. in clinical/healthcare samples and participants of European ancestry.
#Polygenicscores for depression showed higher predictive accuracies than before (R2=5.8%), esp. in clinical/healthcare samples and participants of European ancestry.
January 14, 2025 at 5:31 PM
6/n SNP-based #heritability of depression was comparable to previous studies (h2=8.4%).
#Polygenicscores for depression showed higher predictive accuracies than before (R2=5.8%), esp. in clinical/healthcare samples and participants of European ancestry.
#Polygenicscores for depression showed higher predictive accuracies than before (R2=5.8%), esp. in clinical/healthcare samples and participants of European ancestry.
Some individuals defy their polygenic score.
One explanation for their deviation may be a burden of rare variants with large effect.
To find out more, explore our ✨INTERACTIVE✨ graphic abstract here: nikbaya.github.io/phenotype_de...
#Genetics #RareDisease #PolygenicScores #SciComm #DataViz
One explanation for their deviation may be a burden of rare variants with large effect.
To find out more, explore our ✨INTERACTIVE✨ graphic abstract here: nikbaya.github.io/phenotype_de...
#Genetics #RareDisease #PolygenicScores #SciComm #DataViz
June 24, 2026 at 1:54 PM
Some individuals defy their polygenic score.
One explanation for their deviation may be a burden of rare variants with large effect.
To find out more, explore our ✨INTERACTIVE✨ graphic abstract here: nikbaya.github.io/phenotype_de...
#Genetics #RareDisease #PolygenicScores #SciComm #DataViz
One explanation for their deviation may be a burden of rare variants with large effect.
To find out more, explore our ✨INTERACTIVE✨ graphic abstract here: nikbaya.github.io/phenotype_de...
#Genetics #RareDisease #PolygenicScores #SciComm #DataViz
🧬 PRSs in practice (4/5): Lower-risk PRS results — false reassurance, or false assumption?
A common concern is that lower-risk PRS results cause false reassurance. But evidence & theory do not support this.
Read my paper with @mikeinouye.bsky.social here👉 rdcu.be/eNeKN
#Genomics #PolygenicScores
A common concern is that lower-risk PRS results cause false reassurance. But evidence & theory do not support this.
Read my paper with @mikeinouye.bsky.social here👉 rdcu.be/eNeKN
#Genomics #PolygenicScores
November 10, 2025 at 9:50 AM
🧬 PRSs in practice (4/5): Lower-risk PRS results — false reassurance, or false assumption?
A common concern is that lower-risk PRS results cause false reassurance. But evidence & theory do not support this.
Read my paper with @mikeinouye.bsky.social here👉 rdcu.be/eNeKN
#Genomics #PolygenicScores
A common concern is that lower-risk PRS results cause false reassurance. But evidence & theory do not support this.
Read my paper with @mikeinouye.bsky.social here👉 rdcu.be/eNeKN
#Genomics #PolygenicScores
💡 Special Communication: In psychiatry, #PolygenicScores, rare variant testing, and #Pharmacogenomics may have value when used selectively to inform diagnosis, prognosis, monitoring, and medication safety rather than population-wide screening.
ja.ma/3UD8l1I
ja.ma/3UD8l1I
September 6, 2026 at 2:36 PM
💡 Special Communication: In psychiatry, #PolygenicScores, rare variant testing, and #Pharmacogenomics may have value when used selectively to inform diagnosis, prognosis, monitoring, and medication safety rather than population-wide screening.
ja.ma/3UD8l1I
ja.ma/3UD8l1I
#PolygenicScores: What They Mean for #Aging and #Disability - Learn how #polygenic risk scores work, what they predict, and why they matter for #seniors facing age-related #diseases and #disabilities - www.disabled-world.com/disability/p...
Polygenic Scores: What They Mean for Aging and Disability
Learn how polygenic risk scores work, what they predict, and why they matter for seniors facing age-related diseases and disabilities.
www.disabled-world.com
February 23, 2026 at 7:44 PM
#PolygenicScores: What They Mean for #Aging and #Disability - Learn how #polygenic risk scores work, what they predict, and why they matter for #seniors facing age-related #diseases and #disabilities - www.disabled-world.com/disability/p...
🚨 NEW research⚕️ 🩺
http://dlvr.it/TVMJvV
Byg et al. examine whether PRS for birthweight on adult cardiometabolic risk depend on phenotypic birthweight.
#PolygenicScores #Birthweight #CardiometabolicRisk
http://dlvr.it/TVMJvV
Byg et al. examine whether PRS for birthweight on adult cardiometabolic risk depend on phenotypic birthweight.
#PolygenicScores #Birthweight #CardiometabolicRisk
Birthweight phenotype genotype mismatch in cardiometabolic programming - Communications Medicine
Byg et al., examine whether polygenic scores for birthweight on adult cardiometabolic risk depend on the phenotypic birthweight. The effects of birthweight genes on insulin resistance and BMI changed according to birthweight phenotype, suggesting an increased cardiometabolic risk when there is a birthweight phenotype genotype mismatch.
dlvr.it
September 7, 2026 at 7:20 AM
🚨 NEW research⚕️ 🩺
http://dlvr.it/TVMJvV
Byg et al. examine whether PRS for birthweight on adult cardiometabolic risk depend on phenotypic birthweight.
#PolygenicScores #Birthweight #CardiometabolicRisk
http://dlvr.it/TVMJvV
Byg et al. examine whether PRS for birthweight on adult cardiometabolic risk depend on phenotypic birthweight.
#PolygenicScores #Birthweight #CardiometabolicRisk
Dr Emma Meaburn explains what preimplantation genetic testing for complex traits (PGT-P) is, what polygenic scores are and what information they can/can’t provide us Read in BioNews: www.progress.org.uk/polygenic-sc...
#PGT-P #DNA #ComplexTraits #Genetics #GeneticDisease #Health #PolygenicScores
#PGT-P #DNA #ComplexTraits #Genetics #GeneticDisease #Health #PolygenicScores
August 20, 2025 at 10:23 AM
Dr Emma Meaburn explains what preimplantation genetic testing for complex traits (PGT-P) is, what polygenic scores are and what information they can/can’t provide us Read in BioNews: www.progress.org.uk/polygenic-sc...
#PGT-P #DNA #ComplexTraits #Genetics #GeneticDisease #Health #PolygenicScores
#PGT-P #DNA #ComplexTraits #Genetics #GeneticDisease #Health #PolygenicScores
JJS "the tech itrn of #TheHumanDiversityFoundation is called #polygenicscores, also pointed out in the piece. it is the same small circle of horrible ghouls. wld it surprise you that #ThePioneerFund was big on getting grants for #FAIR/ #thetantonnetwork? ofc not"
#Arday
bsky.app/profile/supr...
#Arday
bsky.app/profile/supr...
ohhh the human diversity foundation. literally (as the article points out) a rebranded pioneer fund (us eugenics org that began contemporaneous with nazi germany)
I don't think people understand the extent to which this has been a decade plus long billionaire funded campaign (obviously Thiel is involved). We've tried to ring the alarm about these eugenicists but it is too easy for them to get parroted by the mainstream media.
bylinetimes.com/2026/08/18/t...
bylinetimes.com/2026/08/18/t...
August 19, 2026 at 6:14 AM
JJS "the tech itrn of #TheHumanDiversityFoundation is called #polygenicscores, also pointed out in the piece. it is the same small circle of horrible ghouls. wld it surprise you that #ThePioneerFund was big on getting grants for #FAIR/ #thetantonnetwork? ofc not"
#Arday
bsky.app/profile/supr...
#Arday
bsky.app/profile/supr...
In a cohort study, #PolygenicScores identified more patients at risk for #ADHD, #Depression, and #Schizophrenia than recurrent copy number variants, while both methods were complementary for risk assessment in #Autism. ja.ma/4h3t0Fg
Variants and Psychiatric Outcomes in the Context of Polygenic Scores
This genetic association study evaluates the association of recurrent copy number variants and polygenic scores with genetic risk factors for psychiatric disorders in the population.
ja.ma
August 14, 2026 at 11:00 AM
In a cohort study, #PolygenicScores identified more patients at risk for #ADHD, #Depression, and #Schizophrenia than recurrent copy number variants, while both methods were complementary for risk assessment in #Autism. ja.ma/4h3t0Fg
Embryonic Selection by #PolygenicScores & #Disability - #EmbryonicSelection is the process by which one or more #embryos created through in #vitrofertilization are evaluated and chosen based on specific #genetic or #chromosomal criteria - www.disabled-world.com/disability/p...
Embryonic Selection by Polygenic Scores and Disability
Explore how embryonic selection based on polygenic scores works, its connection to disability rights, and the scientific and ethical debate shaping its future.
www.disabled-world.com
February 23, 2026 at 9:03 PM
Embryonic Selection by #PolygenicScores & #Disability - #EmbryonicSelection is the process by which one or more #embryos created through in #vitrofertilization are evaluated and chosen based on specific #genetic or #chromosomal criteria - www.disabled-world.com/disability/p...
Research published in Intelligence explores the power of polygenic scores to predict intelligence, finding that these genetic estimates explain about 6% of IQ variation. #Genetics #IQ #Intelligence #PolygenicScores #Research
How well can genetic scores predict IQ? Here’s what the latest research reveals
Research published in Intelligence explores the power of polygenic scores to predict intelligence, finding that these genetic estimates explain about 6% of IQ variation.
www.psypost.org
January 1, 2025 at 4:13 PM
Research published in Intelligence explores the power of polygenic scores to predict intelligence, finding that these genetic estimates explain about 6% of IQ variation. #Genetics #IQ #Intelligence #PolygenicScores #Research
🧬 I’ve started a series on polygenic risk scores (PRSs) in healthcare practice, from my new paper with @mikeinouye.bsky.social in @nathumbehav.nature.com.
Yesterday’s post was on public understanding.
Tomorrow: do higher-risk PRS results cause distress?
👉 rdcu.be/eNeKN
#Genomics #PolygenicScores
Yesterday’s post was on public understanding.
Tomorrow: do higher-risk PRS results cause distress?
👉 rdcu.be/eNeKN
#Genomics #PolygenicScores
Psychological and behavioural considerations for integrating polygenic risk scores for disease into clinical practice
Nature Human Behaviour - The application of polygenic risk scores (PRSs) in clinical practice has advanced but also received criticism. In this Perspective, major psychological and behavioural...
rdcu.be
November 4, 2025 at 11:03 AM
🧬 I’ve started a series on polygenic risk scores (PRSs) in healthcare practice, from my new paper with @mikeinouye.bsky.social in @nathumbehav.nature.com.
Yesterday’s post was on public understanding.
Tomorrow: do higher-risk PRS results cause distress?
👉 rdcu.be/eNeKN
#Genomics #PolygenicScores
Yesterday’s post was on public understanding.
Tomorrow: do higher-risk PRS results cause distress?
👉 rdcu.be/eNeKN
#Genomics #PolygenicScores
#GWAS
#polygenicscores
Meta-analysis to be taken with a large pinch of salt, imo.
Correlations are small, and "Common genetic variants explain a moderate 4.8–9.3% of the variance in measures of each trait, and 9.3–13.3% among instruments with typical measurement reliability."
#polygenicscores
Meta-analysis to be taken with a large pinch of salt, imo.
Correlations are small, and "Common genetic variants explain a moderate 4.8–9.3% of the variance in measures of each trait, and 9.3–13.3% among instruments with typical measurement reliability."
A study of more than one million people has uncovered around 1,200 genetic variants that are associated with personality traits.
go.nature.com/4gMyEd4
go.nature.com/4gMyEd4
Anxious or outgoing? Huge study links ‘Big Five’ personality traits to genetic variants
Researchers identify more than 1,200 personality-linked genetic variants, with effects largely independent of family background.
go.nature.com
September 3, 2026 at 12:38 PM
#GWAS
#polygenicscores
Meta-analysis to be taken with a large pinch of salt, imo.
Correlations are small, and "Common genetic variants explain a moderate 4.8–9.3% of the variance in measures of each trait, and 9.3–13.3% among instruments with typical measurement reliability."
#polygenicscores
Meta-analysis to be taken with a large pinch of salt, imo.
Correlations are small, and "Common genetic variants explain a moderate 4.8–9.3% of the variance in measures of each trait, and 9.3–13.3% among instruments with typical measurement reliability."
In a cohort study, #PolygenicScores identified more patients at risk for #ADHD, #Depression, and #Schizophrenia than recurrent copy number variants, while both methods were complementary for risk assessment in #Autism. ja.ma/4gBALkZ
Variants and Psychiatric Outcomes in the Context of Polygenic Scores
This genetic association study evaluates the association of recurrent copy number variants and polygenic scores with genetic risk factors for psychiatric disorders in the population.
ja.ma
August 24, 2026 at 12:00 PM
In a cohort study, #PolygenicScores identified more patients at risk for #ADHD, #Depression, and #Schizophrenia than recurrent copy number variants, while both methods were complementary for risk assessment in #Autism. ja.ma/4gBALkZ
"a PRS is not an internal predisposition waiting to be realized; it is a risk estimate derived from a model constructed from population-level DNA associations without clearly defined biological mechanisms."
With @remyfurrer.bsky.social, a new piece in Nature Human Behavior. The standard description of a polygenic score as a "genetic predisposition" essentializes a statistical construct. It's not language policing: PGS are a new kind of entity; now is the time to think carefully about what they are.
May 18, 2026 at 1:47 PM
Read More at academy.socos.org/architecting...
#Genetics #TheTaxOnBeingDifferent #EducationPolicy #PolygenicScores #NatureVsNurture
#Genetics #TheTaxOnBeingDifferent #EducationPolicy #PolygenicScores #NatureVsNurture
Architecting Meta-Learning [RR]
We must stop trying to teach meta-learning and start architecting environments that force it to emerge.
<<Support my work: book a keynote or briefing!>> Want to support my work but don't need a keyno...
academy.socos.org
November 26, 2025 at 3:13 PM
In a cohort study, #PolygenicScores identified more patients at risk for #ADHD, #Depression, and #Schizophrenia than recurrent copy number variants, while both methods were complementary for risk assessment in #Autism.
ja.ma/4eemQjD
ja.ma/4eemQjD
June 1, 2026 at 1:23 PM
In a cohort study, #PolygenicScores identified more patients at risk for #ADHD, #Depression, and #Schizophrenia than recurrent copy number variants, while both methods were complementary for risk assessment in #Autism.
ja.ma/4eemQjD
ja.ma/4eemQjD
#obesity #polygenicscores
“..international team of researchers created a genetic test called a polygenic risk score that predicts adulthood obesity already in early childhood. Genetic tests can now predict childhood obesity, especially in whites—and could be employed to sharply curtail it…”
“..international team of researchers created a genetic test called a polygenic risk score that predicts adulthood obesity already in early childhood. Genetic tests can now predict childhood obesity, especially in whites—and could be employed to sharply curtail it…”
Genetic tests can now predict childhood obesity, especially in whites—and could be employed to sharply curtail it
What if we could prevent people from developing obesity? The World Obesity Federation expects more than half the global population to develop overweight
geneticliteracyproject.org
July 25, 2025 at 4:20 PM
#obesity #polygenicscores
“..international team of researchers created a genetic test called a polygenic risk score that predicts adulthood obesity already in early childhood. Genetic tests can now predict childhood obesity, especially in whites—and could be employed to sharply curtail it…”
“..international team of researchers created a genetic test called a polygenic risk score that predicts adulthood obesity already in early childhood. Genetic tests can now predict childhood obesity, especially in whites—and could be employed to sharply curtail it…”
Imputation and polygenic score performance of low coverage whole-genome sequencing and genotyping arrays in diverse human populations
Duong, H. H.-T. et al.
Paper
Details
#GenomicImputation #PolygenicScores #DiversePopulations
Duong, H. H.-T. et al.
Paper
Details
#GenomicImputation #PolygenicScores #DiversePopulations
July 23, 2025 at 4:03 PM
Imputation and polygenic score performance of low coverage whole-genome sequencing and genotyping arrays in diverse human populations
Duong, H. H.-T. et al.
Paper
Details
#GenomicImputation #PolygenicScores #DiversePopulations
Duong, H. H.-T. et al.
Paper
Details
#GenomicImputation #PolygenicScores #DiversePopulations
PGS Browser: a public platform for personalized polygenic score interpretation
Aavikko, M., Artomov, M. et al.
Paper
Details
#PGSBrowser #PersonalizedMedicine #PolygenicScores
Aavikko, M., Artomov, M. et al.
Paper
Details
#PGSBrowser #PersonalizedMedicine #PolygenicScores
July 6, 2025 at 9:02 AM
PGS Browser: a public platform for personalized polygenic score interpretation
Aavikko, M., Artomov, M. et al.
Paper
Details
#PGSBrowser #PersonalizedMedicine #PolygenicScores
Aavikko, M., Artomov, M. et al.
Paper
Details
#PGSBrowser #PersonalizedMedicine #PolygenicScores
Interpretation of #PolygenicScores for educational attainment can be clouded by racism, classism, and ableism bit.ly/43VuBq3 #ELSI #SocioGenomics
March 21, 2025 at 5:07 PM
Interpretation of #PolygenicScores for educational attainment can be clouded by racism, classism, and ableism bit.ly/43VuBq3 #ELSI #SocioGenomics
🚨 PGC African Monthly Meeting Alert!
We are delighted to have Mr. Morné Du Plessis from @suhealthsci.bsky.social joining us for this month's virtual PGC Africa meeting
📆 26th March 2026
⏰ 2PM GMT/3PM WAT/4PM SAST/5PM EAT/9AM EST
📣 Details in the flyer below
#PGCAfrica #PolygenicScores #PTSD
We are delighted to have Mr. Morné Du Plessis from @suhealthsci.bsky.social joining us for this month's virtual PGC Africa meeting
📆 26th March 2026
⏰ 2PM GMT/3PM WAT/4PM SAST/5PM EAT/9AM EST
📣 Details in the flyer below
#PGCAfrica #PolygenicScores #PTSD
March 24, 2026 at 2:46 PM
🚨 PGC African Monthly Meeting Alert!
We are delighted to have Mr. Morné Du Plessis from @suhealthsci.bsky.social joining us for this month's virtual PGC Africa meeting
📆 26th March 2026
⏰ 2PM GMT/3PM WAT/4PM SAST/5PM EAT/9AM EST
📣 Details in the flyer below
#PGCAfrica #PolygenicScores #PTSD
We are delighted to have Mr. Morné Du Plessis from @suhealthsci.bsky.social joining us for this month's virtual PGC Africa meeting
📆 26th March 2026
⏰ 2PM GMT/3PM WAT/4PM SAST/5PM EAT/9AM EST
📣 Details in the flyer below
#PGCAfrica #PolygenicScores #PTSD